Onset of Dysarthria in Third Decade of Life & Slow Speech: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Onset of Dysarthria in Third Decade of Life, Slow Speech,

Negated

None

Unsure

None

Possible Causes

Hallervorden-Spatz Syndrome

Clinical features Dystonia Dysarthria Spasticity Choreoathetosis Parkinsonism Hyperreflexia Extensor toe signs Onset in first to third decade of life Gait change / loss of [ncbi.nlm.nih.gov]

These abnormalities progressed over the years with slowing of voluntary movements, rigidity of limbs and dystonic posturing. Speech was slurred. [jpgmonline.com]

Intermediate forms manifest onset in first decade with slow progression or onset in second decade with rapid progression. [genecards.org]

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Ataxia

[…] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia [emedicine.medscape.com]

Initial symptoms usually include: poor limb coordination speech problems, including slurred and slow speech, difficulty producing speech, and problems controlling volume, [medicalnewstoday.com]

Dysarthria - slurred and slow speech that is difficult to produce. The patient may also have difficulties controlling volume, rhythm, and pitch. [medicalnewstoday.com]

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Spinocerebellar Ataxia Type 5

The onset of symptoms is usually in the third or fourth decade of life; however, more subtle clinical manifestations can start in early childhood. [ncbi.nlm.nih.gov]

Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria [nhs.uk]

Case 5, Part V: Examination at age 61: saccadic speech, slow pursuit, limb ataxia, and right laterocollis. [movementdisorders.org]

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Cerebellar Ataxia with Peripheral Neuropathy Type 2

Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria [nhs.uk]

Other signs and symptoms that might develop as the disease progresses include slow, slurred speech (dysarthria); fatigue; rapid, involuntary eye movements (nystagmus); spinal [mayoclinic.org]

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Spinocerebellar Ataxia Type 13

Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria [nhs.uk]

Clinically, for many years he suffered from unsteady walking, slowness of speech, and abnormal fine motor skills. [cerebellumandataxias.biomedcentral.com]

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Spinocerebellar Ataxia Type 20

Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria [nhs.uk]

Speech is impaired can occur dysarthria and dysphagia, tremor of the head and torso and oculomotor nerve paresis. [medicaldb.blogspot.com]

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Autosomal Recessive Spinocerebellar Ataxia 8

Common initial symptoms include dysarthria, slow speech, and trouble walking. Some affected individuals experience nystagmus and other abnormal eye movements. [rarediseases.info.nih.gov]

Disorder may be a simple slowing of speech or may manifest as a slurring and scanning Dysarthria called because the words are broken into syllables. [slideshare.net]

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Episodic Ataxia

This includes small, shuffling steps, muscle rigidity and slowed speech, as well as neuropathic symptoms. [en.wikipedia.org]

Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria [nhs.uk]

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Adult-Onset Autosomal Recessive Cerebellar Ataxia

Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria [your.md]

Other signs and symptoms that might develop as the disease progresses include slow, slurred speech (dysarthria); fatigue; rapid, involuntary eye movements (nystagmus); spinal [mayoclinic.org]

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Spinocerebellar Ataxia Type 6

Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria [nhs.uk]

Case 5, Part V: Examination at age 61: saccadic speech, slow pursuit, limb ataxia, and right laterocollis. [movementdisorders.org]

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Spinocerebellar Ataxia Type 19

Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria [nhs.uk]

Spinocerebellar ataxia is a long-term debilitating condition involving progressive slowing of gait, often associated with poor coordination of speech, hands and eye movement [ema.europa.eu]

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Spinocerebellar Ataxia Type 4

Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria [nhs.uk]

Case 5, Part V: Examination at age 61: saccadic speech, slow pursuit, limb ataxia, and right laterocollis. [movementdisorders.org]

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Autosomal Recessive Spinocerebellar Ataxia Type 17

Slow progression limb and gait ataxia and slow hesitant speech may be early symptoms. [bobmcinroy.velcomweb.ca]

Disorder may be a simple slowing of speech or may manifest as a slurring and scanning Dysarthria called because the words are broken into syllables. [slideshare.net]

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Spinocerebellar Ataxia Type 23

Case 5, Part V: Examination at age 61: saccadic speech, slow pursuit, limb ataxia, and right laterocollis. [movementdisorders.org]

Physical findings : This disorder causes a slow progression of ataxia of gait, stance, limbs, and dysarthria (speech disturbance) with or without oculomotor (movement of the [secure.ssa.gov]

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Spinocerebellar Ataxia Type 30

Other signs and symptoms that might develop as the disease progresses include slow, slurred speech (dysarthria); fatigue; rapid, involuntary eye movements (nystagmus); spinal [mayoclinic.org]

