Nikolsky's Sign Causes & Reasons

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Nikolsky's Sign Symptom Checker: Possible causes include Bullous Pemphigoid. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Nikolsky's Sign,

Negated

None

Unsure

None

Possible Causes

Bullous Pemphigoid

Placing pressure on the bullae do not lead to their extension into underlying skin, and thus the bullae are negative for "Nikolsky Sign". [pathwaymedicine.org]

The Nikolsky sign, where upper layers of epidermis move laterally with slight pressure or rubbing of skin adjacent to a blister, is negative. [msdmanuals.com]

Skin biopsy and IgG titers Distinguishing Bullous Pemphigoid From Pemphigus Vulgaris Disorder Appearance of Lesion Oral Involvement Itching Nikolsky Sign Prognosis Bullous [msdmanuals.com]

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Pemphigus

Nikolsky’s sign Nikolsky s sign was first described by a Russian dermatologist Pyotr Vasilievich Nikolskiy. [lecturio.com]

sign. [en.wikipedia.org]

Although clinically rare, affected skin displays "Nikolsky's Sign" which means that bullae easily extend into adjacent skin when lateral pressure is placed. [pathwaymedicine.org]

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Pemphigus Vulgaris

Nikolsky’s sign Nikolsky s sign was first described by a Russian dermatologist Pyotr Vasilievich Nikolskiy. [lecturio.com]

The blisters were suspected to represent the Nikolsky's sign. [ncbi.nlm.nih.gov]

sign Treatment Conservative wound care indications for all patients, to prevent secondary bacterial infection antiseptics anesthetic nebulizers for mucosal lesions potent [step2.medbullets.com]

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Pemphigus Foliaceus

Piotr Nikolsky. Bullous pemphigoid forms blister between the epidermis and dermis which result in a thicker skin and are negative for Nikolsky sign. [symptoma.com]

Nikolsky's sign was positive. [e-ijd.org]

The mucosal membranes were respected (fig 1 ), and Nikolsky’s sign was positive. Histological studies of a lesion showed splitting of the upper epidermis. [adc.bmj.com]

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Pemphigus Vegetans

Nikolsky’s sign Nikolsky s sign was first described by a Russian dermatologist Pyotr Vasilievich Nikolskiy. [lecturio.com]

Lesions heal without scarring The Nikolsky sign is positive - this is where firm sliding pressure with a finger will cause an erosion Flexural involvement readily forms vegetating [pcds.org.uk]

[…] and symptoms Flaccid blisters on face, scalp, upper body, and intertriginous areas Nikolsky sign – applying pressure on blister periphery extends lesion laterally Mucosal [arupconsult.com]

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Erythema Multiforme

[…] involvement, Nikolsky sign) Urticaria (annular lesions) Erythema nodosum Viral exanthems Treatment Supportive care Corticosteroids if severe Treat underlying cause if identified [medbullets.com]

sign (as opposed to SJS/TEN) generally mild burning or itchiness; nontender most commonly involves palms/soles backs of hands and feet extensor aspects of forearms and legs [medbullets.com]

’s sign Febrile Staphylococcal scalded skin syndrome (children) Toxic epidermal necrolysis/SJS (adults) Afebrile Toxic epidermal necrolysis Negative Nikolsky’s sign Febrile [wikem.org]

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Bullous Impetigo

sign (sheet-like removal of epidermis with sliding pressure) Highly contagious; may occur in outbreaks ( Antonie Van Leeuwenhoek 2009;95:387, Euro Surveill 2009;14:19372 [pathologyoutlines.com]

sign Localization Face (most common), especially around the nose and mouth Extremities May be pruritic (especially pustules ) but is rarely painful Regional lymphadenopathy [amboss.com]

Associated systemic involvement Staphylococcal scalded skin syndrome Cutaneous tenderness, positive Nikolsky sign, large areas of desquamation or exfoliation. [ncbi.nlm.nih.gov]

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Toxic Epidermal Necrolysis

sign. [ncbi.nlm.nih.gov]

Nikolsky's sign is positive in perilesional skin. [ncbi.nlm.nih.gov]

She presented targetoid lesions affecting approximately 25-30% of her body surface, large erosions with mucosal lesions and positive Nikolsky sign. [ncbi.nlm.nih.gov]

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Epidermolysis Bullosa

RDEB presents with blistering and erosions at birth with positive Nikolsky’s sign (extension of blistering or sloughing of epidermis with application of gentle pressure to [hindawi.com]

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Staphylococcal Scalded Skin Syndrome

[…] acute illness in which the Nikolsky's sign can be easily elicited. [ijpd.in]

