Neutropenia: Causes & Reasons

Possible Causes for Neutropenia

RCH Melbourne CPG – Febrile Neutropenia Management of Fever in the Paediatric Oncology Patient v3.0 17102012 Febrile Neutropenia Protocol QPHON QCCC Miadema et al. [dontforgetthebubbles.com]

Febrile neutropenia is the development of fever, often with other signs of infection, in a patient with neutropenia, an abnormally low number of neutrophil granulocytes (a [en.wikipedia.org]

What is the criteria for febrile neutropenia? Fever is any temperature >38.5°C, or >38.0°C for one hour. [dontforgetthebubbles.com]

Familial Neutropenia

These patients were classified based on their ANCs as having mild neutropenia (2), more profound neutropenia (2), and cycling neutropenia (2). [cags.org.ae]

Neutropenia Definition Neutropenia definition can be summarized as a condition where the neutrophils level is peculiarly low in the blood. [neutropeniasymptoms.com]

Denic et al. (2009) also studied a cohort of seven subjects with benign neutropenia. [cags.org.ae]

Agranulocytosis

A case of profound neutropenia and agranulocytosis associated with the off-label use of ceftaroline is reported. [ncbi.nlm.nih.gov]

Neutropenia. Dipyrone. Incidence. Case-control studies. [scielo.br]

To report a case of severe neutropenia after discontinuing prolonged treatment with vancomycin that progressed to agranulocytosis with vancomycin reexposure. [ncbi.nlm.nih.gov]

Severe Congenital Neutropenia

Neutropenia Other diagnoses confused with cyclic neutropenia include congenital neutropenia and idiopathic, autoimmune, and benign neutropenia of childhood. [ncbi.nlm.nih.gov]

The term "congenital neutropenia" signifies neutropenia that is present at birth. It includes a wide variety of disorders, some transient and others life long. [ncbi.nlm.nih.gov]

The Many Causes of Severe Congenital Neutropenia | NEJM This article is available to subscribers. Subscribe now. Already have an account? [nejm.org]

Leukoerythroblastic Anemia

Cyclic hematopoiesis Periodic neutropenia 288.03 Drug induced neutropenia Use additional E code to identify drug 288.04 Neutropenia due to infection 288.09 Other neutropenia [theodora.com]

For example, if a patient with chemotherapy-induced pancytopenia is admitted and receives Neupogen® for the drug-induced neutropenia, code 288.03 would be the principal followed [hcpro.com]

[…] aplasia + Refractory Anemia + sideroblastic anemia + Thrombocytopenia, Anemia, and Myelofibrosis thrombocytosis + WT Limb Blood Syndrome X-Linked Anemia with or without Neutropenia [rgd.mcw.edu]

Drug-induced Neutropenia

Drug-induced neutropenia accounts for more than 70% of all neutropenias encountered in clinical practice. [symptoma.com]

Almost all the major classes of psychotropic medications have been associated with neutropenia. [ncbi.nlm.nih.gov]

Cyclic neutropenia. neutropenia a diminished number of neutrophils in the blood. cyclic neutropenia periodic neutropenia. [medical-dictionary.thefreedictionary.com]

Chronic Lymphocytic Leukemia

Routine preoperative laboratory studies showed severe neutropenia and increased atypical lymphocytes in the peripheral blood. [ncbi.nlm.nih.gov]

Based on available laboratory assessments, grade 3 or 4 neutropenia occurred in 87% of patients in each cohort, suggesting that the incidence of neutropenia was likely independent [bloodjournal.hematologylibrary.org]

The most common side effects of Venclexta include low white blood cell count (neutropenia), diarrhea, nausea, anemia, upper respiratory tract infection, low platelet count [fda.gov]

Idiopathic Neutropenia

[…] idiopathic neutropenia and primary autoimmune neutropenia. [symptoma.com]

The term idiopathic neutropenia describes various types of neutropenia that may occur at any point in life for unknown reasons. [scnir-neutropenia.uw.edu]

Fitz-Hugh and Krumbharr5 reported a case of chronic neutropenia in which the cellular [jamanetwork.com]

Congenital Neutropenia

Note Severe chronic neutropenia (SCN) is a heterogeneous group of disorders characterized by chronic neutropenia and serious recurrent infections. [atlasgeneticsoncology.org]

The 2 main forms of hereditary neutropenia are cyclic (CN) and severe congenital (SCN) neutropenia. [ncbi.nlm.nih.gov]

Severe congenital neutropenia What every physician needs to know: Severe congenital neutropenia (SCN) is a rare heterogenous disorder characterized by chronic severe neutropenia [cancertherapyadvisor.com]

Shwachman Syndrome

[…] chronic neutropenia (SCN). [bone-marrow-failure-syndromes.de]

We report a boy affected by Shwachman syndrome (SS) who presented severe neutropenia and frequent suppurative infections, which we treated successfully with granulocyte colony-stimulating [ncbi.nlm.nih.gov]

