Possible Causes for neutropenia Vitamin B12 Deficiency […] anemia, increased lactate dehydrogenase, vasoconstriction, increased platelet aggregation, and abnormal activation of the coagulation followed by microangiopathy as well as neutropenia [ncbi.nlm.nih.gov] We present a 9-month-old boy with megaloblastic anaemia, neutropenia and hypogammaglobulinaemia due to vitamin B12 deficiency. [ncbi.nlm.nih.gov] Three (15 %) patients had leukopenia, 7 (35 %) had neutropenia, 2 (10 %) patients had thrombocytopenia. All of the mothers had vitamin B12 deficiency. [ncbi.nlm.nih.gov] Viral Disease Three patients with only HHV6 DNA in urine or serum had fever and abnormal liver function but not neutropenia. [ncbi.nlm.nih.gov] All five CMV-seronegative patients who received positive kidneys developed moderate to severe disease with fever and neutropenia but also had HHV6 DNA in urine or serum. [ncbi.nlm.nih.gov] Influenza ALPS can also cause anemia (low level of red blood cells), thrombocytopenia (low level of platelets), and neutropenia (low level of neutrophils, the most common type of white [niaid.nih.gov] Evidence of harms The trials identified only one serious adverse event ( Nicholson 2000 ) (so labelled in the Japanese data, a patient with neutropenia), and, in particular [dx.doi.org] Febrile Neutropenia RCH Melbourne CPG – Febrile Neutropenia Management of Fever in the Paediatric Oncology Patient v3.0 17102012 Febrile Neutropenia Protocol QPHON QCCC Miadema et al. [dontforgetthebubbles.com] Febrile neutropenia is the development of fever, often with other signs of infection, in a patient with neutropenia, an abnormally low number of neutrophil granulocytes (a [en.wikipedia.org] What is the criteria for febrile neutropenia? Fever is any temperature 38.5 C, or 38.0 C for one hour. [dontforgetthebubbles.com] Infectious Mononucleosis A mild transient neutropenia occurring during the first weeks of acute infection is a common finding however in rare cases a more profound neutropenia and agranulocytosis [ncbi.nlm.nih.gov] […] and absolute lymphocytosis(70%) Atypical monocytosis(90%) Elevated Liver function test(90%) Positive heterophil antibodies(90%) Thrombocytopenia(50%) Relative and absolute neutropenia [clinicclinic2.cafe24.com] […] infectious mononucleosis are: Absolute und relative leukocytosis ( 4000/ml and 50% of leukocytes) with 10% atypical large T-cells ( Pfeiffer cells, fibrocytes) Mild anemia, neutropenia [lecturio.com] Chronic Alcoholism The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show[…] [ncbi.nlm.nih.gov] Familial Neutropenia The periodontal status and treatment of three teenagers in a Finnish family with familial neutropenia is described. The mother was also diagnosed with neutropenia. [ncbi.nlm.nih.gov] Neutropenia Definition Neutropenia definition can be summarized as a condition where the neutrophils level is peculiarly low in the blood. [neutropeniasymptoms.com] These patients were classified based on their ANCs as having mild neutropenia (2), more profound neutropenia (2), and cycling neutropenia (2). [cags.org.ae] Agranulocytosis RESULTS: A total of 13 patients out of 980 clozapine recipients developed neutropenia and 3 developed agranulocytosis during treatment. [ncbi.nlm.nih.gov] A case of profound neutropenia and agranulocytosis associated with the off-label use of ceftaroline is reported. [ncbi.nlm.nih.gov] To report a case of severe neutropenia after discontinuing prolonged treatment with vancomycin that progressed to agranulocytosis with vancomycin reexposure. [ncbi.nlm.nih.gov] Kostmann Syndrome PubMed is a searchable database of medical literature and lists journal articles that discuss Severe congenital neutropenia autosomal dominant. [rarediseases.info.nih.gov] neutropenia, infantile genetic agranulocytosis, severe infantile genetic neutropenia Specialty Hematology Usual onset Infancy a b Neutropenia, Severe Congenital, 2, Autosomal [en.wikipedia.org] These abscesses are due to an almost total disimmunity typical of the neutropenia. [ncbi.nlm.nih.gov] Drug-induced Neutropenia Almost all the major classes of psychotropic medications have been associated with neutropenia. [ncbi.nlm.nih.gov] In 84 cases the neutropenia was probably caused by drugs other than cytostatics, giving an annual incidence of 0.009%. [ncbi.nlm.nih.gov] Abstract Drug therapy plays a significant role in causing neutropenia. The neutropenia may be immune mediated or due to direct inhibition of the bone marrow precursors. [ncbi.nlm.nih.gov] Iron Deficiency Anemia INTRODUCTION Iron