Neutrophil Count Decreased: Causes & Reasons

Possible Causes for Neutrophil Count Decreased

count reduces rate of serious infections decreased mortality in BMT or dose-intensive chemotherapy don’t use in acute leukaemia (may stimulate leukaemic clone) cease once [lifeinthefastlane.com]

≥ 38°C (100.4°F) sustained for 1h AND Neutropenia: absolute neutrophil count (ANC) < 500 cells/mm 3 OR ANC predicted to decrease to < 500 cells/mm 3 in 48h Caveat: Signs and [hopkinsguides.com]

 Definition- decrease in the number of absolute neutrophil count (ANC) in peripheral blood.  Absolute neutrophil count(ANC)= mature granulocytes + neutrophil band cells [slideshare.net]

Drug-induced Neutropenia

At the neutrophil decrease nadir, the mean and median neutrophil counts were 0.15 and 0.08 × 10 9 /L (range 0–0.4) (Table 2 ). [link.springer.com]

[…] abnormal decrease in the neutrophil count associated with acute leukemia, chemotherapy, and idiosyncratic drug reactions, predisposing individuals to infection. [medical-dictionary.thefreedictionary.com]

[…] olanzapine use and decreased neutrophil counts that suggests a causal relationship between olanzapine and neutropenia. [e-ijas.org]

Severe Congenital Neutropenia

Most cases of SCN respond to treatment with granulocyte colony-stimulating factor (filgrastim), which increases the neutrophil count and decreases the severity and frequency [encyclopedia.pub]

[…] leads to a decrease in the absolute neutrophil count and a subsequent increased susceptibility to infections. [en.wikipedia.org]

Kostmann syndrome is a group of diseases that affect myelopoiesis, causing a congenital form of neutropenia (severe congenital neutropenia [SCN]), usually without other physical [encyclopedia.pub]

Familial Neutropenia

A systematic review of case reports of drug-induced agranulocytosis (a decrease in peripheral neutrophil count to 25 TABLE 7 25 lists medications that can be associated with [mdedge.com]

O f t hese, 12 articles described patients with benign ethnic neutropenia whose neutrophil count decreased during treatment with clozapine. [psychiatrist.com]

Idiopathic Neutropenia

Peri-operative G-CSF therapy in patients with chronic idiopathic neutropenia is effective in increasing the total neutrophil count, and decreasing infection complications. [ncbi.nlm.nih.gov]

IN in children is usually characterized by decreased neutrophil counts ( < 1500/ μl) and can result in reduced monocyte count and phagocyte function. [eurekaselect.com]

[…] children is characterized by decreased neutrophil counts [ncbi.nlm.nih.gov]

Congenital Neutropenia

The peripheral blood showed a markedly decreased absolute neutrophil count, and the bone marrow findings revealed maturation arrest of myeloid precursors at the promyelocyte [ncbi.nlm.nih.gov]

In case of an increase of ALT or AST > # ULN, decrease of neutrophil count < #/mm# or any other severe adverse events, treatment should be modified as follows sk Nič [sk.glosbe.com]

count and decreases the severity and frequency of infections. [1] Although this treatment has significantly improved survival, people with SCN are at risk of long-term complications [en.wikipedia.org]

Cyclic Neutropenia

The peak neutrophil count gradually decreased as pregnancy advanced, resulting in the disappearance of its cyclicity. [ncbi.nlm.nih.gov]

Routine blood test revealed that her absolute neutrophil count repeatedly decreased (minimum 0. 04 × 10/L) every 21 days on an average. [ncbi.nlm.nih.gov]

Cyclic neutropenia (CyN) is a rare hematological condition with neutrophil counts decreasing to <0.2 x 109/L, usually at 21 day intervals, accompanied by fever, mouth ulcers [ashpublications.org]

Agranulocytosis

[…] in the number of neutrophilic leukocytes in the blood 288.0 Excludes Applies To Decreased Absolute Neutrophil Count (ANC) Use Additional Use additional code for any associated [icd9data.com]

Background: Nonchemotherapy drug–induced agranulocytosis is a rare adverse reaction that is characterized by a decrease in peripheral neutrophil count to less than 0.5 × 10 [doi.org]

