Onset of Dysarthria in Third Decade of Life & Tremor: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Onset of Dysarthria in Third Decade of Life, Tremor,

Negated

None

Unsure

None

Possible Causes

Ataxia

[…] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia [emedicine.medscape.com]

An adult patient with cerebrotendinous xanthomatosis exhibited ataxia and palatal tremor in the absence of tendon xanthomas and cataracts. [ncbi.nlm.nih.gov]

Case description: The patient was a 53-year-old female farmer with severe tremor in the upper limbs at rest that worsens with movement, tremor in the jaw and tongue, and generalized [ncbi.nlm.nih.gov]

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Spinocerebellar Ataxia Type 1

Among SCA2 patients, bradykinesia was the most frequent (35.3%), followed by reduced facial expression, postural tremor and dystonia (29.4% each), rest tremor, titubation [ncbi.nlm.nih.gov]

[…] features of individuals carrying 39 uninterrupted CAG repeats did not differ from the SCA1 phenotype in general with dysphagia, pale discs, pyramidal signs and cerebellar tremor [ncbi.nlm.nih.gov]

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Spinocerebellar Ataxia Type 5

The onset of symptoms is usually in the third or fourth decade of life; however, more subtle clinical manifestations can start in early childhood. [ncbi.nlm.nih.gov]

We developed a mouse lacking full-length beta-III spectrin and found that homozygous mice reproduced features of SCA5 including gait abnormalities, tremor, deteriorating motor [ncbi.nlm.nih.gov]

Non-cerebellar signs such as facial myokimia, resting tremor, writer's cramp, impaired vibration sense and brisk deep tendon reflexes have been reported in some patients. [orpha.net]

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Hallervorden-Spatz Syndrome

Clinical features Dystonia Dysarthria Spasticity Choreoathetosis Parkinsonism Hyperreflexia Extensor toe signs Onset in first to third decade of life Gait change / loss of [ncbi.nlm.nih.gov]

[…] arm and resting tremor in upper extremities. [ncbi.nlm.nih.gov]

Motor incoordination, dystonia, and tremor progressed until the patient was wheel-chair-bound. [ncbi.nlm.nih.gov]

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Spinocerebellar Ataxia Type 20

The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. [books.google.es]

In addition to ataxia, examination often reveals spasmodic dysphonia and palatal tremor, but the syndrome is otherwise fairly pure. [ncbi.nlm.nih.gov]

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Spinocerebellar Ataxia Type 12

Action tremor, anxiety, and depression in SCA12 have responded to usual treatments for these disorders. [ncbi.nlm.nih.gov]

In 90% patients, tremor was presenting symptom. Action and postural tremor were present in all of them but rest tremor was present in 80 % patients. [mdsabstracts.org]

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Autosomal Recessive Spinocerebellar Ataxia Type 17

The book is divided into sections on Parkinson's disease, Huntington's disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, [books.google.com]

MalaCards based summary : Spinocerebellar Ataxia, Autosomal Recessive 17, is also known as scar17, and has symptoms including tremor and ataxia, truncal. [malacards.org]

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Autosomal Recessive Spinocerebellar Ataxia 8

tremor. 10. [slideshare.net]

Tremor in SCA-12 might respond to medications used for essential tremor. SCA12 is caused by a repeat expansion. [ataxiacenter.umn.edu]

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Spinocerebellar Ataxia Type 19

[…] syndrome, and has symptoms including ataxia, tremor and myalgia. [malacards.org]

A postural head tremor and myoclonic movements were observed occasionally. [ncbi.nlm.nih.gov]

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Adult-Onset Autosomal Recessive Cerebellar Ataxia

[…] advisory boards of national foundations including the Worldwide Education and Awareness for Movement Disorders (WE MOVE), Dystonia Medical Research Foundation, International Tremor [books.google.com]

