Onset at Age <20: Causes & Reasons

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Possible Causes for Onset at Age <20

Kearns-Sayre Syndrome

Kearns-Sayre syndrome (KSS) is a neuromuscular disorder defined by the triad of onset before age 20 years, pigmentary retinopathy (a "salt-and-pepper" pigmentation in the [rarediseases.info.nih.gov]

[…] before age 20, and severe cardiac conduction defects that can lead to death. [ncbi.nlm.nih.gov]

Abstract Kearns-Sayre syndrome (KSS) is a sporadic multisystem mitochondrial disorder characterized by progressive external ophthalmoplegia, pigmentary retinopathy, onset [ncbi.nlm.nih.gov]

Juvenile Huntington Disease

BACKGROUND: Juvenile Huntington disease (JHD) is a rare clinical entity characterized by an age at onset younger than 20 years. [ncbi.nlm.nih.gov]

There were 94 patients with age at onset under 20 years, 537 with onset between the ages of 20 and 34, 953 with onset between 35 and 49, and 484 patients with late onset HD [jnnp.bmj.com]

Abstract The age of onset distribution of Huntington disease (HD) has been defined for siblings of patients who exhibit the disease before age 20. [ncbi.nlm.nih.gov]

Migraine with Aura

Within the subtypes of NHMA, patients with typical aura with migraine headache had an earlier age at onset (20 +/- 10 vs. 23 +/- 13 years, P= .044) and a higher co-occurrence [ncbi.nlm.nih.gov]

RAS-Associated Autoimmune Leukoproliferative Disease

It is extremely rare with fewer than 20 patients reported to date. Clinical description Age of onset of the clinical signs is invariably in infancy or early childhood. [orpha.net]

Progressive Rubella Panencephalitis

The authors present a case, concerning a young man, aged 20 years, died 11 months after the onset of the disease. [idexlab.com]

Obstructive Nephropathy

[…] before age 20 Past or current cigarette use A family history of diabetic nephropathy Pathophysiology [ edit ] Diagram showing the basic outline of nephron structure and function [en.wikipedia.org]

[…] people with diabetes that have one or more of the following conditions: [1] Poor control of blood glucose Uncontrolled high blood pressure Type 1 diabetes mellitus, with onset [en.wikipedia.org]

Myofibrillar Myopathy Type 3

[…] before age 20 years, early involvement of posterior foreleg muscles, and markedly elevated CK levels (20-50 times normal upper limit).18 Progression is slow but relentless [practicalneurology.com]

[…] in improving muscle strength or function, however.17 Miyoshi’s Myopathy Miyoshi’s myopathy is a primary disorder of skeletal muscle usually presenting with the triad of onset [practicalneurology.com]

Adult-Onset Autosomal Recessive Cerebellar Ataxia

Kearns-Sayre syndrome (KSS) is defined by the triad of onset before age 20 years, pigmentary retinopathy, and progressive external ophthalmoplegia (PEO). [refsumdisease.org]

The mean age of onset of SCA2 is in the 4th decade, but is more rapidly progressive when onset occurs before age 20. [ataxia.uchicago.edu]

[…] at age 20–40 years with progressive cerebellar ataxia and, In many patients, spastic paraparesis • The pathological changes are unique with amyloid plaques throughout the [slideshare.net]

Adult-Onset Dystonia - Parkinsonism

Early-onset cases that begin before age 20 may be referred to as juvenile-onset disease. [flybase.org]

Early-onset cases that begin before age 20 are sometimes referred to as juvenile-onset Parkinson's disease. [snpedia.com]

In people with ‘juvenile-onset’ (diagnosed under the age 20) or ‘early-onset’ Parkinson’s disease (diagnosed under the age 40), genetic variations can account for the majority [scienceofparkinsons.com]

Chronic Progressive External Ophthalmoplegia

Clinical presentation is variable and our experience suggested that phenotypic differences exist in CPEO with onset after age 20. [ncbi.nlm.nih.gov]

KSS is characterized by three main features: typical onset before age 20 although may occur in infancy or adulthood paralysis of specific eye muscles (called chronic progressive [umdf.org]

Age In KSS, onset of CPEO is before age 20 years. [emedicine.com]

Parkinson Disease Type 20

Of 1103 individuals with early-onset PD from 16 centers across the United States, only 20 (1.8 percent) reported onset before age 20, with the earliest at age 7. [neurolink.athenadiagnostics.com]

This organization also suggests this mutation affects 32 percent of people who experience onset between age 20 and 30. [healthline.com]

