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23 Possible Causes for Neuronal Loss and Gliosis in the Inferior Olives, Truncal Ataxia

  • Olivopontocerebellar Atrophy

    There is neuronal loss and gliosis in the inferior olives, pons, cerebellum, substantia nigra, locus ceruleus, striatum and the intermediolateral column of the spinal cord[dizziness-and-balance.com] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] Neuropathological examination reveals loss of normal pigmentation in the substantia nigra, OPCA (atrophy of the cerebellum, basis pontis, and inferior olives), and atrophy[neuropathology-web.org]

  • Cerebellar Ataxia

    , hypotonia and cerebellar dysfunction (nystagmus, ataxic gait, truncal ataxia, dysarthric speech and intention tremor), associated with cerebellar hypoplasia.[orpha.net] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] Key points • The peak incidence of acute cerebellar ataxia is in children between 2 and 4 years old, most commonly presenting as truncal, rather than extremity, ataxia. •[medlink.com]

  • Friedreich Ataxia

    The clinical picture consisted of progressive spastic gait, truncal and limb ataxia, dysarthria, nystagmus, hyperreflexia with knee and ankle clonus and extensor plantar response[ncbi.nlm.nih.gov] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] Ataxia (truncal and limb), lower extremity weakness, and sensory loss is progressive and gradually extends from distal to proximal [6] [8].[physio-pedia.com]

  • Ataxia

    […] and presence of subtle truncal ataxia.[ncbi.nlm.nih.gov] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] In addition, mild secondary neuronal cell loss with gliosis was noted in the dentate nucleus and inferior olive.[jneuroinflammation.com]

  • Hereditary Cerebellar Degeneration

    This is another indication of appendicular ataxia. Tests for Truncal Ataxia Truncal ataxia presents as an unsteady gait.[kenhub.com] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] A degenerative process in the midline cerebellum can thus result in the following findings: Gait ataxia (especially difficulty with tandem gait) Imbalance Truncal ataxia Dysmetria[clinicaladvisor.com]

  • Paraneoplastic Neurologic Syndrome

    Treatment with plasmapheresis was successful to improve limb/truncal ataxia, dysarthria, and neuro-otological findings.[jstage.jst.go.jp] In addition, mild secondary neuronal cell loss with gliosis was noted in the dentate nucleus and inferior olive.[jneuroinflammation.com] In opsoclonus-myoclonus syndrome, the abnormal eye movements are associated with arrhythmic action myoclonus that involves trunk, limbs, and head, along with truncal ataxia[bloodjournal.org]

  • Cerebellar Ataxia with Peripheral Neuropathy Type 2

    The vermis is concerned with midline and truncal position and receives input from the spinal cord. Dysfunction is noted by postural instability and gait ataxia.[medexam.net] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] A degenerative process in the midline cerebellum can thus result in the following findings: Gait ataxia (especially difficulty with tandem gait) Imbalance Truncal ataxia Dysmetria[clinicaladvisor.com]

  • Autosomal Recessive Spinocerebellar Ataxia

    SCAR16 is characterized by truncal and limb ataxia resulting in gait instability.[uniprot.org] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] Ataxia, both truncal and cerebellar, is present. Mobility is impaired from early childhood and eventually requires assistance.[disorders.eyes.arizona.edu]

  • Autosomal Recessive Spinocerebellar Ataxia 8

    Typical clinical signs and symptoms of autosomal dominant ataxias (ADCA) include the following: Limb and truncal ataxia Hyperreflexia and spasticity (pyramidal signs) are[centogene.com] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] Though truncal ataxia and gait speed on SARA were sustained at 12 weeks, there was no continued decrease in the number of falls.[movementdisorders.org]

  • Spinocerebellar Ataxia Type 5

    ataxia, slow saccades, wheelchair bound Cerebellar dysarthria, limb and truncal ataxia Saccadic speech, dysphagia, slow saccades, limb and truncal ataxia, titubation, hyporeflexia[movementdisorders.org] loss and gliosis.[link.springer.com] Though truncal ataxia and gait speed on SARA were sustained at 12 weeks, there was no continued decrease in the number of falls.[movementdisorders.org]

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