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218 Possible Causes for Normocytic Anemia, Thrombocytosis

  • Iron Deficiency Anemia

    The CBC at that time revealed normocytic anemia (hemoglobin, 8.5 g/ dL [85 g/L]; hematocrit, 15.5% [0.16]; and MCV, 84 μm 3 [84 fL]), and the serum ferritin level was decreased[] OBJECTIVE: In order to inquire into the pathogenesis of increased platelet counts in peripheral blood of patients with iron deficiency anemia (IDA), the phenomenon of thrombocytosis[] If sufficient blood loss occurs, iron deficiency anemia ensues (see the image below). A single sudden loss of blood produces a posthemorrhagic anemia that is normocytic.[]

  • Polymyalgia Rheumatica

    Such abnormalities can include a mild normocytic anemia due to chronic inflammation, leukocytosis, and thrombocytosis.[] Most people with polymyalgia rheumatica have an unusually high number of these cells (thrombocytosis).[] Abnormal Laboratory Tests in Polymyalgia Rheumatica Acute phase reactants ESR C-reactive protein Alpha 2 globulins Fibrinogen Blood count Normochromic, normocytic anemia Platelet[]

  • Temporal Arteritis

    Neurological examination disclosed chin hypoesthesia while investigations showed a normocytic anemia, ESR of 100, and CRP of 72.[] Laboratory abnormalities associated with TA include a highly elevated erythrocyte sedimentation rate, anemia, and thrombocytosis, and mildly increased alkaline phosphatase[] anemia C-reactive protein (CRP) Erythrocyte sedimentation rate (ESR) – has been used traditionally with threshold of 50 mm/hr Liver function studies – often abnormal Vasculitis[]

  • Hereditary Spherocytosis

    Her labs show a mild normocytic anemia with an elevated reticulocyte count. Peripheral blood smear shows that many of her RBCs have no area of central pallor.[] It also results in leukocytosis and thrombocytosis. On peripheral blood smear, spherocytes are unchanged or may even increase.[] […] develop and cholecystectomy may be associated with an increased risk of ca colon ) d) Visible jaundice but no stones for cosmetic reasons – difficult group Post op develop thrombocytosis[]

  • Anemia

    Normocytic anemia Normocytic anemia is further divided into 2 broad categories: anemia with primary bone marrow involvement and anemia secondary to underlying disease.[] For example, thrombocytosis could indicate bleeding, iron deficiency, or myeloid metaplasia/myelofibrosis in its earlier stages.[] Finally, a number of causes have been identified for normocytic anemia without reticulocytosis, including normocytic megaloblastic anemia and the acquired immunodeficiency[]

  • Non-Cranial Giant Cell Arteritis

    anemia C-reactive protein (CRP) Erythrocyte sedimentation rate (ESR) – has been used traditionally with threshold of 50 mm/hr Liver function studies – often abnormal Vasculitis[] […] can lead to Rouleaux formation of RBCs CRP Mild thrombocytosis Normochromic anemia No autoantibodies Temporal artery biopsy (gold stand ard) : mandatory in all patients Extended[] anemia Speech and respiratory features in giant cell arteritis have been described, but infrequently ( ) Suggested that vasculitis in cases of GCA with speech or respiratory[]

  • Congenital Hemolytic Anemia

    What is characterstic of all congenital hemolytic anemias? normocytic anemias with elevated retic count due to RBC destruction What is mutated in Sickle Cell disease?[] […] coagulability primary: Antithrombin III deficiency · Protein C deficiency / Activated protein C resistance / Protein S deficiency / Factor V Leiden · Hyperprothrombinemia acquired: Thrombocytosis[] The Type I cases showed the following features: normocytic or slightly macrocytic anemia with mild hypochromia and some stippling; a decreased or normal osmotic fragility[]

  • Rheumatoid Arthritis

    A normochromic (or slightly hypochromic)-normocytic anemia occurs in 80%; Hb is usually 10 g/dL.[] FBC: normochromic, normocytic anaemia and reactive thrombocytosis are common in active disease.[] The red cells are of normal size and color (normocytic and normochromic).[]

  • Gastrointestinal Hemorrhage

    Patients with acute bleeding usually have normocytic red blood cells. Microcytic red blood cells or iron deficiency anemia suggests chronic bleeding.[] Other presentations which can accompany both upper and lower GI bleeding include hemodynamic instability, abdominal pain and symptoms of anemia such as lethargy, fatigue,[]

  • Sideroblastic Anemia

    Peripheral Smear Microangiopathic Hemolytic Anemia White cells Not remarkable Platelets Decreased Red cells Normocytic, normochromic anemia ...[] A unique patient with sideroblastic anemia and thrombocytosis with a recurrent and ultimately fatal thromboembolic phenomenon is described.[] We believe this is the first reported case of trisomy 8 with trilineage myelodysplasia and thrombocytosis with primary acquired sideroblastic anemia.[]

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