Nikolsky's Sign Causes & Reasons

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Nikolsky's Sign Symptom Checker: Possible causes include Bullous Pemphigoid. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Bullous Pemphigoid

Placing pressure on the bullae do not lead to their extension into underlying skin, and thus the bullae are negative for "Nikolsky Sign". [pathwaymedicine.org]

The Nikolsky sign, where upper layers of epidermis move laterally with slight pressure or rubbing of skin adjacent to a blister, is negative. [msdmanuals.com]

Skin biopsy and IgG titers Distinguishing Bullous Pemphigoid From Pemphigus Vulgaris Disorder Appearance of Lesion Oral Involvement Itching Nikolsky Sign Prognosis Bullous [msdmanuals.com]

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Pemphigus

Nikolsky’s sign Nikolsky s sign was first described by a Russian dermatologist Pyotr Vasilievich Nikolskiy. [lecturio.com]

sign. [en.wikipedia.org]

Although clinically rare, affected skin displays "Nikolsky's Sign" which means that bullae easily extend into adjacent skin when lateral pressure is placed. [pathwaymedicine.org]

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Pemphigus Vulgaris

Nikolsky’s sign Nikolsky s sign was first described by a Russian dermatologist Pyotr Vasilievich Nikolskiy. [lecturio.com]

The blisters were suspected to represent the Nikolsky's sign. [ncbi.nlm.nih.gov]

sign Treatment Conservative wound care indications for all patients, to prevent secondary bacterial infection antiseptics anesthetic nebulizers for mucosal lesions potent [step2.medbullets.com]

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Pemphigus Foliaceus

Piotr Nikolsky. Bullous pemphigoid forms blister between the epidermis and dermis which result in a thicker skin and are negative for Nikolsky sign. [symptoma.com]

Nikolsky's sign was positive. [e-ijd.org]

The mucosal membranes were respected (fig 1 ), and Nikolsky’s sign was positive. Histological studies of a lesion showed splitting of the upper epidermis. [adc.bmj.com]

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Pemphigus Vegetans

Nikolsky’s sign Nikolsky s sign was first described by a Russian dermatologist Pyotr Vasilievich Nikolskiy. [lecturio.com]

Lesions heal without scarring The Nikolsky sign is positive - this is where firm sliding pressure with a finger will cause an erosion Flexural involvement readily forms vegetating [pcds.org.uk]

[…] and symptoms Flaccid blisters on face, scalp, upper body, and intertriginous areas Nikolsky sign – applying pressure on blister periphery extends lesion laterally Mucosal [arupconsult.com]

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Erythema Multiforme

[…] involvement, Nikolsky sign) Urticaria (annular lesions) Erythema nodosum Viral exanthems Treatment Supportive care Corticosteroids if severe Treat underlying cause if identified [medbullets.com]

sign (as opposed to SJS/TEN) generally mild burning or itchiness; nontender most commonly involves palms/soles backs of hands and feet extensor aspects of forearms and legs [medbullets.com]

’s sign Febrile Staphylococcal scalded skin syndrome (children) Toxic epidermal necrolysis/SJS (adults) Afebrile Toxic epidermal necrolysis Negative Nikolsky’s sign Febrile [wikem.org]

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Bullous Impetigo

sign (sheet-like removal of epidermis with sliding pressure) Highly contagious; may occur in outbreaks ( Antonie Van Leeuwenhoek 2009;95:387, Euro Surveill 2009;14:19372 [pathologyoutlines.com]

sign Localization Face (most common), especially around the nose and mouth Extremities May be pruritic (especially pustules ) but is rarely painful Regional lymphadenopathy [amboss.com]

Associated systemic involvement Staphylococcal scalded skin syndrome Cutaneous tenderness, positive Nikolsky sign, large areas of desquamation or exfoliation. [ncbi.nlm.nih.gov]

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Toxic Epidermal Necrolysis

sign. [ncbi.nlm.nih.gov]

Nikolsky's sign is positive in perilesional skin. [ncbi.nlm.nih.gov]

She presented targetoid lesions affecting approximately 25-30% of her body surface, large erosions with mucosal lesions and positive Nikolsky sign. [ncbi.nlm.nih.gov]

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Epidermolysis Bullosa

RDEB presents with blistering and erosions at birth with positive Nikolsky’s sign (extension of blistering or sloughing of epidermis with application of gentle pressure to [hindawi.com]

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Staphylococcal Scalded Skin Syndrome

[…] acute illness in which the Nikolsky's sign can be easily elicited. [ijpd.in]

