No Muscle Weakness & Wheelchair Bound: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

No Muscle Weakness, Wheelchair Bound,

Negated

None

Unsure

None

Possible Causes

Duchenne Muscular Dystrophy

Muscle weakness Other names Myasthenia Specialty Neurology Muscle weakness is a lack of muscle strength. [en.wikipedia.org]

Children suffering from this disease eventually become wheelchair bound and die in their late teens. [ncbi.nlm.nih.gov]

Patients become wheelchair bound and develop respiratory muscle weakness. [stanfordhealthcare.org]

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Becker Muscular Dystrophy

Later symptoms Muscle weakness: Affects the proximal muscles of the limbs mainly. [patient.info]

Two patients became wheelchair bound in their 40s or beyond, while the other 2 (aged 73 and 69, respectively) were still able to walk at the time of examination. [ncbi.nlm.nih.gov]

The complications due to being wheelchair bound include restricted respiratory activity due to inter-coastal and diaphragm weakness. [symptoma.com]

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Muscular Dystrophy

It causes progressive weakness in muscles of the face, arms, legs, and around the shoulders and chest. [ninds.nih.gov]

Case 2 became wheelchair-bound at the age of 60. No cognitive or behavioral symptoms were noted. [ncbi.nlm.nih.gov]

A small percentage of people become wheelchair-bound. Hearing loss and abnormal heart rhythms may occur, but are rare. [web.archive.org]

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Limb-Girdle Muscular Dystrophy Type 2B

Moreover, polymyositis (PM) is manifested as symmetrical proximal muscle weakness of the four limbs, accompanied by an increased level of serum CK. [ncbi.nlm.nih.gov]

The age at the onset of disease ranged from 9 yr to 33 yr, and none of the patients was wheelchair bound at the neurological examination. [ncbi.nlm.nih.gov]

Patients are usually wheelchair-bound about 25 years after diagnosis, and life expectancy may be shorter than a natural life-span. [sema4genomics.com]

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Limb-Girdle Muscular Dystrophy Type 2C

Limb-girdle muscular dystrophy includes a group of inherited disorders that cause muscle weakness and decreased amount of skeletal muscle involving the muscles around the [geneaware.clinical.bcm.edu]

Progression is rapid, and patients are usually wheelchair-bound in adolescence. [sema4genomics.com]

bound LGMD2H 8–27 years Wheelchair bound LGMD2I 1.5–27 years Wheelchair bound LGMD1A 18–35 years Proximal leg and arm weakness Distal weakness Tight Achilles tendon Problems [encyclopedia.com]

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Limb-Girdle Muscular Dystrophy

However, most patients in the current family showed distal as well as proximal limb weakness rather than weakness of toe and finger flexor muscles that were typical features [ncbi.nlm.nih.gov]

Case 2 became wheelchair-bound at the age of 60. No cognitive or behavioral symptoms were noted. [ncbi.nlm.nih.gov]

The age at the onset of disease ranged from 9 yr to 33 yr, and none of the patients was wheelchair bound at the neurological examination. [ncbi.nlm.nih.gov]

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Muscular Dystrophy-Dystroglycanopathy Type C14

Muscle weakness may spread from the proximal muscles to affect distal muscles. [rarediseases.org]

In addition to proximal muscle weakness, there may or may not be: Distal muscle weakness. Muscle hypertrophy. Contractures. [patient.info]

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CANOMAD Syndrome

paralysis of eye muscles, difficulty swallowing and speaking, and rarely respiratory muscle weakness. [malacards.org]

Significant disability is the rule, with only 3 of 18 able to walk unaided, and 5 of 18 wheelchair bound. [reliasmedia.com]

All 11 patients had sensory ataxia and gait disorders ranged from mild (ambulating independently) to severe (wheelchair bound). [neurology.org]

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Limb-Girdle Muscular Dystrophy Type 2Q

Autosomal recessive limb-girdle muscular dystrophy-17 is characterized by early childhood onset of proximal muscle weakness and atrophy without skin involvement. [ncbi.nlm.nih.gov]

Muscle weakness may spread from the proximal muscles to affect distal muscles. [rarediseases.org]

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Limb-Girdle Muscular Dystrophy Type 2A

Patients are usually wheelchair-bound about 20 years after diagnosis, and death usually occurs in middle age. [sema4genomics.com]

A patient typically becomes wheelchair bound 20 - 30 years after disease onset. [impact.ref.ac.uk]

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Facioscapulohumeral Muscular Dystrophy

BACKGROUND: Although muscle weakness is a hallmark of facioscapulohumeral muscular dystrophy (FSHD), the molecular mechanisms that lead to weakness in FSHD remain largely [ncbi.nlm.nih.gov]

