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31 Possible Causes for Onset of Skin Lesions at Birth, Osteoporosis

  • Winchester Syndrome

    Phenotype Torg syndrome (includes NAO syndrome): multiple, painless, subcutaneous nodules (interphalangeal joints, knees, feet, elbows, pretibial), mild to moderate osteoporosis[iofbonehealth.org] Other manifestations include pigmented lesions on the skin, coarse facies, corneal opacities, and cardiac defects. Most affected children are apparently normal at birth.[ncbi.nlm.nih.gov] On the basis of usefulness of pamidronate in conditions with osteoporosis, we hypothesized that the drug will improve osteolysis and/or osteoporosis in this condition.[ncbi.nlm.nih.gov]

  • Multicentric Osteolysis-Nodulosis-Arthropathy Spectrum

    Phenotype Torg syndrome (includes NAO syndrome): multiple, painless, subcutaneous nodules (interphalangeal joints, knees, feet, elbows, pretibial), mild to moderate osteoporosis[iofbonehealth.org] Onset is usually between ages six months and six years (range: birth to 11 years).[ncbi.nlm.nih.gov] Most people with MONA develop low bone mineral density (osteopenia) and thinning of the bones (osteoporosis) throughout the skeleton.[ncbi.nlm.nih.gov]

  • Hypercalcemia

    Denosumab is used for treatment of osteoporosis.[ncbi.nlm.nih.gov] Data from case reports and case series were collected regarding the presence of hypercalcemia and associated complications, birth history, and age of onset/resolution of skin[ncbi.nlm.nih.gov] A 62-year-old man with a history of osteoporosis had an F-sodium fluoride PET/CT scan for accessing chest pain caused by an accident.[ncbi.nlm.nih.gov]

  • Pemphigus

    […] significant statistical interactions between pemphigus vulgaris and a history of using systemic corticosteroids as predictors of diabetes mellitus type 2, hypertension, osteoporosis[ncbi.nlm.nih.gov] Epidermolysis bullosa : are often present at birth and the lesions when heal leave scarring of the skin and mucous membrane.[drmhijazy.com] Some people cannot tolerate the adverse effects of steroids, which can include high blood pressure, weight gain, thinning of the skin, osteoporosis (thin bones), and elevated[jamanetwork.com]

  • Cutaneous Mastocytosis

    Other bony lesions include osteosclerosis and osteoporosis.[aafp.org] Age at onset of lesions ranged from birth to 7 years. Forty-seven patients (94%) developed skin lesions within the first year of ife.[ncbi.nlm.nih.gov] […] pain Skin lesions Low blood pressure/fainting/dizziness/fatigue Bone/muscle pain Nausea/vomiting/migraines Other Signs & Symptoms Hematological abnormalities Malabsorbtion Osteoporosis[knowcancer.com]

  • Epidermolysis Bullosa

    For some types of EB, the internal mucosa is also affected: nutrition can be compromised, resulting in osteoporosis, and general failure to thrive: quite young children can[debra-international.org] […] of blistering occurs at birth with a predominantly generalized skin distribution, and is associated with milia, atrophic scarring, and dystrophic or absent nails.[nature.com] These infants do not grow at the expected rate and may also develop electrolyte imbalances, hair loss, osteoporosis, and skin cancer.[counsyl.com]

  • Carney Complex

    We report a novel point mutation of the PRKAR1A gene in a patient with CNC who presented with significant osteoporosis and fractures.[ncbi.nlm.nih.gov] In some cases the disease is diagnosed at birth. Onset of the disease occurs commonly at a young age and the median age at detection is 20 years.[atlasgeneticsoncology.org] Our patient, who carried a germline PRKAR1A nonsense mutation (c.205C   T), clinical features included spotty skin pigmentation, osteoporosis, and primary pigmented nodular[ncbi.nlm.nih.gov]

  • Evan's Syndrome

    These include five mini-strokes, heart failure, osteoporosis and diabetes. Life has got better but in a sense he feels he has only been give a stay of execution.[walesonline.co.uk] It is the combination of family history of both tylosis and oesophageal cancer, late onset skin lesions (i.e. substantially after birth but before puberty) and, more recently[ojrd.biomedcentral.com]

  • Pemphigus Erythematosus

    Another side-effect is 'thinning' of the bones ( osteoporosis ).[patient.info] Epidermolysis bullosa : are often present at birth and the lesions when heal leave scarring of the skin and mucous membrane.[drmhijazy.com] If patients will be on chronic corticosteroids (at least 5mg daily prednisone equivalent for at least 3 months), osteoporosis counseling and prevention is indicated.[clinicaladvisor.com]

  • Benign Familial Pemphigus

    One possible side-effect is thinning of bones (osteoporosis). You may be advised to take vitamin D or other medication to help prevent osteoporosis.[dxline.info] Epidermolysis bullosa : are often present at birth and the lesions when heal leave scarring of the skin and mucous membrane.[drmhijazy.com] These drugs have many side effects, including: an increased likelihood of becoming infected osteoporosis cataracts glaucoma increased blood sugar diabetes a loss of muscle[healthline.com]

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