The erythema is followed by cleavage of the upper epidermis in a large sheets mainly in the head, neck and the flexures, with formation of bullae (Nikolsky sign). [ncbi.nlm.nih.gov]

The patients can also be positive for Nikolsky sign. [symptoma.com]

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Epidermolysis Bullosa Acquisita

Nikolsky's sign and bulla spreading sign were positive. Minimal atrophy and pigmentary disturbances were evident on healing. Milia were absent. [ijdvl.com]

Nikolsky’s sign was positive. In addition, mucosal lesions appeared on the tongue and lips. [omicsonline.org]

The Nikolsky and Asboe-Hansen signs (see above) are positive. The crusted lesions may follow an arcuate pattern. Healing occurs without scarring. [plasticsurgerykey.com]

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Mucous Membrane Pemphigoid

sign. [ncbi.nlm.nih.gov]

This is known as a Nikolsky sign. A Nikolsky sign is not always present in patients with mucous membrane pemphigoid. [dentistry.uiowa.edu]

Gentle manipulation of the normal mucosa induced a positive Nikolsky's sign. [jofs.in]

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Brazilian Pemphigus Foliaceus

sign). [medical-dictionary.thefreedictionary.com]

[…] goo sel-va'zhem) [Portuguese, literally “wild fire”], FS An autoimmune disease that causes blistering of the skin of the head, neck or trunk, esp. when the skin is rubbed (Nikolsky's [medical-dictionary.thefreedictionary.com]

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Extensive Burns

Acquired factor X deficiency is an extremely rare situation. It has shown to be associated with systemic amyloidosis, respiratory mycoplasma infection, factor X inhibitors, antiphospholipid antibodies, vitamin K deficiency/liver disease as well as the use of certain medications (meropenem, valproic acid). The pathogenesis[…] [ncbi.nlm.nih.gov]

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Stevens-Johnson Syndrome

Nikolsky's sign is positive in perilesional skin. [ncbi.nlm.nih.gov]

Nikolsky sign can be positive. Mucosal surfaces are spared. [visualdx.com]

Nikolsky sign can be positive. Histology will clearly differentiate AGEP from SJS/TEN. [visualdx.com]

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Pemphigus Erythematosus

The Nikolsky sign is not specific for pemphigus and may also be observed in staphylococcal scalded skin syndrome and toxic epidermal necrolysis. [clinicaladvisor.com]

Nikolsky’s sign appeared to be positive, albeit somewhat indistinct. [omicsonline.org]

Blisters tend to form when the skin is rubbed ( Nikolsky sign ). [dermnetnz.org]

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Herlitz Disease

Disease Type of connection Junctional epidermolysis bullosa, Herlitz type Localized junctional epidermolysis bullosa, non-Herlitz type Junctional epidermolysis bullosa - pyloric atresia Epidermolysis bullosa simplex with pyloric atresia Hypoplastic amelogenesis imperfecta LOC syndrome Junctional epidermolysis bullosa inversa[…] [csbg.cnb.csic.es]

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Bullous Lichen Planus

sign ( Clinical Nikolsky's sign ). [4], [6], [10], [15], [17], [22] Microscopic Nikolsky's sign Microscopic Nikolsky's sign is the subclinical counterpart of Nikolsky's sign [jiaomr.in]

Bulla spread sign and Nikolsky's sign were both negative. Mucosae, nails and hair were normal. General and systemic examination did not reveal any abnormality. [ijdvl.com]

Asboe-Hansen sign and Nikolsky sign were both negative. There were no oral lesions. Nails and hair were also normal. [ncbi.nlm.nih.gov]

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Hydroa Vacciniforme-Like Lymphoma

The blisters were Nikolsky’s sign, filled with clear yellow-colored fluid. Once the blisters were ruptured, there leaved depressed cicatrix. [diagnosticpathology.biomedcentral.com]

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Stomatitis

The Nikolsky sign is usually positive in SJS and pemphigus vulgaris. Cutaneous vesicles are typical with chickenpox or herpes zoster (see Herpesviruses). [msdmanuals.com]

The Nikolsky sign is usually positive in SJS and pemphigus vulgaris. Cutaneous vesicles are typical with chickenpox or herpes zoster (see Herpesviruses ). [merckmanuals.com]

Any bullous lesions are rubbed for the Nikolsky sign (upper layers of epidermis move laterally with slight pressure or rubbing of skin adjacent to a blister). [msdmanuals.com]

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Drug Eruptions

Toxic Epidermal Necrolysis (TEN, Lyell Syndrome): Clinical Picture (1) Toxic Epidermal Necrolysis (TEN, Lyell Syndrome): Clinical picture with positive Nikolsky sign: slight [genevadermatology.ch]

