Onset in Adolescence: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Onset in Adolescence

Childhood Schizophrenia

Schizophrenia with onset before adolescence does seem to differ from later-onset cases in the very high rates of insidious as opposed to acute onset. [academic.oup.com]

Is adolescent-onset first-episode psychosis different from adult onset?. J Am Acad Child Adolesc Psychiatry. 2005 Aug. 44(8):782-9. [Medline]. [emedicine.medscape.com]

Onset of schizophrenia is typically from mid-adolescence to the mid-30s, with a peak age of onset in the 20s. Features in adolescents and young adults are similar. [msdmanuals.com]

Lafora Disease

With the exception of a few missense mutations LD is clinically homogeneous, with onset in adolescence. [ncbi.nlm.nih.gov]

The disease course is progressive and fatal, with death occurring within 10 years of onset. [ncbi.nlm.nih.gov]

Kleine-Levin Syndrome

[…] during adolescence. [ncbi.nlm.nih.gov]

Critchley 1962 : Predominance in adolescent males; Onset in adolescence; Periodic hypersomnia; Hyper/mega/polyphagia; Associated behavioural and psychological changes; Benign [doi.org]

[…] than in patients with adolescent onset. [ncbi.nlm.nih.gov]

Juvenile Cystinosis

[…] cystinosis Adolescent cystinosis, late-onset cystinosis, juvenile cystinosis Adult cystinosis, benign cystinosis, ocular cystinosis It is believed that cystinosis affects [cystaran.com]

Late-onset juvenile or adolescent nephropathic cystinosis is an intermediated form, manifesting first at age 10 to 12 years with proteinuria due to glomerular damage rather [genecards.org]

"The late-onset or adolescent form of cystinosis accounts for about 5% of cases and is very under-recognized," he said. [raredr.com]

Limb-Girdle Muscular Dystrophy Type 2E

onset of progressive pelvic- and shoulder-girdle muscle weakness, particularly affecting the pelvic girdle (adductors and flexors of hip). [orpha.net]

Adolescent, Childhood ICD-10: G71.0 OMIM: 608099 UMLS: C1842550 C2936332 MeSH: - GARD: 438 MedDRA: - The documents contained in this web site are presented for information [orpha.net]

In most cases, childhood onset of LGMD results in a more severe disorder that progresses more rapidly than adolescent or adult onset cases. [rarediseases.org]

Nephronophthisis 12

[…] of onset 10 adolescent (a.k.a. medullary cystic kidney disease): usually develops in patients in their thirties There can be clinical triad comprising of uremia, anemia, [radiopaedia.org]

Juvenile - median age of onset 13 years. Adolescent - median age of onset 19 years. [patient.info]

Three clinical variants based on age of onset for end stage renal disease (ESRD): infantile: before 2 years of age juvenile (a.k.a. nephronophthisis): most common form, age [radiopaedia.org]

Woodhouse-Sakati Syndrome

Movement disorders mainly consist of dystonia and chorea of the limbs with onset in adolescence. Facial muscles are usually spared, but dysarthria is common. [ncbi.nlm.nih.gov]

Usual onset during adolescence. [sites.uclouvain.be]

Clinical description The onset is usually in adolescence. [orpha.net]

Nephronophthisis Type 2

[…] of onset 10 adolescent (a.k.a. medullary cystic kidney disease): usually develops in patients in their thirties There can be clinical triad comprising of uremia, anemia, [radiopaedia.org]

Juvenile - median age of onset 13 years. Adolescent - median age of onset 19 years. [patient.info]

Three clinical variants based on age of onset for end stage renal disease (ESRD): infantile: before 2 years of age juvenile (a.k.a. nephronophthisis): most common form, age [radiopaedia.org]

Nephronophthisis 9

[…] of onset 10 adolescent (a.k.a. medullary cystic kidney disease): usually develops in patients in their thirties There can be clinical triad comprising of uremia, anemia, [radiopaedia.org]

Juvenile - median age of onset 13 years. Adolescent - median age of onset 19 years. [patient.info]

Three clinical variants based on age of onset for end stage renal disease (ESRD): infantile: before 2 years of age juvenile (a.k.a. nephronophthisis): most common form, age [radiopaedia.org]

Adult Neuronal Ceroid Lipofuscinosis

\ ˈku̇fs- \ Medical Definition of Kufs' disease : a hereditary lipid metabolism defect with onset usually in adolescence and characterized by progressive convulsions, paralysis [merriam-webster.com]

Symptoms of Kufs disease may onset anywhere between adolescence and adulthood. However, signs and symptoms typically onset about 30 years of age. [symptoma.com]

X-linked Distal Spinal Muscular Atrophy Type 3

Adolescent, Adult, Infancy, Childhood ICD-10: G12.2 OMIM: 300489 UMLS: C1845359 MeSH: - GARD: - MedDRA: - The documents contained in this web site are presented for information [orpha.net]

