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24 Possible Causes for Normetanephrine Increased

  • Acromegaly

    Context: Acromegaly is characterized by growth hormone (GH) and insulinlike growth factor-1 (IGF-1) hypersecretion, and GH and IGF-1 play important roles in regulating body composition and glucose homeostasis. Objective: The purpose of our study was to investigate body composition including ectopic lipids, measures[…][]

  • Hypertension

    Considering other important secondary causes like pheochromocytoma, hormonal studies were performed and the results showed increased serum norepinephrine, serum normetanephrine[]

  • Metabolic Syndrome

    Psychosocial factors explained a substantial part of the increased normetanephrine output associated with metabolic syndrome.[] Normetanephrine output, reflecting total α- and β-adrenergic activity, may rise due to increase in drive from higher centers and the number of adrenergic neurons in adipose[] BMI in contrast is a more reliable measure and is closely associated with waist to hip ratio and metabolic syndrome variables, but accounted for only 23% of additional normetanephrine[]

  • Sleep Apnea Syndrome

    […] levels of urinary catecholamines (norepinephrine and normetanephrine) in correlation with worsening OSA parameters. 29 In the Bogalusa Heart Study, cardiovascular disease[] Hypoxemia-related increases in sympathetic tone are proposed as the etiology for these changes in BP; supportive evidence for this hypothesis has been provided by the finding of increased[]

  • Labile Hypertension

    Urinary 24 h excretion of total metanephrines and plasma normetanephrine levels normalized post-operatively.[] MIBG scintigraphy: increased left adrenal and pelvic uptake. Fig. 1. MIBG scintigraphy: increased left adrenal and pelvic uptake. Fig. 2.[]

  • Haddad Syndrome

    The specific tests for neuronal specific enolase in serum revealed its increased level: 40.37 ng/ml. The value for ferritin reached 487.2 μg/l.[] Urine was collected daily for measurements of the catecholamines’ metabolites, as further metanephrine and normetanephrine are both metabolized to vanillylmandelic acid.[]

  • Hepatoblastoma

    Increased values of normetanephrine (1.32 μg/mg creatinine, [0.27–1.11]), 3-methoxytyramine (1.31 μg/mg creatinine, [0.37–1.24]) and NSE [40.81 ng/ml, (4–20)] were noted.[] In our patient we also found the elevated values of normetanephrine and 3-methoxytyramine.[] The increase in the concentration of these methylated catecholamine metabolites is observed in most patients with NBL ( 12 ).[]

  • Hereditary Pheochromocytoma-Paraganglioma

    […] also generally had large increases in plasma normetanephrine so that proportional increases in metanephrine were minimal.[] When plasma concentrations of metanephrine are increased, the increases are minor compared to the proportionally much larger increases of normetanephrine.[] In patients with solitary increases of normetanephrine, additional testing of the VHL gene may be considered.[]

  • Glomus Jugulare Tumor

    Catecholamine assessments showed increased levels of epinephrine and normetanephrine in a 24 hour urine study.[]

  • Hemangioblastoma

    A rise in plasma and urine metanephrines is thus indicative of increased tumoural production of catecholamines.[] Prior to the addressal of the brain-stem hemangioblastoma, the pheochromocytoma needs to be resected. [25] Within the chromaffin cells, NE and E are metabolized to normetanephrine[]

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