’s sign, high fever, shortness of breath and skin necrosis. [aocd.org]

[…] drug reaction ( toxic epidermal necrolysis, Stevens Johnson syndrome, hypersensitivity syndrome, and serum sickness) such as mucous membrane erosions, blisters, a positive Nikolsky’s [aocd.org]

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Linear IgA Dermatosis

Nikolsky sign was negative. Mucosal examination findings were normal. [jamanetwork.com]

sign Negative, though may be positive when pustules are confluent Positive 8, 27 Pathology Subepidermal blistering with predominantly neutrophilic and eosinophilic dermal [jaoa.org]

Bulla spread sign and Nikolsky's sign were negative. [idoj.in]

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Peritoneal Adhesion

Nikolsky's sign can appear on perilesional skin or, in some cases, even on healthy skin. [orpha.net]

They will look for an indicator of the condition called Nikolsky’s sign. [healthline.com]

A positive Nikolsky’s sign is when your skin shears off easily when the surface is wiped sideways with a cotton swab or a finger. [healthline.com]

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Benign Familial Pemphigus

They had a peripheral scale, and Nikolsky's sign was positive. The lesions healed without scarring, but residual hyperpigmentation was observed. [jamanetwork.com]

sign may be positive 1/3 of cases are sporadic Healing accompanied by hyperpigmentation, but scarring is rare Longitudinal leukonychia (asymptomatic white longitudinal bands [pathologyoutlines.com]

Lesions are positive for Nikolsky’s sign (lateral pressure of unblistered skin at the periphery of active lesions causes the epidermis to shear off) and for Asboe Hansen’s [dermnet.com]

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Peeling Skin Syndrome

The exam may show that the skin slips off when it is rubbed (positive Nikolsky sign). [medlineplus.gov]

The responsible toxins also cause toxic shock syndrome but skin tenderness and Nikolsky's sign are not classic features. [patient.info]

Other symptoms may include the following: Red, painful areas Blistering Fever Chills Weakness Fluid loss Top layer of skin slips off with rubbing (Nikolsky's sign) In newborns [texaschildrens.org]

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Dermatitis Medicamentosa

Nikolsky sign (sign rubs off), angioedema, blisters, palpable purpura, skin necrosis, LAD Amoxilicillin (5.1%), bactram/septra (4.7%), ampicillin (4.2%)., penicillin (2.9% [quizlet.com]

sign, i.e., formation of blisters in unaffected tissue by application of light pressure. 70, 71 Microscopically, there are subepidermal blisters and a mixed inflammatory [clinicalgate.com]

[…] lichen sclerosus or lichen planus; 72 however, in contrast to lichen sclerosus or lichen planus, cicatricial pemphigoid is associated with small blisters and a positive Nikolsky [clinicalgate.com]

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Viral Exanthem

Applying slight pressure with side to side movement of a finger to the skin lesions results in displacement of the epidermis from the dermis (positive Nikolsky's sign). [atsu.edu]

development of typical lesions at the site of trauma) is characteristic of psoriasis and lichen planus. 7 The Nikolsky sign (i.e., easy separation of the epidermis from [aafp.org]

Several dermatologic signs may help narrow the differential diagnosis. [aafp.org]

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Intertrigo

sign (i.e., disruption of the epidermal layer with lateral pressure, leading to ulceration) Psoriasis Chronic scaling papules and plaques; often affects extensor surfaces [aafp.org]

[…] intense pruritus; personal and/or family history of seasonal allergies and asthma is common Pemphigus vulgaris Serious, often fatal, autoimmune disease; flaccid bullae, Nikolsky [aafp.org]

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Oral Candidiasis

However, a positive Nikolsky sign (i.e., blister formation on normal-appearing mucosa or skin with application of firm lateral pressure) may be elicited. [aafp.org]

sign Oral lesions often are the first manifestation of disease and may precede the onset of skin lesions After initiating systemic therapy, oral lesions may take longer to [aafp.org]

scarring Intact blister formation occasionally may be seen intraorally (before rupture and ulceration) Pemphigus vulgaris Diffuse and painful oral ulceration, positive Nikolsky [aafp.org]

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Staphylococcus Aureus

Nikolsky’s sign was negative. Healing was by coarse desquamation over a period of five or ten days. The male to female ration was 1.5:1. [cirp.org]

The Nikolsky sign is usually positive in SJS and pemphigus vulgaris. Cutaneous vesicles are typical with chickenpox or herpes zoster (see Herpesviruses). [merckmanuals.com]

[…] for Nikolsky's sign. [en.wikipedia.org]

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