Clinical Information A deficiency in the number of granulocytes, a type of white blood cell An abnormal decrease in the number of neutrophils, a type of white blood cell Decrease [icd9data.com]

Felty Syndrome

These include: Rheumatoid arthritis, decrease of neutrophil/granulocyte count called neutropenia (neutrophils- a type of cells found in blood and bone marrow), and an enlarged [dovemed.com]

Three patients (2 T-cell and 1 NK-cell LGLL) were treated with rituximab (two 1000 mg infusions) with a decreased DAS28 and an increased neutrophil count, with subsequent [ncbi.nlm.nih.gov]

Research has shown that removal of the spleen can improve the WBC count by improving the neutrophil count, and can decrease the number of infections [5]. [elynsgroup.com]

Shwachman Syndrome

There may be decreased numbers of neutrophils (the white blood cell that helps fight infection), platelets( the blood cell that helps clot the blood), or red blood cells. [dashforacure.org]

[…] muscle tone Low muscle tone [ more ] 0001290 Neutropenia Low blood neutrophil count Low neutrophil count [ more ] 0001875 30%-79% of people have these symptoms Abnormality [rarediseases.info.nih.gov]

Recurrent infections are related to neutropenia, chemotactic defect, impaired neutrophil mobility, and impaired complement activation. [mirc.rsna.org]

Leukoerythroblastic Anemia

THIS IS NOT A TRUE DECREASE BUT RESULTS FROM INCREASED MARGINATION BY NEUTROPHILS. [meddean.luc.edu]

[…] leukocytosis increased bone marrow production or release of neutrophils; decreased activation of neutrophil adhesion molecules Neutropenia absolute neutrophil count etiology [memorize.com]

Decreased Absolute Neutrophil Count (ANC) Use additional code for any associated: fever (780.6) mucositis (478.11, 528.00-528.09, 538, 616.81) Excludes: neutropenic splenomegaly [theodora.com]

Methylmalonic Acidemia with Homocystinuria Type cblJ

count decreased Neutrophil count decreased phenotype Finding 71 2 0.100 0 CUI: C0878787 Disease: Growth failure Growth failure phenotype Disease or Syndrome 211 3 0.100 0 [disgenet.org]

The patient had an episode of neutropenia later in childhood. [findzebra.com]

[…] reflux Abnormality of the eye Hypertelorism Abnormality of the genitourinary system Cryptorchidism Homocystinuria Methylmalonic aciduria Abnormality of the immune system Neutropenia [ncbi.nlm.nih.gov]

Vitamin B12 Deficiency

[…] anemia, increased lactate dehydrogenase, vasoconstriction, increased platelet aggregation, and abnormal activation of the coagulation followed by microangiopathy as well as neutropenia [ncbi.nlm.nih.gov]

We present a 9-month-old boy with megaloblastic anaemia, neutropenia and hypogammaglobulinaemia due to vitamin B12 deficiency. [ncbi.nlm.nih.gov]

Three (15 %) patients had leukopenia, 7 (35 %) had neutropenia, 2 (10 %) patients had thrombocytopenia. All of the mothers had vitamin B12 deficiency. [ncbi.nlm.nih.gov]

Immunodeficiency Type 23

[…] blood lymphocyte number Low lymphocyte number [ more ] 0001888 Neutropenia Low blood neutrophil count Low neutrophil count [ more ] 0001875 Recurrent respiratory infections [rarediseases.info.nih.gov]

We identified three unrelated children with recurrent infections, congenital leukopenia including neutropenia, B and T cell lymphopenia, and progression to bone marrow failure [uniprot.org]

[…] immune function 0002721 Intellectual disability Mental deficiency Mental retardation Mental retardation, nonspecific Mental-retardation [ more ] 0001249 Lymphopenia Decreased [rarediseases.info.nih.gov]

Viral Disease

Three patients with only HHV6 DNA in urine or serum had fever and abnormal liver function but not neutropenia. [ncbi.nlm.nih.gov]