However, the clinical spectrum of facioscapulohumeral muscular dystrophy (FSHD) ranges from asymptomatic individuals with minimal clinical signs to patients who are wheelchair-bound [ncbi.nlm.nih.gov]

Symmetrical limb muscle weakness appeared at 15 years of age, which progressed such that she was wheelchair-bound at 18 years of age. [ncbi.nlm.nih.gov]

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Autosomal Dominant Spastic Paraplegia Type 8

The disease involves spasticity of leg muscles and muscle weakness. [ivami.com]

The disorder has an adult-onset and some affected individuals become wheelchair-bound as the disease progresses. [cags.org.ae]

Some patients may become wheelchair-bound after several decades. [diseaseinfosearch.org]

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Paraplegia

He admitted to our hospital due to lumbago and progressive muscle weakness of bilateral lower thighs lasting for 1. month, while he had the history of the systemic chemotherapy [ncbi.nlm.nih.gov]

Patients with progressive HSP are often wheelchair-bound by the age of 70 years. Patients with HSP have a normal life-expectancy. [amboss.com]

This is because it's difficult for them to bend their toes upwards as a result of having weak hip muscles. [nhs.uk]

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Autosomal Recessive Limb-Girdle Muscular Dystrophy

Clinical features include variable age of onset, proximal limb muscle weakness and wasting predominantly affecting the pelvic girdle, and variable course between siblings. [ncbi.nlm.nih.gov]

Abstract BACKGROUND: Autosomal recessive limb girdle muscular dystrophy (LGMD2) is a heterogeneous group of myopathies characterised by progressive muscle weakness involving [ncbi.nlm.nih.gov]

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Distal Myopathy Type 3

[…] of head due to neck muscle weakness (“swan neck”). [neuroweb.us]

Patients may become wheelchair bound 10-30 years after onset of symptoms. [orpha.net]

Muscle weakness is a common complaint among patients presenting to family physicians. [aafp.org]

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Neuropathy

It is manifested with pain, tingling, numbness, and muscle weakness. [fpnotebook.com]

Usually, only 10 percent of patients become severely disabled and wheelchair-bound. [gbs-cidp.org]

This syndrome is associated with myokymia, muscle cramps and stiffness, delayed muscle relaxation after contraction, muscle weakness, and hyperhydrosis. [go.gale.com]

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Infantile-Onset Ascending Hereditary Spastic Paralysis

weakness * Progressive muscle stiffness * Stiff leg muscles by age of 2 * Weak leg muscles by age of 2 * Arm weakness by age of 8 * Arm stiffness by age of 8 * Slow eye movements [checkorphan.org]

All the patients were wheelchair-bound by the age of 10 years. In the second decade, the disease progressed to tetraplegia, anarthria, dysphagia, and slow eye movements. [ncbi.nlm.nih.gov]

Over time, muscle weakness and stiffness travels up (ascends) the body from the legs to the head and neck. [ghr.nlm.nih.gov]

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Friedreich Ataxia

In addition to neuropathological disabilities such as ataxia, sensory loss, and muscle weakness, common signs are scoliosis, foot deformity, and hypertrophic cardiomyopathy [ncbi.nlm.nih.gov]

Trinucleotide expansion length was determined and lymphocyte frataxin levels measured. p.R165P mutation carriers became wheelchair bound early, but had retained reflexes, [ncbi.nlm.nih.gov]

The muscle weakness caused by FA may eventually require use of a wheelchair. [web.archive.org]

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Congenital Hypothyroidism without Goiter

Affected males also present with muscle hypoplasia, generalized muscle weakness, and limited speech. [ncbi.nlm.nih.gov]

Many people with Allan–Herndon–Dudley syndrome are unable to walk independently and become wheelchair-bound by adulthood. [en.wikipedia.org]

As a result, many people with Allan-Herndon-Dudley syndrome are unable to walk independently and become wheelchair-bound by adulthood. [hellodoktor.com]

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Oncogenic Osteomalacia

We report a case of a 27-year-old male presented with complaints of progressive and generalized muscle weakness, bone pains and multiple fractures. [ncbi.nlm.nih.gov]

bound incapacitated state of 1-year duration. [ncbi.nlm.nih.gov]

Oncogenic osteomalacia is an uncommon syndrome characterized by bone pain, proximal muscle weakness, hypophosphatemia, hyperphosphaturia, and a low plasma concentration of [ncbi.nlm.nih.gov]

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Hypomyelinating Leukodystrophy Type 5

weakness and cataracts, and a brain MRI that indicates a loss of the myelin surrounding the neurons. [rarediseases.info.nih.gov]

Most patients become wheelchair-bound late in the first decade of life and some do not survive beyond childhood. [disorders.eyes.arizona.edu]

