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14 Possible Causes for Onset of Symptoms in Third to Sixth Decade of Life

  • Restless Legs Syndrome

    Although one third of patients are affected before the age of 20 years, clinical presentation typically occurs between the fourth and sixth decades of life, when sensory symptoms[dx.doi.org] […] of disease, sensory symptoms are mild and punctuated by asymptomatic periods of variable duration.[dx.doi.org] […] age-dependent expressivity; the influences of anemia, uremia, diabetes, and peripheral neuropathy; and possibly the modulation of phenotype by body iron stores. 18 At the onset[dx.doi.org]

  • Retinitis Pigmentosa

    The autosomal dominant forms tend to have milder symptoms with onset usually seen at around fifth or sixth decades of life.[news-medical.net] The X-linked form is the most severe with loss of central vision seen as early as in the third decade of life itself.[news-medical.net]

  • Retroperitoneal Abscess

    [FIGURE 1 OMITTED] [FIGURE 2 OMITTED] The incidence of retroperitoneal abscess is reported to be highest in the third to sixth decades of life, with a slightly higher predominance[thefreelibrary.com] […] in males. (3) Patients present with an insidious onset of a chronic debilitating illness and generalized symptoms of a serious infection including flank, abdominal, and groin[thefreelibrary.com]

  • Macular Dystrophy with Central Cone Involvement

    Definition An ocular disease characterized by decreased visual acuity, slight pigmentary changes and color vision abnormalities, becoming apparent in the third to sixth decade of life. Fundus anomalies are variable and include bull's eye maculopathy, severe atrophy of central fovea, relatively spared fovea with[…][uniprot.org]

  • Amyloidosis

    Symptoms begin in the second or third decade of life, but in some patients, late onset is evident and symptoms do not occur until the sixth or seventh decade.[circ.ahajournals.org]

  • Secondary Amyloidosis

    Symptoms begin in the second or third decade of life, but in some patients, late onset is evident and symptoms do not occur until the sixth or seventh decade.[circ.ahajournals.org]

  • Hereditary Amyloidosis with Primary Renal Involement

    Symptoms begin in the second or third decade of life, but in some patients, late onset is evident and symptoms do not occur until the sixth or seventh decade.[circ.ahajournals.org]

  • Glycogen Storage Disease due to Phosphoglycerate Kinase 1 Deficiency

    […] limited to skeletal muscles Respiratory insufficiency Adult [8, 9, 10, 11, 12] Onset occurs in the second or third decade of life.[emedicine.medscape.com] Muscle weakness progresses in the third to sixth decades of life. Proximal muscle weakness is greater than distal muscle weakness.[emedicine.medscape.com] Macroglossia Moderate hepatomegaly Mental retardation "Metabolic" anterior horn cell pathology (uncommon) Juvenile [8, 9, 10, 11, 12] Motor delay Progressive myopathy Signs and symptoms[emedicine.medscape.com]

  • Retinitis

    The autosomal dominant forms tend to have milder symptoms with onset usually seen at around fifth or sixth decades of life.[news-medical.net] The X-linked form is the most severe with loss of central vision seen as early as in the third decade of life itself.[news-medical.net]

  • Retinitis pigmentosa 40

    The autosomal dominant forms tend to have milder symptoms with onset usually seen at around fifth or sixth decades of life.[news-medical.net] The X-linked form is the most severe with loss of central vision seen as early as in the third decade of life itself.[news-medical.net]

Further symptoms