LATE ADOLESCENCE/ ADULTHOOD (adult-onset) LATE ADOLESCENCE/ADULTHOOD (adult-onset) 1,2,4 Highest motor milestone achieved ALL Life expectancy (untreated SMA) NORMAL Clinical [togetherinsma-hcp.com]

It onsets at some point between adolescence and mid-life and symptoms include generalised muscle weakness, cramping and spasms, as well as difficulties with speech and swallowing [www2.warwick.ac.uk]

Autosomal Dominant Spastic Paraplegia Type 17

ORPHA:100998 Synonym(s): SPG17 Silver syndrome Spastic paraplegia-amyotrophy of hands and feet Prevalence: Inheritance: Autosomal dominant Age of onset: Childhood, Adolescent [orpha.net]

ORPHA:100988 Synonym(s): SPG6 Prevalence: Inheritance: Autosomal dominant Age of onset: Childhood, Adolescent, Adult ICD-10: G11.4 OMIM: 600363 UMLS: C1838192 MeSH: C536866 [orpha.net]

Nephronophthisis Type 3

[…] of onset 10 adolescent (a.k.a. medullary cystic kidney disease): usually develops in patients in their thirties There can be clinical triad comprising of uremia, anemia, [radiopaedia.org]

Juvenile - median age of onset 13 years. Adolescent - median age of onset 19 years. [patient.info]

Three clinical variants based on age of onset for end stage renal disease (ESRD): infantile: before 2 years of age juvenile (a.k.a. nephronophthisis): most common form, age [radiopaedia.org]

Progressive Myoclonic Epilepsy Type 7

Abstract Many of the progressive epilepsy syndromes with adolescent onset are classified as progressive myoclonus epilepsies. [thieme-connect.com]

[…] in adolescence or in late childhood; progresses to death between 17–24 years in 90% of patients Generalized tonic-clonic seizures are presenting features; status epilepticus [neurodiffdx.com]

Rare diseases Search Search for a rare disease Progressive myoclonic epilepsy type 7 Disease definition A rare, genetic, neurological disorder characterized by childhood to adolescent [orpha.net]

Distal Hereditary Motor Neuropathy Type 5A

139536 Synonym(s): Distal HMN V Distal hereditary motor neuropathy type V Distal spinal muscular atrophy type 5 dHMN5 Prevalence: - Inheritance: Autosomal dominant Age of onset [orpha.net]

Symptoms of distal hereditary motor neuropathy, type V usually begin during adolescence, but onset varies from infancy to the mid-thirties. [ghr.nlm.nih.gov]

Muscular Dystrophy-Dystroglycanopathy Type C4

Others have milder disease with onset in adolescence or adulthood. This disorder may cause weakening of heart muscles in some people. [geneaware.clinical.bcm.edu]

onset of progressive pelvic - and shoulder-girdle muscle weakness, particularly affecting the pelvic girdle (adductors and flexors of hip). [rarediseases.info.nih.gov]

In CMD, onset of symptoms is at birth or within the first 6 months of life; in LGMD onset of symptoms is in late childhood, adolescence or even adult life. [dmd.nl]

Unverricht-Lundborg Syndrome

Synonym(s): PME type 1 Progressive myoclonic epilepsy type 1 Progressive myoclonus epilepsy type 1 ULD Prevalence: 1-9 / 1 000 000 Inheritance: Autosomal recessive Age of onset [orpha.net]

Childhood, Adolescent ICD-10: G40.3 OMIM: 254800 310370 612437 UMLS: C0751785 MeSH: D020194 GARD: 3876 MedDRA: 10054895 The documents contained in this web site are presented [orpha.net]

Cystinosis

[…] cystinosis Adolescent cystinosis, late-onset cystinosis, juvenile cystinosis Adult cystinosis, benign cystinosis, ocular cystinosis It is believed that cystinosis affects [cystaran.com]

The late-onset form of cystinosis has comparable manifestations, but with onset generally around adolescence or early adult life. [orphan-europe.com]

# 219900 CYSTINOSIS, LATE-ONSET JUVENILE OR ADOLESCENT NEPHROPATHIC TYPE Alternative titles; symbols CYSTINOSIS, INTERMEDIATE SNOMEDCT: 22830006; ORPHA: 411634, 213; DO: 1064 [ncbi.nlm.nih.gov]

Autosomal Dominant Spastic Paraplegia Type 10

ORPHA:100991 Synonym(s): SPG10 Prevalence: Inheritance: Autosomal dominant Age of onset: Childhood, Adolescent, Adult ICD-10: G11.4 OMIM: 604187 UMLS: C1858712 MeSH: C537482 [orpha.net]

