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142 Possible Causes for Nuclear Clumps

  • Pelger-Huet Anomaly

    […] segments, and coarse clumping of the nuclear chromatin.[en.wikipedia.org] […] characteristic leukocyte appearance was first reported in 1928 by Pelger , a Dutch hematologist, who described leukocytes with dumbbell-shaped bilobed nuclei, a reduced number of nuclear[askhematologist.com] […] appearance was first reported in 1928 by Karel Pelger (1885-1931), a Dutch Hematologist, who described leukocytes with dumbbell-shaped bilobed nuclei, a reduced number of nuclear[en.wikipedia.org]

  • Focal Myositis

    clumps.[orpha.net] […] chronic inflammation and fibrosis accompanied by myopathic changes such as regenerating/degenerating fibers, myophagocytosis and sometimes angular atrophic fibers and pyknotic nuclear[orpha.net]

  • Muscular Atrophy

    […] between muscle fibers VvG stain H&E stain Less involved region Hypertrophic muscle fibers Small regions of grouped muscle fiber atrophy Pyknotic nuclear clumps VvG stain[neuromuscular.wustl.edu] clumps: None Large muscle fibers : Hypertrophy Larger muscle fibers Hypertrophied Commonly type I Clustered Smaller muscle fibers Round Commonly type II, May also be I or[neuromuscular.wustl.edu] Axon loss: Not proven Axons may become p-rogressively dysfunctional or lost SMA 5q: General Features H&E stain Grouped atrophy Small muscle fibers: Often rounded Pyknotic nuclear[neuromuscular.wustl.edu]

  • Spinal Muscular Atrophy Type 1

    […] between muscle fibers VvG stain H&E stain Less involved region Hypertrophic muscle fibers Small regions of grouped muscle fiber atrophy Pyknotic nuclear clumps VvG stain[neuromuscular.wustl.edu] clumps: None Large muscle fibers : Hypertrophy Larger muscle fibers Hypertrophied Commonly type I Clustered Smaller muscle fibers Round Commonly type II, May also be I or[neuromuscular.wustl.edu] Axon loss: Not proven Axons may become p-rogressively dysfunctional or lost SMA 5q: General Features H&E stain Grouped atrophy Small muscle fibers: Often rounded Pyknotic nuclear[neuromuscular.wustl.edu]

  • Spinal Muscular Atrophy Type 3

    […] between muscle fibers VvG stain H&E stain Less involved region Hypertrophic muscle fibers Small regions of grouped muscle fiber atrophy Pyknotic nuclear clumps VvG stain[neuromuscular.wustl.edu] clumps: None Large muscle fibers : Hypertrophy Larger muscle fibers Hypertrophied Commonly type I Clustered Smaller muscle fibers Round Commonly type II, May also be I or[neuromuscular.wustl.edu] Axon loss: Not proven Axons may become p-rogressively dysfunctional or lost SMA 5q: General Features H&E stain Grouped atrophy Small muscle fibers: Often rounded Pyknotic nuclear[neuromuscular.wustl.edu]

  • Distal Hereditary Motor Neuropathy Type 2C

    Meggen Walsh, University of Kentucky (USA): Skeletal muscle: multiple nuclear "clumps" or nuclear "bags"; also few atrophic angulated myofibers (H&E) Positive stains In some[pathologyoutlines.com] clump" or "nuclear bag" left In cases with deinnervation / reinnervation, there will be myofiber type grouping on ATPase staining or myofiber immunohistochemical stain Surrounding[pathologyoutlines.com] […] description General / ALS / HMSN : Myofibers are smaller and angulated No increase in central nucleation In areas, myofiber may become atrophic to the point that there is only a "nuclear[pathologyoutlines.com]

  • Distal Hereditary Motor Neuropathy Type 2

    Meggen Walsh, University of Kentucky (USA): Skeletal muscle: multiple nuclear "clumps" or nuclear "bags"; also few atrophic angulated myofibers (H&E) Positive stains In some[pathologyoutlines.com] clump" or "nuclear bag" left In cases with deinnervation / reinnervation, there will be myofiber type grouping on ATPase staining or myofiber immunohistochemical stain Surrounding[pathologyoutlines.com] […] description General / ALS / HMSN : Myofibers are smaller and angulated No increase in central nucleation In areas, myofiber may become atrophic to the point that there is only a "nuclear[pathologyoutlines.com]

  • Distal Hereditary Motor Neuropathy Type 7A

    Meggen Walsh, University of Kentucky (USA): Skeletal muscle: multiple nuclear "clumps" or nuclear "bags"; also few atrophic angulated myofibers (H&E) Positive stains In some[pathologyoutlines.com] clump" or "nuclear bag" left In cases with deinnervation / reinnervation, there will be myofiber type grouping on ATPase staining or myofiber immunohistochemical stain Surrounding[pathologyoutlines.com] […] description General / ALS / HMSN : Myofibers are smaller and angulated No increase in central nucleation In areas, myofiber may become atrophic to the point that there is only a "nuclear[pathologyoutlines.com]

  • Lower Motor Neuron Syndrome with Late-Adult Onset

    Muscle biopsy confirmed this pattern, demonstrating fiber type grouping, group atrophy, nuclear clump fibers, and type II atrophy.[ahcmedia.com]

  • Spinal Muscular Atrophy

    […] between muscle fibers VvG stain H&E stain Less involved region Hypertrophic muscle fibers Small regions of grouped muscle fiber atrophy Pyknotic nuclear clumps VvG stain[neuromuscular.wustl.edu] clumps: None Large muscle fibers : Hypertrophy Larger muscle fibers Hypertrophied Commonly type I Clustered Smaller muscle fibers Round Commonly type II, May also be I or[neuromuscular.wustl.edu] Axon loss: Not proven Axons may become p-rogressively dysfunctional or lost SMA 5q: General Features H&E stain Grouped atrophy Small muscle fibers: Often rounded Pyknotic nuclear[neuromuscular.wustl.edu]

Further symptoms