deficiency anemia (IDA) is a common complication in routine clinical practice that frequently originates in the gastrointestinal (GI) tract[ 1 - 3 ]. Patients with IDA are therefore often referred to gastroenterologists for further examination and/or treatment. IDA associated with GI disorders can[…] [dx.doi.org] Non-Hodgkin Lymphoma Any patient with severe neutropenia should be given antibiotic prophylaxis with chemotherapy. [patient.info] The most common grade 3/4 adverse events included hyperglycemia (11.1%) and neutropenia (5.6%). [ncbi.nlm.nih.gov] We examine toxicities of idelalisib, including bacterial infections (possibly secondary to drug-induced neutropenia), opportunistic infections (possibly attributable to on-target [ncbi.nlm.nih.gov] Recurrent Small-Cell Carcinoma of the Lung DLTs were defined as grade 4 neutropenia, febrile neutropenia, grade 4 thrombocytopenia, non-hematologic toxicity grade 3, any toxicity precluding the treatment on days 8 [ncbi.nlm.nih.gov] Grade III/IV neutropenia occurred in 3 (15%) of 21 patients, 1 patient had a lethal Gram-negative sepsis in neutropenia. [ncbi.nlm.nih.gov] Dose-limiting toxicity was observed in two of six patients at level 2 (neutropenia and febrile neutropenia) and in one of six at level 3 (thrombocytopenia and infection). [ncbi.nlm.nih.gov] Idiopathic Neutropenia We report a patient with chronic neutropenia and severe polyclonal hypergammaglobulinemia. [ncbi.nlm.nih.gov] Clinically it is useful to classify immune mediated neutropenias as isoimmune, autoimmune (including some drug-associated neutropenias), and idiopathic (cases possibly with [ncbi.nlm.nih.gov] Seven patients had idiopathic sporadic neutropenia, 2 idiopathic congenital neutropenia and 2 cyclic neutropenia. [ncbi.nlm.nih.gov] Congenital Neutropenia Note Severe chronic neutropenia (SCN) is a heterogeneous group of disorders characterized by chronic neutropenia and serious recurrent infections. [atlasgeneticsoncology.org] Severe congenital neutropenia (SCN) is a rare primary myelopoiesis disorder, characterized by persistent severe neutropenia and early-onset bacterial infections. [ncbi.nlm.nih.gov] Severe congenital neutropenia (SCN) and Clostridium septicum myonecrosis is an uncommon and life-threatening association requiring urgent combined aggressive medical and surgical [ncbi.nlm.nih.gov] Sjögren Syndrome [0.59–1.86] 2.07 [1.20–3.58] ‡ Leukopenia ( 3 ) 227/1297 (17.5) 1.49 [0.87–2.55] 0.96 [0.50–1.86] Thrombocytopenia ( 3 ) 87/1297 (6.7) 1.18 [0.54–2.57] 1.17 [0.50–2.72] Neutropenia [jhoonline.biomedcentral.com] […] effects Insufficient effect of HCQ on chronic complaints Liver and severe renal failure, severe respiratory failure, alcohol abuse, pregnant or lactating women GI effects, neutropenia [medsci.org] –2.61] 2.58 [1.01–6.58] 4.02 [1.42–11.38] Leukopenia ( 3 ) 0.51 [0.15–1.69] 0.84 [0.24–2.89] 2.54 [0.86–7.52] Thrombocytopenia ( 3 ) 0.47 [0.06–3.48] – 4.85 [1.64–14.34] Neutropenia [jhoonline.biomedcentral.com] Shwachman Syndrome We report a boy affected by Shwachman syndrome (SS) who presented severe neutropenia and frequent suppurative infections, which we treated successfully with granulocyte colony-stimulating [ncbi.nlm.nih.gov] […] chronic neutropenia (SCN). [bone-marrow-failure-syndromes.de] Hematopoietic stem cell transplantation in severe congenital neutropenia: experience of the French SCN register. [doi.org] Refractory Anemia with Excess Blasts in Transformation Patients are primarily over the age of 50 years and present with symptoms related to bone marrow failure including anemia, thrombocytopenia, and neutropenia. [imagebank.hematology.org] […] classification Median survival of 16 months for RAEB-1 and 9 months for RAEB-2 (Br J Haematol 2006;132:162) Laboratory Anemia (normochromic, normocytic or macrocytic), usually neutropenia [pathologyoutlines.com] People with RAEB may have refractory anemia (low red blood cells), refractory neutropenia (low neutrophils), refractory thrombocytopenia (low platelets), or a combination [verywellhealth.com] Acute Respiratory Distress Syndrome […] enrollment, actual body weight exceeding 1 kg per centimeter of height, severe chronic liver disease (Child–Pugh class C), bone marrow transplantation or chemotherapy-induced neutropenia [ncbi.nlm.nih.gov] Ognibene FP, Martin SE, Parker MM, Schlesinger T, Roach P, Burch C, et al: Adult respiratory distress syndrome in patients with severe neutropenia. [karger.com] Glycogen Storage Disease Increasing glucose requirements, worsening lipid profile, neutropenia