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194 Possible Causes for Non-Hemolytic Unconjugated Hyperbilirubinemia, Unconjugated Bilirubin Increased

  • Gilbert Syndrome

    Constitutional liver dysfunction Familial non-hemolytic non-obstructive jaundice Icterus intermittens juvenilis Low-grade chronic hyperbilirubinemia Unconjugated benign bilirubinemia[] […] is being presented by mild jaundice as a result of an increase in the unconjugated bilirubin.[] Tagged as: constitutional liver dysfunction, familial benign unconjugated hyperbilirubinaemia, familial non-hemolytic non-obstructive jaundice, Gilbert–Meulengracht syndrome[]

  • Crigler-Najjar Syndrome Type 1

    Mutations in the UGT1A1 gene cause Crigler-Najjar syndrome (CN), which causes non-hemolytic unconjugated hyperbilirubinemia, and is categorized as CN1 and CN2 according to[] The serum unconjugated bilirubin increased in the proband from 156.4 micromol/L to 243.5 micromol/L after he started a low calorie intake, and it decreased to 51.8 micromol[] Crigler-Najjar (CN) syndrome is a rare autosomal recessive inherited disorder characterized by non-hemolytic, unconjugated hyperbilirubinemia.[]

  • Pyruvate Kinase Deficiency

    It constitutes one of the common causes of hereditary non-spherocytic hemolytic anemia.[] The aim of this study was to screen newborns in India for pyruvate kinase (PK) deficiency in relation to unconjugated hyperbilirubinemia.[]

  • Thalassemia

    Plain radiographs are not usually required to confirm the diagnosis of thalassemai. However, when radiographs are utilized, the complete skeleton is involved. [8, 9] Radiographically, the skeletal response to marrow proliferation consists of expansion of the medulla, thinning of cortical bone, and resorption of[…][]

    Missing: Non-Hemolytic Unconjugated Hyperbilirubinemia
  • Biliary Atresia

    The conjugated bilirubin is elevated (conjugated bilirubin 2 mg/dL).[] Also mild or moderate elevations in serum aminotransferases with a disproportionately increased gGTP are measured.[] Fractionation of the serum bilirubin is performed to determine if the associated hyperbilirubinemia is conjugated or unconjugated.[]

    Missing: Non-Hemolytic Unconjugated Hyperbilirubinemia
  • Dubin-Johnson Syndrome

    Dubin-Johnson syndrome (DJS, OMIM 237500) is a rare, autosomal recessive disorder characterized by non-hemolytic hyperbilirubinemia with no progression to end-stage liver[] Dubin-Johnson syndrome or high levels of conjugated bilirubin often secondarily increase the level of unconjugated bilirubin.[] These results indicate that defects in both conjugated and unconjugated bilirubin metabolism exist in DJS.[]

  • Crigler-Najjar Syndrome Type 2

    In severe CNS-I, the absence of UGT1A1 enzyme activity lead to non-hemolytic unconjugated hyperbilirubinemia, marked jaundice and may cause bilirubin encephalopathy (kernicterus[] […] concentration None Reduction Bile Usually pale: contains small amounts of unconjugated bilirubin Increased proportion of bilirubin monoglucoronide Prognosis Kernicterus Usually[] […] resulting in increased total serum bilirubin, mostly of the unconjugated form.[]

  • Vitamin B12 Deficiency

    Biochemistry There may be an increase in plasma unconjugated bilirubin due to increased destruction of red cell precursors in the marrow.[]

    Missing: Non-Hemolytic Unconjugated Hyperbilirubinemia
  • Cholelithiasis

    ., sickle cell disease, hereditary spherocytosis ) Cirrhosis Pathophysiology : hemolysis increase in circulating unconjugated bilirubin increased uptake and conjugation of[] unconjugated bilirubin (from hemolytic syndromes, ileal dysfunction / bypass, bacterial contamination of biliary tree) Clofibrate: Anticholesterol drug that increases HMG[] […] and lecithin in the bile increased unconjugated bilirubin and fatty acids precipitation of calcium carbonate, cholesterol, and calcium bilirubinate in bile Clinical features[]

    Missing: Non-Hemolytic Unconjugated Hyperbilirubinemia
  • Jaundice

    This can lead to an increase in both unconjugated and/or conjugated bilirubin levels.[] Serum: increased unconjugated bilirubin. Kernicterus is associated with increased unconjugated bilirubin not carried by albumin.[] bilirubin increase.[]

    Missing: Non-Hemolytic Unconjugated Hyperbilirubinemia

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