X-linked ataxia Fragile X associated Tremor-Ataxia syndrome (FXTAS) Major Diagnostic criteria:  Onset 50 years, M F  Neurologic: Gait ataxia, tremor, parkinsonism, cognitive [slideshare.net]

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Spinocerebellar Ataxia Type 30

In 90% patients, tremor was presenting symptom. Action and postural tremor were present in all of them but rest tremor was present in 80 % patients. [mdsabstracts.org]

There was a rapid and fine tremor of mostly the right hand that with skilled movements became coarse: the handwriting tremor was so violent that her writing was illegible. [omicsonline.org]

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Autosomal Recessive Spinocerebellar Ataxia

The combination of postural tremor plus limb ataxia has been referred to as ataxic tremor and is part of cerebellar disease. [jmg.bmj.com]

Cayman Island, which is characterised by early-onset hypotonia, marked psychomotor retardation and prominent nonprogressive cerebellar dysfunction (nystagmus), intention tremor [medical-dictionary.thefreedictionary.com]

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Autosomal Dominant Spastic Ataxia Type 1

12q24.1 with 31CAG repeats (Exonic) Ataxin2 Ataxia with slow saccades, ophthalmoplegia, and minimal pyramidal and extrapyramidal findings, levodopa-responsive parkinsonism, tremor [bcm.edu]

There was a rapid and fine tremor of mostly the right hand that with skilled movements became coarse: the handwriting tremor was so violent that her writing was illegible. [omicsonline.org]

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Cerebellar Ataxia with Peripheral Neuropathy Type 2

A tremor may appear in a patient with peripheral neuropathy - neuropathic tremor (NT). [news-medical.net]

Polyneuropathy was found in 97.5% of AOA2 patients, cerebellar atrophy in 96%, occasional oculomotor apraxia in 51%, pyramidal signs in 20.5%, head tremor in 14%, dystonia [lib.ugent.be]

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Spastic Ataxia with Congenital Miosis

Tremor Cerebellar lesions can produce unilateral or bilateral intention tremor, or a truncal tremor. [patient.info]

[…] the third to fourth decade of life. [findzebra.com]

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Spinocerebellar Ataxia Type 6

[…] are recorded in two patient groups with an autosomal dominantly inherited cerebellar disorder, i.e. spinocerebellar ataxia type 6 (SCA6) and familial cortical myoclonic tremor [ncbi.nlm.nih.gov]

There was a rapid and fine tremor of mostly the right hand that with skilled movements became coarse: the handwriting tremor was so violent that her writing was illegible. [omicsonline.org]

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Infantile-Onset Autosomal Recessive Nonprogressive Cerebellar Ataxia

[…] coordinate movements when walking 0002066 Generalized hypotonia Decreased muscle tone Low muscle tone [ more ] 0001290 Hyperreflexia Increased reflexes 0001347 Intention tremor [rarediseases.info.nih.gov]

12q24.1 with 31CAG repeats (Exonic) Ataxin2 Ataxia with slow saccades, ophthalmoplegia, and minimal pyramidal and extrapyramidal findings, levodopa-responsive parkinsonism, tremor [bcm.edu]

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Spinocerebellar Ataxia with Axonal Neuropathy

The book is divided into sections on Parkinson's disease, Huntington's disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, [books.google.com]

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Episodic Ataxia

Abstract Episodic ataxia type1 (EA1) is an autosomal dominant disorder characterised by episodes of ataxia, dysarthria, tremor and visual disturbances lasting for seconds [ncbi.nlm.nih.gov]

We present a case of a 15-year-old female with EA1 who had never had episodes of ataxia, and whose hand movements were initially thought to represent a tremor. [ncbi.nlm.nih.gov]

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X-Linked Spinocerebellar Ataxia Type 5

The secondary endpoint analysis suggested a significant improvement in gait, tremor, and dysmetria. [movementdisorders.org]

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Autosomal Recessive Spastic Ataxia with Leukoencephalopathy

