Pruritus, fatigue, and dry mouth and eyes are the initial symptoms in > 50% of patients and can precede other symptoms by months or years.
[merckmanuals.com]
The case of a 78-year-old man with PBC who presented with pruritus is discussed. Liver biopsy and antimitochondrial antibody serology were diagnostic of early-stage PBC.
[ncbi.nlm.nih.gov]
Treatment includes ursodeoxycholic acid, obeticholic acid, cholestyramine (for pruritus), supplementary fat-soluble vitamins, and, ultimately for advanced disease, liver transplantation
[msdmanuals.com]