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8 Possible Causes for Onset of Symptoms in the Fourth to Sixth Decade of Life

  • Atrial Standstill

    Temporary atrial standstill is a relatively rare event requiring intraatrial electrogram recordings for its documentation. Previous reports have emphasized its relationship to drug intoxication, infarction, the immediate post open-heart surgery period, or the premorbid state; significant impairment of atrial excitability[…][ncbi.nlm.nih.gov]

  • Restless Legs Syndrome

    Although one third of patients are affected before the age of 20 years, clinical presentation typically occurs between the fourth and sixth decades of life, when sensory symptoms[content.nejm.org] […] of disease, sensory symptoms are mild and punctuated by asymptomatic periods of variable duration.[content.nejm.org] […] age-dependent expressivity; the influences of anemia, uremia, diabetes, and peripheral neuropathy; and possibly the modulation of phenotype by body iron stores. 18 At the onset[content.nejm.org]

  • Recurrent Corneal Erosion

    The first stage is the onset of cornea guttata, usually in the fourth decade of life. Subjective symptoms rarely occur until the fifth or sixth decade.[emedicine.com]

  • Charcot-Marie-Tooth Disease Type 2S

    Clinical and electrophysiological data Limbs Onset of peripheral neuropathic symptoms was between the fourth and the sixth decades of life in five out of the seven patients[jnnp.bmj.com] […] investigated; the two remaining patients (II.2 and III.1) showed an earlier onset, with lightning pains as first symptom.[jnnp.bmj.com]

  • Progressive Cone Dystrophy

    […] of life. 4 In most patients, the first symptoms occur between the first and the third decade of life.[jamanetwork.com] Later onset, in the fourth 2 , 6 or even after the sixth decade, is rare. 1 , 5 , 6 Therefore, the diagnosis of cone dystrophy is not often considered in older patients.[jamanetwork.com] […] range from normal to unspecific retinal pigment irregularities, to bull's eye maculopathy. 1 , 3 Clinical signs of cone dystrophies may develop progressively during all decades[jamanetwork.com]

  • Nonsyndromic Isolated Dilated Cardiomyopathy

    DCM may be asymptomatic for many years with onset that can occur in the fourth to sixth decade of life.[cambridge.org] A common clinical presentation, such as the one described in this report, is sudden heart failure symptoms elicited by a non-related insult (infection, strenuous activity[cambridge.org]

  • Peripheral Cone Dystrophy

    […] of life. 4 In most patients, the first symptoms occur between the first and the third decade of life.[jamanetwork.com] Later onset, in the fourth 2 , 6 or even after the sixth decade, is rare. 1 , 5 , 6 Therefore, the diagnosis of cone dystrophy is not often considered in older patients.[jamanetwork.com] […] range from normal to unspecific retinal pigment irregularities, to bull's eye maculopathy. 1 , 3 Clinical signs of cone dystrophies may develop progressively during all decades[jamanetwork.com]

  • TTR Amyloidosis with Polyneuropathy

    Onset of symptoms can be described as bimodal, with one peak in the third to fourth decade of life (early onset) and another distinct peak in the sixth decade of life (late[journals.lww.com]

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