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133 Possible Causes for Nocturnal Leg Cramp, Pain

  • Restless Legs Syndrome

    Two common causes of pain or discomfort in legs are nocturnal leg cramps (NLC) and restless leg syndrome (RLS).[doi.org] Although the neurobiological mechanism in the development of pain remains unclear, a range of non-dopaminergic structures likely mediated pain processing in DLB in the present[ncbi.nlm.nih.gov] Pain can make sleeping difficult, and fatigue from a poor night’s sleep can exacerbate pain.[paindoctor.com]

  • Peripheral Neuropathy

    CONCLUSIONS: Nerve decompression surgery was able to alleviate pain in patients with painful diabetic peripheral neuropathy.[ncbi.nlm.nih.gov] In one large study focusing on pulsed electromagnetic fields, no beneficial effect on pain was registered.[doi.org] The patient was initially diagnosed with complex regional pain syndrome and treated with a variety of pain medications, including lidocaine infusions, hydromorphone, methadone[ncbi.nlm.nih.gov]

  • Deep Vein Thrombosis

    Background Painful swollen leg is a common clinical scenario.[ncbi.nlm.nih.gov] This is a report of three patients who presented with a painful swollen leg and were initially treated as a deep vein thrombosis or a baker's cyst, but later diagnosed as[ncbi.nlm.nih.gov] Deep vein thrombosis (DVT) often presents as a painful swollen leg and prompt management is vital to prevent fatal pulmonary embolism.[doi.org]

  • Amyotrophic Lateral Sclerosis

    FDA bans quinine for nocturnal leg cramps. Drug Utilization Rev . 1995; Oct:150. 26. Moss AH, Casey P, Stocking CB, Roos RP, Brooks BR, Siegler M.[aafp.org] The site of pain depends on the pain type or underlying mechanism (eg, painful cramps, nociceptive pain, or neuropathic pain).[ncbi.nlm.nih.gov] FDA bans quinine for nocturnal leg cramps. Drug Utilization Rev. 1995; Oct:150. 26. Moss AH, Casey P, Stocking CB, Roos RP, Brooks BR, Siegler M.[aafp.org]

  • Peripheral Vascular Disease

    Additional conditions to consider are acute embolism, deep or superficial venous thrombosis, restless legs syndrome, systemic vasculitides, nocturnal leg cramps, muscle or[aafp.org] Making a Differential Diagnosis of Leg Pain The patient who presents with complaints of pain in the calves after exercising is likely to have advanced PAD.[practicalpainmanagement.com] Approximately 48 hours after the procedure, the patient developed severe, right lower leg pain.[ncbi.nlm.nih.gov]

  • Alcoholic Neuropathy

    Five patients suffering from painful alcoholic neuropathy showed severe painful sensory disturbance in their extremities.[ncbi.nlm.nih.gov] All this is accompanied by the chronic pain typical in cases of peripheral neuropathy.[neuropathydr.com] The symptoms they face can range from mildly uncomfortable to unbearable pain.[quitalcohol.com]

  • Pes Planus

    A team led by the University of East Anglia has made an advance in understanding the causes of adult-acquired flat feet -- a painful condition particularly affecting middle-aged[sciencedaily.com] These factors could lead to the development of plantar heel pain.[ncbi.nlm.nih.gov] BACKGROUND: Anterior knee pain and intermittent low back pain are among the most common orthopedic complaints of adolescents.[ncbi.nlm.nih.gov]

  • Muscle Spasm

    There were 29 patients with nocturnal leg cramps, 28 with cervical spondylosis, 13 with thalamic pain and 11 with carpal tunnel syndrome, for which the effectiveness was assessed[ncbi.nlm.nih.gov] All patients complained of radicular leg pain and were divided into the following three groups according to the presence of and the region of low-back pain: no low-back pain[ncbi.nlm.nih.gov] Muscle fatigue and nerve dysfunction are believed to be contribute to nocturnal leg cramps.[onhealth.com]

  • Nocturnal Leg Cramp

    Nocturnal leg cramps. Am Fam Physician. 2012;86(4):350-355. Butler JV, Mulkerrin EC, et al. Nocturnal leg cramps in older people. Postgrad Med J. 2002;78:596-598.[stjosepheureka.myhospitalwebsite.com] Health Nocturnal Leg Cramps: Night-time Calf Muscle Pain Nocturnal leg cramps can lead to a rude awakening: You’re suddenly sleepless and in pain in the middle of the night[dummies.com] Because night leg cramps can be painful and disrupt sleep, it is important to understand how to prevent them. Drink between six and eight glasses of water every day.[livestrong.com]

  • Diabetic Peripheral Neuropathy

    CONCLUSIONS: Nerve decompression surgery was able to alleviate pain in patients with painful diabetic peripheral neuropathy.[ncbi.nlm.nih.gov] It typically causes burning pain, paresthesias, and numbness in a stocking-glove pattern that progresses proximally from the feet and hands.[ncbi.nlm.nih.gov] The BPI-DPN includes the four-item pain Severity scale (Worst Pain, Least Pain, Average Pain, and Pain Now) and the seven-item pain Interference scale (General Activity, Mood[journals.plos.org]

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