Oral Ulcers: Causes & Reasons

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Possible Causes for Oral Ulcers

Aphthous Stomatitis

This rare, chronic, multisystem disorder is characterised by recurrent genital ulceration, oral ulceration and inflammatory disease of the eye. [medicinetoday.com.au]

Herpetiform aphthous ulcers Herpetiform ulcers occur as multiple lesions, up to 100 at a time, and can range from Etiology of Oral Ulcerations The exact etiology of RAU is [dentalacademyofce.com]

Figure 1 (a) Minor-type oral aphthous ulcers, (b) major-type oral aphthous ulcer, (c) herpetiform oral aphthous ulcers Another classification is based on the time course. [aerzteblatt.de]

Mucous Membrane Pemphigoid

A 37-year-old man presented to his primary care physician with a chief concern of a sore throat and oral ulcers. [mdedge.com]

Oral ulceration can present a diagnostic problem. [ 6 ] The main sites and types of involvement are: Mouth Painful and recurrent erosions present anywhere in the mouth, starting [patient.info]

Mucous membrane Pemphigoid, - Intra orally .intact bullae may sometime be present - More often patients present with ulcerated area of mucosa involving the buccal, palatal [slideshare.net]

Hand-Foot-Mouth Disease

The diagnostic hallmarks are oral ulcers and maculo-papular or vesicular rash on the hands and feet. [ncbi.nlm.nih.gov]

It is marked by fever, oral ulcers, and skin manifestations affecting the palms, soles, and buttocks, with symptoms usually lasting less than 1 week. [ncbi.nlm.nih.gov]

The diagnosis is usually based on the characteristic clinical aspect: vesicles and papules on the hands and feet and superficial oral ulcers. [ncbi.nlm.nih.gov]

Idiopathic Neutropenia

Life-threatening infections can follow neutropenic nadir of the cycle, with frequent aphthous gingivitis, periodontitis, oral ulcerations, fever and occasional sepsis. [news-medical.net]

Eosinophilic ulcer of oral mucosa: A case report. Ann Stomatol (Roma) 2012;3:11-3. 8. Khocht A, Viera-Negron YE, Ameri A, Abdelsayed R. [jisponline.com]

The nonspecific oral ulcerations, precocious exfoliation of teeth, advanced periodontal disease associated with otitis media, and anemia as reported in some of the investigations [jisponline.com]

Discoid Lupus Erythematosus

Oral ulcers, findings on skin biopsy, a positive antinuclear antibody test, and transverse myelitis on MRI all confirm the presence of systemic lupus erythematosus (SLE). [atm.amegroups.com]

Over the next 13 months, the patient developed severe photosensitivity, oral ulcers, Raynaud phenomenon, anemia, and nephrotic-range proteinuria. [mdedge.com]

Other lesions associated with ACLE include oral ulcers, hives, and temporary hair loss, which are replaced by new hair once the disease flare is treated. [americanskin.org]

Stevens-Johnson Syndrome

TREATMENT: Oral ulcers had been topically treated with an oral balance gel. [ncbi.nlm.nih.gov]

[…] dry oral mucous membranes, ulceration of the head of the penis, and a generalized rash that consisted of target lesions with central erosions. [web.archive.org]

Oropharyngeal (mouth) lesions may be so intolerable as to prevent eating, and there may be recurring oral ulcers. [healthcentral.com]

HIV Infection

Cutaneous involvement is observed in 38% to 85% of cases, with oral mucosal involvement in 30% to 60% of cases. [ncbi.nlm.nih.gov]

Symptoms of early HIV infection may include non-specific, flu-like symptoms, such as: fever, swollen glands, a sore throat, oral ulcers or thrush, weight loss, tiredness, [aidsmap.com]

ulcers. [health24.com]

Squamous Cell Carcinoma of the Head and Neck

Noteworthy, the patient presented with multiple oral ulcers[28]. Oral involvement in PR Oral lesions in PR are more common in dark skinned people[29]. [ncbi.nlm.nih.gov]

The lesions are difficult to differentiate from aphthous ulcers. Its appearance should coincide with a generalized eruption with the characteristics of PR[4]. [ncbi.nlm.nih.gov]

Acrodermatitis Enteropathica

No oral ulcers were present. [mdedge.com]

Otherwise, zinc sulphate is used orally for treating skin ulcers and acceleration of wound healing. Eye and pancreas are especially rich in zinc. [healio.com]

The patient denied any oral ulcers. [mdedge.com]

