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30 Possible Causes for Nocturnal Awakening, Nocturnal Leg Cramp

  • Restless Legs Syndrome

    Two common causes of pain or discomfort in legs are nocturnal leg cramps (NLC) and restless leg syndrome (RLS).[doi.org] As a result, they have difficulty falling asleep, repeated nocturnal awakenings, or both. Symptoms may be worsened by stress.[merckmanuals.com] Our data also showed that in these populations nightmares must be considered as a primary cause of frequent nocturnal awakening.[doi.org]

  • Chronic Alcoholism

    The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show[…][ncbi.nlm.nih.gov]

  • Peripheral Vascular Disease

    Additional conditions to consider are acute embolism, deep or superficial venous thrombosis, restless legs syndrome, systemic vasculitides, nocturnal leg cramps, muscle or[aafp.org]

  • Nocturnal Leg Cramp

    Nocturnal leg cramps can lead to a rude awakening: you’re suddenly sleepless and in pain in the middle of the night.[psmgroup.com.au] Nocturnal leg cramps. Am Fam Physician. 2012;86(4):350-355. Butler JV, Mulkerrin EC, et al. Nocturnal leg cramps in older people. Postgrad Med J. 2002;78:596-598.[stjosepheureka.myhospitalwebsite.com] Health Nocturnal Leg Cramps: Night-time Calf Muscle Pain Nocturnal leg cramps can lead to a rude awakening: You’re suddenly sleepless and in pain in the middle of the night[dummies.com]

  • Alcoholic Neuropathy

    Abstract Characteristics of alcoholic neuropathy have been obscured by difficulty in isolating them from features of thiamine-deficiency neuropathy. We assessed 64 patients with alcoholic neuropathy including subgroups without (ALN) and with (ALN-TD) coexisting thiamine deficiency. Thirty-two patients with[…][ncbi.nlm.nih.gov]

  • Diabetic Peripheral Neuropathy

    PURPOSE: The aim of this paper is to review the published studies on the characteristics of impairments in the postural control and gait performance in diabetic peripheral neuropathy (DPN). METHODS: A review was performed by obtaining publication of all papers reporting on the postural control and gait[…][ncbi.nlm.nih.gov]

  • Hypokalemic Periodic Paralysis

    Hypokalemic periodic paralysis (hypoKPP) is a rare, autosomal dominant channelopathy characterized by muscle weakness or paralysis when there is a fall in potassium levels in the blood. In individuals with this mutation, attacks often begin in adolescence and most commonly occur on awakening or after sleep or rest[…][en.wikipedia.org]

  • Parasomnia

    NES is characterized by consumption of excessive amounts of food either before bed or during nocturnal awakenings.[emedicine.com] Nocturnal head banging, sleep talking and nocturnal leg cramps are other rare forms of parasomnia.’[lexico.com] Nocturnal Leg Cramps: This mostly occurs in the older population, who experience a few seconds of leg cramping that can last even up to a few minutes.[epainassist.com]

  • Insomnia

    Thus, the presence of a long sleep latency, frequent nocturnal awakenings, or prolonged periods of wakefulness during the sleep period or even frequent transient arousals[ncbi.nlm.nih.gov] Cramps. N Engl J Med 1971;285:31-40. PubMed Google Scholar 118. Monderer RS, Wu WP, Thorpy MJ. Nocturnal leg cramps. Curr Neurol Neurosci Rep 2010;10:53-59.[doi.org] […] for patients who have difficulty falling asleep to also have nocturnal awakenings with difficulty returning to sleep.[en.wikipedia.org]

  • Obstructive Sleep Apnea

    In adults, the most common symptoms are snoring, witnessed breathing cessations during sleep, excessive sleepiness, awakening headaches, nocturnal awakenings, and (less commonly[clinicaladvisor.com] We describe a case series of 4 patients with varying degrees of obstructive sleep apnea who incidentally had a history of nocturnal leg cramps.[ncbi.nlm.nih.gov] Frequent nocturnal awakening in early life is associated with nonatopic asthma in children. Eur Respir J. 34, 1288–95 (2009). 19. Shen, T. C. et al.[nature.com]

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