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28 Possible Causes for Onset of Disease in Fourth or Fifth Decade of Life

  • Alzheimer Disease

    […] in the fourth decade of life, usually leading to death in the fifth decade of life. 42-44 Loss-of-function mutations in DAP12 and TREM2 were originally found in patients[doi.org] […] in the fourth decade of life, usually leading to death in the fifth decade of life. 42 – 44 Loss-of-function mutations in DAP12 and TREM2 were originally found in patients[ncbi.nlm.nih.gov] It is a rare recessively inherited disease that is characterized by painful bone cysts in wrists and ankles, psychotic symptoms, and progressive presenile dementia with onset[doi.org]

  • Delirium

    Hypochondriasis often begins during the fourth and fifth decades of life but is also common at other times, such as during pregnancy .[britannica.com] The onset of this disorder may be associated with precipitating factors such as an actual organic disease with physical and psychological aftereffects—e.g., coronary thrombosis[britannica.com]

  • Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1H

    Five subjects presented with a slowly progressive proximal muscle weakness, in both upper and lower limbs, with onset during the fourth-fifth decade of life, which fulfilled[moh-it.pure.elsevier.com] Five subjects presented with a slowly progressive proximal muscle weakness, in both upper and lower limbs, with onset during the fourthfifth decade of life, which fulfilled[scinapse.io] Clinical findings showed variable expressivity in terms of age at onset and disease severity.[moh-it.pure.elsevier.com]

  • Spinal and Bulbar Muscular Atrophy

    ) is characterized by onset of progressive muscle weakness, atrophy, and fasciculations typically in the fourth or fifth decade of life.[mayomedicallaboratories.com] […] pathophysiology, and general clinical aspects, as they relate to a laboratory test X-linked spinal and bulbar muscular atrophy (spinobulbar muscular atrophy: SBMA; or Kennedy disease[mayomedicallaboratories.com]

  • Psoriatic Arthritis

    The onset of psoriatic arthritis generally occurs in the fourth and fifth decades of life. Males and females are affected equally.[medicinenet.com] The skin disease (psoriasis) and the joint disease (arthritis) often appear separately. In fact, the skin disease precedes the arthritis in nearly 80% of people.[medicinenet.com]

  • Juvenile Psoriatic Arthritis

    The onset of psoriatic arthritis generally occurs in the fourth and fifth decades of life. Males and females are affected equally.[medicinenet.com] The skin disease (psoriasis) and the joint disease (arthritis) often appear separately. In fact, the skin disease precedes the arthritis in nearly 80% of people.[medicinenet.com]

  • Lermoyez Syndrome

    […] at onset is in the fourth and fifth decades of life, although presentation can be at almost any age. • The incidence of bilateral disease probably is in the range of 19%[slideshare.net] INCIDENCE • The disease seems to be more prevalent among whites, with a variable female-to-male ratio ( ranging from 1:1, 1.3:1, 2:1 ; female preponderance ). • The peak age[slideshare.net]

  • Macular Degeneration, Early Onset

    Posted by and Miriam Garcia-Fernandez on Oct 7, 2013 in Hereditary diseases Comments Off on Mutation in the Exon 6 of Gene RDH12 Associated to Severe Early-onset Macular Degeneration Poster 4 Joaquin Castro Navarro Advantages: To show the clinical evolution of a child with a novel mutation in exon 6 of gene[…][evrs.eu]

  • Adult-Onset Cervical Dystonia Type DYT23

    […] with onset typically in the fourth or fifth decade of life that has material basis in heterozygous mutation in the CACNA1B gene on chromosome 9q34.[malacards.org] Related phenotypes are torticollis and cerebellar atrophy Disease Ontology : 12 A focal dystonia characterized by autosomal dominant inheritance of adult-onset cervical dystonia[malacards.org]

  • Huntington's Disease

    The onset of disease usually occurs in the fourth or fifth decade of life, with a wide range in age from childhood to later years in life.[emedicine.medscape.com] Juvenile onset has a large repeat expansion and occurs most often when the father is the affected parent (a form of genetic anticipation). Lipe H, Bird T.[emedicine.medscape.com] […] estimated and that new mutations may account for as many as 3% of the cases is now apparent; therefore, new mutations, in addition to European migration, may account for the disease's[emedicine.medscape.com]

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