Possible Causes for onset first weeks of life Congenital Bile Acid Synthesis Defect Type 2 Due to impaired bile acid synthesis, within the first weeks of life, affected infants start to present with malabsorption of lipids and lipid-soluble vitamins from the gastrointestinal [preventiongenetics.com] Clinical Features Congenital bile acid synthesis defect type 2 (CBAS2) is a progressive liver disease of neonatal onset characterized by cholestasis (Lemonde et al. 2003; [preventiongenetics.com] Citrullinemia Type 1 Classic neonatal-onset citrullinemia type I is suspected in infants who have been on a full protein diet and who present in the first week of life with hyperammonemia, lethargy [egl-eurofins.com] 18-Hydroxylase Deficiency A 15-year-old phenotypic female with XY genotype presented with male pseudohermaphroditism, gynecomastia, hypokalemic alkalosis, and hypertension. Being raised as a girl, the patient failed to menstruate and developed no sexual hair. At laparatomy no Müllerian structures were found but testes were removed which[…] [ncbi.nlm.nih.gov] Mitochondrial Myopathy with Reversible Cytochrome C Oxidase Deficiency Abstract A 1-month-old Japanese girl had profound generalized weakness, hypotonia, and severe lactic acidosis. The infant improved gradually: she held her head at 9 months, learned to walk by 15 months. At the first muscle biopsy at 11 weeks of age, the specimen was characterized by numerous ragged-red fibers and[…] [ncbi.nlm.nih.gov] Sexually Transmitted Disease Early-onset sepsis is seen in the first week of life. Late onset sepsis occurs after 1 week through 3 months of age. [medlineplus.gov] Early-onset sepsis was defined as the first sepsis episode occurring 3 days of life, and late-onset sepsis was defined as occurring 3 days [17], but less than 4 weeks of life [hindawi.com] […] that time Amoxycillin - 50 mg/kg/dose 12-hourly for preterm babies or term babies in the first week of life, eight-hourly after that time Late-onset sepsis Flucloxacillin [bettersafercare.vic.gov.au] Acne Vulgaris first few weeks of life Clinical presentation: papulopustular rash Treatment: self-limiting disease ; no specific treatment Infantile acne Age of onset: 3 months Clinical [amboss.com] […] and variants Hidradenitis suppurativa (also acne inversa): inflammation of the hair follicles and apocrine glands, most likely triggered by a blockage Neonatal acne Age of onset [amboss.com] Streptococcal Infection Sometimes evident within a few hours of birth and always apparent within the first week of life, this condition causes inflammation of the membranes covering the brain and [medical-dictionary.thefreedictionary.com] These infections are early-onset since they appear within the first week of life, often in the first hours after birth. [emedicinehealth.com] About 75 percent of them develop early-onset infection. [encyclopedia.com] Thrombocytopenia Most cases occur in the first week of life and are related to vaginal carriage in the mother. [doi.org] Late onset GBS disease (more than seven days after birth) is less common, and has been linked to cross infection from the hands of healthcare workers. 1 Alternatively, it [doi.org] Otitis Media Around 60% to 85% of children have AOM during the first year of life. acute onset pain in the ear is the most common symptom. pain is a result of inflammatory reaction Otalgia [medicaljoyworks.com] ( ear pain) first 3 weeks of a process which includes rapid onset of symptoms, middle ear effusion, and signs and symptoms of middle ear inflammation is the diagnostic criteria [medicaljoyworks.com] Neonatal Sepsis When there is late-onset sepsis (after the first week of life) there is usually central nervous system involvement. [allnurses.com] Early-onset sepsis is seen in the first week of life. Late-onset sepsis occurs between days 8 and 89. [coordinatedhealth.com] Early-onset sepsis is seen in the first week of life. Occurs after 1 week and before 3 months of age. [omicsonline.org] Herpes Zoster Herpes zoster in the first years of life: Maternal