Onset of Dystonia in Childhood Causes & Reasons

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Onset of Dystonia in Childhood Symptom Checker: Possible causes include Primary Torsion Dystonia. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Primary Torsion Dystonia

Three siblings had childhood onset of limb dystonia, and slow progression to generalized dystonia with predominant cranio-cervical involvement. [ncbi.nlm.nih.gov]

It usually begins as limb-onset dystonia in childhood and tends to spread to other sites and has been reported as the most common cause of early onset PTD in Ashkenazi Jews [jkna.org]

Childhood- and adolescent-onset primary dystonia is more common in Jews of Eastern European or Ashkenazi ancestry than in other groups. [symptoma.com]

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Adult-Onset Cervical Dystonia Type DYT23

DYT12 Dystonia (Rapid-Onset Dystonia Parkinsonism, Allelic to Alternating Hemiplegia of Childhood) Associated with ATP1A3 Gene Mutations Rapid-onset dystonia parkinsonism [neupsykey.com]

AETIOLOGY: PRIMARY HEREDITARY DYT11 159900 SGCE 7q21 Myoclonic dystonia DYT12 128235 ATP1A3 19q12-q13.2 Rapid onset dystonia parkinsonism and alternating hemiplegia of childhood [documents.tips]

DYT5 Dystonia (Dopa-Responsive Dystonia or Segawa Syndrome) Dopa-responsive dystonia (DRD) is characterized by the triad of childhood-onset dystonia (in the first decade of [neupsykey.com]

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Scoliosis

Segawa's syndrome or dopa-responsive dystonia is a rare hereditary disorder characterized by progressive dystonia of childhood onset, diurnal fluctuation of symptoms and complete [ncbi.nlm.nih.gov]

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Biotin-Responsive Basal Ganglia Disease

dystonia-parkinsonism and alternating hemiplegia of childhood (AHC). [medworm.com]

Unfortunately there's no figure of the pathway available at this moment is a recessive disorder with childhood onset that presents as a subacute encephalopathy, with confusion [treatable-id.org]

Abstract Biotin-responsive basal ganglia disease (BBGD) is a recessive disorder with childhood onset that presents as a subacute encephalopathy, with confusion, dysarthria [ncbi.nlm.nih.gov]

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Anxiety Disorder

Late-onset forms are sometimes called late-onset Tay-Sachs disease, despite the fact that minimal signs can initially appear during childhood. [ncbi.nlm.nih.gov]

GM2 gangliosidosis presents with neurological disorders (peripheral motor involvement, cerebellar ataxia or dystonia) associated with psychiatric signs in 20%-40% of cases [dx.doi.org]

GM2 gangliosidosis presents with neurological disorders (peripheral motor involvement, cerebellar ataxia or dystonia) associated with psychiatric signs in 20%–40% of cases [ncbi.nlm.nih.gov]

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Familial Hypercholanemia

onset review BIALLELIC, autosomal or pseudoautosomal Sources London North GLH NHS GMS Expert Review Green Phenotypes Hypercholanemia, familial BAAT in Childhood onset dystonia [panelapp.genomicsengland.co.uk]

[…] errors of metabolism Version 2.5 Signed off v.2.3 on 17 Feb 2020 Component of the following Super Panels: Hypotonic infant Paediatric disorders White matter disorders - childhood [panelapp.genomicsengland.co.uk]

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X-linked Parkinsonism-Spasticity Syndrome

MEPAN SYNDROME Is also known as childhood-onset generalized dystonia-optic atrophy syndrome dystonia 29 dyt29 autosomal recessive childhood-onset dystonia, dyt29 type dystonia [mendelian.co]

Young onset or childhood Adolescent onset Adult onset References Classification by Body Distribution Generalised dystonia or Early-Onset Childhood Dystonia affects all or [brainfoundation.org.au]

Dystonia-Parkinsonism Dystonia-12 rapid-onset dystonia-parkinsonism alternating hemiplegia of childhood CAPOS syndrome Tags Green Green List (high evidence) ATXN1_CAG STR [panelapp.genomicsengland.co.uk]

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Cardiomyopathy

[…] age: 15 months to 7 years Movement disorders Dystonia Other (Some patients): Facial dystonia, myoclonus, chorea, dyskinesias Optic atrophy Onset age: Childhood; After dystonia [neuromuscular.wustl.edu]

Triceps brachii, Sternocleidomastoid Heterozygotes may have: Exercise intolerance; Myalgias Also see Triglyceride disorders Lipid disorders Fatty Acid Synthesis: Disorder Childhood-Onset [neuromuscular.wustl.edu]

[…] dehydrogenase Glycine cleavage system FAS pathway Acetyl group: Elongated Growing acyl chains: Bound to an acyl carrier protein (ACP) Lipoic acid disorders: Other Clinical Onset [neuromuscular.wustl.edu]