associated with multiple infections, and anemia were noted. [ncbi.nlm.nih.gov] (G-CSF) corrected neutropenia. [ncbi.nlm.nih.gov] Presence of neutropenia further confirms GSD Ib. Even critical hypoglycaemia can be clinically unapparent in affected children. [ncbi.nlm.nih.gov] Chronic Lymphocytic Leukemia Routine preoperative laboratory studies showed severe neutropenia and increased atypical lymphocytes in the peripheral blood. [ncbi.nlm.nih.gov] Based on available laboratory assessments, grade 3 or 4 neutropenia occurred in 87% of patients in each cohort, suggesting that the incidence of neutropenia was likely independent [bloodjournal.hematologylibrary.org] During the rituximab maintenance, grade 3 neutropenia was seen in 6% of cycles and grade 4 neutropenia in 2% of cycles. [oadoi.org] Folic Acid Deficiency Less commonly, neutropenia and thrombocytopenia also will occur, although it usually will not be as severe as the anemia. [emedicine.com] Rheumatoid Arthritis We report the case of a 54-year-old female with rheumatoid arthritis and following development of chronic neutropenia. [ncbi.nlm.nih.gov] Figures and Tables - Analysis 1.4 Comparison 1 Folic acid versus placebo, Outcome 4 Neutropenia. [doi.org] The most common TEAEs were neutropenia, injection site erythema, increased alanine aminotransferase and upper respiratory tract infections. [ncbi.nlm.nih.gov] Adult Idiopathic Neutropenia […] of febrile neutropenia. - For the treatment of congenital, idiopathic, and cyclic neutropenia and hastens the recovery of marrow from neutropenia after cancer chemotherapy [checkorphan.org] Mild neutropenia (neutrophils 1700-2499/microl) accounted for 6.81% and moderate neutropenia (neutrophils 600-1699/microl) for the remaining 1.41%. [ncbi.nlm.nih.gov] Namely ethnic neutropenia and chronic idiopathic neutropenia. Neutropenia Fact Sheet. The hematologist who treats adults should also be. [friends-acronym.ga] Post-Polycythemia Vera Myelofibrosis Treatment with cladribine temporarily reversed the patient’s neutropenia. [duo.uio.no] IMPORTANT SAFETY INFORMATION • Treatment with Jakafi can cause thrombocytopenia, anemia and neutropenia, which are each dose‐related effects. [pvreporter.com] In this case report, we describe a patient with polycythemia vera and unexplained neutropenia who later turned out to also have hairy cell leukemia. [duo.uio.no] Pancytopenia Septic screen is required for patients with febrile neutropenia, including aseptic sampling of any indwelling lines for culture. [onlinelibrary.wiley.com] KEYWORDS: G6PC3; congenital neutropenia; lymphopenia; variable bone marrow phenotype [ncbi.nlm.nih.gov] Pancytopenia is an uncommon adverse effect of vancomycin therapy, with only a few cases of vancomycin-related neutropenia and pancytopenia described in the literature. [ncbi.nlm.nih.gov] Leukoerythroblastic Anemia […] red-cell aplasia Refractory Anemia sideroblastic anemia Thrombocytopenia, Anemia, and Myelofibrosis thrombocytosis WT Limb Blood Syndrome X-Linked Anemia with or without Neutropenia [rgd.mcw.edu] Cyclic hematopoiesis Periodic neutropenia 288.03 Drug induced neutropenia Use additional E code to identify drug 288.04 Neutropenia due to infection 288.09 Other neutropenia [theodora.com] For example, if a patient with chemotherapy-induced pancytopenia is admitted and receives Neupogen for the drug-induced neutropenia, code 288.03 would be the principal followed [hcpro.com] Streptococcus Viridans Initial empiric therapy for febrile neutropenia consisted of mezlocillin, gentamicin and cefazolin; glycopeptide was excluded. [ncbi.nlm.nih.gov] […] in patients with less-severe neutropenia [ 13, 14, 19 ]. [academic.oup.com] […] in patients with less-severe neutropenia [13, 14, 19]. [academic.oup.com] Typhlitis The classic triad of abdominal pain, fever, and neutropenia may be absent. [ncbi.nlm.nih.gov] Therefore, typhlitis may present in elderly patients even in the absence of neutropenia or immunosuppression. [ncbi.nlm.nih.gov] Twenty-five patients had episodes of typhlitis, characterized by fever, abdominal pain, and tenderness, occurring during periods of neutropenia. [ncbi.nlm.nih.gov] Felty Syndrome Neutropenia is also common in systemic lupus erythematosus and it is included in the current systemic lupus classification criteria. [ncbi.nlm.nih.gov] A durable remission was achieved without complication, despite persistent severe peripheral neutropenia. [ncbi.nlm.nih.gov] Neutropenia in Felty's Syndrome predisposes patients to recurrent bacterial infections. [ncbi.nlm.nih.gov]
