Hallervorden-Spatz Syndrome
These abnormalities progressed over the years with slowing of voluntary movements, rigidity of limbs and dystonic posturing. Speech was slurred.[jpgmonline.com]
Clinical features Dystonia Dysarthria Spasticity Choreoathetosis Parkinsonism Hyperreflexia Extensor toe signs Onset in first to third decade of life Gait change / loss of[ncbi.nlm.nih.gov]
Intermediate forms manifest onset in first decade with slow progression or onset in second decade with rapid progression.[genecards.org]
Ataxia
Initial symptoms usually include: poor limb coordination speech problems, including slurred and slow speech, difficulty producing speech, and problems controlling volume,[medicalnewstoday.com]
[…] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com]
Dysarthria - slurred and slow speech that is difficult to produce. The patient may also have difficulties controlling volume, rhythm, and pitch.[medicalnewstoday.com]
Spinocerebellar Ataxia Type 5
Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria[nhs.uk]
The onset of symptoms is usually in the third or fourth decade of life; however, more subtle clinical manifestations can start in early childhood.[ncbi.nlm.nih.gov]
Case 5, Part V: Examination at age 61: saccadic speech, slow pursuit, limb ataxia, and right laterocollis.[movementdisorders.org]
Spinocerebellar Ataxia Type 13
Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria[nhs.uk]
[…] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.com]
Clinically, for many years he suffered from unsteady walking, slowness of speech, and abnormal fine motor skills.[cerebellumandataxias.biomedcentral.com]
Cerebellar Ataxia with Peripheral Neuropathy Type 2
Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria[nhs.uk]
[…] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com]
Other signs and symptoms that might develop as the disease progresses include slow, slurred speech (dysarthria); fatigue; rapid, involuntary eye movements (nystagmus); spinal[mayoclinic.org]
Episodic Ataxia
[…] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.com]
Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria[nhs.uk]
This includes small, shuffling steps, muscle rigidity and slowed speech, as well as neuropathic symptoms.[en.wikipedia.org]
Spinocerebellar Ataxia Type 6
Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria[nhs.uk]
[…] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.com]
Case 5, Part V: Examination at age 61: saccadic speech, slow pursuit, limb ataxia, and right laterocollis.[movementdisorders.org]
Autosomal Recessive Spinocerebellar Ataxia 8
Common initial symptoms include dysarthria , slow speech, and trouble walking. Some affected individuals experience nystagmus and other abnormal eye movements.[rarediseases.info.nih.gov]
[…] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com]
Disorder may be a simple slowing of speech or may manifest as a slurring and scanning Dysarthria called because the words are broken into syllables.[slideshare.net]
Adult-Onset Autosomal Recessive Cerebellar Ataxia
Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria[your.md]
[…] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com]
Other signs and symptoms that might develop as the disease progresses include slow, slurred speech (dysarthria); fatigue; rapid, involuntary eye movements (nystagmus); spinal[mayoclinic.org]
Spinocerebellar Ataxia Type 20
Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria[nhs.uk]
[…] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com]
Speech is impaired can occur dysarthria and dysphagia, tremor of the head and torso and oculomotor nerve paresis.[medicaldb.blogspot.com]