Hematopoietic stem cell transplantation in severe congenital neutropenia: experience of the French SCN register. [doi.org]

Pancytopenia

Septic screen is required for patients with febrile neutropenia, including aseptic sampling of any indwelling lines for culture. [onlinelibrary.wiley.com]

KEYWORDS: G6PC3; congenital neutropenia; lymphopenia; variable bone marrow phenotype [ncbi.nlm.nih.gov]

Neutropenia, Leukopenia Immunocompromised antibiotics Aplastic anemia External Links References [wikem.org]

Glycogen Storage Disease

Increasing glucose requirements, worsening lipid profile, neutropenia associated with multiple infections, and anemia were noted. [ncbi.nlm.nih.gov]

Neutropenia is characteristically seen in GSD type Ib. All content herein referring to type I GSD includes type Ia and type Ib unless stated otherwise. [bestpractice.bmj.com]

Presence of neutropenia further confirms GSD Ib. Even critical hypoglycaemia can be clinically unapparent in affected children. [ncbi.nlm.nih.gov]

Sideroblastic Anemia

Anemia and neutropenia developed in a man who took pharmacologic doses of supplemental zinc. [ncbi.nlm.nih.gov]

Neutropenia may be treated with colony stimulating factor. Pancreatic enzyme replacement treats malabsorption due to exocrine pancreatic insufficiency. [secure.ssa.gov]

ICD-9: 277.87 ICD-10: D64.0 PROGRESSION Most children with Pearson syndrome die in infancy or early childhood due to bacterial sepsis resulting from neutropenia, metabolic [secure.ssa.gov]

Hypocupremia

Keywords Zinc toxicity, pancytopenia, copper deficiency, anaemia, neutropenia Abstract Introduction: Copper deficiency or hypocupraemia is a rare cause of anaemia and neutropenia [ejcrim.com]

Marked, persistent neutropenia was its earliest and most constant manifestation. [ashpublications.org]

The haematologic abnormalities associated with copper deficiency are neutropenia, sideroblastic anaemia and/or pancytopenia. [ejcrim.com]

Waldenstrom Macroglobulinemia

This can result in anemia (low levels of red blood cells), neutropenia (low levels of white blood cells called neutrophils), and thrombocytopenia (low levels of platelets) [lymphoma.org]

Currently, there are only 2 case reports of Waldenström macroglobulinemia (WM) associated with severe neutropenia. [ncbi.nlm.nih.gov]

After the first occurrence of a drug-related grade 3 or worse adverse event, such as grade 4 neutropenia for more than 7 days or grade 3 or 4 thrombocytopenia, ibrutinib was [onclive.com]

Felty Syndrome

Neutropenia is also common in systemic lupus erythematosus and it is included in the current systemic lupus classification criteria. [ncbi.nlm.nih.gov]

A durable remission was achieved without complication, despite persistent severe peripheral neutropenia. [ncbi.nlm.nih.gov]

Abstract The mechanism of neutropenia in Felty's Syndrome (FS) was tested. [jci.org]

Agammaglobulinemia

His neutropenia was initially treated with GCSF. [frontiersin.org]

The mechanism of neutropenia is poorly understood. [pediatrics.aappublications.org]

[…] the combination of antibody deficiency and neutropenia. [frontiersin.org]

Propionic Acidemia

In the infantile chronic form, failure to thrive, chronic vomiting and neutropenia may mimic cow milk intolerance, celiac disease (see this term) or immune deficiencies. [orpha.net]

Genetics Home Reference :Propionic Acidemia,2007 COMPLICATIONS The most common complications in patients were hematological abnormalities including anemia, neutropenia, thrombocytopenia [flipper.diff.org]

[…] high-anion gap metabolic acidosis -Elevated ketones in blood or urine (normally absent in healthy newborns) -Low to normal blood glucose concentration -Hyperammonemia (frequent) -Neutropenia [flipper.diff.org]

Hairy Cell Leukemia

Polycythemia vera is a myeloproliferative disease that sometimes evolves to myelofibrosis, causing splenomegaly and neutropenia. [ncbi.nlm.nih.gov]

[…] of neutropenia is also shown in Table 3. [bloodjournal.hematologylibrary.org]

This can be neutropenia, anaemia or thrombocytopenia [3] Neutropenia Not enough neutrophils in the blood. [cllsupport.org.uk]

X-Linked Agammaglobulinemia Type 1

Eight out of 30 XLA patients (26.7%) developed neutropenia during the course of the disease. [ncbi.nlm.nih.gov]

The mechanism of neutropenia is poorly understood. [pediatrics.aappublications.org]

The neutropenia typically resolves after the infectious episode is properly treated. [immunodeficiencysearch.com]

Cyclic Neutropenia

[…] diminished number of neutrophils in the blood. cyclic neutropenia periodic neutropenia. [medical-dictionary.thefreedictionary.com]

