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15 Possible Causes for Onset in Early Childhood - 4 to 5 Years

  • Keratoconus

    Onset of keratoconus can occur in early childhood, especially in patients with Down syndrome.[ncbi.nlm.nih.gov] In this case, CXL was performed at 4 and 5 years of age without complications and stopped further keratoconus progression.[ncbi.nlm.nih.gov]

  • Trichotillomania

    The peak age at onset is 12–13 years, and the disorder is often chronic and difficult to treat (3, 4). Hair pulling in early childhood ( (2, 5).[ajp.psychiatryonline.org]

  • Cardiac Dilatation

    & 5 Clinical Onset age Common: Early Childhood (60%) to Adolescent or Adult Mean 13 years Range 1 to 40 years No relation between early onset age & genotype Rhabdomyolysis[neuromuscular.wustl.edu] […] heterozygotes: Ser113Leu, Arg503Cys Polymorphisms: 3 identified May contribute to reduced CPT2 activity in combination with disease allele Mutations most common in exons 4[neuromuscular.wustl.edu]

  • Juvenile Myxedema

    Clinical suspicion of AITD was based on late onset of symptoms above 4 to 5 years of age, normal progress and development during infancy and early childhood, history of familial[indianpediatrics.net] […] prevalence of thyroid disorders, presence of a diffuse firm thyromegaly of relatively recent onset with or without clinical signs of thyroid dysfunction, and associated clinical[indianpediatrics.net]

  • Down Syndrome

    CONCLUSIONS: Onset of keratoconus can occur in early childhood, especially in patients with Down syndrome.[ncbi.nlm.nih.gov] In this case, CXL was performed at 4 and 5 years of age without complications and stopped further keratoconus progression.[ncbi.nlm.nih.gov]

  • Leukodystrophy

    It can also produce optic atrophy and progressive macrocephaly. 5 The most frequent clinical forms of the disease have their onset during childhood: the early childhood-onset[doi.org] […] appears before five years of age and the late childhood-onset between ages 5 and 15. 4, 6 The disease may have a chronic progressive course or an acute form, and it is difficult[doi.org] […] produces a progressive neurological deterioration with some acute exacerbations in reaction to certain stimuli, such as infections, cranial trauma, and acute fright. 3, 4[doi.org]

  • Short Chain Acyl CoA Dehydrogenase Deficiency

    & 5 Clinical Onset age Common: Early Childhood (60%) to Adolescent or Adult Mean 13 years Range 1 to 40 years No relation between early onset age & genotype Rhabdomyolysis[neuromuscular.wustl.edu] […] heterozygotes: Ser113Leu, Arg503Cys Polymorphisms: 3 identified May contribute to reduced CPT2 activity in combination with disease allele Mutations most common in exons 4[neuromuscular.wustl.edu]

  • Mulibrey Nanism Syndrome

    & 5 Clinical Onset age Common: Early Childhood (60%) to Adolescent or Adult Mean 13 years Range 1 to 40 years No relation between early onset age & genotype Rhabdomyolysis[neuromuscular.wustl.edu] […] heterozygotes: Ser113Leu, Arg503Cys Polymorphisms: 3 identified May contribute to reduced CPT2 activity in combination with disease allele Mutations most common in exons 4[neuromuscular.wustl.edu]

  • Duodenal Duplication

    The clinical presentation or onset symptoms of this malformation range from infancy and early childhood to adulthood. [4], [5], [6], [7] Of the cases, 70-80% presented within[afrjpaedsurg.org] […] the 1 st year of life. [4], [5], [6], [7] Although there are some reports that duplications are more common in males, most authors agree that duplications occur more commonly[afrjpaedsurg.org]

  • Juvenile Myasthenia Gravis

    Patients were divided into the following categories according to age at onset: (1) infancy, less than 1 year; (2) early childhood, 1–3 years; (3) pre-school age, 3–6 years[frontiersin.org] ; (4) school age, 6–12 years; and (5) puberty, 12–18 years.[frontiersin.org]

Further symptoms