Congenital AIDS

Resistant thrush, oral ulcers and conjunctivitis. Diarrhoea and malabsorption. Failure to thrive and delayed or incomplete recovery from illness. 7. [slideshare.net]

ulcerations Absolute neutropenia, relative monocytosis Bone marrow aspirate: normal or decreased cellularity; arrest of myeloid lineage Complement disorders Immunodeficiency [amboss.com]

[…] without any pus exudate and oral ulcers [Figure 5]. [idoj.in]

Burn Injury

Children with significant burn injuries are at risk of acute gastric ulceration and a H2 antagonist should be considered for these patients. [rch.org.au]

[…] care with chlorhexidine, daily sedation interruption with assessment of readiness to wean from mechanical ventilation, and prophylaxis against stress ulceration and deep [accjournal.org]

Referral to the Burns Team Dietician is recommended for all patients with significant burn injuries, facial burns, infants as well as patients who are not tolerating adequate oral [rch.org.au]

Basal Cell Carcinoma

The exact pathogenesis of vermilion lip BCC is not clear but it has been postulated that the neoplasm originates from the pluripotential epithelial cells of the oral mucosa [ncbi.nlm.nih.gov]

Herein, we report a 34- year-old man with an asymptomatic ulcerated lesion on the upper left lip vermilion mucosa .The diagnosis of BCC was confirmed with histopathological [ncbi.nlm.nih.gov]

Squamous Cell Carcinoma of the Skin

Burn scar or thermal injury Venous ulcer Lymphedema Discoid lupus erythematosus [4] Erosive oral lichen planus Lichen sclerosis et atrophicus Mutilating keratoderma Necrobiotic [web.archive.org]

[…] actinic type, linear type) Nevus sebaceous KID (keratitis, ichthyosis, deafness) syndrome A cSCC may arise at a site of chronic inflammation, such as the following: Marjolin ulcer [web.archive.org]

Malignant Melanoma of the Skin

Oral melanomas are largely macular, but nodular and even pedunculated lesions occur. Pain, ulceration, and bleeding are rare in oral melanoma until late in the disease. [oralcancerfoundation.org]

The tumors are asymmetric, irregular in outline and occasionally multiple. [6] Pain, ulceration and bleeding are rare in oral melanoma until late in the disease. [8] Most [dx.doi.org]

Oral malignant melanoma pictures Caption: Picture 1. Oral malignant melanoma. [oralcancerfoundation.org]

Acute Myelomonocytic Leukemia

C hemotherapy-induced mucositis and infection, including herpes simplex ulcers and oral candidiasis are commonly observed complications of leukemia in the oral cavity. [cda-adc.ca]

The most frequently observed oral findings of leukemia are mucosal bleeding and ulceration, petechiae, and gingival hyperplasia. [ncbi.nlm.nih.gov]

[…] leukemia is erythematous or cyanotic gingival hyperplasia with or without necrosis, petechiae, ecchymosis, mucosal ulcers and hemorrhage. [2], [3] In 1936, Love reported the [jisponline.com]

HIV-2 Infection

The presence of cervical ectopia, oral contraceptive use, or pregnancy in women, intact foreskin in men, and genital ulcer disease in either sex increases the risk for HIV [library.med.utah.edu]

Stomatitis

Severe necrotic oral ulcerative lesions were accompanied by cutaneous purpura, blood-filled blisters and bedsores. [ncbi.nlm.nih.gov]

The clinical history of CUS patients is of painful, exacerbating and remitting oral erosions, and ulcerations. [doi.org]

Abstract We present a case of a malnourished 68-year old man with occult hypothyroidism who presented with malaise, pyrexia, tongue swelling, oral ulceration and dysphagia [ncbi.nlm.nih.gov]

Malignant Neoplasm of the Skin

You are here: Cancer information / Cancer types / Skin - non-melanoma / Signs and symptoms Non-melanoma skin cancer usually starts as an abnormal area or change on any part of the skin. How non-melanoma skin cancer looks often depends on the type of cancer. Other health conditions can also look like[…] [cancer.ca]

Acute Myeloid Leukemia

History Patients with acute myeloid leukemia (AML) present with signs and symptoms resulting from bone marrow failure, organ infiltration with leukemic cells, or both. The time course is variable. Some patients, particularly younger ones, present with acute symptoms that develop over a few days to 1-2 weeks. Others[…] [emedicine.medscape.com]

Tongue Ulcer

Epidemiology [ 1, 2 ] Oral ulceration is a common condition. [patient.info]

In all of the mentioned conditions, oral ulcers are one of the key presenting signs. [symptoma.com]

Local causes of oral ulceration Mechanical trauma The most common cause of oral mucosal ulceration. It is most often caused by dentures, braces or sharp/broken teeth. [patient.info]

