Neutropenia: Causes & Reasons

Possible Causes for Neutropenia

[…] idiopathic neutropenia and primary autoimmune neutropenia. [symptoma.com]

The term idiopathic neutropenia describes various types of neutropenia that may occur at any point in life for unknown reasons. [scnir-neutropenia.uw.edu]

Fitz-Hugh and Krumbharr5 reported a case of chronic neutropenia in which the cellular [jamanetwork.com]

Shwachman Syndrome

[…] chronic neutropenia (SCN). [bone-marrow-failure-syndromes.de]

We report a boy affected by Shwachman syndrome (SS) who presented severe neutropenia and frequent suppurative infections, which we treated successfully with granulocyte colony-stimulating [ncbi.nlm.nih.gov]

Hematopoietic stem cell transplantation in severe congenital neutropenia: experience of the French SCN register. [doi.org]

Glycogen Storage Disease

Increasing glucose requirements, worsening lipid profile, neutropenia associated with multiple infections, and anemia were noted. [ncbi.nlm.nih.gov]

Neutropenia is characteristically seen in GSD type Ib. All content herein referring to type I GSD includes type Ia and type Ib unless stated otherwise. [bestpractice.bmj.com]

Presence of neutropenia further confirms GSD Ib. Even critical hypoglycaemia can be clinically unapparent in affected children. [ncbi.nlm.nih.gov]

Felty Syndrome

Neutropenia is also common in systemic lupus erythematosus and it is included in the current systemic lupus classification criteria. [ncbi.nlm.nih.gov]

A durable remission was achieved without complication, despite persistent severe peripheral neutropenia. [ncbi.nlm.nih.gov]

Abstract The mechanism of neutropenia in Felty's Syndrome (FS) was tested. [jci.org]

Agammaglobulinemia

His neutropenia was initially treated with GCSF. [frontiersin.org]

The mechanism of neutropenia is poorly understood. [pediatrics.aappublications.org]

[…] the combination of antibody deficiency and neutropenia. [frontiersin.org]

Cyclic Neutropenia

[…] diminished number of neutrophils in the blood. cyclic neutropenia periodic neutropenia. [medical-dictionary.thefreedictionary.com]

Cyclic neutropenia is a rare hematologic disorder, characterized by repetitive episodes of fever, mouth ulcers, and infections attributable to recurrent severe neutropenia [iths.pure.elsevier.com]

Cyclic neutropenia is characterized by periodic episodes of neutropenia that are often associated with infectious complications. [ncbi.nlm.nih.gov]

Hypersplenism

Primary causes are idiopathic thrombocytopenic purpura, congenital hemolytic anaemia and primary splenic neutropenia or pancytopenia. [explainmedicine.com]

Some of these—anemia, neutropenia, and thrombocytopenia—are attributed to hypersplenism. [annals.org]

More than half of cirrhotics will have low platelet counts, but neutropenia is much less common. [arizona.pure.elsevier.com]

Chédiak-Higashi Syndrome

Abstract Neutropenia is an almost constant feature of Chediak-Higashi syndrome (CHS). There is evidence for a central mechanism of neutropenia. [unboundmedicine.com]

Chédiak-Higashi syndrome (C-HS) is a rare congenital disease characterized by defective neutrophil function with abnormal lysosomal inclusions, neutropenia, and reduced chemotaxis [ncbi.nlm.nih.gov]

For less clear reasons, neutropenia and a peripheral neuropathy result. [pathwaymedicine.org]

Agranulocytosis

A case of profound neutropenia and agranulocytosis associated with the off-label use of ceftaroline is reported. [ncbi.nlm.nih.gov]

Neutropenia. Dipyrone. Incidence. Case-control studies. [scielo.br]

Benign familial leukopenia and neutropenia in different ethnic groups. Eur J Haematol 1988 ; 41 : 273 –7. ↵ Kuno E, Rothbard AB. [pmj.bmj.com]

Myelodysplasia

Abstract X-linked neutropenia (XLN) is a rare form of Congenital Neutropenia (CN) caused by inherited gain-of-function mutations of WAS. [ncbi.nlm.nih.gov]

Neutropenia Neutropenia often occurs and is variable in severity. [patient.info]

Neutropenia Neutropenia occurs in nearly 50% of newly diagnosed patients with MDS, including 70-80% of higher-risk MDS patients, and 15-20% of lower-risk MDS patients. [haematologica.org]

Congenital Neutropenia

Note Severe chronic neutropenia (SCN) is a heterogeneous group of disorders characterized by chronic neutropenia and serious recurrent infections. [atlasgeneticsoncology.org]

The 2 main forms of hereditary neutropenia are cyclic (CN) and severe congenital (SCN) neutropenia. [ncbi.nlm.nih.gov]

