Neutropenia: Causes & Reasons

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Possible Causes for Neutropenia

Idiopathic Neutropenia

[…] idiopathic neutropenia and primary autoimmune neutropenia. [symptoma.com]

Severity of the Condition Defined Mild neutropenia: The ANC ranges between 1000-1500/μL Moderate neutropenia: The ANC ranges between 500-1000/μL Severe neutropenia: The ANC [luriechildrens.org]

We report a patient with chronic neutropenia and severe polyclonal hypergammaglobulinemia. [ncbi.nlm.nih.gov]

Shwachman Syndrome

[…] chronic neutropenia (SCN). [bone-marrow-failure-syndromes.de]

We report a boy affected by Shwachman syndrome (SS) who presented severe neutropenia and frequent suppurative infections, which we treated successfully with granulocyte colony-stimulating [ncbi.nlm.nih.gov]

Hematopoietic stem cell transplantation in severe congenital neutropenia: experience of the French SCN register. [doi.org]

Glycogen Storage Disease

Increasing glucose requirements, worsening lipid profile, neutropenia associated with multiple infections, and anemia were noted. [ncbi.nlm.nih.gov]

Presence of neutropenia further confirms GSD Ib. Even critical hypoglycaemia can be clinically unapparent in affected children. [ncbi.nlm.nih.gov]

Due to the severe neutropenia the patient had developed nosocomial sepsis and the dose of G-CSF was increased. [ncbi.nlm.nih.gov]

Felty Syndrome

A durable remission was achieved without complication, despite persistent severe peripheral neutropenia. [ncbi.nlm.nih.gov]

Neutropenia in Felty's Syndrome predisposes patients to recurrent bacterial infections. [ncbi.nlm.nih.gov]

Neutropenia is also common in systemic lupus erythematosus and it is included in the current systemic lupus classification criteria. [ncbi.nlm.nih.gov]

Cyclic Neutropenia

Cyclic neutropenia (CN) is a type of neutropenia in which neutrophil levels follow a 21-day cycle. [symptoma.com]

External links[edit] Severe Chronic Neutropenia International Registry "Understanding Neutropenia: The 20 Year Experience of the Severe Chronic Neutropenia International Registry [en.wikipedia.org]

Cyclic neutropenia is characterized by periodic episodes of neutropenia that are often associated with infectious complications. [ncbi.nlm.nih.gov]

Agammaglobulinemia

The mechanism of neutropenia is poorly understood. [pediatrics.aappublications.org]

Initial laboratory testing reveals neutropenia in about 15% of cases, whereas reductions in serum immunoglobulins (IgG, IgM and IgA) are readily encountered. [symptoma.com]

The recurrent infections and persistent neutropenia had raised the possibility of an immune deficiency. [pediatrics.aappublications.org]

Chédiak-Higashi Syndrome

Abstract Neutropenia is an almost constant feature of Chediak-Higashi syndrome (CHS). There is evidence for a central mechanism of neutropenia. [unboundmedicine.com]

Chédiak-Higashi syndrome (C-HS) is a rare congenital disease characterized by defective neutrophil function with abnormal lysosomal inclusions, neutropenia, and reduced chemotaxis [ncbi.nlm.nih.gov]

Reference work entry DOI: https://doi.org/ 10.1007/978-3-540-29676-8_317 Synonyms CHS; Beguez-Cesar disease; Chediak-Steinbrinck-Higashi syndrome; Neutropenia and hyperlymphocytosis [link.springer.com]

Hypersplenism

Some of these—anemia, neutropenia, and thrombocytopenia—are attributed to hypersplenism. [annals.org]

Primary causes are idiopathic thrombocytopenic purpura, congenital hemolytic anaemia and primary splenic neutropenia or pancytopenia. [explainmedicine.com]

More than half of cirrhotics will have low platelet counts, but neutropenia is much less common. [arizona.pure.elsevier.com]

Febrile Neutropenia

RCH Melbourne CPG – Febrile Neutropenia Management of Fever in the Paediatric Oncology Patient v3.0 17102012 Febrile Neutropenia Protocol QPHON QCCC Miadema et al. [dontforgetthebubbles.com]

Febrile neutropenia is the development of fever, often with other signs of infection, in a patient with neutropenia, an abnormally low number of neutrophil granulocytes (a [en.wikipedia.org]

What is the criteria for febrile neutropenia? Fever is any temperature >38.5°C, or >38.0°C for one hour. [dontforgetthebubbles.com]

Familial Neutropenia

These patients were classified based on their ANCs as having mild neutropenia (2), more profound neutropenia (2), and cycling neutropenia (2). [cags.org.ae]

Denic et al. (2009) also studied a cohort of seven subjects with benign neutropenia. [cags.org.ae]

Neutropenia Definition Neutropenia definition can be summarized as a condition where the neutrophils level is peculiarly low in the blood. [neutropeniasymptoms.com]