Acatalasia

The disorder is relatively benign, although it causes an increased incidence of oral ulcers, and can under rare circumstances lead to gangrene. [en.wikipedia.org]

The disorder is usually asymptomatic but may be associated with oral ulcerations and gangrene, or diabetes mellitus and atherosclerosis in certain populations. [assignmentpoint.com]

[…] recurrent infection or ulceration of the gums and related oral structures. [dictionary.university]

Gingivostomatitis

Materials and Methods: 135 patients infected with HIV developing oral ulcers were included in this study. [jioh.org]

The clinical history of CUS patients is of painful, exacerbating and remitting oral erosions, and ulcerations. [doi.org]

The purpose of this study was to characterize the clinical features of oral ulcers associated with herpes simplex virus (HSV) infection in AIDS. [jioh.org]

Hughes-Stovin Syndrome

The patient had history of bilateral iliofemoral thrombosis and recurrent oral ulcers. [lungindia.com]

He had erythematous macules, follicular papules, oral ulcers and weight loss with positive pathergy. [ard.bmj.com]

We present a case of hemoptysis with multiple pulmonary artery aneurysms, femoral vein thrombosis, and oral ulcers with emphasis on its CT features. [lungindia.com]

Recurrent Oral Ulceration

Behçet's syndrome (BS), 42 with other ulcerative oral lesions, 35 patients with non-ulcerative oral lesions and in 78 controls. [ncbi.nlm.nih.gov]

Types of ulceration covered in this paper include traumatic, infective, aphthous, ulceration related to the oral dermatoses, drug-induced, ulceration as a manifestation of [ncbi.nlm.nih.gov]

Hematologic abnormalities in recurrent oral ulceration. [acronyms.thefreedictionary.com]

Radiation Stomatitis

oral ulcers that are initially pin-point but fuse to produce irregular painful ulcers. [nature.com]

Differential Diagnosis: Oral Local, Denture-Related Lesion Oral Thrush Aphthous Ulcer Oral Mucositis*  Because these conditions can coexist in immunocompromised patients, [slideshare.net]

Signs and symptoms of oral mucositis Signs and symptoms of oral mucositis include: Red, shiny, or swollen mouth and gums Blood in the mouth Mouth and tongue ulcers or sores [gelclair.com]

Behçet Disease

Whilst the primary aim of many trials for Behç̧et's disease is not necessarily reduction of oral ulceration, reporting of oral ulcers in these studies should be standardised [ncbi.nlm.nih.gov]

Types of outcome measures Primary outcomes Pain associated with oral ulcers. Episode duration associated with oral ulcers. Episode frequency associated with oral ulcers. [doi.org]

The use of a core outcome set for oral ulcer trials would be beneficial. Read the full abstract... [cochrane.org]

Herpes Simplex Gingivostomatitis

Diagnostic Features of Common Oral Ulcerative Lesions: An Updated Decision Tree. [ncbi.nlm.nih.gov]

[…] mucosa -- Keratoses and related disorders of oral mucosa -- Oral epithelial tumors, melanocytic naevi, and malignant melanoma -- Infections of the oral mucosa -- Oral ulceration [worldcat.org]

[…] mucosa. necrotizing ulcerative gingivostomatitis that due to extension to the oral mucosa of necrotizing ulcerative gingivitis. [medical-dictionary.thefreedictionary.com]

Vulvar Ulceration

Such ulcers can, as in this patient’s case, have a white coagulum initially, and can be large (up to 3 cm) in comparison with oral ulcers. [consultant360.com]

She denied recent sexual intercourse, trauma and oral ulcerations, but referred a history of flu-like symptoms 1 week before. [casereports.bmj.com]

Patients with genital aphthous ulcers frequently have a history of oral ulcers. [caredownthere.com.au]

Severe Aplastic Anemia

Ann Hematol. 2015 Jul;94(7):1105-10. doi: 10.1007/s00277-015-2348-5. Epub 2015 Mar 19. Zhao X 1, Zhang L, Jing L, Zhou K, Li Y, Peng G, Ye L, Li Y, Li J, Fan H, Song L, Yang W, Zhang F. Author information 1 Department of Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of[…] [ncbi.nlm.nih.gov]

Acute Sarcoidosis

ulcers) or extrapulmonary (e.g., splenomegaly) manifestations Caseating granulomas Identification of H. capsulatum yeast with silver stain Positive polysaccharide urine and [amboss.com]

Treatment-resistant pneumonia Glomerulonephritis Non-caseating granulomas Positive cytoplasmic ANCA Histoplasmosis AIDS Exposure to bird or bat excrement Pulmonary (e.g., dry cough, oral [amboss.com]