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88 Possible Causes for No Muscle Weakness, Positive Gower's Sign

  • Duchenne Muscular Dystrophy

    Occasionally, however, females who carry a DMD gene mutation may have muscle weakness and cramping.[ghr.nlm.nih.gov] A physical examination revealed proximal muscle weakness, calf hypertrophy, deep tendon hyporflexia and a positive Gower's sign.[ncbi.nlm.nih.gov] The condition progresses rapidly and the child develops a waddling gait and a positive Gower's sign.[orpha.net]

  • Muscular Dystrophy

    It causes progressive weakness in muscles of the face, arms, legs, and around the shoulders and chest.[ninds.nih.gov] Boys with DMD demonstrate a positive Gowerssign, a maneuver used by individuals with proximal muscle weakness to rise from a seated position.[natera.com] ' sign.[chw.org]

  • Limb-Girdle Muscular Dystrophy

    However, most patients in the current family showed distal as well as proximal limb weakness rather than weakness of toe and finger flexor muscles that were typical features[ncbi.nlm.nih.gov] We report a Saudi Arabian family with weakness in limb-girdle distribution: waddling gait, positive Gowers' sign, and marked muscle atrophy in the shoulder and pelvic girdle[ncbi.nlm.nih.gov] Gower sign, and variable muscle cramps after exercise; Isolated hyperCKemia (i.e., elevated serum concentration of creatine kinase (CK) in the absence of signs of muscle[ncbi.nlm.nih.gov]

  • Limb-Girdle Muscular Dystrophy Type 2A

    Limb-girdle muscular dystrophy includes a group of inherited disorders that cause muscle weakness and decreased amount of skeletal muscle involving the muscles around the[geneaware.clinical.bcm.edu] At presentation, waddling gait, positive Gowers' sign, and marked muscle atrophy in pelvic and leg muscles were noted.[ncbi.nlm.nih.gov] Many pathogenic mutations have been identified in calpain3, encoded by the CAPN3 gene, which leads to weakness of the pelvic and shoulder girdle muscles.[uniprot.org]

  • Limb-Girdle Muscular Dystrophy Type 2C

    Limb-girdle muscular dystrophy includes a group of inherited disorders that cause muscle weakness and decreased amount of skeletal muscle involving the muscles around the[geneaware.clinical.bcm.edu] Mild to moderate elevated serum creatine kinase levels and positive Gowers sign are reported.[orpha.net] Life span may be affected by severity of muscle weakness; as muscles deteriorate, respiratory function may decrease leading to early death as a result of respiratory failure[geneaware.clinical.bcm.edu]

  • Vitamin D Deficiency

    Apart from the well-known effects on bone metabolism, this condition is also associated with muscle weakness, predominantly of the proximal muscle groups.[ncbi.nlm.nih.gov] Gower’s sign can provide an early clue (representing proximal myopathy).[rcpch.ac.uk] All had generalized bone pain and tenderness, muscle weakness, stooping posture, difficulty walking, and waddling gait due to severe proximal muscle weakness for a period[ncbi.nlm.nih.gov]

  • Central Core Disease

    The muscle weakness in these mice was caused by defects that hindered the release of calcium ions from internal stores and resulted in leakage of potassium ions from the muscle[ucdenver.edu] On physical examination, she had a high-arched palate, nasal tone vocalization, a positive Gowers' sign, waddling gait, and decreased deep tendon reflexes.[ncbi.nlm.nih.gov] The presence of an alternate mechanism of muscle weakness in CCD is supported by the observation that muscle cells expressing a CCD mutation in the putative pore-forming segment[ncbi.nlm.nih.gov]

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy

    Clinical features include variable age of onset, proximal limb muscle weakness and wasting predominantly affecting the pelvic girdle, and variable course between siblings.[ncbi.nlm.nih.gov] Mild to moderate elevated serum creatine kinase levels and positive Gowers sign are reported.[orpha.net] Abstract BACKGROUND: Autosomal recessive limb girdle muscular dystrophy (LGMD2) is a heterogeneous group of myopathies characterised by progressive muscle weakness involving[ncbi.nlm.nih.gov]

  • Emery-Dreifuss Muscular Dystrophy Type 2

    […] proximal muscle weakness with autosomal patterns of inheritance.[omicsonline.org] […] showed a positive Gowers sign.[elsevier.es] LGMDIC is characterized by an onset usually in the first decade, a mild-to-moderate proximal muscle weakness, calf hypertrophy, positive Gower sign, and variable muscle cramps[archive.org]

  • Becker Muscular Dystrophy

    Later symptoms Muscle weakness: Affects the proximal muscles of the limbs mainly.[patient.info] From age 27 years, he developed proximal muscle weakness predominantly of the lower limbs, a positive Gower sign, and a waddling gait.[ncbi.nlm.nih.gov] A clinical examination may reveal decreased or lost muscle reflexes and, commonly, a positive Gower sign.[bcidaho.com]

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