Create issue ticket

90 Possible Causes for NK-Cell Dysfunction

  • Insulin Resistance

    Chen M, Bergman RN, Porte D Jr: Insulin resistance and beta-cell dysfunction in aging: the importance of dietary carbohydrate. J Clin Endocrinol Metab 1988, 67 :951–957.[doi.org] Fukagawa NK, Anderson JW, Hageman G, et al. : High-carbohydrate, high-fiber diets increase peripheral insulin sensitivity in healthy young and old adults.[doi.org]

  • Chronic Fatigue Syndrome

    TGF-β modulation is also of note because of its role in NK-cell regulation and suppression [ 24 ], with NK-cell dysfunction a consistent CFS/ME observation for 25 years [[dx.doi.org] TGF-β1 inhibited NK cell DNA synthesis and production of cytokines, as well as weakly inhibited cytotoxic activity [ 26 ], with the inhibition of NK cell activity by TGF-β[dx.doi.org]

  • Burn Injury

    cells.[ncbi.nlm.nih.gov] However, IL-15 SA treatment failed to prevent burn wound sepsis-induced loss of CD4 , CD8 , B, NK and NKT cells and failed to improve bacterial clearance and survival.[ncbi.nlm.nih.gov] CONCLUSION: Cutaneous burn injury and infection cause significant adaptive immune dysfunction.[ncbi.nlm.nih.gov]

  • Preeclampsia

    ) cells and fetal human leukocyte antigen (HLA)-C, and results in histologic changes similar to those seen in acute graft rejection.[emedicine.com] […] to paternally derived placental and fetal antigens. [21] This maternal-fetal immune maladaptation is characterized by defective cooperation between uterine natural killer(NK[emedicine.com] The endothelial cell dysfunction that is characteristic of preeclampsia may be partially due to an extreme activation of leukocytes in the maternal circulation, as evidenced[emedicine.com]

  • Pancreatic Neoplasm

    Moreover, high expression of IDO in pancreatic cancer cells can mediate nature killer (NK) cells dysfunction [ 30 ].[doi.org] Indoleamine 2,3-dioxygenase (IDO) catalyzes the conversion from tryptophan to kynurenine, which leads to anergy of anti-tumor T cells and enhances Treg function [ 27 – 29[doi.org]

  • Primary Immune Deficiency Disorder

    X-linked SCID is characterized by the absence of T and NK cells but a normal number of dysfunctional B cells (T– B NK– SCID).[emedicine.medscape.com] JAK3 deficiency results in a rare SCID syndrome that is also associated with absent T and NK cells but a normal number of dysfunctional B cells (T–B NK–SCID).[emedicine.medscape.com] , and B cells.[emedicine.medscape.com]

  • Pulmonary Hypertension

    Dhillon NK, et al. Effect of cocaine on human immunodeficiency virus-mediated pulmonary endothelial and smooth muscle dysfunction.[doi.org] Am J Respir Cell Mol Biol. 2011;45(1):40–52. Eddahibi S, et al.[doi.org]

  • Pregnancy-induced Hypertension

    )-cell abnormalities, cause placental dysfunction and impaired placental perfusion.[hormones.gr] […] in women with PE. 60 One study showed that women with early-onset severe preeclampsia have increased NK cell function related to cytokine production. 61 Angiogenic factors[hormones.gr] Bueno-Sanchez JC, Agudelo-Jaramillo B, Escobar-Aguilerae LF, et al, 2013 Cytokine production by non-stimulated peripheral blood NK cells and lymphocytes in early-onset severe[hormones.gr]

  • Testicular Embryonal Carcinoma

    Research output : Contribution to journal › Article 2018 2B4 dysfunction in XLP1 NK cells: More than inability to control EBV infection Pende, D. , Meazza, R. , Marcenaro,[moh-it.pure.elsevier.com]

  • Testicular Teratocarcinoma

    Research output : Contribution to journal › Article 2018 2B4 dysfunction in XLP1 NK cells: More than inability to control EBV infection Pende, D. , Meazza, R. , Marcenaro,[moh-it.pure.elsevier.com]

Further symptoms