All five CMV-seronegative patients who received positive kidneys developed moderate to severe disease with fever and neutropenia but also had HHV6 DNA in urine or serum. [ncbi.nlm.nih.gov]

Pancytopenia

Blood Film 1.RBC morphology ( size & shape) 2.WBC and RBC precursor 3.Platelets count & size 4.Abnormal increase or decrease granulation in Neutrophil 5. [slideshare.net]

The criteria for autoimmune neutropenia diagnosis are as follows: A decrease in the circulating absolute neutrophil count to −1 caused by serum anti-neutrophil antibodies. [smjonline.org]

Although the absolute neutrophil count (ANC) initially reached normal levels, it decreased to subnormal levels after filgrastim treatment was discontinued. [ashpublications.org]

Hypocupremia

The hypocupremia was associated with microcytosis and relative neutropenia. Administration of copper resulted in an increase in RBC size and leukocyte counts. [typeset.io]

Keywords Zinc toxicity, pancytopenia, copper deficiency, anaemia, neutropenia Abstract Introduction: Copper deficiency or hypocupraemia is a rare cause of anaemia and neutropenia [ejcrim.com]

Anemia and neutropenia are well known hematological manifestations of acquired copper deficiency. [journals.lww.com]

Severe Aplastic Anemia

CsA was reduced, however, his neutrophil counts decreased, and CsA could not be discontinued. [ncbi.nlm.nih.gov]

[…] aplastic anemia that did not respond to classic and immunosuppressive treatment for disease and developing invasive cardiac mucormycosis despite empiric treatment for febrile neutropenia [ncbi.nlm.nih.gov]

The patient had diabetes arising from the hemochromatosis, chronic anal fissures, and a kidney abscess due to neutropenia. [ncbi.nlm.nih.gov]

Non-Hodgkin Lymphoma

The most common grade ≥3 adverse events (AEs) were anemia (43%), neutropenia (39%), decreased neutrophil count (32%), febrile neutropenia (31%), decreased white blood cell [onclive.com]

Any patient with severe neutropenia should be given antibiotic prophylaxis with chemotherapy. [patient.info]

The most common grade 3/4 adverse events included hyperglycemia (11.1%) and neutropenia (5.6%). [ncbi.nlm.nih.gov]

Influenza

ALPS can also cause anemia (low level of red blood cells), thrombocytopenia (low level of platelets), and neutropenia (low level of neutrophils, the most common type of white [niaid.nih.gov]

Evidence of harms The trials identified only one serious adverse event ( Nicholson 2000 ) (so labelled in the Japanese data, a patient with neutropenia), and, in particular [dx.doi.org]

Chédiak-Higashi Syndrome

Abstract Neutropenia is an almost constant feature of Chediak-Higashi syndrome (CHS). There is evidence for a central mechanism of neutropenia. [unboundmedicine.com]

Chédiak-Higashi syndrome (C-HS) is a rare congenital disease characterized by defective neutrophil function with abnormal lysosomal inclusions, neutropenia, and reduced chemotaxis [ncbi.nlm.nih.gov]

For less clear reasons, neutropenia and a peripheral neuropathy result. [pathwaymedicine.org]

Fusarium Infection

[…] and 4% for patients with persistent neutropenia only. [ncbi.nlm.nih.gov]

Disseminated Fusarium infection should be suspected in immunocompromised patients with fever and neutropenia who have generalized, eroded, violaceous papules, vesicles, and [ncbi.nlm.nih.gov]

Abstract Fusarium spp. causes infections mostly in patients with prolonged neutropenia. [ncbi.nlm.nih.gov]

Chronic Lymphocytic Leukemia

≥ 1500/μL absolute neutrophil count, > 100000/μL platelets, > 11.0 g/dL hemoglobin or 50% improvement for either of these parameters without transfusions or growth factors [clinicaltrials.gov]

A high lymphocyte count with a low neutrophil count might be caused by lymphoma. [en.wikipedia.org]

Routine preoperative laboratory studies showed severe neutropenia and increased atypical lymphocytes in the peripheral blood. [ncbi.nlm.nih.gov]

