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18 Possible Causes for Onset of Symptoms in First or Second Decade of Life, Psychomotor Retardation, Pyramidal Tract Signs

  • Hallervorden-Spatz Syndrome

    Table-1: Diagnostic features of Hallervorden spatz disease [11] Obligate Features Collaborate Features Exclusion Features Onset during first two decades Pyramidal tract signs[medresearch.in] There is an early onset classic form with symptoms of extrapyramidal disease beginning in the first decade of life and rapid progression to loss of ambulation in about 15[disorders.eyes.arizona.edu] tract signs. 1 Choreoathetotic movements or tremor may also be present but these features have not been described in isolation.[jnnp.bmj.com]

  • Spastic Paraplegia

    […] than the pyramidal tract signs.[nature.com] Clinical Correlations: Spastic paraplegia 7 may have its onset in the second decade of life but sometimes much later.[disorders.eyes.arizona.edu] Retardation and Characteristic Facies 2 AR 616801 Mast Syndrome AR 248900 Mental Retardation, X-Linked, Syndromic, Claes-Jensen Type XL 300534 Neuropathy, Hereditary Sensory[preventiongenetics.com]

  • Paraplegia

    Is it a anterior horn cell pyramidal tract lesion • Diffuse LMN Signs and Diffuse UMN signs • Sluggish DTR in upper limbs Exaggerated in lower limbs • Abdominal reflexes characteristically[slideshare.net] Clinical Correlations: Spastic paraplegia 7 may have its onset in the second decade of life but sometimes much later.[disorders.eyes.arizona.edu] retardation with or without seizures AR 13 13 HSPD1 * Spastic paraplegia, Leukodystrophy, hypomyelinating AD/AR 5 5 IBA57 Multiple mitochondrial dysfunctions syndrome 3,[blueprintgenetics.com]

  • Hereditary Spastic Paraplegia

    We present three patients with complicated HSP from two unrelated families, who had early onset progressive cerebellar signs and developed pyramidal tract signs during follow-up[ncbi.nlm.nih.gov] Clinical Correlations: Spastic paraplegia 7 may have its onset in the second decade of life but sometimes much later.[disorders.eyes.arizona.edu] Retardation and Characteristic Facies 2 AR 616801 Mast Syndrome AR 248900 Mental Retardation, X-Linked, Syndromic, Claes-Jensen Type XL 300534 Neuropathy, Hereditary Sensory[preventiongenetics.com]

  • Friedreich Ataxia

    tract signs, scoliosis, and in some, cardiomyopathy, diabetes mellitus, visual loss and defective hearing.[orpha.net] Most affected people become wheelchair dependent by the second or third decade of life.[web.archive.org] […] and dysequlibrium syndrome CEREBELLAR ATROPHY, DEVELOPMENTAL DELAY, AND SEIZURES Cerebellar Atrophy, Visual Impairment, and Psychomotor Retardation Charlevoix-Saguenay spastic[rgd.mcw.edu]

  • Autosomal Dominant Spastic Paraplegia Type 42

    tract signs: synonyms for the same disorder?.[ojrd.biomedcentral.com] onset, usually within the first or second decades of life.[jamanetwork.com] CCHLND is an autosomal recessive disorder characterized by congenital cataracts, severe psychomotor retardation, and hearing loss associated with decreased serum ceruloplasmin[slc.bioparadigms.org]

  • Pseudo-Zellweger Syndrome

    Clinical features Some patients present with pyramidal, others with extrapyramidal tract signs (e.g.[mrineonatalbrain.com] Similarly, the single patient with sterol carrier protein X (SCPX, now named SCP2) deficiency first experienced neurologic symptoms in the second decade of life ( Ferdinandusse[medlink.com] Migrational abnormalities are the most likely causes of the severe seizures and psychomotor retardation associated with many types of peroxisomal disorders.[repository.innermed.eu]

  • Autosomal Recessive Spastic Paraplegia Type 7

    […] than the pyramidal tract signs.[nature.com] Clinical Correlations: Spastic paraplegia 7 may have its onset in the second decade of life but sometimes much later.[disorders.eyes.arizona.edu] retardation; the late childhood form causes poor coordination, gait and language acquisition disorders, and gelastic cataplexy; the juvenile form causes ataxia, epilepsy,[elsevier.es]

  • Young Adult-Onset Distal Hereditary Motor Neuropathy

    Sensory abnormalities and pyramidal tract signs were absent in all cases, as was pes cavus.[nature.com] Age of onset is in the second and third decades of life and rarely in the first. Recovery is usually complete and begins weeks to months after the onset of symptoms.[emedicine.medscape.com] retardation Oculoauriculofrontonasal syndrome Arts syndrome Erythropoietic protoporphyria Fuhrmann syndrome Mastocytosis cutaneous with short stature conductive hearing loss[checkrare.com]

  • Glutaric Aciduria Type 2

    Abstract A 32-year-old female patient presented with migraine and a bipolar disorder with frontal lobe dysfunction and bilateral pyramidal tract signs on examination.[nzma.org.nz] Although most patients become symptomatic within the first two decades, onset of symptoms ranges from the second month of life to late adulthood.[ojrd.biomedcentral.com] At hospital discharge, there was a mild psychomotor retardation, especially of language (developmental quotient 80).[nature.com]

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