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Diverticulosis

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Paroxysmal Exertion-Induced Dyskinesia

With or Without Epilepsy And/Or Hemolytic Anemia PxMD-SLC2A1 childhood onset GLUT1 deficiency syndrome type 2 Dystonia 18 Paroxysmal exertion-induced dyskinesia edit English [wikidata.org]

Age of onset is usually sometime in childhood, but can range from 1–30 years old. In one study it was found that the mean age of onset was around 8 years. [en.wikipedia.org]

Onset is usually during childhood or adolescence. Most cases of myoclonus-dystonia are caused by mutations in the SGCE gene. [rarediseases.org]

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Epilepsy

Mutations of the ATP1A3 gene are associated with a wide spectrum of neurological disorders including rapid onset dystonia-parkinsonism and alternating hemiplegia of childhood [ncbi.nlm.nih.gov]

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Hereditary Late-Onset Parkinson Disease

Rapid-onset Dystonia Parkinsonism (RDP) is a rare inherited disorder with onset in childhood or adulthood. [dystonia-parkinsons.org]

Dopa-responsive Dystonia (DRD) is a genetic disorder of childhood onset. It affects girls more commonly than boys. [dystonia-parkinsons.org]

Secondary Dystonia Myoclonus Dystonia, characterized by variable combinations of dystonia and myoclonus (marked, rapid, lightning-like muscle movements), with onset in childhood [dystonia-parkinsons.org]

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Parkinson's Disease Type 3

However, there are specific primary dystonias with childhood or adolescent onset that have been linked to genetic mutations. [aans.org]

The majority of early-onset primary dystonias, which may appear during childhood or early adulthood, are due to mutations of a gene known as DYT1. [aans.org]

Childhood onset – 0 to age 12 Adolescent onset – age 13 to 20 Adult onset – older than age 20 Focal dystonia is limited to one area of the body and can affect the neck (cervical [aans.org]

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Pallidopyramidal Syndrome

Parkinsonism in PKAN is not levodopa responsive; whereas in PLAN (childhood-onset and dystonia parkinsonism), MPAN, BPAN, and Kufor–Rakeb syndrome respond initially but early [annalsofian.org]

pyramidal tract signs, and cognitive/psychiatric features without pallidal and nigral iron deposition.19,20 Thus, patients with childhood- or young adult–onset parkinsonism [jamanetwork.com]

Broadening the phenotype of childhood-onset dopa-responsive dystonia. Arch Neurol 2006;63(8):1185–1188. 21. Jeon BS, Jeong JM, Park SS, Lee MC. [synapse.koreamed.org]

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Drug-induced Dystonia

Sporadic Juvenile-onset primary dystonia typically presents in childhood or adolescence. [medicbind.com]

They produce a good response in childhood-onset dystonias, more severe dystonias and those with focal dystonias. [netdoctor.co.uk]

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Waisman Syndrome

[…] than males) Sources NHS GMS London North GLH Expert Review Green Phenotypes Waisman syndrome 311510 early-onset parkinsonism and intellectual disability RAB39B in Childhood [panelapp.genomicsengland.co.uk]

onset dystonia or chorea or related movement disorder Version 1.4 Signed off v.1.2 on 25 Feb 2020 review X-LINKED: hemizygous mutation in males, biallelic mutations in females [panelapp.genomicsengland.co.uk]

[…] disorder Version 1.5 Signed off v.1.2 on 2 Mar 2020 review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset [panelapp.genomicsengland.co.uk]

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Mental Disorder

Late-onset forms are sometimes called late-onset Tay-Sachs disease, despite the fact that minimal signs can initially appear during childhood. [ncbi.nlm.nih.gov]

GM2 gangliosidosis presents with neurological disorders (peripheral motor involvement, cerebellar ataxia or dystonia) associated with psychiatric signs in 20%-40% of cases [dx.doi.org]

GM2 gangliosidosis presents with neurological disorders (peripheral motor involvement, cerebellar ataxia or dystonia) associated with psychiatric signs in 20%–40% of cases [ncbi.nlm.nih.gov]

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Alternating Hemiplegia of Childhood

[…] or rapid-onset dystonia parkinsonism. [ncbi.nlm.nih.gov]

BACKGROUND: ATP1A3 mutations have now been recognized in infants and children presenting with a diverse group of neurological phenotypes, including Rapid-onset Dystonia-Parkinsonism [ncbi.nlm.nih.gov]

Alternating hemiplegia of childhood (AHC) is a rare neurological disorder characterised by early-onset episodes of hemiplegia, dystonia, various paroxysmal symptoms, and developmental [ncbi.nlm.nih.gov]