ORPHA:100988 Synonym(s): SPG6 Prevalence: Inheritance: Autosomal dominant Age of onset: Childhood, Adolescent, Adult ICD-10: G11.4 OMIM: 600363 UMLS: C1838192 MeSH: C536866 [orpha.net]

Schizophrenia Type 1

Citation metadata Abstract : The onset of schizophrenia in children and adolescents is polymorphic and can be expressed by an acute psychosis, lucid or confused, by a surprising [go.gale.com]

Melanocytic Nevus

Characteristics of Atypical vs Typical Moles Criteria Typical Moles Atypical Moles Age of onset Childhood or adolescence Continue to appear after adolescence Color Flesh-colored [merckmanuals.com]

Charcot-Marie-Tooth Disease Type 2E

ORPHA:99939 Classification level: Disorder Synonym(s): CMT2E Prevalence: Unknown Inheritance: Autosomal dominant Age of onset: Childhood, Adolescent, Adult, Infancy ICD-10 [orpha.net]

Charcot-Marie-Tooth disease usually becomes apparent in adolescence or early adulthood, but onset may occur anytime from early childhood through late adulthood. [ghr.nlm.nih.gov]

Exhibitionism

Onset is usually during adolescence; occasionally, the first act occurs during preadolescence or middle age. [merckmanuals.com]

Proximal Myopathy with Focal Depletion of Mitochondria

ORPHA:521305 Classification level: Disorder Synonym(s): - Prevalence: <1 / 1 000 000 Inheritance: - Age of onset: Childhood, Adolescent, Adult ICD-10: - OMIM: 600706 UMLS: [orpha.net]

[…] in adolescence Muscle: severe myalgias after exercise mild proximal weakness Lab: elevated creatine kinase large areas of about one-third of type ii muscle fibers devoid [malacards.org]

31 HP:0003236 2 proximal muscle weakness 31 HP:0003701 3 exercise-induced myalgia 31 HP:0003738 Symptoms via clinical synopsis from OMIM®: 57 (Updated 05-Apr-2021) Misc: onset [malacards.org]

Primary Dystonia Type DYT2

Onset Primary; Mixed Type Autosomal Dominant Adolescent onset, mostly segmental, rarely generalizes DYT-7 18pter-p11.32 Adult Onset Focal Primary Autosomal Dominant Adult [cmdg.org]

With regard to primary dystonia type DYT2 or DYT2-like primary dystonia (PD-DYT2), symptom onset occurs in childhood or adolescence. [symptoma.com]

Childhood onset – 0 to age 12 Adolescent onset – age 13 to 20 Adult onset – older than age 20 Focal dystonia is limited to one area of the body and can affect the neck (cervical [aans.org]

Familial Temporal Lobe Epilepsy Type 3

Seizure onset for twin and nontwin subjects usually occurred during adolescence or early adult life. [pubmed.ncbi.nlm.nih.gov]

Pompe Disease

If GAA activity is less severely reduced, patients may not develop any symptoms until adolescence or adulthood. They may then be diagnosed with late-onset GSD2. [symptoma.com]

Antenatal, Neonatal, Infancy, Childhood, Adolescent, Adult ICD-10: E74.0 OMIM: 232300 UMLS: C0017921 MeSH: D006009 GARD: 5714 MedDRA: 10053185 The documents contained in [orpha.net]

Less severe reductions of GAA activity result in late-onset GSD2. Adolescents or adults may experience progressive muscle weakness, breathing and walking difficulties. [symptoma.com]

Myoclonic Epilepsy

Diagnostic criteria included myoclonic jerks and seizure onset in adolescence. We applied no limitation on age for enrolment. [cochranelibrary.com]

Progressive Myoclonic Epilepsy Type 8

Rare diseases Search Search for a rare disease Progressive myoclonic epilepsy type 8 Disease definition A rare, genetic, neurological disorder characterized by childhood to adolescent-onset [orpha.net]

[…] in adolescence. [jmg.bmj.com]

Levetiracetam as add-on therapy for idiopathic generalized epilepsy syndromes with onset during adolescence: analysis of two randomized, double-blind, placebo-controlled studies [emedicine.medscape.com]

Mitochondrial Trifunctional Protein Deficiency

[…] infant death (SIDS; OMIM:272120 ), infantile onset of a hepatic Reye-like syndrome, and late-adolescent onset of primarily a skeletal myopathy (Spiekerkoetter et al., 2003 [flybase.org]

Childhood- or adolescent-onset recurrent rhabdomyolysis is a common muscular manifestation and is preceded frequently by clinically overt peripheral neuropathy. [ncbi.nlm.nih.gov]

Clinically, classic trifunctional protein deficiency can be classified into 3 main clinical phenotypes: neonatal onset of a severe, lethal condition resulting in sudden unexplained [flybase.org]