The erythema is followed by cleavage of the upper epidermis in a large sheets mainly in the head, neck and the flexures, with formation of bullae (Nikolsky sign). [ncbi.nlm.nih.gov]

The patients can also be positive for Nikolsky sign. [symptoma.com]

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Epidermolysis Bullosa Acquisita

Nikolsky's sign and bulla spreading sign were positive. Minimal atrophy and pigmentary disturbances were evident on healing. Milia were absent. [ijdvl.com]

Nikolsky’s sign was positive. In addition, mucosal lesions appeared on the tongue and lips. [omicsonline.org]

The Nikolsky and Asboe-Hansen signs (see above) are positive. The crusted lesions may follow an arcuate pattern. Healing occurs without scarring. [plasticsurgerykey.com]

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Mucous Membrane Pemphigoid

sign. [ncbi.nlm.nih.gov]

This is known as a Nikolsky sign. A Nikolsky sign is not always present in patients with mucous membrane pemphigoid. [dentistry.uiowa.edu]

Gentle manipulation of the normal mucosa induced a positive Nikolsky's sign. [jofs.in]

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Brazilian Pemphigus Foliaceus

sign). [medical-dictionary.thefreedictionary.com]

[…] goo sel-va'zhem) [Portuguese, literally “wild fire”], FS An autoimmune disease that causes blistering of the skin of the head, neck or trunk, esp. when the skin is rubbed (Nikolsky's [medical-dictionary.thefreedictionary.com]

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Extensive Burns

Abstract Classic determinants of burn mortality are age, burn size, and the presence of inhalation injury. Our objective was to describe temporal trends in patient and burn characteristics, inpatient mortality, and the relationship between these characteristics and inpatient mortality over time. All patients aged 18[…] [ncbi.nlm.nih.gov]

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Stevens-Johnson Syndrome

Nikolsky's sign is positive in perilesional skin. [ncbi.nlm.nih.gov]

Nikolsky sign can be positive. Mucosal surfaces are spared. [visualdx.com]

Nikolsky sign can be positive. Histology will clearly differentiate AGEP from SJS/TEN. [visualdx.com]

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Pemphigus Erythematosus

The Nikolsky sign is not specific for pemphigus and may also be observed in staphylococcal scalded skin syndrome and toxic epidermal necrolysis. [clinicaladvisor.com]

Nikolsky’s sign appeared to be positive, albeit somewhat indistinct. [omicsonline.org]

Blisters tend to form when the skin is rubbed ( Nikolsky sign ). [dermnetnz.org]

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Herlitz Disease

Disease Type of connection Junctional epidermolysis bullosa, Herlitz type Localized junctional epidermolysis bullosa, non-Herlitz type Junctional epidermolysis bullosa - pyloric atresia Epidermolysis bullosa simplex with pyloric atresia Hypoplastic amelogenesis imperfecta LOC syndrome Junctional epidermolysis bullosa inversa[…] [csbg.cnb.csic.es]

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Bullous Lichen Planus

sign ( Clinical Nikolsky's sign ). [4], [6], [10], [15], [17], [22] Microscopic Nikolsky's sign Microscopic Nikolsky's sign is the subclinical counterpart of Nikolsky's sign [jiaomr.in]

Bulla spread sign and Nikolsky's sign were both negative. Mucosae, nails and hair were normal. General and systemic examination did not reveal any abnormality. [ijdvl.com]

Asboe-Hansen sign and Nikolsky sign were both negative. There were no oral lesions. Nails and hair were also normal. [ncbi.nlm.nih.gov]

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Hydroa Vacciniforme-Like Lymphoma

The blisters were Nikolsky’s sign, filled with clear yellow-colored fluid. Once the blisters were ruptured, there leaved depressed cicatrix. [diagnosticpathology.biomedcentral.com]

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Stomatitis

The Nikolsky sign is usually positive in SJS and pemphigus vulgaris. Cutaneous vesicles are typical with chickenpox or herpes zoster (see Herpesviruses). [msdmanuals.com]

The Nikolsky sign is usually positive in SJS and pemphigus vulgaris. Cutaneous vesicles are typical with chickenpox or herpes zoster (see Herpesviruses ). [merckmanuals.com]

Any bullous lesions are rubbed for the Nikolsky sign (upper layers of epidermis move laterally with slight pressure or rubbing of skin adjacent to a blister). [msdmanuals.com]

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Drug Eruptions

Toxic Epidermal Necrolysis (TEN, Lyell Syndrome): Clinical Picture (1) Toxic Epidermal Necrolysis (TEN, Lyell Syndrome): Clinical picture with positive Nikolsky sign: slight [genevadermatology.ch]

