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1,075 Possible Causes for Number of B Cells Decreased, Onset of Disease between 25 and 40 Years of Age, Uric Acid Increased

  • Chronic Alcoholism

    CONCLUSIONS: AH and AWLD patients display a significantly reduced PB B-cell count, at the expense of decreased numbers of recently produced immature/regulatory B cells and[ncbi.nlm.nih.gov] Gout Gout is a type of arthritis caused by the formation of uric acid crystals in the joints. It can be very painful.[onhealth.com] RESULTS: Patients with AH showed significantly decreased numbers of total PB B lymphocytes (vs. controls and AWLD), at the expense of immature, memory, and, to a lesser extent[ncbi.nlm.nih.gov]

    Missing: Onset of Disease between 25 and 40 Years of Age
  • Obesity

    NKT cells are enriched in normal mouse liver, and their numbers decrease in ob/ob or high-fat diet models of obesity ( 81, 82 ).[dx.doi.org] Endocrine-disrupting chemicals in foods and increased uric acid levels from meat and sugar intake may increase obesity risk.[nutritionfacts.org] […] lowering uric acid levels prevented the increase in mean arterial blood pressure ( 40 ).[doi.org]

    Missing: Onset of Disease between 25 and 40 Years of Age
  • Psoriasis

    […] involved in the adaptive immune system, which can be subdivided into T cells and B cells Lymphocytopenia or lymphopenia Decreased number of lymphocytes in the blood Major[doi.org] In psoriasis, hyperuricemia may occur by increased epidermal cell turnover, which accelerates purine metabolism and has uric acid as the product of its catabolism.[ncbi.nlm.nih.gov] acid concentration may be increased Low levels of circulating immune complexes have been detected in 56% of patients Serum immunoglobulin A levels are increased in two thirds[emedicine.medscape.com]

    Missing: Onset of Disease between 25 and 40 Years of Age
  • Multiple Myeloma

    The growing number of malignant plasma cells themselves crowd out other healthy blood cells in the bone marrow, resulting in decreased numbers of red blood cells, white blood[themmrf.org] The increased number of growing cancerous cells can lead to the overproduction and excretion of uric acid in the urine, which can lead to kidney stones.[merckmanuals.com] acid levels may be elevated as a complication of multiple myeloma.[labtestsonline.org]

    Missing: Onset of Disease between 25 and 40 Years of Age
  • Pernicious Anemia

    RESULTS: In vitamin B(12)-deficient patients, absolute numbers of CD4 and especially CD8 lymphocytes were found to be decreased; CD4/CD8 ratio increased, and NK cell activity[ncbi.nlm.nih.gov] Definition of pernicious anemia : a severe megaloblastic anemia that is marked by a progressive decrease in the number of red blood cells and by pallor, weakness, and gastrointestinal[merriam-webster.com] […] in number and increase in size and hemoglobin content of the red blood cells and by pallor, weakness, and gastrointestinal and nervous disturbances and associated with reduced[merriam-webster.com]

    Missing: Onset of Disease between 25 and 40 Years of Age
  • Precursor-Cell Lymphoblastic Leukemia

    After induction of chemotherapy, the numbers of MDSCs and T reg cells showed higher increases and decreases, respectively as compared to the numbers in patients during chemotherapy[ncbi.nlm.nih.gov] Sodium bicarbonate may be used to alkalinize the urine to increase uric acid excretion. The dietary restriction of potassium and calcium may also be required.[lecturio.com] This is done to maintain good flow through the kidneys to prevent renal damage from tumor lysis and to increase the solubility of uric acid that is excreted in the urine.[clinicaladvisor.com]

    Missing: Onset of Disease between 25 and 40 Years of Age
  • Waldenstrom Macroglobulinemia

    Flow cytometry revealed a small abnormal population of B cells (CD22 positive and lambda restricted).[pubs.sciepub.com] With plasmapheresis, his serum IgM was lowered to less than 4 g/dl and his serum viscosity decreased to 4.4 cP.[pubs.sciepub.com] […] light chain and negative staining for kappa light chain supporting a clonal lambda light chain restricted population The megakaryocytes appeared adequate in morphology and number[pubs.sciepub.com]

    Missing: Onset of Disease between 25 and 40 Years of Age
  • Acute Alcohol Intoxication

    While uncommon, ingestion of ethanol-based hand sanitizers by children may be associated with significant intoxication. We report the case of a 7-year-old with acute alcohol intoxication following hand sanitizer ingestion. Alcohol elimination in this patient followed zero-order kinetics with a clearance rate of 22.5[…][ncbi.nlm.nih.gov]

    Missing: Number of B Cells Decreased Onset of Disease between 25 and 40 Years of Age
  • Essential Hypertension

    Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension 2001; 38 : 1101–1106. 19.[doi.org] Higher doses have been shown to add little additional antihypertensive efficacy but are associated with more hypokalemia and other adverse effects. 119–122 Uric acid will[doi.org] […] prevalence of obesity and metabolic syndrome that occurs with age. 9 Recently, there has been a renewed interest on the function of uric acid in hypertension.[doi.org]

    Missing: Number of B Cells Decreased Onset of Disease between 25 and 40 Years of Age
  • Blast Phase

    Especially noteworthy and potentially significant in the progression program were the deregulation of the WNT/β-catenin pathway, the decreased expression of Jun B and Fos,[pnas.org] […] of leukemia blast cells.[pnas.org] […] blast crisis) CML is a two-step rather than a three-step process, with new gene expression changes occurring early in accelerated phase before the accumulation of increased numbers[pnas.org]

    Missing: Onset of Disease between 25 and 40 Years of Age

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