Early-onset cases that begin before age 20 are sometimes referred to as juvenile-onset Parkinson disease. [ Read More ] [icdlist.com]

Autosomal Dominant Progressive External Ophthalmoplegia Type 6

KSS requires onset before age 20 years, although some investigators have reported individuals with CPEO-plus and a disease onset below age 20 years. [ncbi.nlm.nih.gov]

Age In KSS, onset of CPEO is before age 20 years. [emedicine.medscape.com]

Of these patients, three had typical Kearns-Sayre syndrome (KSS) as defined by the presence of the invariable triad of CPEO, retinitis pigmentosa and an onset before the age [ncbi.nlm.nih.gov]

Autosomal Recessive Spinocerebellar Ataxia

[…] occurring before the age of 20 years. [digital.csic.es]

[…] occurring before the age of 20 years (Palau and Espinos, 2006; pubmed:17112370 ). [flybase.org]

usually around the age of 20. [en.wikipedia.org]

Sacral Radiculopathy

[…] of onset (bimodal -- Age < 20 years or Age > 55 years) A full neurologic exam shoulder is performed, including an assessment for upper motor neuron findings (Babinski sign [ncbi.nlm.nih.gov]

[…] night, pain at rest, unexplained weight loss, or night sweats Significant medical comorbidities Neurologic deficit or serial exam deterioration Gait ataxia Saddle anesthesia Age [ncbi.nlm.nih.gov]

Colonic Inertia

Onset of symptoms was between age 10 and 20 in more than half of the patients. [semanticscholar.org]

Huntington Disease-Like Syndrome

[…] before the age of 20, less frequently when onset is between ages 20 and 40, and rarely with onset above the age of 40.18 Seizures in DRPLA can be tonic, clonic, tonic-clonic [jnnp.bmj.com]

Mean onset age is in early adulthood between 20 to 45 years. Mean survival time is 1 to 10 years, and rapid progression is suspicious of this cause. [movementdisorders.org]

[…] unclear.19 Similar to HD, there is a negative correlation between age of onset and repeat length.20 In contrast to HD, however, the anticipation phenomenon is more likely [movementdisorders.onlinelibrary.wiley.com]

Ring Chromosome 20 Syndrome

SIGNIFICANCE: In ring(20) syndrome, epilepsy has an age dependent course and a worse outcome when age at seizure onset is earlier. [ncbi.nlm.nih.gov]

Methods: We describe three children with [r(20)] syndrome in whom the onset of epilepsy (age at onset range: 4 years and 6 months to 9 years and 4 months) determined a kind [moh-it.pure.elsevier.com]

METHODS: We describe three children with [r(20)] syndrome in whom the onset of epilepsy (age at onset range: 4 years and 6 months to 9 years and 4 months) determined a kind [ncbi.nlm.nih.gov]

Huntington Disease-Like Type 3

The disease usually starts in the 30s and 40s, but about 10 percent of HD cases have their onset before age 20 (juvenile HD). [bcm.edu]

[…] before the age of 20, less frequently when onset is between ages 20 and 40, and rarely with onset above the age of 40. 18 Seizures in DRPLA can be tonic, clonic, tonic-clonic [jnnp.bmj.com]

In contrast, adult HD usually presents with the gradual onset of clumsiness, chorea and cognitive and behavioral changes. [bcm.edu]

Welander Distal Myopathy

Age: Usually > 40 years; Median 5th decade; Range 20 to 77 Location Arms; Wrist & Finger extensors: Most common Legs (Foot drop): 25% Weakness Hands > Legs in most Muscles [neuromuscular.wustl.edu]

Age: 20 to 54 years Weakness: Fingers Walking difficulty: Steppage gait Weakness Distal > > Proximal Arms before Legs in some Finger extensors & Interossei Atrophy: Distal [neuromuscular.wustl.edu]

age: 20 to 60 years Weakness Distal > Proximal Arms: Finger extensor Legs: Ankle dorsiflexor Respiratory: Normal Scapular winging (40%) Course: Slow progression; Ambulation [neuromuscular.wustl.edu]

Juvenile Paralysis Agitans of Hunt

Early-onset cases that begin before age 20 are sometimes referred to as juvenile-onset Parkinson disease. [ Read More ] [icdlist.com]

Sixty had clinical onset between the ages of 20–40, representing 10.2% of our PD population; in the others the symptoms began after the 40th birthday. [onlinelibrary.wiley.com]

Juvenile Parkinson’s disease in patients under the age of 20 is extremely rare. [sharecare.com]

