Onset of Dysarthria in Third Decade of Life & Vestibuloocular Reflex Abnormal: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Onset of Dysarthria in Third Decade of Life, Vestibuloocular Reflex Abnormal,

Negated

None

Unsure

None

Possible Causes

Spinocerebellar Ataxia Type 6

[…] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia [emedicine.com]

[…] nystagmus, limb spasticity, limb and gait ataxia, and diminished vibration perception Progression generally slow Spinocerebellar ataxia 10 See the list below: Clinical features Onset [emedicine.com]

Onset of symptoms ranging from age 18-65 years, with a mean of 39 years Dysarthria and gait instability (commonly initial symptoms) Examination findings including spastic dysarthria [emedicine.com]

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Episodic Ataxia

[…] eye movements (incl abnormal smooth pursuit, nystagmus, & abnormal vestibuloocular reflex) Slowly progressive cerebellar ataxia in some Early adulthood (range: 3rd-6th decade [ncbi.nlm.nih.gov]

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Spastic Ataxia with Congenital Miosis

Symptoms INHERITANCE: Autosomal dominant HEAD AND NECK: [Ears]; Tinnitus; [Eyes]; Diplopia; Oscillopsia; Abnormal smooth pursuits; Inability to suppress vestibuloocular reflex [findzebra.com]

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Vomiting of Pregnancy

The first demonstration that a subset of women with hyperemesis gravidarum has abnormalities in the vestibuloocular reflex pathway. [emedicine.medscape.com]

Abnormal stimulation of the thyrotrophin receptor during gestation. Hum Reprod Update. 2004 Mar-Apr. 10(2):95-105. [Medline]. Panesar NS, Li CY, Rogers MS. [emedicine.medscape.com]

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Normal Pressure Hydrocephalus

[…] of vestibuloocular reflexes (13, 25). [ajnr.org]

The gait disturbance is a gait “apraxia” and represents a combination of motor deficits, failure of postural righting reflexes, abnormal smooth pursuit, and failed suppression [ajnr.org]

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Spinocerebellar Ataxia Type 5

The onset of symptoms is usually in the third or fourth decade of life; however, more subtle clinical manifestations can start in early childhood. [ncbi.nlm.nih.gov]

They are characterized by progressive cerebellar ataxia resulting in unsteady gait, clumsiness, dysarthria, and swallowing difficulty. [ncbi.nlm.nih.gov]

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Progressive Supranuclear Palsy

The patients may fail to suppress their vestibuloocular reflex and may have abnormalities of convergence. 25 A visual glabellar reflex (inability to suppress a blink to a [pmj.bmj.com]

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Hallervorden-Spatz Syndrome

Clinical features Dystonia Dysarthria Spasticity Choreoathetosis Parkinsonism Hyperreflexia Extensor toe signs Onset in first to third decade of life Gait change / loss of [ncbi.nlm.nih.gov]

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Optic Atrophy

(3) onset of progressive motor and sensory axonal neuropathy in late childhood/early adolescence; (4) dysarthria starting in the third decade of life; (5) exacerbated acoustic [ncbi.nlm.nih.gov]

This condition is characterized by (1) subnormal vision secondary to apparently nonprogressive congenital optic atrophy; (2) onset of progressive spastic paraplegia in infancy [ncbi.nlm.nih.gov]

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Ataxia

Onset of symptoms ranging from age 18-65 years, with a mean of 39 years Dysarthria and gait instability (commonly initial symptoms) Examination findings including spastic dysarthria [emedicine.medscape.com]

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Spinocerebellar Ataxia Type 13

Onset of symptoms ranging from age 18-65 years, with a mean of 39 years Dysarthria and gait instability (commonly initial symptoms) Examination findings including spastic dysarthria [emedicine.com]

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Spinocerebellar Ataxia Type 1

Onset of symptoms ranging from age 18-65 years, with a mean of 39 years Dysarthria and gait instability (commonly initial symptoms) Examination findings including spastic dysarthria [emedicine.com]

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Adult-Onset Autosomal Recessive Cerebellar Ataxia

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Spinocerebellar Ataxia Type 30

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Spinocerebellar Ataxia Type 20

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Spinocerebellar Ataxia Type 19

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Autosomal Recessive Spinocerebellar Ataxia 8

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Spinocerebellar Ataxia Type 23

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Spinocerebellar Ataxia Type 4

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Spinocerebellar Ataxia Type 12

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Autosomal Recessive Spinocerebellar Ataxia Type 17

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Autosomal Recessive Spinocerebellar Ataxia

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Autosomal Dominant Spastic Ataxia Type 1

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Autosomal Recessive Spastic Ataxia with Leukoencephalopathy

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Hereditary Orotic Aciduria

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Neurodegeneration with Brain Iron Accumulation

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Cerebellar Ataxia with Peripheral Neuropathy Type 2

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Spinocerebellar Ataxia with Axonal Neuropathy

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Infantile-Onset Autosomal Recessive Nonprogressive Cerebellar Ataxia

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X-Linked Spinocerebellar Ataxia Type 5

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