Agranulocytosis

Many drugs can cause agranulocytosis and neutropenia. The mechanism of neutropenia can be varied depending on the drug. [medicineworld.org]

RESULTS: A total of 13 patients out of 980 clozapine recipients developed neutropenia and 3 developed agranulocytosis during treatment. [ncbi.nlm.nih.gov]

Neutropenia. Dipyrone. Incidence. Case-control studies. [scielo.br]

Kostmann Syndrome

Severe congenital neutropenia Other names Kostmann disease, Kostmann's agranulocytosis, Kostmann's syndrome, congenital agranulocytosis, congenital neutropenia, permanent [en.wikipedia.org]

Neutropenia Other diagnoses confused with cyclic neutropenia include congenital neutropenia and idiopathic, autoimmune, and benign neutropenia of childhood. [ncbi.nlm.nih.gov]

PROMOTING ACCESS TO AFRICAN RESEARCH Severe congenital neutropenia (Kostmann Syndrome) Abstract Severe congenital neutropenia (SCN), Kostmann syndrome is a heterogenous disorder [ajol.info]

Drug-induced Neutropenia

Drug-induced neutropenia accounts for more than 70% of all neutropenias encountered in clinical practice. [symptoma.com]

Almost all the major classes of psychotropic medications have been associated with neutropenia. [ncbi.nlm.nih.gov]

Cyclic neutropenia. neutropenia a diminished number of neutrophils in the blood. cyclic neutropenia periodic neutropenia. [medical-dictionary.thefreedictionary.com]

Congenital Neutropenia

Congenital neutropenia is a form of chronic neutropenia. [symptoma.com]

Note Severe chronic neutropenia (SCN) is a heterogeneous group of disorders characterized by chronic neutropenia and serious recurrent infections. [atlasgeneticsoncology.org]

Congenital neutropenia syndromes also may be referred to as congenital agranulocytosis, severe congenital neutropenia, severe infantile genetic neutropenia, infantile genetic [niaid.nih.gov]

Leukoerythroblastic Anemia

Cyclic hematopoiesis Periodic neutropenia 288.03 Drug induced neutropenia Use additional E code to identify drug 288.04 Neutropenia due to infection 288.09 Other neutropenia [theodora.com]

[…] aplasia + Refractory Anemia + sideroblastic anemia + Thrombocytopenia, Anemia, and Myelofibrosis thrombocytosis + WT Limb Blood Syndrome X-Linked Anemia with or without Neutropenia [rgd.mcw.edu]

For example, if a patient with chemotherapy-induced pancytopenia is admitted and receives Neupogen® for the drug-induced neutropenia, code 288.03 would be the principal followed [hcpro.com]

Chronic Lymphocytic Leukemia

Routine preoperative laboratory studies showed severe neutropenia and increased atypical lymphocytes in the peripheral blood. [ncbi.nlm.nih.gov]

Based on available laboratory assessments, grade 3 or 4 neutropenia occurred in 87% of patients in each cohort, suggesting that the incidence of neutropenia was likely independent [bloodjournal.hematologylibrary.org]

Grade 4 neutropenia developed in 5% of patients. [dx.doi.org]

Pancytopenia

Septic screen is required for patients with febrile neutropenia, including aseptic sampling of any indwelling lines for culture. [onlinelibrary.wiley.com]

KEYWORDS: G6PC3; congenital neutropenia; lymphopenia; variable bone marrow phenotype [ncbi.nlm.nih.gov]

Neutropenia, Leukopenia Immunocompromised antibiotics Aplastic anemia External Links References [wikem.org]

Hypocupremia

Marked, persistent neutropenia was its earliest and most constant manifestation. [ashpublications.org]

Anemia and neutropenia are well known hematological manifestations of acquired copper deficiency. [journals.lww.com]

Her blood tests showed anemia with hemoglobin of 10.1 gm/dl and neutropenia with neutrophil count of 29.2%. [journals.lww.com]

Immunodeficiency Type 23

We identified three unrelated children with recurrent infections, congenital leukopenia including neutropenia, B and T cell lymphopenia, and progression to bone marrow failure [f1000.com]

[…] anemia, hepatosplenomegaly, and neutropenia. [en.wikipedia.org]

Two children received hematopoietic stem cell transplantation of cord blood and bone marrow from matched related donors; both had successful engraftment and correction of neutropenia [f1000.com]

Fusarium Infection

[…] and 4% for patients with persistent neutropenia only. [ncbi.nlm.nih.gov]

All patients (except 3 with onychomycosis) had hematologic malignancies and neutropenia. [ncbi.nlm.nih.gov]

Seven of the patients had chemotherapy-induced neutropenia when the Fusarium was isolated. [ncbi.nlm.nih.gov]

Post-Polycythemia Vera Myelofibrosis

Treatment with cladribine temporarily reversed the patient’s neutropenia. [duo.uio.no]

IMPORTANT SAFETY INFORMATION • Treatment with Jakafi can cause thrombocytopenia, anemia and neutropenia, which are each dose‐related effects. [pvreporter.com]

