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3,704 Possible Causes for Onset of Symptoms in the Fourth to Sixth Decade of Life, Splenomegaly, Xerostomia

  • Hemochromatosis

    Regression on SF revealed significant associations: TS; male sex; age; GGT; transfusion units (positive); and splenomegaly (negative) (p 0.0001, 0.0016, 0.0281, 0.0025, 0.0001[ncbi.nlm.nih.gov] Here we report the case of a 16-year-old Chinese boy, who was admitted with hepatalgia, jaundice, hyperpigmentation, and splenomegaly to our hospital.[ncbi.nlm.nih.gov] An abnormally enlarged spleen (splenomegaly) may also occur. Additional symptoms occur depending on the specific organs involved.[rarediseases.org]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Rheumatoid Arthritis

    It is extremely rare for RA to present as FS or develop after initially presenting as neutropaenia and splenomegaly.[ncbi.nlm.nih.gov] Sjogren’s syndrome is an autoimmune condition that affects exocrine gland function, leading to a reduction in tear production (keratoconjunctivitis sicca), oral dryness (xerostomia[hopkinsarthritis.org] Sjögren’s syndrome used in this and other studies, 36, 37 the frequency of the diagnosis depends heavily on the availability of specific tests for the evaluation of possible xerostomia[doi.org]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Sjögren Syndrome

    On admission, she presented with anemia, elevated C-reactive protein levels, anasarca, and hepato-splenomegaly.[ncbi.nlm.nih.gov] Sjogren's syndrome, involving sicca symptoms with xerostomia, stomatitis, and considerable pain is a difficult-to-treat autoimmune disease where the treatment options are[ncbi.nlm.nih.gov] Clinical predictors of lymphoma development in SS include persistently enlarged parotid glands, with associated splenomegaly, lymphadenopathy, and cutaneous vasculitis (palpable[rheumatologyadvisor.com]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Primary Biliary Cirrhosis

    […] of the caudate lobe hepatic surface irregularity due to regenerative nodules regional lymphadenopathy: tends to dominate in the gastrohepatic ligament and porta hepatis 4 splenomegaly[radiopaedia.org] She was 38 years old and was admitted to our hospital for generalized pruritus, xerostomia, xerophthalmia, fatigue, and reticulonodular changes on her chest X-ray.[ncbi.nlm.nih.gov] The multivariate analysis identified two independent predictive factors: low albumin level and splenomegaly ( Table 3 ).[nejm.org]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Amyloidosis

    PATIENT CONCERNS: We reported two cases with ApoA-1 amyloidosis, a 64-year-old man suffering from nephrotic syndrome and a 40-year-old man with nephrotic syndrome and splenomegaly[ncbi.nlm.nih.gov] Areas of swelling, hemorrhages under the skin (purpura), hair loss (alopecia), inflammation of the tongue (glossitis) and a dry mouth (xerostomia) may also be present.[rarediseases.org] Hepatomegaly is a frequent finding, 39 and although palpable splenomegaly is rare, evidence of splenic dysfunction is often apparent (table 5 ).[pmj.bmj.com]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Multicentric Castleman's Disease

    Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present.[ncbi.nlm.nih.gov] Additional complaints consistent with MCD are xerostomia, rash and neurological deficits.[symptoma.com] We report the case of a 35 year patient from Nigeria who presented with fever and splenomegaly. The initial diagnosis was Salmonellosis.[ncbi.nlm.nih.gov]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Splenic Rupture

    Splenomegaly Splenomegaly has traditionally been diagnosed by the physical exam finding of having a palpable spleen but in one study 16% of patients with such were found to[omicsonline.org] On review of symptoms with the patient, a history of oligoarthralgia, photosensitivity, xerostomia and Raynaud phenomenon was elicited.[ncbi.nlm.nih.gov] CONCLUSION: This is the second case of spontaneous splenic rupture without preceding splenomegaly in a patient with APL during induction chemotherapy described so far.[ncbi.nlm.nih.gov]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Acute Renal Failure

    […] essential thrombocythemia, and primary myelofibrosis / Ayalew Tefferi -- Leukocytosis and leukopenia / Nancy Berliner -- Approach to the patient with lymphadenopathy and splenomegaly[worldcat.org]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Systemic Candidiasis

    Clinical symptoms include fever, murmur, congestive heart failure, anemia and splenomegaly.[mycology.adelaide.edu.au] Candidiasis is seen in people with altered ecology, which in oral cases can be attributed to dental appliances, xerostomia, antimicrobials, nasopharyngeal steroids, or oral[emedicine.medscape.com] Acute pseudomembranous candidosis (thrush) Thrush may be observed in healthy neonates or in persons in whom antibiotics, corticosteroids, or xerostomia disturb the oral microflora[web.archive.org]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Liver Disease

    Splenomegaly can persist. Georg Thieme Verlag KG Stuttgart · New York.[ncbi.nlm.nih.gov] In 2016, the patient was admitted with compensated cirrhosis and splenomegaly for a ligature of esophageal varices which was complicated by vomiting of blood followed by severe[ncbi.nlm.nih.gov] Portal hypertension is characterized by caput medusa (varicose veins of abdomen), ascites and splenomegaly.[symptoma.com]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life

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