’s sign, high fever, shortness of breath and skin necrosis. [aocd.org]

[…] drug reaction ( toxic epidermal necrolysis, Stevens Johnson syndrome, hypersensitivity syndrome, and serum sickness) such as mucous membrane erosions, blisters, a positive Nikolsky’s [aocd.org]

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Linear IgA Dermatosis

Nikolsky sign was negative. Mucosal examination findings were normal. [jamanetwork.com]

sign Negative, though may be positive when pustules are confluent Positive 8, 27 Pathology Subepidermal blistering with predominantly neutrophilic and eosinophilic dermal [jaoa.org]

Bulla spread sign and Nikolsky's sign were negative. [idoj.in]

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Peritoneal Adhesion

Nikolsky's sign can appear on perilesional skin or, in some cases, even on healthy skin. [orpha.net]

They will look for an indicator of the condition called Nikolsky’s sign. [healthline.com]

A positive Nikolsky’s sign is when your skin shears off easily when the surface is wiped sideways with a cotton swab or a finger. [healthline.com]

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Benign Familial Pemphigus

They had a peripheral scale, and Nikolsky's sign was positive. The lesions healed without scarring, but residual hyperpigmentation was observed. [jamanetwork.com]

sign may be positive 1/3 of cases are sporadic Healing accompanied by hyperpigmentation, but scarring is rare Longitudinal leukonychia (asymptomatic white longitudinal bands [pathologyoutlines.com]

Lesions are positive for Nikolsky’s sign (lateral pressure of unblistered skin at the periphery of active lesions causes the epidermis to shear off) and for Asboe Hansen’s [dermnet.com]

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Peeling Skin Syndrome

The exam may show that the skin slips off when it is rubbed (positive Nikolsky sign). [medlineplus.gov]

The responsible toxins also cause toxic shock syndrome but skin tenderness and Nikolsky's sign are not classic features. [patient.info]

Other symptoms may include the following: Red, painful areas Blistering Fever Chills Weakness Fluid loss Top layer of skin slips off with rubbing (Nikolsky's sign) In newborns [texaschildrens.org]

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Dermatitis Medicamentosa

Nikolsky sign (sign rubs off), angioedema, blisters, palpable purpura, skin necrosis, LAD Amoxilicillin (5.1%), bactram/septra (4.7%), ampicillin (4.2%)., penicillin (2.9% [quizlet.com]

sign, i.e., formation of blisters in unaffected tissue by application of light pressure. 70, 71 Microscopically, there are subepidermal blisters and a mixed inflammatory [clinicalgate.com]

[…] lichen sclerosus or lichen planus; 72 however, in contrast to lichen sclerosus or lichen planus, cicatricial pemphigoid is associated with small blisters and a positive Nikolsky [clinicalgate.com]

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Viral Exanthem

Applying slight pressure with side to side movement of a finger to the skin lesions results in displacement of the epidermis from the dermis (positive Nikolsky's sign). [atsu.edu]

development of typical lesions at the site of trauma) is characteristic of psoriasis and lichen planus. 7 The Nikolsky sign (i.e., easy separation of the epidermis from [aafp.org]

Several dermatologic signs may help narrow the differential diagnosis. [aafp.org]

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Intertrigo

sign (i.e., disruption of the epidermal layer with lateral pressure, leading to ulceration) Psoriasis Chronic scaling papules and plaques; often affects extensor surfaces [aafp.org]

[…] intense pruritus; personal and/or family history of seasonal allergies and asthma is common Pemphigus vulgaris Serious, often fatal, autoimmune disease; flaccid bullae, Nikolsky [aafp.org]

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Oral Candidiasis

However, a positive Nikolsky sign (i.e., blister formation on normal-appearing mucosa or skin with application of firm lateral pressure) may be elicited. [aafp.org]

sign Oral lesions often are the first manifestation of disease and may precede the onset of skin lesions After initiating systemic therapy, oral lesions may take longer to [aafp.org]

scarring Intact blister formation occasionally may be seen intraorally (before rupture and ulceration) Pemphigus vulgaris Diffuse and painful oral ulceration, positive Nikolsky [aafp.org]

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Staphylococcus Aureus

Nikolsky’s sign was negative. Healing was by coarse desquamation over a period of five or ten days. The male to female ration was 1.5:1. [cirp.org]

The Nikolsky sign is usually positive in SJS and pemphigus vulgaris. Cutaneous vesicles are typical with chickenpox or herpes zoster (see Herpesviruses). [merckmanuals.com]

[…] for Nikolsky's sign. [en.wikipedia.org]

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