Severe congenital neutropenia What every physician needs to know: Severe congenital neutropenia (SCN) is a rare heterogenous disorder characterized by chronic severe neutropenia [cancertherapyadvisor.com]

Post-Polycythemia Vera Myelofibrosis

Later he developed leukopenia and pancytopenia. Bone marrow biopsies showed fibrosis. [duo.uio.no]

IMPORTANT SAFETY INFORMATION Treatment with Jakafi® (ruxolitinib) can cause thrombocytopenia, anemia and neutropenia, which are each dose‐related effects. [hcp.incytecares.com]

IMPORTANT SAFETY INFORMATION • Treatment with Jakafi can cause thrombocytopenia, anemia and neutropenia, which are each dose‐related effects. [pvreporter.com]

Myelophthisis

[…] case, the marrow's ability to produce blood cells is reduced, typically yielding pancytopenia that includes some combination of normocytic anemia, thrombocytopenia, and neutropenia [pathwaymedicine.org]

Signs and symptoms associated with leukopenia Leukopenia is usually secondary to a reduction in the number of neutrophils. [cancertherapyadvisor.com]

Thus, patients may have any combination of anemia, leukopenia, or thrombocytopenia, similar to other bone marrow failure syndromes, such as aplastic anemia. [clinicaladvisor.com]

Propionic Acidemia

In the infantile chronic form, failure to thrive, chronic vomiting and neutropenia may mimic cow milk intolerance, celiac disease (see this term) or immune deficiencies. [orpha.net]

Genetics Home Reference :Propionic Acidemia,2007 COMPLICATIONS The most common complications in patients were hematological abnormalities including anemia, neutropenia, thrombocytopenia [flipper.diff.org]

[…] high-anion gap metabolic acidosis -Elevated ketones in blood or urine (normally absent in healthy newborns) -Low to normal blood glucose concentration -Hyperammonemia (frequent) -Neutropenia [flipper.diff.org]

Fusarium Infection

[…] and 4% for patients with persistent neutropenia only. [ncbi.nlm.nih.gov]

Disseminated Fusarium infection should be suspected in immunocompromised patients with fever and neutropenia who have generalized, eroded, violaceous papules, vesicles, and [ncbi.nlm.nih.gov]

Abstract Fusarium spp. causes infections mostly in patients with prolonged neutropenia. [ncbi.nlm.nih.gov]

Hairy Cell Leukemia

Later he developed leukopenia and pancytopenia. Bone marrow biopsies showed fibrosis. [ncbi.nlm.nih.gov]

[…] of neutropenia is also shown in Table 3. [bloodjournal.hematologylibrary.org]

This can be neutropenia, anaemia or thrombocytopenia [3] Neutropenia Not enough neutrophils in the blood. [cllsupport.org.uk]

Isovaleric Acidemia

Pancytopenia, as well as isolated neutropenia and thrombocytopenia, can occur due to bone marrow suppression. [e-imd.org]

Isovaleric acid is an inhibitor of granulopoietic progenitor cell proliferation in bone marrow cultures with half-maximal inhibition at 1.6 mM, and this may account for the neutropenia [e-imd.org]

Congenital AIDS

Cyclic neutropenia is a form of neutropenia that tends to occur every three weeks and lasting three to six days at a time due to changing rates of cell production by the [slideshare.net]

[…] patients aged 20–40 years Hyper-IgM syndrome with AID or UNG deficiencies Autosomal recessive AID, UNG Similar to X-linked hyper-IgM syndrome but with lymphoid hyperplasia No leukopenia [msdmanuals.com]

[…] lineage Recurrent bacterial infections, e.g. gingivitis, otitis media, respiratory infections, and cellulitis (Streptococcus and Staphylococcus) Oral ulcerations Absolute neutropenia [amboss.com]

B-Cell Acute Lymphoblastic Leukemia

Neutropenia and Febrile Neutropenia, including life-threatening cases, have been observed. [prnewswire.com]

[…] course od febrile neutropenia were predictors of a worse outcome. [search.ndltd.org]

Adverse events The most common adverse reactions occurring in greater than 20% of patients were thrombocytopenia, neutropenia, infection, anemia, leukopenia, fatigue, hemorrhage [adcreview.com]

Vitamin B12 Deficiency

[…] anemia, increased lactate dehydrogenase, vasoconstriction, increased platelet aggregation, and abnormal activation of the coagulation followed by microangiopathy as well as neutropenia [ncbi.nlm.nih.gov]

We present a 9-month-old boy with megaloblastic anaemia, neutropenia and hypogammaglobulinaemia due to vitamin B12 deficiency. [ncbi.nlm.nih.gov]

Three (15 %) patients had leukopenia, 7 (35 %) had neutropenia, 2 (10 %) patients had thrombocytopenia. All of the mothers had vitamin B12 deficiency. [ncbi.nlm.nih.gov]

