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42 Possible Causes for Nodular Skin Lesions, Onset at Age 5-10 Years

  • Acne Vulgaris

    Inflammatory mediations move out into the surrounding dermis and cause often more nodular and/or cystic lesions, which can in some cases lead to permanent scarring.[6] Nodules[] 5 40 years Genetic background , long course, polygenic , polygenic Age of onset circa 10 years circa 1 year Spontaneous remission 80% (3rd decade) 80% (2nd–3rd decade) Recurrences[] Postinflammatory hyperpigmentation (PIH) is usually the result of nodular acne lesions.[]

  • Atopic Dermatitis

    Lichenification is a result of scratching and rubbing, and most frequently in adults, this may result in the prurigo type of AD with predominant excoriated nodular lesions[] Less than 2% will have an onset after age 20 years. Most sources agree that persistence after age 20 years is uncommon.[] […] disease onset occurs before the ages of 1 and 5 years in 65% and 85% of affected children, respectively. 1 The number of office visits for children with AD is increasing.[]

  • Mammary Paget Disease

    The skin surface is grey-tan brown-and-yellow, bosselated and firm, with nodular and granular lesions.[] The average age of patients with mammary Paget disease is 5-10 years older than individuals with breast carcinoma.[] The cut surface of the scrotal skin (not shown) demonstrated the lesion to be white, tan to red-brown and firm.[]

  • Pilomatrixoma

    Microscopic description revealed fibrocollagenous tissue showing a nodular lesion exhibiting nests of basophilic cells with few areas showing ghost-appearing cells.[] years and 60% of cases occur before the age of 20 years. 5, 6, 10 However, a second, smaller peak of onset has been reported in the elderly. 10 In our study, 26.8% of cases[] Treatment: Surgical excision. [2] Microscopic Features: [4] Nodular circumscribed lower dermis/subcutaneous adipose lesion; thus, usu. surrounded by connective tissue.[]

  • Cronkhite-Canada Syndrome

    Upper endoscopy showed mucosal erythema and nodularity with polypoid-like lesions.[] The average patient age at the onset of symptoms is 32 years, but the first symptoms may appear at any age between 5 and 55 years.[] His skin manifestations were treated topically and with mineral supplements. He improved within 10 weeks and is currently asymptomatic.[]

  • Crohn's Disease

    Its classic form is more common in women and presents itself as papular-nodular, painful and erythematous or violaceous lesions.[] Indications and results of surgery in patients with Crohn’s disease with onset under 10 years of age: a series of 18 patients. Eur J Pediatr Surg 2002 ; 12 : 180 –5.[] Abstract Sweet's syndrome is an uncommon benign skin disorder, whose pathogenesis remains unknown.[]

  • Lupus Erythematosus

    Panniculitis can cause subcutaneous nodular lesions (sometimes called lupus panniculitis or profundus).[] Clinical Features • Serious cutaneous-systemic disorder • Repeated remissions and exacerbations. • Peak age of onset: 30 years in females but about 40 years in males • Female[] Vasculitic skin lesions may include mottled erythema on the palms and fingers, periungual erythema, nail-fold infarcts, urticaria, and palpable purpura.[]

  • Familial Spontaneous Pneumothorax

    Common skin findings of TSC include: Angiofibromas (acne-like small reddish nodular lesions on the face, especially the nose and cheeks) Subungual fibromas (fibrous nodules[] The skin lesions started to occur at age 40 and 45 years, respectively, which is approximately 510 years later than the mean age of onset reported in the literature.[]

  • Epithelioid Cell Sarcoma

    However, in others, a wide-range of behavior is observed They may grow at a slow rate and appear as painless inflammatory irregular (or nodular) lesions below the skin surface[] The median survival rate depends on the histology subtype ( 3 ) and age at onset of the disease and is 1 year, with only 10% of cases surviving for up to 5 years ( 2 ).[] In such patients, with significant differences depending on histology subtype and age at disease onset, the overall median survival is around one year and about 10% of cases[]

  • Polyarteritis Nodosa

    skin lesions, or livedo reticularis ( 2 ) Renal disease in PAN usually manifests as HTN and mild proteinuria with/without azotemia.[] RESULTS: The median age of onset was 57.0 years. The 1-year survival rate was 100% (16/16) and the 5-year survival rate was 80.0% (8/10).[] The primary lesions were maculopapular, which had gradually evolved to tender and locally warm nodular skin lesions, later becoming necrotic.[]

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