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67 Possible Causes for Onset of Renal Dysfunction in Early Childhood, Reduced Pancreatic Beta Cells

  • Wolcott-Rallison Syndrome

    [Crossref], [Web of Science ], [Google Scholar] ) showed that acute ablation of PERK results in reduced cell proliferation with abnormal insulin trafficking and secretion.[doi.org] Initially, patients with neonatal or early-childhood onset diabetes are possible candidates for having Wolcott–Rallison syndrome.[en.wikipedia.org] Diagnosis Initially, patients with neonatal or early-childhood onset diabetes are possible candidates for having Wolcott–Rallison syndrome. [1] The other symptoms include[wikiwand.com]

  • Hypoglycemia

    If the tumor is malignant or cannot be operated on, certain medications may be able to suppress insulin release from the diseased pancreatic beta cells.[emedicinehealth.com] Special tests by the endocrinologist may assist the surgeon in removing less pancreatic tissue, reducing the risk of diabetes after surgery.[emedicinehealth.com]

    Missing: Onset of Renal Dysfunction in Early Childhood
  • Insulin Resistance

    Reducing pancreatic beta-cell activity b. Increasing the amount of glucose circulating in the blood c. Raising blood pressure d.[todaysdietitian.com] Fructose will generally produce smaller insulin excursions upon consumption because it does not stimulate the secretion of insulin from pancreatic beta cells, whereas glucose[doi.org] It is believed that the ability of the pancreatic beta cells to meet the demand posed by progressive insulin resistance ultimately reaches its limits.[doi.org]

    Missing: Onset of Renal Dysfunction in Early Childhood
  • Diabetic Enteropathy

    […] autoimmune activity that destroys pancreatic beta cells.[vector.childrenshospital.org] Thus far, their mouse data indicate that the genetically engineered cells home to the pancreas, reduce abnormal immune-cell activity and reverse hyperglycemia, and that cells[hms.harvard.edu] Thus far, their mouse data indicate that the genetically engineered cells home to the pancreas, reduce abnormal immune-cell activity and reverse hyperglycemia (see abstract[vector.childrenshospital.org]

    Missing: Onset of Renal Dysfunction in Early Childhood
  • Diabetes Mellitus

    Reduced insulin exocytosis in human pancreatic beta-cells with gene variants linked to type 2 diabetes.[ncbi.nlm.nih.gov] They lower plasma glucose by stimulating pancreatic beta-cell insulin secretion and may secondarily improve peripheral and hepatic insulin sensitivity by reducing glucose[msdmanuals.com] The biguanides, unlike the SUs, do not stimulate insulin secretion by the pancreatic beta cells.[revespcardiol.org]

    Missing: Onset of Renal Dysfunction in Early Childhood
  • Chronic Kidney Insufficiency

    Amylin is secreted along with insulin by pancreatic beta-cells and levels are low in patients with diabetes.[clindiabetesendo.biomedcentral.com] It typically reduces A1c by 0.5–1.0 % [ 28 ] with a cost of about 400 for two of the 1.5 mL pens (1000 mcg/mL) [ 26 ].[clindiabetesendo.biomedcentral.com]

    Missing: Onset of Renal Dysfunction in Early Childhood
  • Diabetes Mellitus Type 2

    Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes. Physiology (Bethesda) 2009; 24 :325–331. [ PubMed ] [ Google Scholar ] 37.[ncbi.nlm.nih.gov] Beta-cell dysfunction Beta-cell dysfunction is a major factor across the spectrum of prediabetes to diabetes.[emedicine.medscape.com] IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat.[ncbi.nlm.nih.gov]

    Missing: Onset of Renal Dysfunction in Early Childhood
  • Cardiomyopathy

    It is caused due to pancreatic beta cell destruction/loss, and mostly found in juveniles (juvenile DM).[ncbi.nlm.nih.gov] T1D is diagnosed by reduced levels of insulin and high levels of glucose in the blood.[ncbi.nlm.nih.gov]

    Missing: Onset of Renal Dysfunction in Early Childhood
  • Chronic Kidney Disease

    Amylin is secreted along with insulin by pancreatic beta-cells and levels are low in patients with diabetes.[clindiabetesendo.biomedcentral.com] It typically reduces A1c by 0.5–1.0 % [ 28 ] with a cost of about 400 for two of the 1.5 mL pens (1000 mcg/mL) [ 26 ].[clindiabetesendo.biomedcentral.com]

    Missing: Onset of Renal Dysfunction in Early Childhood
  • Pancreatic Neoplasm

    Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-beta-catenin signaling to slow tumor progression.[ncbi.nlm.nih.gov] As noted earlier, insulin release is reduced when isolated rat pancreatic islets are incubated with conditioned media of Panc-1 and HPAF cell lines or co-cultured with Panc[ncbi.nlm.nih.gov] Upon molecular weight fractionation of conditioned media, metabolic effects were retained by proteins or peptides in fractions with a molecular weight of 55 ] Beta-cell dysfunction[ncbi.nlm.nih.gov]

    Missing: Onset of Renal Dysfunction in Early Childhood

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