In this case report, we describe a patient with polycythemia vera and unexplained neutropenia who later turned out to also have hairy cell leukemia. [duo.uio.no]

Sideroblastic Anemia

Anemia and neutropenia developed in a man who took pharmacologic doses of supplemental zinc. [ncbi.nlm.nih.gov]

Neutropenia may be treated with colony stimulating factor. Pancreatic enzyme replacement treats malabsorption due to exocrine pancreatic insufficiency. [secure.ssa.gov]

Typical hematologic symptoms (transfusion-dependent severe macrocytic anemia, neutropenia, thrombocytopenia) in early infancy. [accessanesthesiology.mhmedical.com]

Propionic Acidemia

Laboratory findings include metabolic acidosis, hyperglycinemia, ketone bodies, ketosis, hyperammonemia, and possible thrombocytopenia and neutropenia. [visualdx.com]

B cell lymphopenia (20 cells microliters-1) was associated with transient neutropenia, anemia and subsequent hypogamma-globulinemia (IgG < 294 mg dl-1, IgM < 8 mg dl-1, IgA [ncbi.nlm.nih.gov]

Hairy Cell Leukemia

Polycythemia vera is a myeloproliferative disease that sometimes evolves to myelofibrosis, causing splenomegaly and neutropenia. [ncbi.nlm.nih.gov]

[…] of neutropenia is also shown in Table 3. [bloodjournal.hematologylibrary.org]

We performed a study of priming filgrastim followed by cladribine and then filgrastim again to determine if filgrastim would lead to a reduction of neutropenia and febrile [ncbi.nlm.nih.gov]

Waldenstrom Macroglobulinemia

Currently, there are only 2 case reports of Waldenström macroglobulinemia (WM) associated with severe neutropenia. [ncbi.nlm.nih.gov]

(low levels of red blood cells), neutropenia An abnormally low level of neutrophils. [lymphoma.org]

After the first occurrence of a drug-related grade 3 or worse adverse event, such as grade 4 neutropenia for more than 7 days or grade 3 or 4 thrombocytopenia, ibrutinib was [onclive.com]

Cartilage Hair Hypoplasia

Chronic neutropenia is common in children with cartilage-hair hypoplasia (CHH). [ncbi.nlm.nih.gov]

Hematologic studies in one child disclosed chronic neutropenia secondary to a failure of myeloid maturation. [nejm.org]

Sixty-two percent of the patients had had lymphopenia and 24% neutropenia. [ncbi.nlm.nih.gov]

Vitamin B12 Deficiency

[…] anemia, increased lactate dehydrogenase, vasoconstriction, increased platelet aggregation, and abnormal activation of the coagulation followed by microangiopathy as well as neutropenia [ncbi.nlm.nih.gov]

We present a 9-month-old boy with megaloblastic anaemia, neutropenia and hypogammaglobulinaemia due to vitamin B12 deficiency. [ncbi.nlm.nih.gov]

Three (15 %) patients had leukopenia, 7 (35 %) had neutropenia, 2 (10 %) patients had thrombocytopenia. All of the mothers had vitamin B12 deficiency. [ncbi.nlm.nih.gov]

Lazy Leukocyte Syndrome

2012 ICD-9-CM Diagnosis Code 288.09 Other neutropenia Short description: Neutropenia NEC. [icd9data.com]

Cyclic neutropenia D70.8 Other neutropenia D70.9 Neutropenia, unspecified D71 Functional disorders of polymorphonuclear neutrophils D72 Other disorders of white blood cells [icd10data.com]

[…] neutrophils. lazy leukocyte syndrome an immunodeficiency disease of children characterized by recurrent stomatitis, gingivitis, otitis media, and low-grade fever with severe neutropenia [medical-dictionary.thefreedictionary.com]

Congenital Neutropenia - Myelofibrosis - Nephromegaly Syndrome

ANC 10001500/lModerate neutropenia ANC 5001000/lSevere neutropenia ANC, 500/lPersistent neutropenia ANC continuously ,1500/lIntermittent neutropenia ANC occasionally ,1500 [dokumen.tips]

How to approach neutropenia. Pediat. Rev. 2013; 34:173-184. Dale DC, Welte K. Cyclic and chronic neutropenia. Cancer Treat Res. 2011;157:97-108. [rarediseases.org]

Congenital neutropenia (CN) includes hematologic disorders characterized by severe neutropenia with an absolute neutrophil count (ANC) below 0.5 x 10(9)/L associated with [ncbi.nlm.nih.gov]

Hyper-IgM Syndrome Type 3

[…] associated with the neutropenia. [primaryimmune.org]

[…] complications associated with the neutropenia. [disabled-world.com]

IgE deficiency IgG deficiency Impaired Ig class switch recombination Impaired memory B-cell generation Increased IgM level Abnormality of blood and blood-forming tissues Neutropenia [ncbi.nlm.nih.gov]