Neutropenia: Causes & Reasons

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Possible Causes for Neutropenia

Idiopathic Neutropenia

[…] idiopathic neutropenia and primary autoimmune neutropenia. [symptoma.com]

Of these patients, 42 had pronounced neutropenia with neutrophil counts < 1500/microL, and 115 had mild neutropenia with neutrophil counts ranging from 1500 to 2499/microL [ncbi.nlm.nih.gov]

The Severe Chronic Neutropenia International Registry Idiopathic Neutropenia The term ‘idiopathic neutropenia’ describes various types of neutropenia that may occur at any [depts.washington.edu]

Shwachman Syndrome

[…] man syn·drome ( shwahk'măn ), [MIM*260400] an autosomal recessive disorder characterized by sinusitis, bronchiectasis, pancreatic insufficiency resulting in malabsorption, neutropenia [medical-dictionary.thefreedictionary.com]

[…] syndrome, Blackfan-Diamond anemia, celiac disease, and autosomal recessive severe congenital neutropenia due to G6PC3 deficiency (see these terms). [orpha.net]

Shwachman syndrome - an autosomal recessive disorder characterized by sinusitis, bronchiectasis, pancreatic insufficiency, neutropenia, short stature, and skeletal changes [medical-dictionary.thefreedictionary.com]

Glycogen Storage Disease

Increasing glucose requirements, worsening lipid profile, neutropenia associated with multiple infections, and anemia were noted. [ncbi.nlm.nih.gov]

Presence of neutropenia further confirms GSD Ib. Even critical hypoglycaemia can be clinically unapparent in affected children. [ncbi.nlm.nih.gov]

Due to the severe neutropenia the patient had developed nosocomial sepsis and the dose of G-CSF was increased. [ncbi.nlm.nih.gov]

Felty Syndrome

[…] and leukopenia Felty's syndrome Familial Felty's syndrome Rheumatoid arthritis, splenomegaly and neutropenia Splenomegaly-neutropenia-rheumatoid arthritis syndrome edit English [wikidata.org]

We present a case of severe neutropenia and mild splenomegaly in a patient with high titers of RF and anti-CCP. For 4 years, patient's neutropenia remained asymptomatic. [ncbi.nlm.nih.gov]

Felty's syndrome is characterized by neutropenia, splenomegaly, and leg ulcers in patients with rheumatoid arthritis. [ncbi.nlm.nih.gov]

Agammaglobulinemia

The mechanism of neutropenia is poorly understood. [pediatrics.aappublications.org]

Initial laboratory testing reveals neutropenia in about 15% of cases, whereas reductions in serum immunoglobulins (IgG, IgM and IgA) are readily encountered. [symptoma.com]

The recurrent infections and persistent neutropenia had raised the possibility of an immune deficiency. [pediatrics.aappublications.org]

Hypersplenism

Some of these—anemia, neutropenia, and thrombocytopenia—are attributed to hypersplenism. [annals.org]

Primary causes are idiopathic thrombocytopenic purpura, congenital hemolytic anaemia and primary splenic neutropenia or pancytopenia. [explainmedicine.com]

More than half of cirrhotics will have low platelet counts, but neutropenia is much less common. [arizona.pure.elsevier.com]

Cyclic Neutropenia

External links[edit] Severe Chronic Neutropenia International Registry "Understanding Neutropenia: The 20 Year Experience of the Severe Chronic Neutropenia International Registry [en.wikipedia.org]

Seven patients had idiopathic sporadic neutropenia, 2 idiopathic congenital neutropenia and 2 cyclic neutropenia. [ncbi.nlm.nih.gov]

Cyclic neutropenia is characterized by periodic episodes of neutropenia that are often associated with infectious complications. [ncbi.nlm.nih.gov]

Chédiak-Higashi Syndrome

Abstract Neutropenia is an almost constant feature of Chediak-Higashi syndrome (CHS). There is evidence for a central mechanism of neutropenia. [unboundmedicine.com]

Chédiak-Higashi syndrome (C-HS) is a rare congenital disease characterized by defective neutrophil function with abnormal lysosomal inclusions, neutropenia, and reduced chemotaxis [ncbi.nlm.nih.gov]

Reference work entry DOI: https://doi.org/ 10.1007/978-3-540-29676-8_317 Synonyms CHS; Beguez-Cesar disease; Chediak-Steinbrinck-Higashi syndrome; Neutropenia and hyperlymphocytosis [link.springer.com]

Febrile Neutropenia

Colony-stimulating factors for chemotherapy-induced febrile neutropenia: A meta-analysis of randomized controlled trials. [ncbi.nlm.nih.gov]

Empirical antibiotic monotherapy for febrile neutropenia: Systematic review and meta-analysis of randomized controlled trials. [ncbi.nlm.nih.gov]

Risk assessment and treatment of low-risk patients with febrile neutropenia. Clin Infect Dis. 2006; 42 :533–540. [ PubMed ] 31. [ncbi.nlm.nih.gov]

Post-Polycythemia Vera Myelofibrosis

Treatment with cladribine temporarily reversed the patient’s neutropenia. [duo.uio.no]