Fasano’s academic interests are in the areas of advanced management of movement disorders, particularly deep brain stimulation for Parkinson’s disease, dystonia and tremor [books.google.es]

/homeostasis Hyporeflexia Abnormality of the eye Muscle cramps Fasciculations Ophthalmoparesis Abnormality of the mitochondrion Cerebellar Purkinje layer atrophy Kinetic tremor [mendelian.co]

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Spinocerebellar Ataxia Type 13

Note: Tremor-controlling drugs are not effective for cerebellar tremors. [ncbi.nlm.nih.gov]

None had extensor plantar reflex, chorea, dystonia, tremor, or other extrapyramidal signs. [link.springer.com]

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Spinocerebellar Ataxia Type 23

A general pattern of evolution of symptoms was tremor, followed by ataxia and speech slurring/tremor. [brain.oxfordjournals.org]

[…] in SCA 2 patients, [1] we believe that this tremor was probably the result of damage to cerebellar outflow pathways. [movementdisorders.org]

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Neurodegeneration with Brain Iron Accumulation

At the age of 22, she suffered from akinesia, resting tremor, and rigidity. [ncbi.nlm.nih.gov]

Other symptoms may include: Dementia Difficulty speaking Difficulty swallowing Muscle problems such as rigidity or involuntary muscle contractions ( dystonia ) Seizures Tremor [medlineplus.gov]

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Spinocerebellar Ataxia Type 4

[…] in SCA 2 patients, [1] we believe that this tremor was probably the result of damage to cerebellar outflow pathways. [movementdisorders.org]

Tremor in SCA-12 might respond to medications used for essential tremor. SCA12 is caused by a repeat expansion. [ataxiacenter.umn.edu]

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Optic Atrophy

(3) onset of progressive motor and sensory axonal neuropathy in late childhood/early adolescence; (4) dysarthria starting in the third decade of life; (5) exacerbated acoustic [ncbi.nlm.nih.gov]

The disease presented before age 10 with slowly progressive tremor, dystonia, and spasticity. [ncbi.nlm.nih.gov]

Systemic Features: A large number of associated neurologic abnormalities have been reported including ataxia, hyperreflexia, nonspecific myopathy, tremors, movement disorders [disorders.eyes.arizona.edu]

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Spinocerebellar Ataxia with Rigidity and Peripheral Neuropathy

[…] axial tremor in orthostatism). [springerlink.com]

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Vestibulocerebellar Ataxia

Tremor, if present, is slight. Reflexes and vibration and position senses are lost. Talipes equinovarus (clubfoot), scoliosis, and progressive cardiomyopathy are common. [merckmanuals.com]

(postural, action, intention tremor ) Dysdiadochokinesia Rebound phenomenon ( Stewart-Holmes sign) The patient bends their arm at the elbow, resisting the examiner's pull [amboss.com]

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Autosomal Recessive Spinocerebellar Ataxia 3

12q24.1 with 31CAG repeats (Exonic) Ataxin2 Ataxia with slow saccades, ophthalmoplegia, and minimal pyramidal and extrapyramidal findings, levodopa-responsive parkinsonism, tremor [bcm.edu]

[…] eyelids 0000524 Difficulty walking Difficulty in walking 0002355 Elevated alpha-fetoprotein 0006254 Gait ataxia Inability to coordinate movements when walking 0002066 Head tremor [rarediseases.info.nih.gov]

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Autosomal Dominant Sensory Ataxia

[…] initiation of voluntary movement with progressive reduction in speed and amplitude of repetitive actions) • And at least one of the following: muscular rigidity 4—6 Hz rest tremor [books.google.com]

12q24.1 with 31CAG repeats (Exonic) Ataxin2 Ataxia with slow saccades, ophthalmoplegia, and minimal pyramidal and extrapyramidal findings, levodopa-responsive parkinsonism, tremor [bcm.edu]

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