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627 Possible Causes for of, sterol, transport, upregulation

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  • Bile Salt

    We aimed to determine whether BE-specific miRNAs are upregulated in an esophageal SQ cell line (Het-1A) in an environment with acid and/or bile salts and whether this is nuclear[ncbi.nlm.nih.gov] Solutes other than bile salts are also transported by NTCP. However, ASBT has not been shown to be a transporter for non-bile salt substrates.[ncbi.nlm.nih.gov] Increases in BA were largely maintained post-week 1 and were generally correlated with FGF-19 and inversely correlated with plant sterols.[ncbi.nlm.nih.gov] In addition, three bile salt hydrolases were significantly upregulated by bile exposure.[ncbi.nlm.nih.gov]

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  • Ezetimibe

    […] of hepatic HMG-CoA reductase activity. 10,11,18 The upregulation of hepatic cholesterol synthesis resulted in a normalization of circulating cholesterol levels.[atvb.ahajournals.org] KEYWORDS: bile salt; biliary cholesterol; reverse cholesterol transport; transintestinal cholesterol transport [Indexed for MEDLINE] Free full text[ncbi.nlm.nih.gov] Ezetimibe also reduces the gastrointestinal absorption of plant sterols, thereby also lowering the serum concentrations of plant sterols.[ncbi.nlm.nih.gov] Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport.[ncbi.nlm.nih.gov]

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  • Tangier Disease

    A striking feature of ABCA1 gene expression is its marked upregulation in foam cells ( 28 ), which was recently shown to be mediated by binding of the oxysterol-activated[jci.org] ATP-binding cassette transporter A1 (ABCA1) A second important mechanism for reverse cholesterol transport involves the ATP-binding cassette transporter A1 (ABCA1).[usmle.biochemistryformedics.com] Under these conditions, specific HDL3-mediated efflux of sterols was almost absent in Tangier fibroblasts.[ncbi.nlm.nih.gov] Recently, Langmann and coworkers ( 27 ) reported that ABC1 expression is upregulated in cultured macrophages by acetylated LDL.[jci.org]

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  • Sterol 27-Hydroxylase Deficiency

    The disease can be treated successfully with chenodeoxycholic acid, which reduces the upregulation of cholesterol 7 alpha-hydroxylase and, therefore, the formation of cholestanol[ncbi.nlm.nih.gov] However, almost 95% are reclaimed by the ileal BA transporter (IBAT), also known as apical sodium-dependent BA transporter, abundantly expressed in the terminal ileum[ 8 ,[wjgnet.com] […] alteration in the sterol 27-hydroxylase gene.[symptoma.com] However, the RXR (retinoid X receptor) ligand, 9- cis -retinoic acid, upregulates CYP27A1 expression.[biochemj.org]

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  • Idiopathic Pulmonary Fibrosis

    These results indicate that a significant increase in the number of primary cilia in IPF contributes to the upregulation of SHH signals.[ncbi.nlm.nih.gov] This ultimately leads to lesser amount of oxygen that can be transported into the body and less carbon dioxide that can be expelled out.[stemcellthailand.org] […] levels in IPF patients, a total of 62 unique lipids were identified by statistical analysis including 24 kinds of glycerophoslipids, 30 kinds of glycerolipids, 3 kinds of sterol[ncbi.nlm.nih.gov] […] via increased steroid binding and cholesterol transporter activity.[nature.com]

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  • Smith Lemli Opitz Syndrome

    HMG-CoA synthase and squalene synthase activities in the patient were upregulated to 149% and 532%, respectively, while the activity of HMG-CoA reductase, the rate-limiting[ncbi.nlm.nih.gov] The cholesterol transporters Abca1, Abcg1, and Sr-b1 are present in placenta; however, their potential role in placental transport remains undetermined.[ncbi.nlm.nih.gov] RSH/SLOS, possibly one affecting intracellular transport of sterols.[ncbi.nlm.nih.gov] Increased Dhcr7 expression is likely due to a coordinated upregulation of SREBP2-regulated cholesterol biosynthetic genes in response to simvastatin treatment.[doi.org]

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  • Cerebrotendinous Xanthomatosis

    Cholesterol 7alpha-hydroxylase (CYP7A1) and Na /taurocholate-cotransporting polypeptide (NTCP) were upregulated 84- and 8-fold, respectively.[ncbi.nlm.nih.gov] They are classified either by the enzyme defect or by the type of lipid involved Disturbance of lipid metabolism with abnormal deposit of lipids in the cells Intestinal fat transport[icd9data.com] Additionally, sterol 27-hydroxylase activity in cultured monocyte-derived macrophages from this patient was[ncbi.nlm.nih.gov] Citrullin-Transporter Citrullinämie I Argininosuccinat-Synthase ASS 9q34.1 Argininbernsteinsäurekrankheit Argininosuccinat-Lyase ASL 7cen-q11.2 Argininämie Arginase ARG1[de.wikibooks.org]

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  • Xanthomatosis

    Statins inhibit HMG-CoA reductase, the rate-limiting step in cholesterol biosynthesis Statins induce cellular inhibition of cholesterol synthesis and upregulation of LDL receptor[vdocuments.mx] […] back out into the intestinal lumen via the action of the two transporters—ATP-binding cassette transporters G5 and G8 (ABCG5 and ABCG8).[plasticsurgerykey.com] […] tissue danger signal which needs to be recognized by the clinician, and its relationship with monogenetic lipoprotein disorders (cholesterol, triglycerides), bile acid and sterol[ncbi.nlm.nih.gov] Key points • Cerebrotendinous xanthomatosis (MIM 213700) is caused by a deficiency of the mitochondrial enzyme sterol 27-hydroxylase. • Sterol 27-hydroxylase (CYP27A1, NP_[medlink.com]

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  • Biotin-Responsive Basal Ganglia Disease

    Stress‐induced upregulation of SLC19A3 is impaired in biotin‐thiamine‐responsive basal ganglia disease Schänzer, A.; Döring, B.; Ondrouschek, M.; Goos, S.; Garvalov, B.[deepdyve.com] , a known biotin transporter.[ncbi.nlm.nih.gov] […] biosynthesis disorder Sterol metabolism disorder Succinic semialdehyde dehydrogenase deficiency Succinyl-CoA:3-ketoacid CoA transferase deficiency Sulfite oxidase deficiency[se-atlas.de] (encoded by SLC19A1) and thiamin (encoded by SLC19A2) transporters.[ncbi.nlm.nih.gov]

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  • High Fat Diet

    NaB acts as a histone deacetylase inhibitor to upregulate PPARα expression with enhanced H3K9Ac modification on it promoter.[ncbi.nlm.nih.gov] In addition, salsalate increased the expression of genes related to glucose and fatty acid transport and oxidation in skeletal muscle.[ncbi.nlm.nih.gov] GHE reduced hepatic sterol regulatory element-binding proteins (SREBP) including SREBP 1 and SREBP 2 protein expressions.[ncbi.nlm.nih.gov] However, AIT upregulated neuron SIRT3 expression and decreased the acetylation of MnSOD.[ncbi.nlm.nih.gov]

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