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21 Possible Causes for Night Sweats, Polyclonal Hyperglobulinemia

  • Castleman Disease

    Herein we present the case of a 49-year-old female with a 3-year history of progressively worsening lymphadenopathy associated with fevers, chills and night sweats.[ncbi.nlm.nih.gov] The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[ncbi.nlm.nih.gov] […] and night sweats, and more severely, multi-organ system failure and progression to lymphoma.[targetedonc.com]

  • Multicentric Castleman's Disease

    He presented with fevers, dry cough, weight loss and drenching night sweats. Routine investigations were all unremarkable.[ncbi.nlm.nih.gov] hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[pagepress.org] A 49-year-old man with HIV infection presented with 1-week duration of low-grade fever, night sweats, left sided abdominal pain, and generalized weakness.[ncbi.nlm.nih.gov]

  • HIV Infection

    Other symptoms can include chills , night sweats , and mouth ulcers .[medicinenet.com] Hyperactivation is reflected in dramatic polyclonal hyperglobulinemia, only a portion of which is directed against HIV antigens;(59) bone marrow plasmacytosis;(60) heightened[hivinsite.ucsf.edu] Other symptoms can include chills, night sweats, and mouth ulcers.[medicinenet.com]

  • Primary Myelofibrosis

    Constitutional symptoms, such as night sweats, pruritus, weight loss and fever may be treated with Jakafi.[mpnresearchfoundation.org] Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[patient-help.com] No new therapeutic intervention was initially required; however, 2 years later, the patient reported symptomatic splenomegaly and drenching night sweats, so ruxolitinib therapy[ncbi.nlm.nih.gov]

  • Angioimmunoblastic Lymphadenopathy

    sweats, and hepatosplenomegaly.[ncbi.nlm.nih.gov] In one series, other symptoms included weight loss (58%), hepatomegaly (60%), polyclonal hyperglobulinemia (65%), and generalized adenopathy (87%).[emedicine.medscape.com] A patient presented with fever, night sweats, generalized lymphadenopathy, cold agglutinin hemolytic anemia, and thrombocytopenia.[ncbi.nlm.nih.gov]

  • Rosai-Dorfman Disease

    Additional findings may include fever, malaise, epistaxis, night sweats, weight loss, leukocytosis, elevated erythrocyte sedimentation rate and hypergammaglobulinemia.[orpha.net] hyperglobulinemia.[ncbi.nlm.nih.gov] Fever, weight loss, night sweats, malaise, and pharyngitis are additional symptoms, while enlargement of other lymph nodes (axillary, mediastinal, inguinal, retroperitoneal[symptoma.com]

  • Allergic Gastritis

    The symptoms during this phase can include feeling generally unwell with weight loss, fever, and night sweats.[cssassociation.org] Elevated serum IgE, elevated levels of tumor necrosis factor (TNF-α) and interleukin-5 (IL-5) [ 17 ], polyclonal hyperglobulinemia, and good response to steroids are additional[clinicalmolecularallergy.biomedcentral.com] Since diagnosis there had been a 6.8 kg (15 lbs) weight loss, night sweats, swelling of her hands and feet, hyperventilation, generalized weakness, and chest discomfort.[clinicalmolecularallergy.biomedcentral.com]

  • MALT Lymphoma

    sweats Fatigue Fever (for no known reason) Pain in the chest, abdomen, or bone s (for no known reason) Skin rash or itchy skin Weight loss (for no known reason) Diagnostic[seer.cancer.gov] Not only MALT lymphoma, but also SjS can cause secondary hyperglobulinemia. Indeed, immunoelectrophoresis-serum test showed a polyclonal pattern of hyperglobulinemia.[ncbi.nlm.nih.gov] Systemic symptoms (night sweats, weight loss, fever, lethargy) and bone marrow involvement are less common. Most are localised to the stomach at presentation.[patient.info]

  • IgG4-Related Retroperitoneal Fibrosis

    On detailed history of patient noted the presence of intermittent night sweats for five years, a recent unintentional weight loss of 15 lbs., Raynaud’s phenomenon, malar rash[elynsgroup.com] hyperglobulinemia.[hematologyandoncology.net] Fever, weight loss and night sweats, however, are uncommon in IgG4-RD [[ 94 ]]. Interestingly, histopathology of lymph nodes in IgG4-RD differs from the usual findings.[ojrd.biomedcentral.com]

  • Autoimmune Pancreatitis

    Patients with multicentric CD often complain of systemic manifestations, such as fever, night sweats, malaise, and weight loss.[hematologyandoncology.net] hyperglobulinemia.[hematologyandoncology.net] (IL) 6 and vascular endothelial growth factor (VEGF) are commonly found in multicentric CD, as are acute phase reactants, anemia, thrombocytopenia, hypoalbuminemia, and polyclonal[hematologyandoncology.net]

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