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17 Possible Causes for Nocturnal Awakening, Severe Peripheral Motor Neuropathy, Slow Pulse

  • Diabetic Autonomic Neuropathy

    Bradycardia did not respond to atropine. Postoperative autonomic nervous function tests showed advanced autonomic neuropathy.[ncbi.nlm.nih.gov] Diabetic autonomic neuropathy is a subgroup of diabetic neuropathy, a group of nerve diseases affecting the peripheral nerves outside the brain and spinal cord.[columbianeurology.org] Cardiac autonomic neuropathy (CAN) has been linked to resting tachycardia, postural hypotension, orthostatic bradycardia and orthostatic tachycardia (POTTS), exercise intolerance[ncbi.nlm.nih.gov]

  • Diabetic Enteropathy

    IVIg: Hastens recovery; dose 2g/kg q month x3 Prognosis Slow recovery over 6 to 24 months after diabetic control Partial or complete Variant syndrome: Diabetic amyotrophy[neuromuscular.wustl.edu] Peripheral sensori-motor neuropathy  Distal, bilateral,symmetrical, stocking-glove distribution.  Symptoms range from numbness (“deadness”) to severe pain.[slideshare.net] Subperineurial space Axon loss Myelinated & Unmyelinated axons Differential fascicular Treatment Pain control Diabetic control Corticosteroids Treatment: Solumedrol, iv, pulse[neuromuscular.wustl.edu]

  • Diabetic Polyneuropathy

    Signs and symptoms [ edit ] Illustration depicting areas affected by diabetic neuropathy Diabetic neuropathy affects all peripheral nerves including sensory neurons, motor[en.wikipedia.org] It may present with: Cardiac autonomic neuropathy, which has been linked to [ 5 ] : Resting tachycardia, postural hypotension, orthostatic bradycardia and orthostatic tachycardia[patient.info] Clinical findings may include exercise intolerance, persistent sinus tachycardia, no variation in heart rate during activities, and bradycardia.[aafp.org]

  • Alcoholic Neuropathy

    Rarely if the neuropathy is severe patients may also develop peripheral weakness (motor symptoms).[braindiseases.info] Reflex bradycardia in phase IV of the Valsalva maneuver and the variation coefficient of R-R intervals in the electrocardiogram were lower, indicating parasympathetic hypofunction[ncbi.nlm.nih.gov] The HR response (reflex bradycardia) in phase IV of the Valsalva maneuver was significantly decreased only in alcoholics with prominent neuropathy.[ncbi.nlm.nih.gov]

  • Diabetic Peripheral Neuropathy

    It may present with: Cardiac autonomic neuropathy, which has been linked to [ 5 ] : Resting tachycardia, postural hypotension, orthostatic bradycardia and orthostatic tachycardia[patient.info] Diabetic peripheral neuropathy affects several types of nerves, including sensory, motor, and autonomic.[paindoctor.com] Signs and symptoms [ edit ] Illustration depicting areas affected by diabetic neuropathy Diabetic neuropathy affects all peripheral nerves including sensory neurons, motor[en.wikipedia.org]

  • Ischemic Peripheral Neuropathy

    Nocturnal cramping is much more common in older patients.[podiatrytoday.com] […] abdominal pain, nausea, vomiting, malabsorption, fecal incontinence, gastroparesis, diarrhoea, constipation Cardiovascular system : disturbances of heart rate ( tachycardia, bradycardia[en.wikipedia.org] Diagnostic Approach The differential diagnosis of peripheral neuropathy is significantly narrowed by a focused clinical assessment that addresses several key issues ( Figure[aafp.org]

  • Young Adult-Onset Distal Hereditary Motor Neuropathy

    Sleep/wake rhythm disorders, multiple nocturnal awakenings, and difficult sleep onset are reported in 20–80% of the patients.[frontiersin.org] The Charcot foot has been documented to occur as a consequence of various peripheral neuropathies; however, diabetic neuropathy has become the most common etiology.[care.diabetesjournals.org] The typical course is very slow improvement. In this condition early judicious use of IVIG and pulse IV steroids may be helpful.[dartmouth.edu]

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    In patients who present with neuromuscular restrictive lung disease, the earliest signs are often nocturnal and include poor sleep with frequent awakening, early morning headaches[clinicalgate.com] The typical course is very slow improvement. In this condition early judicious use of IVIG and pulse IV steroids may be helpful.[dartmouth.edu] Several subtypes of inherited peripheral neuropathies were delineated and classified as hereditary motor and sensory neuropathies (HMSN), hereditary motor neuropathies (HMN[molgen.ua.ac.be]

  • Ataxia

    Mood changes with irritability, aggressivity and nocturnal awakening are also relevant diagnostic signs.[ijponline.biomedcentral.com] The symptoms of bradycardia are palpitations, dizziness, and loss of consiousness.[lacaf.org] Peripheral nerve conduction and nerve biopsy findings may show moderate to severe axonal sensory-motor neuropathy with axonal regeneration.[orpha.net]

  • Paroxysmal Non-Kinesigenic Dyskinesia

    A 2012 cross-sectional study, published in the Journal of American Geriatrics, showed an association between low vitamin B12 levels and impaired peripheral motor and sensory[ndnr.com] Nocturnal frontal lobe seizures typically occur throughout the night, and more frequently within half an hour of falling asleep or awakening.[epilepsydiagnosis.org] […] nerve function. 6 Several large-scale studies and subsequent reviews have demonstrated positive results using vitamin B12 supplementation in the treatment of diabetic neuropathy[ndnr.com]

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