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21 Possible Causes for Night Sweats, Polyclonal Hyperglobulinemia

  • Castleman Disease

    Herein we present the case of a 49-year-old female with a 3-year history of progressively worsening lymphadenopathy associated with fevers, chills and night sweats.[] The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[] […] and night sweats, and more severely, multi-organ system failure and progression to lymphoma.[]

  • Multicentric Castleman's Disease

    He presented with fevers, dry cough, weight loss and drenching night sweats. Routine investigations were all unremarkable.[] hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[] A 49-year-old man with HIV infection presented with 1-week duration of low-grade fever, night sweats, left sided abdominal pain, and generalized weakness.[]

  • HIV Infection

    Other symptoms can include chills , night sweats , and mouth ulcers .[] Hyperactivation is reflected in dramatic polyclonal hyperglobulinemia, only a portion of which is directed against HIV antigens;(59) bone marrow plasmacytosis;(60) heightened[] Other symptoms can include chills, night sweats, and mouth ulcers.[]

  • Primary Myelofibrosis

    Constitutional symptoms, such as night sweats, pruritus, weight loss and fever may be treated with Jakafi.[] Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[] No new therapeutic intervention was initially required; however, 2 years later, the patient reported symptomatic splenomegaly and drenching night sweats, so ruxolitinib therapy[]

  • Angioimmunoblastic Lymphadenopathy

    sweats, and hepatosplenomegaly.[] In one series, other symptoms included weight loss (58%), hepatomegaly (60%), polyclonal hyperglobulinemia (65%), and generalized adenopathy (87%).[] A patient presented with fever, night sweats, generalized lymphadenopathy, cold agglutinin hemolytic anemia, and thrombocytopenia.[]

  • Rosai-Dorfman Disease

    Additional findings may include fever, malaise, epistaxis, night sweats, weight loss, leukocytosis, elevated erythrocyte sedimentation rate and hypergammaglobulinemia.[] hyperglobulinemia.[] Fever, weight loss, night sweats, malaise, and pharyngitis are additional symptoms, while enlargement of other lymph nodes (axillary, mediastinal, inguinal, retroperitoneal[]

  • Allergic Gastritis

    The symptoms during this phase can include feeling generally unwell with weight loss, fever, and night sweats.[] Elevated serum IgE, elevated levels of tumor necrosis factor (TNF-α) and interleukin-5 (IL-5) [ 17 ], polyclonal hyperglobulinemia, and good response to steroids are additional[] Since diagnosis there had been a 6.8 kg (15 lbs) weight loss, night sweats, swelling of her hands and feet, hyperventilation, generalized weakness, and chest discomfort.[]

  • MALT Lymphoma

    sweats Fatigue Fever (for no known reason) Pain in the chest, abdomen, or bone s (for no known reason) Skin rash or itchy skin Weight loss (for no known reason) Diagnostic[] Not only MALT lymphoma, but also SjS can cause secondary hyperglobulinemia. Indeed, immunoelectrophoresis-serum test showed a polyclonal pattern of hyperglobulinemia.[] Systemic symptoms (night sweats, weight loss, fever, lethargy) and bone marrow involvement are less common. Most are localised to the stomach at presentation.[]

  • IgG4-Related Retroperitoneal Fibrosis

    On detailed history of patient noted the presence of intermittent night sweats for five years, a recent unintentional weight loss of 15 lbs., Raynaud’s phenomenon, malar rash[] hyperglobulinemia.[] Fever, weight loss and night sweats, however, are uncommon in IgG4-RD [[ 94 ]]. Interestingly, histopathology of lymph nodes in IgG4-RD differs from the usual findings.[]

  • Autoimmune Pancreatitis

    Patients with multicentric CD often complain of systemic manifestations, such as fever, night sweats, malaise, and weight loss.[] hyperglobulinemia.[] (IL) 6 and vascular endothelial growth factor (VEGF) are commonly found in multicentric CD, as are acute phase reactants, anemia, thrombocytopenia, hypoalbuminemia, and polyclonal[]

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