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40 Possible Causes for Neutrophil Count Decreased, Progressive Polyneuropathy

  • Vitamin B12 Deficiency

    peripheral neuropathy, and spinal degeneration.[] […] normal One-Carbon metabolism leading to the observed clinical neurological manifestations such as nerve damage and, demyelination, degeneration of PNS leading to paralysis, progressive[]

  • Chronic Alcoholism

    The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show[…][]

  • Multiple Myeloma

    […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[] […] absolute neutrophil count, decreased phosphorus, anemia, neutropenia, decreased total white blood cell count, decreased platelets, diarrhea, fatigue, thrombocytopenia, pyrexia[] Trial-ineligibility was determined by presence of at least one of the common exclusion criteria: heart/renal failure, liver/renal diseases, polyneuropathy, HIV positivity.[]

  • Pernicious Anemia

    Autoimmun Rev. 2014 Apr-May;13(4-5):565-8. doi: 10.1016/j.autrev.2014.01.042. Epub 2014 Jan 11. Author information 1 Laboratory of Clinical Pathology, San Antonio Hospital, via Morgagni 18, 33028 Tolmezzo, UD, Italy. Electronic address: 2 Laboratory of Clinical Pathology, Civic Hospital, via[…][]

  • Waldenstrom Macroglobulinemia

    Neuropathy is typically slowly progressive, distal, symmetrical, and sensorimotor.[] POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) also may be associated with Waldenström macroglobulinemia.[]

  • Chediak Higashi Syndrome

    peripheral neuropathy and the tendency to develop a life threatening lymphoma like syndrome. 1 Susceptibility to infection from phagocytic dysfunction ranges from mild recurrent[] […] susceptibility to infections due to defective granulation of neutrophil and abnormal function of natural killer cell with bleeding diathesis, partial occulocutanous albinism, progressive[]

  • Addison's Disease

    This disease is milder and progresses more slowly than adrenoleukodystrophy.[] It is further confirmed by cosyntropin stimulation test, which is done by administering ACTH and then measuring serum cortisol levels Complete blood count that may show decreased[] Adrenomyeloneuropathy begins in adolescence or early adulthood with weakness, spasticity, and distal polyneuropathy.[]

  • Systemic Lupus Erythematosus

    progressive course of acute demyelinating polyneuropathy have been reported.[] Normal WBC counts Leukopenia is caused due to decrease in number of WBCs, particularly neutrophils.[] To determine the effect of diflunisal on polyneuropathy progression in patients with familial amyloid polyneuropathy.[]

  • Subacute Combined Degeneration of Spinal Cord

    References: [2] [4] Diagnostics Hematological findings Signs of megaloblastic anemia Hb MCV ( macrocytic ), MCH ( hyperchromic ) Hypersegmented neutrophils (lobe count 4 )[] Reticulocytes, iron Frequently thrombocytopenia and leukopenia (possibly pancytopenia ) Approach If vitamin B12 serum levels are decreased determine the underlying cause[]

  • Propionic Acidemia

    […] demyelination, which results in progressive neurologic dysfunction, includ-ing pyramidal signs, polyneuropathy, bulbar symptoms, ataxia, or even psychiatric symptoms in adult[] […] strokes, cornea verticillata, proteinuria, cardiomyopathy, angiokeratomas, hearing lossLow -galactosidase activityEnzymotherapy -Galactosidase(leucocytes)Gaucher diseaseAR Any Progressive[] […] function studies; VLCFAvery long-chain fatty acid; VWMvanishing white matter.Diagnosis of Leukodystrophies and Other White Matter Disease Vanderver 115characterized by a progressive[]

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