Infectious Mononucleosis

A mild transient neutropenia occurring during the first weeks of acute infection is a common finding however in rare cases a more profound neutropenia and agranulocytosis [ncbi.nlm.nih.gov]

[…] and absolute lymphocytosis(70%) Atypical monocytosis(90%) Elevated Liver function test(90%) Positive heterophil antibodies(90%) Thrombocytopenia(50%) Relative and absolute neutropenia [clinicclinic2.cafe24.com]

[…] infectious mononucleosis are: Absolute und relative leukocytosis (> 4000/ml and > 50% of leukocytes) with > 10% atypical large T-cells ( Pfeiffer cells, fibrocytes) Mild anemia, neutropenia [lecturio.com]

Cartilage Hair Hypoplasia

The defect in colony formation did not correlate with the haemoglobin concentration, platelet count or neutrophil count. [ncbi.nlm.nih.gov]

Sixty-two percent of the patients had had lymphopenia and 24% neutropenia. [ncbi.nlm.nih.gov]

Chronic neutropenia is common in children with cartilage-hair hypoplasia (CHH). [ncbi.nlm.nih.gov]

Streptococcal Septicemia

In newborns, characteristic findings of elevated neutrophil counts and protein concentrations and decreased glucose concentrations are obscured by normal elevations of the [clinicaladvisor.com]

[…] change toward an increase of infections by Staphylococcus epidermidis and alpha-hemolytic Streptococci has been noticed in the predominant etiology of infections during neutropenia [ncbi.nlm.nih.gov]

JJ, van der Nordaa J, de Kraker J, Voute PA, van Leeuwen EF, Terpstra WJ, Ansink-Schipper MC (1987) α-hemolytic streptococcal septicemia with severe complications during neutropenia [link.springer.com]

Aplastic Anemia

The diagnosis usually requires the presence of pancytopenia with a neutrophil count fewer than 1500/ μ L (1.5 × 10 9 /L), a platelet count fewer than 50,000/ μ L (50 × 10 [accessmedicine.mhmedical.com]

May present with sequelae of neutropenia (infections), anaemia (fatigue, pallor, dyspnoea, tachycardia), or thrombocytopenia (bleeding, bruising). [bestpractice.bmj.com]

Soon after that, she was admitted with severe neutropenia, which progressed to pancytopenia confirmed as aplastic anemia on a bone marrow biopsy. [ncbi.nlm.nih.gov]

Propionic Acidemia

Low blood neutrophil count Low neutrophil count [ more ] 0001875 Osteoporosis 0000939 Pancreatitis Pancreatic inflammation 0001733 Pancytopenia Low blood cell count 0001876 [rarediseases.info.nih.gov]

In the infantile chronic form, failure to thrive, chronic vomiting and neutropenia may mimic cow milk intolerance, celiac disease (see this term) or immune deficiencies. [orpha.net]

Poor appetite Decreased appetite 0004396 Psychomotor retardation 0025356 Seizures Seizure 0001250 Short stature Decreased body height Small stature [ more ] 0004322 Tachypnea [rarediseases.info.nih.gov]

Glycogen Storage Disease

Increasing glucose requirements, worsening lipid profile, neutropenia associated with multiple infections, and anemia were noted. [ncbi.nlm.nih.gov]

Neutropenia is characteristically seen in GSD type Ib. All content herein referring to type I GSD includes type Ia and type Ib unless stated otherwise. [bestpractice.bmj.com]

Presence of neutropenia further confirms GSD Ib. Even critical hypoglycaemia can be clinically unapparent in affected children. [ncbi.nlm.nih.gov]

Sideroblastic Anemia

Anemia and neutropenia developed in a man who took pharmacologic doses of supplemental zinc. [ncbi.nlm.nih.gov]

Neutropenia may be treated with colony stimulating factor. Pancreatic enzyme replacement treats malabsorption due to exocrine pancreatic insufficiency. [secure.ssa.gov]

ICD-9: 277.87 ICD-10: D64.0 PROGRESSION Most children with Pearson syndrome die in infancy or early childhood due to bacterial sepsis resulting from neutropenia, metabolic [secure.ssa.gov]