Citrullinemia Type 2

An autosomal recessive disorder of the urea cycle (OMIM:603471), usually of abrupt onset between age 20 and 50, which is clinically characterised by neuropsychiatric symptoms [medical-dictionary.thefreedictionary.com]

Onset is sudden and usually between the ages of 20 and 50 years. [uniprot.org]

Acronym CTLN2 Synonyms Adult-onset citrullinemia type 2 Citrin deficiency Citrullinemia type II Any medical or genetic information present in this entry is provided for research [uniprot.org]

Ophthalmoplegia

KSS is a slowly progressive mitochondrial disorder with onset before age 20 years. [ajnr.org]

Age In KSS, onset of CPEO is before age 20 years. [emedicine.medscape.com]

[…] before age 20 years, and pigmentary retinopathy. [emedicine.medscape.com]

Cone Rod Dystrophy Type 16

Onset is usually before the age of 20 years. The macula presents with yellow-white spots of irregular shapes. [accessanesthesiology.mhmedical.com]

With age at presentation between 25 and 59 years the BCVA ranged from hand movements detection to 20/32. [nature.com]

[…] the age of 43 years. [jamanetwork.com]

Early-Onset Cerebellar Ataxia

In 1989, 16 cases on EOCA were diagnosed in children with a mean onset age of 7.1 In 1990, 20 patients affected by EOCA were studied. [en.wikipedia.org]

[…] at age 20–40 years with progressive cerebellar ataxia and, In many patients, spastic paraparesis • The pathological changes are unique with amyloid plaques throughout the [slideshare.net]

Abstract A clinical and genetic study was performed on 20 patients affected by early onset cerebellar ataxia with retained tendon reflexes (EOCA). [ncbi.nlm.nih.gov]

Occipital Horn Syndrome

[…] of onset and being associated with far less severe central neurodegeneration. [en.wikipedia.org]

The milder nature of OHS is often attributable to ‘leaky’ splice junction mutations that allow 20–30% of ATP7A messenger RNA (mRNA) transcripts to be correctly processed. [en.wikipedia.org]

Ceruloplasmin Levels (9-29mg/dL) [6] Damage to the Central Nervous System [7] Muscle Wasting [7] Causes [ edit ] OHS is a milder allelic variant of Menkes disease, having a later age [en.wikipedia.org]

Primary Dystonia Type DYT2

Childhood onset – 0 to age 12 Adolescent onset – age 13 to 20 Adult onset – older than age 20 Focal dystonia is limited to one area of the body and can affect the neck (cervical [aans.org]

By age at onset Early‐onset (variably defined as ≤20–30 years): usually starts in a leg or arm and frequently progresses to involve other limbs and the trunk. [onlinelibrary.wiley.com]

Conversely, the older one is at onset, the more likely that the disorder will remain more moderate. [aans.org]

Postural Orthostatic Tachycardia Syndrome

All but 2 patients reported a history of headache, 73% of patients reported a headache onset prior to age 20, and 12% reported headache onset in conjunction with autonomic [n.neurology.org]

[…] between 20 and 40, with an average onset of 30. [18] Diagnoses of POTS beyond age 40 are rare, perhaps because symptoms improve with age. [9] History [ edit ] In 1871, physician [en.wikipedia.org]

[…] groups from menarche to menopause females predominate over males by 5:1 mean age of onset in adults is about 30 years and most patients are between the ages of 20-40 years [gpnotebook.co.uk]

Eosinophilic Rhinitis

Nonallergic rhinitis usually has an onset after age 20 years, unlike allergic rhinitis, which usually has an onset before age 20 years. [clinicaladvisor.com]

Dentatorubral-Pallidoluysian Atrophy

On the other hand, patients with non-PME phenotype showed later ages of onset (onset after age 20) and smaller expansions (54-67 repeats). [ncbi.nlm.nih.gov]

Patients with earlier onset (below 20 years of age) tend to show myoclonus epilepsy and intellectual deficit. [orpha.net]

[…] and coordination ( ataxia ) Epileptic seizures occur in all people with onset before 20 years of age. [3] When DRPLA begins after 20 years of age, the most frequent signs [rarediseases.info.nih.gov]

Spinocerebellar Ataxia Type 20

The mean age of onset of SCA2 is in the 4th decade, but is more rapidly progressive when onset occurs before age 20. [ataxia.uchicago.edu]

The onset of symptoms started at the age of 20 years and extends up to 30 years. [healthsaline.com]

Onset varies from ages 2-52 years and usually occurs in people younger than 20 years; it slowly progresses over decades. [emedicine.medscape.com]