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157 Possible Causes for Normocytic Normochromic Anemia, Reticulocytes Increased

  • Toxic Hemolytic Anemia

    Signs and Symptoms Pallor Jaundice Lethargy Abdominal pain Low-grade fever Dark urine (sever hemolysis) Hepatosplenomegaly Diagnostic tests CBC with smear Normocytic, normochromic[pedclerk.bsd.uchicago.edu] Increased reticulocytes lead to increased MCV but not like megaloblastic anemias. Serum bilirubin is raised. Urine urobilinogen is positive.[labpedia.net] Hemolysis, in these patients, usually occurs 24 to 48 hours after exposure and is characterized by diminished hemoglobin and hematocrit, increase in reticulocyte count, increase[path.upmc.edu]

  • Autoimmune Hemolytic Anemia

    Signs and Symptoms Pallor Jaundice Lethargy Abdominal pain Low-grade fever Dark urine (sever hemolysis) Hepatosplenomegaly Diagnostic tests CBC with smear Normocytic, normochromic[pedclerk.bsd.uchicago.edu] Over the course of the next 5 days, the Hb and Hct decreased to 4.1 g/dL and 12%, respectively, direct bili increased to 12.3 mg/day, reticulocytes slightly increased to 0.9%[ncbi.nlm.nih.gov] Laboratory data showed low hemoglobin levels and slightly increased reticulocyte counts, while direct and indirect antiglobulin tests were positive.[ncbi.nlm.nih.gov]

  • Nonimmune Hemolysis

    Signs and Symptoms Pallor Jaundice Lethargy Abdominal pain Low-grade fever Dark urine (sever hemolysis) Hepatosplenomegaly Diagnostic tests CBC with smear Normocytic, normochromic[pedclerk.bsd.uchicago.edu] […] breakdown Indirect/ unconjugated bilirubin Reticulocytes : loss of erythrocytes reactive increase in erythropoiesis increase in reticulocytes in the peripheral blood In extreme[amboss.com] Examination New onset of pallor and anemia Jaundice Gallstones Splenomegaly /- hepatomegaly INVESTIGATIONS Confirm haemolysis Increased absolute reticulocyte count LDH (elevation[lifeinthefastlane.com]

  • Hypersplenism

    Normocytic, normochromic anemia Reticulocytes increased Increased MCV is due to prominent reticulocytosis Spherocytes Bone marrow Hypercellular with erythroid precursors[5minuteconsult.com] […] in red cell production usually is evident by an increase in the reticulocyte count.[medtextfree.wordpress.com] Normocytic, normochromic anemia Reticulocytes increased Increased MCV is due to prominent reticulocytosis Spherocytes Bone marrow Hypercellular with erythroid precursors[5minuteconsult.com]

  • Congenital Hemolytic Anemia

    Diamond–Blackfan anemia Acquired: PRCA Sideroblastic anemia Myelophthisic Blood tests MCV Normocytic Microcytic Macrocytic MCHC Normochromic Hypochromic Other Methemoglobinemia[en.wikipedia.org] The alpha-, and beta-globin mRNA content of the reticulocytes after interleukin-3 incubation, as measured by RT-PCR, increased.[ncbi.nlm.nih.gov] · Diamond–Blackfan anemia Acquired: PRCA · Sideroblastic anemia · Myelophthisic Blood tests MCV ( Normocytic , Microcytic , Macrocytic ) · MCHC ( Normochromic , Hypochromic[en.academic.ru]

  • Cold Agglutinin Disease

    At birth, infant’s RBCs express i-antigen, which is converted to I antigen.[ 3 ] This pathologic entity is diagnosed by the presence of severe anemia (normocytic normochromic[jbclinpharm.org] Typical bloodwork results would show: decreased hemoglobin (due to the red cell lysis) increased reticulocyte count (reflecting the marrow kicking red cell production into[transfusion.ca] […] breakdown Indirect/ unconjugated bilirubin Reticulocytes : loss of erythrocytes reactive increase in erythropoiesis increase in reticulocytes in the peripheral blood In extreme[amboss.com]

  • Pyruvate Kinase Deficiency

    In most cases, the morphological RBC characteristics are unremarkable and are normocytic/normochromic.[clinicaladvisor.com] Char10C mice also display a reduction in anemia phenotypes associated with the PklrG338D mutation including decreased splenomegaly, decreased circulating reticulocytes, increased[ncbi.nlm.nih.gov] As a result of splenectomy, reticulocyte counts often increase and transfusion needs are reduced.[orpha.net]

  • Congenital Dyserythropoietic Anemia

    normochromic anemia • Autosomal dominant • No megaloblastic changes • Hereditary, multinuclear erythroblasts • Negative HAM's test/Acidified Serum Test • Autosomal recessive[quizlet.com] On this treatment, hemoglobin and reticulocytes increased and transfusions became unnecessary.[ncbi.nlm.nih.gov] The reticulocyte count was always low, in spite of the increased erythropoietic activity. A beta-thalassemia trait inherited from the mother was demonstrated.[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    Erythrocytes fractionated by centrifugation revealed increased glycolytic enzyme activities of hexokinase, G3PD, PGK, TPI, PK, LDH, G6PD, and 6PGD in the reticulocyte-rich[pediatrics.aappublications.org] Intravascular hemolysis with moderate to severe anemia, an elevated reticulocyte count, and up to a 10-fold increase in lactate dehydrogenase (LDH) is common in classical[bloodjournal.org] PFK, known to be decreased in the erythrocyte of neonates, showed normal activity, but it was lowest in the reticulocyte-rich layer.[pediatrics.aappublications.org]

  • Fetal Erythroblastosis

    He or she will be anemic, with increased reticulocyte count, anisocytosis, spherocytosis, and young (nucleated, immature) red blood cells released into circulation.[symptoma.com] Reticulocyte count is increased.[quizlet.com] Peripheral blood morphology shows increased reticulocytes. Erythroblasts (also known as nucleated red blood cells) occur in moderate and severe disease.[moondragon.org]

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