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60 Possible Causes for 'Onion Bulbs' on Nerve Biopsy

  • Neuropathy

    Demyelination and remyelination occur, producing enlarged peripheral nerves and onion bulbs, detected by nerve biopsy.[merckmanuals.com]

  • Hereditary Areflexic Dystasia

    Slow nerve conduction and demyelination of nerve fibers with onion bulb formations in nerve biopsy specimens led to the Roussy-Lévy syndrome (RLS) being considered a variant[ncbi.nlm.nih.gov] Lapresle , J and Salisachs , P ( 1973 ) Onion bulbs in a nerve biopsy specimen from an original case of Roussy-Levy disease . Arch Neurol 29 : 346 – 348 .[cambridge.org] Slow nerve conduction and demyelination of nerve fibers with onion bulb formations in nerve biopsy specimens led to the Roussy‐Lévy syndrome (RLS) being considered a variant[doi.org]

  • Polyneuropathy

    biopsy shows evidence of endoneurial edema, onion bulb formation and endoneurial mononuclear cell infiltration.[omicsgroup.org] There is some debate about the diagnostic utility of performing a biopsy on the sural nerve [ 2 ].[omicsgroup.org] […] delay/disappearance of F-waves, and distal, temporal dispersion of motor action potential); cerebrospinal fluid analysis reveals an increase in proteins without pleocytosis; nerve[omicsgroup.org]

  • Hypertrophic Interstitial Neuropathy

    Demyelination and remyelination occur, producing enlarged peripheral nerves and onion bulbs, detected by nerve biopsy.[msdmanuals.com] biopsy shows "onion-bulb formation" Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) What is the treatment for CIDP?[quizlet.com] […] history and neurological examination Lumbar puncture reveals elevated protein with no cells Electrodiagnostic studies reveal findings consistent with demyelinating neuropathy Nerve[quizlet.com]

  • Hereditary Motor and Sensory Neuropathies

    Motor nerve conduction velocities are extremely slow, and nerve biopsy shows partial hypomyelination with atypical onion-bulb formation.[healio.com] Demyelination and remyelination occur, producing enlarged peripheral nerves and onion bulbs, detected by nerve biopsy.[merckmanuals.com] bulb appearance CMT type 4 autosomal recessive inheritance 5 Axonal forms Preserved or mildly affected nerve conduction velocity ( 38 m/s) and nerve biopsy evidence of degeneration[radiopaedia.org]

  • Dejerine-Sottas Disease

    Light and electron microscopy of the sural nerve biopsy specimens revealed many onion-bulb shapes formed by the Schwann cell processes or basement membranes without any evidence[ncbi.nlm.nih.gov] A sural nerve biopsy specimen showed marked decreases in the numbers of both large and small myelinated fibers, abundant onion-bulb formation, and hypomyelination.[ncbi.nlm.nih.gov] Sural nerve biopsy showed axons surrounded by a thin myelin sheath and concentrically arranged cytoplasmic processes of Schwann cells forming onion-bulbs.[ncbi.nlm.nih.gov]

  • Chronic Inflammatory Demyelinating Polyneuropathy

    Sural nerve biopsy revealed demyelination and onion bulbs. Inflammatory perivascular CD3 positive infiltrates were present in muscle and nerve biopsies.[ncbi.nlm.nih.gov] All sural nerve biopsies demonstrated Congo red staining. Only occasional onion bulb formation was evident.[ahcmedia.com] biopsy shows evidence of endoneurial edema, onion bulb formation and endoneurial mononuclear cell infiltration.[omicsonline.org]

  • X-linked Distal Spinal Muscular Atrophy Type 3

    bulb" formation on sural nerve biopsies; divided by mutations but all are clinically similar and have distal weakness, nerve hypertrophy but ambulation is maintained; CMT1A[pathologyoutlines.com] […] lower motor neuron findings Spinal muscular atrophy : SMA : most common is deletion of exon 7 or 8 on 5q Hereditary motor and sensory neuropathy : CMT1 : pathology shows "onion[pathologyoutlines.com]

  • Young Adult-Onset Distal Hereditary Motor Neuropathy

    Nerve conduction studies are markedly slow and onion bulb formations are observed in nerve biopsies.[cmtausa.org]

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    Nerve conduction studies are markedly slow and onion bulb formations are observed in nerve biopsies.[cmtausa.org]

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