Create issue ticket

181 Possible Causes for Nuclear Clumps

  • Focal Myositis

    clumps.[orpha.net] […] chronic inflammation and fibrosis accompanied by myopathic changes such as regenerating/degenerating fibers, myophagocytosis and sometimes angular atrophic fibers and pyknotic nuclear[orpha.net]

  • Spinal Muscular Atrophy Type 1

    […] between muscle fibers VvG stain H&E stain Less involved region Hypertrophic muscle fibers Small regions of grouped muscle fiber atrophy Pyknotic nuclear clumps VvG stain[neuromuscular.wustl.edu] clumps: None Large muscle fibers : Hypertrophy Larger muscle fibers Hypertrophied Commonly type I Clustered Smaller muscle fibers Round Commonly type II, May also be I or[neuromuscular.wustl.edu] Axon loss: Not proven Axons may become p-rogressively dysfunctional or lost SMA 5q: General Features H&E stain Grouped atrophy Small muscle fibers: Often rounded Pyknotic nuclear[neuromuscular.wustl.edu]

  • X-linked Distal Spinal Muscular Atrophy Type 3

    Meggen Walsh, University of Kentucky (USA): Skeletal muscle: multiple nuclear "clumps" or nuclear "bags"; also few atrophic angulated myofibers (H&E) Positive stains In some[pathologyoutlines.com] clump" or "nuclear bag" left In cases with deinnervation / reinnervation, there will be myofiber type grouping on ATPase staining or myofiber immunohistochemical stain Surrounding[pathologyoutlines.com] […] description General / ALS / HMSN : Myofibers are smaller and angulated No increase in central nucleation In areas, myofiber may become atrophic to the point that there is only a "nuclear[pathologyoutlines.com]

  • Vulvar Intraepithelial Neoplasia

    clumping with mitotic figures Intact basement membrane Variable extension into skin appendages Microscopic (histologic) images Images hosted on other servers: Vulvar Intraepithelial[pathologyoutlines.com] […] description Hyperkeratosis and parakeratosis Acanthosis with club shaped rete ridges Disorientation of the cells above the basal cell layer with variable extension to the surface Nuclear[pathologyoutlines.com]

  • Spinal Muscular Atrophy Type 3

    […] between muscle fibers VvG stain H&E stain Less involved region Hypertrophic muscle fibers Small regions of grouped muscle fiber atrophy Pyknotic nuclear clumps VvG stain[neuromuscular.wustl.edu] clumps: None Large muscle fibers : Hypertrophy Larger muscle fibers Hypertrophied Commonly type I Clustered Smaller muscle fibers Round Commonly type II, May also be I or[neuromuscular.wustl.edu] Axon loss: Not proven Axons may become p-rogressively dysfunctional or lost SMA 5q: General Features H&E stain Grouped atrophy Small muscle fibers: Often rounded Pyknotic nuclear[neuromuscular.wustl.edu]

  • Churg-Strauss Syndrome

    Most prominent was the presence of atrophic angulated or split fibers, internalized nuclei, nuclear clumps, grouped atrophy, and foci of endomysial fibrosis (Figure 1 B).[bmcmusculoskeletdisord.biomedcentral.com] A-E (HES stain), muscle cryostat sections showing: A , necrotizing vasculitis of medium-sized artery with abundant eosinophils; B , atrophic angulated fibers, nuclear clumps[bmcmusculoskeletdisord.biomedcentral.com]

  • Primary Biliary Cirrhosis

    Angular fibers were present with nuclei condensed into aggregates, a phenomenon known as nuclear clumps. We also noted fibers with centrally located nuclei.[scielo.br]

  • Distal Hereditary Motor Neuropathy Type 2C

    Meggen Walsh, University of Kentucky (USA): Skeletal muscle: multiple nuclear "clumps" or nuclear "bags"; also few atrophic angulated myofibers (H&E) Positive stains In some[pathologyoutlines.com] clump" or "nuclear bag" left In cases with deinnervation / reinnervation, there will be myofiber type grouping on ATPase staining or myofiber immunohistochemical stain Surrounding[pathologyoutlines.com] […] description General / ALS / HMSN : Myofibers are smaller and angulated No increase in central nucleation In areas, myofiber may become atrophic to the point that there is only a "nuclear[pathologyoutlines.com]

  • Lower Motor Neuron Syndrome with Late-Adult Onset

    Muscle biopsy confirmed this pattern, demonstrating fiber type grouping, group atrophy, nuclear clump fibers, and type II atrophy.[ahcmedia.com]

  • Distal Hereditary Motor Neuropathy Type 7A

    Meggen Walsh, University of Kentucky (USA): Skeletal muscle: multiple nuclear "clumps" or nuclear "bags"; also few atrophic angulated myofibers (H&E) Positive stains In some[pathologyoutlines.com] clump" or "nuclear bag" left In cases with deinnervation / reinnervation, there will be myofiber type grouping on ATPase staining or myofiber immunohistochemical stain Surrounding[pathologyoutlines.com] […] description General / ALS / HMSN : Myofibers are smaller and angulated No increase in central nucleation In areas, myofiber may become atrophic to the point that there is only a "nuclear[pathologyoutlines.com]

Further symptoms