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Psychosomatic Disorder

dystonia and chorea, dysarthria, and dysphagia Sensorineural hearing loss (SNHL) with onset in childhood (62%) Intellectual disability (58%) Supportive Findings On MRI: [ncbi.nlm.nih.gov]

Seizures with onset in early childhood, tremors, and mild Parkinsonism features were rarely reported [Al-Semari & Bohlega 2007, Schneider & Bhatia 2008]. [ncbi.nlm.nih.gov]

It is typically mild and usually overshadowed by accompanying severe and disabling dystonia, dysarthria, and SNHL. [ncbi.nlm.nih.gov]

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Parkinson Disease

Ocular system involvement Childhood-onset cataract is a typical sign of CTX [ 13 ]-[ 15 ]. [doi.org]

Lees, John Hardy, Tamas Revesz and Henry Houlden, Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations, [doi.org]

[…] and adult onset dystonia-parkinsonism cases with PLA2G6 mutations. [doi.org]

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Rib Fracture

dystonia [56]. [hindawi.com]

[…] variants identified in Case 1; SRMS and ZNF4 were not linked to any disease phenotypes, whereas mutations in KMT2B, which encodes lysine-specific methyltransferase 2B, cause childhood-onset [hindawi.com]

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Dilated Cardiomyopathy 1NN

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Familial Isolated Dilated Cardiomyopathy

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Progressive Myoclonic Epilepsy Type 7

severe; GLUT1 deficiency syndrome 2, childhood onset; Stomatin-deficient cryohydrocytosis with neurologic defects; Dystonia 9; Epilepsy, idiopathic generalized, susceptibility [asperbio.com]

Adult neuronal ceroid lipofuscinosis Adult-onset autosomal recessive cerebellar ataxia Adult-onset dystonia-parkinsonism Aicardi syndrome Alobar holoprosencephaly Ataxia-deafness-intellectual [se-atlas.de]

[…] susceptibility to, 14 SLC13A5 Epileptic encephalopathy, early infantile, 25 SLC25A22 Epileptic encephalopathy, early infantile, 3 SLC2A1 GLUT1 deficiency syndrome 1, infantile onset [asperbio.com]

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Chronic Anxiety

Late-onset forms are sometimes called late-onset Tay-Sachs disease, despite the fact that minimal signs can initially appear during childhood. [ncbi.nlm.nih.gov]

GM2 gangliosidosis presents with neurological disorders (peripheral motor involvement, cerebellar ataxia or dystonia) associated with psychiatric signs in 20%-40% of cases [dx.doi.org]

GM2 gangliosidosis presents with neurological disorders (peripheral motor involvement, cerebellar ataxia or dystonia) associated with psychiatric signs in 20%–40% of cases [ncbi.nlm.nih.gov]

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Solid Ovarian Teratoma

dystonia and chorea, dysarthria, and dysphagia Sensorineural hearing loss (SNHL) with onset in childhood (62%) Intellectual disability (58%) Supportive Findings On MRI: [ncbi.nlm.nih.gov]

Seizures with onset in early childhood, tremors, and mild Parkinsonism features were rarely reported [Al-Semari & Bohlega 2007, Schneider & Bhatia 2008]. [ncbi.nlm.nih.gov]

It is typically mild and usually overshadowed by accompanying severe and disabling dystonia, dysarthria, and SNHL. [ncbi.nlm.nih.gov]

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Familial Infantile Myoclonic Epilepsy

severe; GLUT1 deficiency syndrome 2, childhood onset; Stomatin-deficient cryohydrocytosis with neurologic defects; Dystonia 9; Epilepsy, idiopathic generalized, susceptibility [asperbio.com]

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Dilated Cardiomyopathy Type 2B

9/GLUT1 deficiency syndrome 1, infantile onset, severe/GLUT1 deficiency syndrome 2, childhood onset/Epilepsy, idiopathic generalized, susceptibility to, 12 138140 EPI Epilepsy [lhsc.on.ca]

28, childhood-onset 617284 606834 Autosomal dominant KMT2D 12q13.12 Kabuki syndrome 1 147920 602113 Autosomal dominant KPTN 19q13.32 Mental retardation, autosomal recessive [mnglabs.com]

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Dilated Cardiomyopathy 1R

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Progressive Myoclonic Epilepsy Type 3

9/GLUT1 deficiency syndrome 1, infantile onset, severe/GLUT1 deficiency syndrome 2, childhood onset/Epilepsy, idiopathic generalized, susceptibility to, 12 138140 EPI Epilepsy [lhsc.on.ca]

[…] syndrome 12A-AD, 12B-AR, Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 2 103220 MITO Mitochondrial Genome sequence panel SLC2A1 Dystonia [lhsc.on.ca]

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