IMPORTANT SAFETY INFORMATION • Treatment with Jakafi can cause thrombocytopenia, anemia and neutropenia, which are each dose‐related effects. [pvreporter.com]

In this case report, we describe a patient with polycythemia vera and unexplained neutropenia who later turned out to also have hairy cell leukemia. [duo.uio.no]

Familial Neutropenia

These patients were classified based on their ANCs as having mild neutropenia (2), more profound neutropenia (2), and cycling neutropenia (2). [cags.org.ae]

Denic et al. (2009) also studied a cohort of seven subjects with benign neutropenia. [cags.org.ae]

Benign familial neutropenia (BFN) is a condition where there is a decrease in circulating neutrophils in the blood and patients suffer from oral manifestations which include [ncbi.nlm.nih.gov]

Agranulocytosis

All neutropenia episodes resolved; median time to resolution was similar whether or not treatment was interrupted; and no case of neutropenia progressed to agranulocytosis [ncbi.nlm.nih.gov]

Only 1/7 novel neutropenia cases in CT progressed to agranulocytosis with continued treatment, indicating that neutropenia does not necessarily lead to agranulocytosis. [ncbi.nlm.nih.gov]

To report a case of severe neutropenia after discontinuing prolonged treatment with vancomycin that progressed to agranulocytosis with vancomycin reexposure. [ncbi.nlm.nih.gov]

Kostmann Syndrome

Neutropenia International Registry, American Journal of Hematology, 72, 2, (82), (2003). [doi.org]

Kostmann syndrome is a group of diseases that affect myelopoiesis, causing a congenital form of neutropenia ( severe congenital neutropenia [ SCN ]), usually without other [en.wikipedia.org]

[…] encoding an anti-apoptotic protein, in autosomal recessive neutropenia. [ncbi.nlm.nih.gov]

Leukoerythroblastic Anemia

Cyclic hematopoiesis Periodic neutropenia 288.03 Drug induced neutropenia Use additional E code to identify drug 288.04 Neutropenia due to infection 288.09 Other neutropenia [theodora.com]

[…] aplasia + Refractory Anemia + sideroblastic anemia + Thrombocytopenia, Anemia, and Myelofibrosis thrombocytosis + WT Limb Blood Syndrome X-Linked Anemia with or without Neutropenia [rgd.mcw.edu]

For example, if a patient with chemotherapy-induced pancytopenia is admitted and receives Neupogen® for the drug-induced neutropenia, code 288.03 would be the principal followed [hcpro.com]

Drug-induced Neutropenia

Drug-induced neutropenia accounts for more than 70% of all neutropenias encountered in clinical practice. [symptoma.com]

[…] of neutropenia compared to healthy controls as well as to case controls. [ncbi.nlm.nih.gov]

Almost all the major classes of psychotropic medications have been associated with neutropenia. [ncbi.nlm.nih.gov]

Chronic Lymphocytic Leukemia

Routine preoperative laboratory studies showed severe neutropenia and increased atypical lymphocytes in the peripheral blood. [ncbi.nlm.nih.gov]

Based on available laboratory assessments, grade 3 or 4 neutropenia occurred in 87% of patients in each cohort, suggesting that the incidence of neutropenia was likely independent [bloodjournal.hematologylibrary.org]

Grade 4 neutropenia developed in 5% of patients. [dx.doi.org]

Congenital Neutropenia

Severe congenital neutropenia (SCN) is a rare primary myelopoiesis disorder, characterized by persistent severe neutropenia and early-onset bacterial infections. [ncbi.nlm.nih.gov]

Congenital neutropenia is a form of chronic neutropenia. [symptoma.com]

Note Severe chronic neutropenia (SCN) is a heterogeneous group of disorders characterized by chronic neutropenia and serious recurrent infections. [atlasgeneticsoncology.org]

Pancytopenia

KEYWORDS: G6PC3; congenital neutropenia; lymphopenia; variable bone marrow phenotype [ncbi.nlm.nih.gov]

Neutropenia, Leukopenia Immunocompromised antibiotics Aplastic anemia External Links References [wikem.org]

Pancytopenia is an uncommon adverse effect of vancomycin therapy, with only a few cases of vancomycin-related neutropenia and pancytopenia described in the literature. [ncbi.nlm.nih.gov]

Hypocupremia

Anemia and neutropenia are well known hematological manifestations of acquired copper deficiency. [journals.lww.com]

Correction of anemia and neutropenia in all patients indicates that copper deficiency was the underlying cause ( Table 2 ). [doi.org]

The hypocupremia was associated with microcytosis and relative neutropenia. Administration of copper resulted in an increase in RBC size and leukocyte counts. [ncbi.nlm.nih.gov]

Propionic Acidemia

Laboratory findings include metabolic acidosis, hyperglycinemia, ketone bodies, ketosis, hyperammonemia, and possible thrombocytopenia and neutropenia. [visualdx.com]

B cell lymphopenia (20 cells microliters-1) was associated with transient neutropenia, anemia and subsequent hypogamma-globulinemia (IgG < 294 mg dl-1, IgM < 8 mg dl-1, IgA [ncbi.nlm.nih.gov]