Cyclic neutropenia is a rare hematologic disorder, characterized by repetitive episodes of fever, mouth ulcers, and infections attributable to recurrent severe neutropenia [iths.pure.elsevier.com]

Cyclic neutropenia is characterized by periodic episodes of neutropenia that are often associated with infectious complications. [ncbi.nlm.nih.gov]

Hypersplenism

Primary causes are idiopathic thrombocytopenic purpura, congenital hemolytic anaemia and primary splenic neutropenia or pancytopenia. [explainmedicine.com]

Some of these—anemia, neutropenia, and thrombocytopenia—are attributed to hypersplenism. [annals.org]

More than half of cirrhotics will have low platelet counts, but neutropenia is much less common. [arizona.pure.elsevier.com]

Immunodeficiency Type 23

We identified three unrelated children with recurrent infections, congenital leukopenia including neutropenia, B and T cell lymphopenia, and progression to bone marrow failure [uniprot.org]

[…] anemia, hepatosplenomegaly, and neutropenia. [en.wikipedia.org]

Two children received hematopoietic stem cell transplantation of cord blood and bone marrow from matched related donors; both had successful engraftment and correction of neutropenia [uniprot.org]

Chédiak-Higashi Syndrome

Abstract Neutropenia is an almost constant feature of Chediak-Higashi syndrome (CHS). There is evidence for a central mechanism of neutropenia. [unboundmedicine.com]

Chédiak-Higashi syndrome (C-HS) is a rare congenital disease characterized by defective neutrophil function with abnormal lysosomal inclusions, neutropenia, and reduced chemotaxis [ncbi.nlm.nih.gov]

For less clear reasons, neutropenia and a peripheral neuropathy result. [pathwaymedicine.org]

Fusarium Infection

[…] and 4% for patients with persistent neutropenia only. [ncbi.nlm.nih.gov]

Disseminated Fusarium infection should be suspected in immunocompromised patients with fever and neutropenia who have generalized, eroded, violaceous papules, vesicles, and [ncbi.nlm.nih.gov]

Abstract Fusarium spp. causes infections mostly in patients with prolonged neutropenia. [ncbi.nlm.nih.gov]

Cartilage Hair Hypoplasia

Chronic neutropenia is common in children with cartilage-hair hypoplasia (CHH). [ncbi.nlm.nih.gov]

Hematologic studies in one child disclosed chronic neutropenia secondary to a failure of myeloid maturation. [nejm.org]

Sixty-two percent of the patients had had lymphopenia and 24% neutropenia. [ncbi.nlm.nih.gov]

Aplastic Anemia

May present with sequelae of neutropenia (infections), anaemia (fatigue, pallor, dyspnoea, tachycardia), or thrombocytopenia (bleeding, bruising). [bestpractice.bmj.com]

Soon after that, she was admitted with severe neutropenia, which progressed to pancytopenia confirmed as aplastic anemia on a bone marrow biopsy. [ncbi.nlm.nih.gov]

The regimen has a low incidence of bone marrow suppression, and the incidences of anemia, leukopenia, neutropenia and thrombocytopenia exceeding grade 3 are less than 5%. [ncbi.nlm.nih.gov]

Familial Myelofibrosis

Patients may experience anaemia, neutropenia, and/or thrombocytopaenia. Patients may also experience pain secondary to hepatosplenomegaly. [healthengine.com.au]

A diagnosis of MDS in patients with neutropenia or thrombocytopenia without anemia should be made with caution. [en.wikipedia.org]

Recipient Evaluation Management of Graft-Versus-Host Disease Hematopoietic Growth Factors NCCN Guidelines Management of Cancer- and Chemotherapy-Induced Anemia Management of Neutropenia [nccn.org]

Dyskeratosis Congenita

[…] ordering the Dyskeratosis Congenita Panel ICD-10 Disease Q82.8 Hoyeraal Hreidarsson syndrome D81.0 Reticular dysgenesis H35.00 Coats plus syndrome D82.8 Poikiloderma with neutropenia [immunology.blueprintgenetics.com]

[…] fibrosis and/or bone marrow failure, telomere-related, Dyskeratosis congenita AD/AR 48 156 TINF2 Revesz syndrome, Dyskeratosis congenita AD 25 42 USB1 Poikiloderma with neutropenia [immunology.blueprintgenetics.com]

[…] dyskeratosis congenita panel covers classical genes associated with Hoyeraal Hreidarsson syndrome, Revesz syndrome, reticular dysgenesis, Coats plus syndrome, poikiloderma with neutropenia [immunology.blueprintgenetics.com]

Secondary Myelofibrosis

Dose limiting toxicities include thrombocytopenia and neutropenia. [geron.com]

Grade 4 thrombocytopenia, regardless of attribution to the study drug, occurred in 21% of the patients, grade 4 neutropenia in 18%, and grade 3 anemia in 52%. [nejm.org]

Splenectomy should be avoided if possible; splenic irradiation has only a temporary effect and can cause severe neutropenia and infection. [merckmanuals.com]