Aplastic Anemia

Laboratory findings may include leukopenia, neutropenia, anaemia, and thrombocytopenia. Bone marrow biopsy shows hypocellular marrow without abnormal cells. [bestpractice.bmj.com]

Soon after that, she was admitted with severe neutropenia, which progressed to pancytopenia confirmed as aplastic anemia on a bone marrow biopsy. [ncbi.nlm.nih.gov]

The regimen has a low incidence of bone marrow suppression, and the incidences of anemia, leukopenia, neutropenia and thrombocytopenia exceeding grade 3 are less than 5%. [ncbi.nlm.nih.gov]

Familial Myelofibrosis

Patients may experience anaemia, neutropenia, and/or thrombocytopaenia. Patients may also experience pain secondary to hepatosplenomegaly. [healthengine.com.au]

[…] causes of cytopenias, along with a dysplastic bone marrow, is required to diagnose a myelodysplastic syndrome, so differentiating MDS from anemia, thrombocytopenia, and leukopenia [en.wikipedia.org]

Recipient Evaluation Management of Graft-Versus-Host Disease Hematopoietic Growth Factors NCCN Guidelines Management of Cancer- and Chemotherapy-Induced Anemia Management of Neutropenia [nccn.org]

Severe Aplastic Anemia

[…] aplastic anemia that did not respond to classic and immunosuppressive treatment for disease and developing invasive cardiac mucormycosis despite empiric treatment for febrile neutropenia [ncbi.nlm.nih.gov]

The patient had diabetes arising from the hemochromatosis, chronic anal fissures, and a kidney abscess due to neutropenia. [ncbi.nlm.nih.gov]

Symptoms associated with SAA correspond to those of severe anemia, thrombocytopenia and - usually during later stages of the disease - neutropenia. [symptoma.com]

Follicular Lymphoma

neutropenia in 14 (17%) patients. [ncbi.nlm.nih.gov]

The most common grades 3 and 4 toxicities were thrombocytopenia (31%) and neutropenia (22%). [current-oncology.com]

The most common adverse event was neutropenia (80 [26%] of 312 patients in the GP2013-CVP group and 93 [30%] of 315 patients in the R-CVP group in the combination phase and [ncbi.nlm.nih.gov]

Mucopolysaccharidosis-plus Syndrome

[…] type 2E 604286 CLCN1 Myotonia congenita, dominant; recessive 160800; 255700 NEB Nemaline myopathy 2, autosomal recessive 256030 NPHS1 Nephrotic syndrome, type 1 256300 HAX1 Neutropenia [qgenomics.com]

Clostridium Perfringens Infection

RESUMEN Clostridium perfringens forma parte de la microbiota intestinal del ser humano y otros animales, sin embargo, en ciertas condiciones como isquemia, neutropenia y trombocitopenia [medigraphic.com]

Folic Acid Deficiency

Less commonly, neutropenia and thrombocytopenia also will occur, although it usually will not be as severe as the anemia. [emedicine.com]

Precursor-Cell Lymphoblastic Leukemia

Data about treatment phase, steroids, neutropenia, type and site of infection, and outcome of infection were collected. [ncbi.nlm.nih.gov]

Trichosporonosis is a rare, life-threatening, opportunistic fungal infection that affects immunocompromised individuals with neutropenia, particularly those with underlying [ncbi.nlm.nih.gov]

[…] hematologic malignancies and hematopoietic stem cell transplantation (HSCT) recipients are at high risk for invasive fungal diseases (IFDs) mainly due to the severe and prolonged neutropenia [ncbi.nlm.nih.gov]

Sjögren Syndrome

For non-B-cell hematological cancers, prognostic factors included anemia (HR 4.02; p = 0.009), neutropenia (HR 5.86; p = 0.002), thrombocytopenia (HR 4.85; p = 0.004), and [jhoonline.biomedcentral.com]

Cytopenia due to drug-induced toxicity, viral infections or haematological disorder other than autoimmunity or lymphoma; Anaemia due to iron or vitamin deficiency; Neutropenia [rmdopen.bmj.com]

[…] effects Insufficient effect of HCQ on chronic complaints Liver and severe renal failure, severe respiratory failure, alcohol abuse, pregnant or lactating women GI effects, neutropenia [medsci.org]

Chronic Myelomonocytic Leukemia

Absolute neutropenia was the dominant feature at presentation, with mild anemia, thrombocytopenia, monocytosis (as a percentage), multilineage dysplasia, and increased myeloblasts [ncbi.nlm.nih.gov]

Additionally, patients often suffer from anemia, neutropenia, and thrombocytopenia. [symptoma.com]

[…] myeloproliferative neoplasm with isolated isochromosome 17q Myelodysplastic Syndromes (MDS) Refractory cytopenia with unilineage dysplasia (RCUD) Refractory anemia Refractory neutropenia [surgpathcriteria.stanford.edu]