Waldenstrom Macroglobulinemia

Currently, there are only 2 case reports of Waldenström macroglobulinemia (WM) associated with severe neutropenia. [ncbi.nlm.nih.gov]

(low levels of red blood cells), neutropenia An abnormally low level of neutrophils. [lymphoma.org]

After the first occurrence of a drug-related grade 3 or worse adverse event, such as grade 4 neutropenia for more than 7 days or grade 3 or 4 thrombocytopenia, ibrutinib was [onclive.com]

Hairy Cell Leukemia

[…] of neutropenia is also shown in Table 3. [bloodjournal.hematologylibrary.org]

Polycythemia vera is a myeloproliferative disease that sometimes evolves to myelofibrosis, causing splenomegaly and neutropenia. [ncbi.nlm.nih.gov]

We performed a study of priming filgrastim followed by cladribine and then filgrastim again to determine if filgrastim would lead to a reduction of neutropenia and febrile [ncbi.nlm.nih.gov]

Sideroblastic Anemia

Anemia and neutropenia developed in a man who took pharmacologic doses of supplemental zinc. [ncbi.nlm.nih.gov]

Neutropenia may be treated with colony stimulating factor. Pancreatic enzyme replacement treats malabsorption due to exocrine pancreatic insufficiency. [secure.ssa.gov]

In these patients neutropenia may result from cellular degeneration or abnormal cellular metabolism. [aspergillus.org.uk]

Immunodeficiency Type 23

We identified three unrelated children with recurrent infections, congenital leukopenia including neutropenia, B and T cell lymphopenia, and progression to bone marrow failure [f1000.com]

[…] anemia, hepatosplenomegaly, and neutropenia. [en.wikipedia.org]

Two children received hematopoietic stem cell transplantation of cord blood and bone marrow from matched related donors; both had successful engraftment and correction of neutropenia [f1000.com]

Fusarium Infection

[…] and 4% for patients with persistent neutropenia only. [ncbi.nlm.nih.gov]

All patients (except 3 with onychomycosis) had hematologic malignancies and neutropenia. [ncbi.nlm.nih.gov]

Seven of the patients had chemotherapy-induced neutropenia when the Fusarium was isolated. [ncbi.nlm.nih.gov]

Cartilage Hair Hypoplasia

Sixty-two percent of the patients had had lymphopenia and 24% neutropenia. [ncbi.nlm.nih.gov]

Laboratory studies will reveal transient macrocytic anemia, lymphopenia with a decreased CD4+/CD8+ T-cell count, and neutropenia. [symptoma.com]

Chronic neutropenia is common in children with cartilage-hair hypoplasia (CHH). [ncbi.nlm.nih.gov]

Acute Leukemia

[…] for febrile neutropenia, and the use of granulocyte-colony stimulating factor. [ncbi.nlm.nih.gov]

Script Download on iTunes Related Content: Podcast: Approach to Pediatric Anemia Part 1 and Part 2 Podcast: Approach to Lymphadenopathy Podcast: Febrile Neutropenia [pedscases.com]

There is an association between the type of leukemia and the incidence of pneumonia even after adjustment for neutropenia. [klinikrespirasimalang.com]

Methylmalonic Aciduria Type cblA

Hyperammonemia ; Hyperglycinemia ; Infantile onset ; Ketonuria ; Ketosis ; Lethargy ; Metabolic acidosis ; Methylmalonic acidemia ; Methylmalonic aciduria ; Muscular hypotonia ; Neutropenia [mousephenotype.org]

Neutropenia, thrombocytopenia and osteoporosis are common complications. Natural history without treatment Variable depending on the enzyme defect. [newbornscreening.info]

[…] bodies 0001946 Lethargy 0001254 Metabolic acidosis 0001942 Methylmalonic acidemia 0002912 Methylmalonic aciduria 0012120 Muscular hypotonia Low or weak muscle tone 0001252 Neutropenia [rarediseases.info.nih.gov]

Severe Aplastic Anemia

[…] aplastic anemia that did not respond to classic and immunosuppressive treatment for disease and developing invasive cardiac mucormycosis despite empiric treatment for febrile neutropenia [ncbi.nlm.nih.gov]

The patient had diabetes arising from the hemochromatosis, chronic anal fissures, and a kidney abscess due to neutropenia. [ncbi.nlm.nih.gov]

Symptoms associated with SAA correspond to those of severe anemia, thrombocytopenia and - usually during later stages of the disease - neutropenia. [symptoma.com]

Transcobalamin 2 Deficiency

The neutropenia is due to failure of the bone marrow to release granulocytes into the blood stream (myelokathexis). [primaryimmune.org]

D708Other neutropenia D709Neutropenia, unspecified D72810Lymphocytopenia D72818Other decreased white blood cell count D72819Decreased white blood cell count, unspecified [cms.gov]

Individuals with transcobalamin deficiency may also have a shortage of white blood cells (neutropenia), which can lead to reduced immune system function. [ghr.nlm.nih.gov]