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237 Possible Causes for NK Cells Decreased

  • Common Cold

    […] proliferation, 15 shifts in T helper cell cytokine responses, 16, , 17 decreases in natural killer (NK) cell cytotoxicity, 18, , 19 and increased activation of proinflammatory[doi.org] […] proliferation, 15 shifts in T helper cell cytokine responses, 16, 17 decreases in natural killer (NK) cell cytotoxicity, 18, 19 and increased activation of proinflammatory[ncbi.nlm.nih.gov] […] pathway. 12 – 14 For instance, total and partial sleep deprivation in humans results in modulation of immune parameters critical to host resistance, including diminished T cell[doi.org]

  • Metabolic Syndrome

    Beside macrophages, other immune cells like natural killer cells (NK cells), and lymphocytes increase in AT.[germanjournalsportsmedicine.com] Regarding lymphocytes, animal studies demonstrated an increased ratio of CD8 to CD4 cells and a decreased number of immunoregulatory T regulatory cells (Tregs).[germanjournalsportsmedicine.com]

  • Obesity

    Decreased NK cell functions in obesity can be reactivated by fat mass reduction. Obesity (Silver Spring) 23, 2233–2241 (2015). 21. Perdu, S. et al.[doi.org] A wide variety of other immune cells are present in normal liver and may also play roles in inflammation-induced insulin resistance, including T and B lymphocytes, NK cells[jci.org] Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke. PloS ONE 5, e8660 (2010). 20. Jahn, J. et al.[doi.org]

  • Toxoplasmosis

    cell IFN-gamma production.[dx.doi.org] Jankovic D, Feng CG, Caspar P, Winkler-Pickett R, Trinchieri G, Sher A (2007) TAP-1 indirectly regulates CD4 T cell priming in Toxoplasma gondii infection by controlling NK[dx.doi.org] Kang H, Remington JS, Suzuki Y (2000) Decreased resistance of B cell-deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-gamma, TNF-alpha[dx.doi.org]

  • Furunculosis

    […] increase in the number and percentage of NKT-like cells with a CD3 CD16 CD56 phenotype; a significant decrease in the number and percentage of T CD3 cells.[ncbi.nlm.nih.gov] Additionally, they presented with the following changes in the blood picture: a significant increase in the number of NK cells with a CD3 CD16 CD56 phenotype; a proportional[ncbi.nlm.nih.gov] The number of NK cells was strongly positively correlated with the number of CD3 cells (r   0.6162).[ncbi.nlm.nih.gov]

  • Infectious Mononucleosis

    The mitogen responses were decreased and natural killer (NK) cell activity was low.[dx.doi.org] After PBSCT, the number of EBV-bearing CD8-positive cells and the titer of anti-EBV antibodies had decreased.[dx.doi.org] Furthermore, an increase in mitogen response and NK cell activity was observed and her physical condition improved.[dx.doi.org]

  • Herpes Zoster

    ], whereas the natural killer (NK) cell at month 6 was protective for the occurrence of late HZ [aHR (per 10-cells/μl increase): 0.94; 95% CI: 0.88-1.00; P-value 0.054].[ncbi.nlm.nih.gov] The receipt of anti-cytomegalovirus (CMV) prophylaxis with (val)ganciclovir decreased the risk of early HZ [adjusted hazard ratio (aHR): 0.08; 95% CI: 0.01-1.13; P-value 0.062[ncbi.nlm.nih.gov]

  • Liver Cirrhosis

    On the other hand, natural killer T (NKT) cells, a T cell subset that co-expresses the NK cell marker, regulate immune system by inducing apoptosis of altered hepatocytes.[dx.doi.org] Decreased NK cell frequency in chronic hepatitis C does not affect ex vivo cytolytic killing. Hepatology. 2006; 43 :573–580. [ PubMed ] [ Google Scholar ] 425.[ncbi.nlm.nih.gov] A decrease in the number and function of Treg [ 17, 18 ] and NKT cells [ 19 ] eventually leads to the facilitation of type 2 cytokine (IL-4, IL-10) responses which expand[dx.doi.org]

  • Herpes Labialis

    In conclusion, our results suggest that decreased TLR3 response of NK cells is associated with HL susceptibility; and potentially explain why symptomatic outbreak of HL usually[ncbi.nlm.nih.gov] The TLR3 response detected in HL total peripheral blood mononuclear cells (PBMCs), however, was not impaired, indicating restoration of NK cell TLR3-deficiency through co-stimulatory[ncbi.nlm.nih.gov]

  • Chronic Fatigue Syndrome

    Comparative assessment of TRPM3 on Natural Killer cells and B lymphocytes between healthy controls and CFS/ME patients CD56 Bright NK cells showed significantly decreased[ncbi.nlm.nih.gov] Decreased NK cell activity is found in CFS patients and correlates with severity of symptoms.[en.wikipedia.org] CD56 bright NK cells also had a significant decrease in cytoplasmic calcium in the presence of 2-APB and thapsigargin in CFS/ME patients.[ncbi.nlm.nih.gov]

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