varicella occurring after the twenty-fourth week of gestation leads to asymptomatic fetal seroconversion and the birth of [doi.org] Herpes zoster may also occur after 2-41 mo of life in 15% of newborns with CVS if the onset of maternal varicella was between the eighth and twenty-fourth week of gestation [doi.org] Consequently, in the case of planned childbirth, it is advisable to avoid delivery during the 5-7 d after the onset of the rash in order to allow the passive transmission [doi.org] Sepsis Early-onset sepsis is seen in the first week of life. Late onset sepsis occurs after 1 week through 3 months of age. [medlineplus.gov] […] of life. [ncbi.nlm.nih.gov] To better understand the assembly of the gut microbiota in preterm infants, fecal samples were collected from 32 very low birth weight preterm infants over the first 6 weeks [ncbi.nlm.nih.gov] Viral Exanthem […] four weeks of life), adults, pregnant women and those who are immunocompromised due to illness or treatments such as chemotherapy or high-dose steroids, may experience more [pcds.org.uk] The most infectious period is from 1 to 2 days before the rash appears but infectivity continues until all the lesions have crusted over (commonly about 5 to 6 days after onset [pcds.org.uk] Complications Chickenpox is usually a mild illness and most healthy children recover with no complications Certain groups of people, however, such as neonates (infants within the first [pcds.org.uk] Intestinal Obstruction failure to pass stool in first days of life, explosive expulsion of gas, and stool after digital rectal exam Intussusception: distention, intermittent abdominal pain, currant [unboundmedicine.com] […] of age with postprandial, nonbilious, projectile vomiting Intestinal malrotation/volvulus: sudden-onset, bilious vomiting with acute abdomen symptoms Hirschsprung disease [unboundmedicine.com] […] constipation/fecal impaction Pseudoobstruction (Ogilvie syndrome) Volvulus Pediatric Considerations In young children and infants, consider: Pyloric stenosis: infant 3 to 6 weeks [unboundmedicine.com] Traveler's Diarrhea The onset of TD usually occurs within the first week of travel but may occur at any time while traveling, and even after returning home. Most TD cases begin abruptly. [web.archive.org] […] usually is a self-limited disorder,but in the very young and the very old, as well as in those who are immunocompromised, or who get serious infections, TD can occasionally be life-threatening.The [web.archive.org] Electrolyte Imbalance Late-onset hypocalcemia develops after the first week of life and is usually associated with conditions with high serum phosphate levels, including hypoparathyroidism, maternal [emedicine.medscape.com] Upper Urinary Tract Infection Of those affected, the median age at onset was 3 weeks, and 26 of 71 (36.6%) experienced a first occurrence during the first year of life. [jamanetwork.com] Coagulase-Negative Staphylococcus Epidemiologists defined two types of infections in neonates: early-onset neonatal sepsis (EONS), which manifests in the first 72 hours of life (up to 7 days) and late-onset [hindawi.com] Epidemiology of Neonatal Sepsis Neonatal sepsis is defined as infection in the first 28 days of life, or up to 4 weeks after the expected due date for preterm infants [1]. [hindawi.com] […] neonatal sepsis (LONS), whose incidence peaks in the 2nd to 3rd week of postnatal life [1]. [hindawi.com] Infantile Colic This syndrome has its onset typically in the first few weeks of life. It spontaneously resolves by age 4 to 6 months. [mdedge.com] The peak onset of colic occurs at age 6–8 weeks and it usually resolves by age 10–12 weeks. [smj.org.sg] The mean onset of colic is 1.8 weeks of age ( Paradise 1966 ), and infants whose colic begins in the first two weeks of life seem to have a longer duration of symptoms than [doi.org] Intestinal Pseudo-Obstruction Patients tended to have symptom onset either in the first two decades of life, or after the age of 40. [gut.bmj.com] The median age of onset of symptoms was 17 years (range