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10 Possible Causes for Non-Hemolytic Unconjugated Hyperbilirubinemia

  • Gilbert Syndrome

    Constitutional liver dysfunction Familial non-hemolytic non-obstructive jaundice Icterus intermittens juvenilis Low-grade chronic hyperbilirubinemia Unconjugated benign bilirubinemia[en.wikipedia.org] Tagged as: constitutional liver dysfunction, familial benign unconjugated hyperbilirubinaemia, familial non-hemolytic non-obstructive jaundice, Gilbert–Meulengracht syndrome[highrisklifeinsuranceagency.com] Icterus intermittens juvenilis; Low-grade chronic hyperbilirubinemia; Familial non-hemolytic-non-obstructive jaundice; Constitutional liver dysfunction; Unconjugated benign[nlm.nih.gov]

  • Crigler-Najjar Syndrome Type 1

    Mutations in the UGT1A1 gene cause Crigler-Najjar syndrome (CN), which causes non-hemolytic unconjugated hyperbilirubinemia, and is categorized as CN1 and CN2 according to[ncbi.nlm.nih.gov] Crigler-Najjar (CN) syndrome is a rare autosomal recessive inherited disorder characterized by non-hemolytic, unconjugated hyperbilirubinemia.[ncbi.nlm.nih.gov] In severe CNS-I, the absence of UGT1A1 enzyme activity lead to non-hemolytic unconjugated hyperbilirubinemia, marked jaundice and may cause bilirubin encephalopathy (kernicterus[bmcpediatr.biomedcentral.com]

  • Massive Hepatic Necrosis

    Gilbert’s Disease Chronic, benign, intermittent, familial (AD), non-hemolytic unconjugated hyperbilirubinemia with evanescent increases of B1 Due to defective transport and[slideshare.net]

  • Early Infantile Epileptic Encephalopathy Type 6

    , resulting from exacerbated hemolysis) Chronic, non-immune hemolytic anemia High mean corpuscular hemoglobin concentration (MCHC) Presence of spherocytes in the peripheral[centogene.com] Clinical diagnosis of hereditary spherocytosis is suspected in individuals with any of the following findings: Jaundice (usually intermittent and due to unconjugated hyperbilirubinemia[centogene.com]

  • Brandt Syndrome

    Icterus intermittens juvenilis; Low-grade chronic hyperbilirubinemia; Familial non-hemolytic-non-obstructive jaundice; Constitutional liver dysfunction; Unconjugated benign[medlineplus.gov]

  • Dubin-Johnson Syndrome

    Dubin-Johnson syndrome (DJS, OMIM 237500) is a rare, autosomal recessive disorder characterized by non-hemolytic hyperbilirubinemia with no progression to end-stage liver[wjgnet.com] Both the conjugated and unconjugated form of bilirubin can be elevated in DJS subjects, with the former ranging from 17% to 88% of the total bilirubin with a mean value of[wjgnet.com]

  • Dicarboxylic Aminoaciduria

    Cringler-Najjar Syndrome : a form of congenital non-hemolytic/intrahepatic jaundice. Toxic hyperbilirubinemia caused by alcohol-induced liver damage or by Acetomenophin.[flashcardmachine.com] Results in unconjugated hyperbilirubinemia Examples include: Newborn Jaundice, Kernicterus, Gilbert's Syndrome, and hepatitis (discussed on seperate cards) as well as...[flashcardmachine.com] Term Definition A form of Intrahepatic Juandice (unconjugated hyperbilirubinemia) that occurs in 50% of newborns.[flashcardmachine.com]

  • Pyruvate Kinase Deficiency

    It constitutes one of the common causes of hereditary non-spherocytic hemolytic anemia.[ncbi.nlm.nih.gov] The aim of this study was to screen newborns in India for pyruvate kinase (PK) deficiency in relation to unconjugated hyperbilirubinemia.[ncbi.nlm.nih.gov]

  • Crigler-Najjar Syndrome Type 2

    In severe CNS-I, the absence of UGT1A1 enzyme activity lead to non-hemolytic unconjugated hyperbilirubinemia, marked jaundice and may cause bilirubin encephalopathy (kernicterus[bmcpediatr.biomedcentral.com] Kreek MJ, Sleisinger MH: Reduction of serum-unconjugated bilirubin with phenobarbitone in adult congenital non-hemolytic unconjugated hyperbilirubinemia.[link.springer.com] unconjugated hyperbilirubinemia.[bmcpediatr.biomedcentral.com]

  • Hereditary Elliptocytosis 2

    , resulting from exacerbated hemolysis) Chronic, non-immune hemolytic anemia High mean corpuscular hemoglobin concentration (MCHC) Presence of spherocytes in the peripheral[centogene.com] Clinical diagnosis of hereditary spherocytosis is suspected in individuals with any of the following findings: Jaundice (usually intermittent and due to unconjugated hyperbilirubinemia[centogene.com]

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