Most individuals become wheelchair bound between ages eight and nine years [ Biancheri et al 2007 ]. Cognitive skills. [ncbi.nlm.nih.gov]

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Hereditary Proximal Myopathy with Early Respiratory Failure

Other muscles that become weak in people with HMERF include those of the hips, thighs, upper arms, and neck. [ghr.nlm.nih.gov]

Intermediate filaments were identified in association with sarcoplasmic bodies in a severe progressive late-onset autosomal dominant distal myopathy, with patients becoming wheelchair-bound [medlink.com]

Over the following several years, the weakness spread to distal leg muscles, upper limbs and neck. [bmcneurol.biomedcentral.com]

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Peripheral Neuropathy

A 55-year-old woman with consanguineous parents developed slowly progressive, asymmetric muscle weakness and atrophy in her forearms, while her ability to walk remained unaffected [ncbi.nlm.nih.gov]

[…] initiation of darunavir/ritonavir the patient exhibited clinical symptoms of severe pain and progressive weakness of his lower limbs; he was unable to walk and was totally wheelchair-bound [ncbi.nlm.nih.gov]

We present a 70-year-old male patient of Greek origin with choreatic movements of the tongue and face, lower limb muscle weakness, peripheral neuropathy, elevated creatinephosphokinase [ncbi.nlm.nih.gov]

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Autosomal Recessive Centronuclear Myopathy

The autosomal recessive (AR) form presents from birth to childhood, followed by a mild progression of muscle weakness. [ncbi.nlm.nih.gov]

It is slowly progressive, but most patients die or are wheelchair-bound by the second or third decade of life. [anesthesiology.pubs.asahq.org]

The X-linked neonatal form (XLCNM) is due to mutations in MTM1 and involves a severe and generalized muscle weakness at birth. [ncbi.nlm.nih.gov]

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Distal Spinal Muscular Atrophy Type 1

Most patients presented at the age of 1 to 6 months with respiratory distress due to diaphragmatic paralysis and progressive muscle weakness with predominantly distal lower [ncbi.nlm.nih.gov]

Wheelchair-bound Ellen has spinal muscular Atrophy Type II, meaning she has no control over her lower limbs, suffers from chest infections and requires a special diet. [medical-dictionary.thefreedictionary.com]

It is possible those affected are wheelchair bound in time. [actsma.co.uk]

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Muscular Dystrophy-Dystroglycanopathy Type C2

Muscle weakness may spread from the proximal muscles to affect distal muscles. [rarediseases.org]

In addition to proximal muscle weakness, there may or may not be: Distal muscle weakness. Muscle hypertrophy. Contractures. [patient.info]

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Distal Spinal Muscular Atrophy Type 5

Definition A neurodegenerative disorder characterized by young adult onset of proximal muscle weakness and atrophy, muscle cramps, and fasciculations, with later onset of [uniprot.org]

She developed feet drop and difficulty pinching at age 8 and became almost wheelchair-bound at age 11. [journals.plos.org]

Get Update Overview HMSNO is an autosomal dominant neurodegenerative disorder characterized by young adult onset of proximal or distal muscle weakness and atrophy, muscle [diseaseinfosearch.org]

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Distal Spinal Muscular Atrophy Type 4

Four of the five affected patients had muscle weakness since age 3, strongly worsening during childhood and leading to generalized tetraplegia in adulthood. [ncbi.nlm.nih.gov]

bound No Yes (80%) Nerve conduction study Sensorimotor neuropathy Motor neuropathy Electromyography Muscle denervation Muscle denervation Sural nerve biopsy Severe loss of [ojrd.biomedcentral.com]

Slowly progressive wheelchair bound in the 4 th and 5 th decades. [neuroweb.us]

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Limb-Girdle Muscular Dystrophy Type 2E

Symptoms - Limb-girdle muscular dystrophy- type 2E Weakness Toe walking Muscle pain Muscle cramps Shoulder girdle muscle weakness Causes - Limb-girdle muscular dystrophy- [checkorphan.org]

[…] fiber diameter 0003557 Myopathic facies 0002058 Myopathy Muscle tissue disease 0003198 Pelvic girdle muscle weakness 0003749 Waddling gait 'Waddling' gait Waddling walk [ [rarediseases.info.nih.gov]

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Sarcotubular Myopathy

[…] had nonprogressive muscle weakness since infancy. [mayoclinic.pure.elsevier.com]

This condition is progressive and many patients become wheelchair-bound in the second and third decades. [wohproject.org]

[…] of face muscles Abnormality of limbs Calf muscle pseudohypertrophy Quadriceps muscle weakness Abnormality of metabolism/homeostasis CREATINE PHOSPHOKINASE INCREASED Abnormality [familydiagnosis.com]

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