two weeks to 59 years) (fig 1 ). [gut.bmj.com] Patent Ductus Arteriosus Although a PDA is most commonly diagnosed during the first week of life, the DA may close spontaneously, or after medical therapy, and subsequently re-open. [cancertherapyadvisor.com] This occurs more commonly among extremely premature infants who develop late-onset sepsis. What causes the ductus arteriosus to remain patent? [cancertherapyadvisor.com] Congenital Laryngomalacia Stridor usually is not present at birth, but onset is usually within the first 1-2 weeks of life. [cancertherapyadvisor.com] Increased muscle mass, strength, and respiratory effort during the first weeks of life is thought to be the genesis of the early onset that is not present at birth. [cancertherapyadvisor.com] Familial Infantile Myoclonic Epilepsy Mayo Clinic Video Asset: Neonatal and Infantile Onset Epilepsy Seizures beginning during first weeks of life: Benign neonatal and benign infantile epilepsies. [epilepsyfoundationmn.org] Epileptic encephalopathy, early infantile, 16 (EIEE16) [MIM:615338]: A severe autosomal recessive neurologic disorder characterized by onset of seizures in the first weeks [genecards.org] Here are some of the best classified pediatric epilepsy syndromes, according to age of onset. [epilepsyfoundationmn.org] Neonatal Infection Classification early onset occurs in the first week of life and as an intrauterine pneumonia often caused by group B streptococcus or gram negative bacteria late onset occurs [radiopaedia.org] Early-onset sepsis is seen in the first week of life. Late onset sepsis occurs after 1 week through 3 months of age. [medlineplus.gov] Streptococcus Agalactiae Infections occurring within the first week of life are considered early-onset; those occurring in infants greater than 1 week of age are considered late-onset. [mayocliniclabs.com] week of life (known as early-onset GBS infections). [chromagar.com] or after the first week of life (late-onset). [1] Infection in women can occur if the bacteria enters the endometrium during childbirth, and then puerperal fever can occur [austincc.edu] Proliferating Angioendotheliomatosis First 4 weeks of life [1] Types Superficial, deep, mixed [1] Risk factors Females, white people, preemies, low birth weight babies [1] Diagnostic method Based on symptoms [en.wikipedia.org] […] infancy Specialty Dermatology, gastroenterology Symptoms Raised red or blue lesion [2] Complications Pain, bleeding, ulcer formation, heart failure, disfigurement [1] Usual onset [en.wikipedia.org] Sepsis in Premature Infants Early-onset sepsis is seen in the first week of life. Late onset sepsis occurs after 1 week through 3 months of age. [medlineplus.gov] […] with occurrence of 42% in the first week of life (3, 4). [pedinfect.com] Early-onset sepsis was defined as the first sepsis episode occurring 3 days of life, and late-onset sepsis was defined as occurring 3 days [17], but less than 4 weeks of life [hindawi.com] Umbilical Sepsis Early-onset sepsis is seen in the first week of life and most often appears within 24 hours of birth. Late-onset occurs after 1 week and before 3 months of age. [medvik.cz] Benign Familial Infantile Epilepsy Type 4 (often first week) of life Etiologies: often inborn errors of metabolism (nonketotic hyperglycinemia, PA, MMA, Menkes, Zellweger) Clinical features: Triad: Myoclonic jerks [emilytam.com] Detection rate of causal variants in severe childhood epilepsy is highest in patients with seizure onset within the first four weeks of life. [journals.sagepub.com] Onset is usually in the first week of life; in 80% of patients, onset is on day 2 or 3 of life. [emedicine.medscape.com] Meningitis Meningitis due to group B streptococcus (GBS meningitis) may occur in the first week of life, accompanying early-onset neonatal sepsis and frequently manifesting initially [msdmanuals.com] Often, however, GBS meningitis occurs after this period (most commonly in the first 3 mo of life) as an isolated illness characterized by absence of antecedent obstetric or [msdmanuals.com]