SCA-14 is characterized by poor coordination of the arms, legs, gait, and speech and jerky movements that affect the trunk of the body. [ataxiacenter.umn.edu]

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Spinocerebellar Ataxia Type 12

Based on the information provided by the family members, their affected ancestor (I-1) had an unstable gait, slow speech, and poor handwriting and died of stroke at 59 years [jamanetwork.com]

Speech and Swallowing Abnormalities: The patient may speak in a manner that is slow, indistinct, or slurred. [medindia.net]

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Spinocerebellar Ataxia Type 1

Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria [nhs.uk]

[…] saccadic eye movements Slow eye movements 0000514 Slurred speech 0001350 Staring gaze 0025401 Upgaze palsy 0025331 5%-29% of people have these symptoms Abnormality of masticatory [rarediseases.info.nih.gov]

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Spastic Ataxia with Congenital Miosis

The first symptoms often include clumsiness, fatigue, unsteady walking (gait), slow or slurred speech, difficulty swallowing (dysphagia) and dementia. [findzebra.com]

[…] the third to fourth decade of life. [findzebra.com]

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Neurodegeneration with Brain Iron Accumulation

[…] trunk), dysarthria (slurred or slow speech) choreoathetosis (involuntary, purposeless jerky muscle movements), muscle rigidity (uncontrolled tightness of the muscles), spasticity [ninds.nih.gov]

Others may present with speech delay and autistic features, which may remain as the only evidence of disease for a year or more, given the slow progression of atypical NAD [ncbi.nlm.nih.gov]

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Autosomal Recessive Spastic Ataxia with Leukoencephalopathy

Disorder may be a simple slowing of speech or may manifest as a slurring and scanning Dysarthria called because the words are broken into syllables. [slideshare.net]

Several children experienced sudden deterioration with minor infections or after vaccination with slow recovery. [missionmassimo.com]

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Autosomal Dominant Spastic Ataxia Type 1

Disorder may be a simple slowing of speech or may manifest as a slurring and scanning Dysarthria called because the words are broken into syllables. [slideshare.net]

[…] disturbances and ophthalmoparesis, saccade slowing and - at late disease stage - cognitive impairment [1]. [journals.plos.org]

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Autosomal Recessive Spinocerebellar Ataxia

Speech is slow, each syllable is interrupted and is articulated with variable emphasis. [jpgmonline.com]

[…] nystagmus, limb spasticity, limb and gait ataxia, and diminished vibration perception Progression generally slow Spinocerebellar ataxia 10 See the list below: Clinical features Onset [emedicine.medscape.com]

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Hereditary Orotic Aciduria

[…] and dysphagia Intermittent saccadic pursuits Gaze directed horizontal nystagmus Spinocerebellar ataxia 23 See the list below: Clinical features Age of onset - 43-56 years Slow [emedicine.medscape.com]

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Spinocerebellar Ataxia with Axonal Neuropathy

Disorder may be a simple slowing of speech or may manifest as a slurring and scanning Dysarthria called because the words are broken into syllables. [slideshare.net]

Speech is slow, each syllable is interrupted and is articulated with variable emphasis. [jpgmonline.com]

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Infantile-Onset Autosomal Recessive Nonprogressive Cerebellar Ataxia

Speech is slow, each syllable is interrupted and is articulated with variable emphasis. [jpgmonline.com]

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X-Linked Spinocerebellar Ataxia Type 5

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Vestibulocerebellar Ataxia

Initial symptoms usually include: poor limb coordination speech problems, including slurred and slow speech, difficulty producing speech, and problems controlling volume, [medicalnewstoday.com]

Speech and swallowing difficulties - Speech: slurred, slow, indistinct, abnormal in rhythm. Swallowing: difficulty swallowing or choking (especially with liquids). [hopkinsmedicine.org]

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Early-Onset Spastic Ataxia - Neuropathy Syndrome

Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria [nhs.uk]

Dysarthria - slurred and slow speech that is difficult to produce. The patient may also have difficulties controlling volume, rhythm, and pitch. [medicalnewstoday.com]

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Autosomal Dominant Sensory Ataxia

Symptoms may include problems with balance and coordination, slurred or slow speech, muscle stiffness and cramps and memory loss. [belmarrahealth.com]

Based on the information provided by the family members, their affected ancestor (I-1) had an unstable gait, slow speech, and poor handwriting and died of stroke at 59 years [jamanetwork.com]

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Spinocerebellar Ataxia Type 2

Case 5, Part V: Examination at age 61: saccadic speech, slow pursuit, limb ataxia, and right laterocollis. [movementdisorders.org]

Signs and symptoms of AT can include: difficulty walking – most children need to use a wheelchair by 10 years of age increasingly slurred, slow and unclear speech (dysarthria [nhs.uk]

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