Possible Causes for oral ulcers Stomatitis Severe necrotic oral ulcerative lesions were accompanied by cutaneous purpura, blood-filled blisters and bedsores. [ncbi.nlm.nih.gov] The clinical history of CUS patients is of painful, exacerbating and remitting oral erosions, and ulcerations. [dx.doi.org] Abstract We present a case of a malnourished 68-year old man with occult hypothyroidism who presented with malaise, pyrexia, tongue swelling, oral ulceration and dysphagia [ncbi.nlm.nih.gov] Burn Injury Children with significant burn injuries are at risk of acute gastric ulceration and a H2 antagonist should be considered for these patients. [rch.org.au] […] care with chlorhexidine, daily sedation interruption with assessment of readiness to wean from mechanical ventilation, and prophylaxis against stress ulceration and deep [accjournal.org] Referral to the Burns Team Dietician is recommended for all patients with significant burn injuries, facial burns, infants as well as patients who are not tolerating adequate oral [rch.org.au] Basal Cell Carcinoma The exact pathogenesis of vermilion lip BCC is not clear but it has been postulated that the neoplasm originates from the pluripotential epithelial cells of the oral mucosa [ncbi.nlm.nih.gov] Herein, we report a 34- year-old man with an asymptomatic ulcerated lesion on the upper left lip vermilion mucosa .The diagnosis of BCC was confirmed with histopathological [ncbi.nlm.nih.gov] Squamous Cell Carcinoma of the Skin Burn scar or thermal injury Venous ulcer Lymphedema Discoid lupus erythematosus [4] Erosive oral lichen planus Lichen sclerosis et atrophicus Mutilating keratoderma Necrobiotic [web.archive.org] […] actinic type, linear type) Nevus sebaceous KID (keratitis, ichthyosis, deafness) syndrome A cSCC may arise at a site of chronic inflammation, such as the following: Marjolin ulcer [web.archive.org] Aphthous Stomatitis Recurrent aphthous stomatitis consists on recurring oral ulcers of unknown etiology. [ncbi.nlm.nih.gov] ulcers warrant further studies; (3) Oral ulcers may be associated with CD; however, these ulcers may not be RAS; RAS is rarely associated with B12 deficiency; nevertheless [ncbi.nlm.nih.gov] […] causes of oral ulceration. [en.wikipedia.org] Malignant Neoplasm of the Skin You are here: Cancer information / Cancer types / Skin - non-melanoma / Signs and symptoms Non-melanoma skin cancer usually starts as an abnormal area or change on any part of the skin. How non-melanoma skin cancer looks often depends on the type of cancer. Other health conditions can also look like[…] [cancer.ca] Malignant Melanoma of the Skin Oral melanomas are largely macular, but nodular and even pedunculated lesions occur. Pain, ulceration, and bleeding are rare in oral melanoma until late in the disease. [oralcancerfoundation.org] Oral endoscopy revealed 3 thin varicose cords and scarring from a duodenal ulcer. [scielo.br] Oral malignant melanoma pictures Caption: Picture 1. Oral malignant melanoma. [oralcancerfoundation.org] HIV Infection Cutaneous involvement is observed in 38% to 85% of cases, with oral mucosal involvement in 30% to 60% of cases. [ncbi.nlm.nih.gov] Symptoms of early HIV infection may include non-specific, flu-like symptoms, such as: fever, swollen glands, a sore throat, oral ulcers or thrush, weight loss, tiredness, [aidsmap.com] ulcers. [health24.com] Mucous Membrane Pemphigoid A 37-year-old man presented to his primary care physician with a chief concern of a sore throat and oral ulcers. [mdedge.com] Oral ulceration can present a diagnostic problem. [ 6 ] The main sites and types of involvement are: Mouth Painful and recurrent erosions present anywhere in the mouth, starting [patient.info] The oral mucosa is often affected, and sometimes the disease is limited to the mouth. [ncbi.nlm.nih.gov] Discoid Lupus Erythematosus Oral ulcers, findings on skin biopsy, a positive antinuclear antibody test, and transverse myelitis on MRI all confirm the presence of systemic lupus erythematosus (SLE). [atm.amegroups.com] Over the next 13 months, the patient developed severe photosensitivity, oral ulcers, Raynaud phenomenon, anemia, and nephrotic-range proteinuria. [mdedge.com] Other lesions associated with ACLE include oral ulcers, hives, and temporary hair loss, which are replaced by new hair once the disease flare is treated. [americanskin.org] Brandt Syndrome No oral ulcers were present. [mdedge.com] Otherwise, zinc sulphate is used orally for treating skin ulcers and acceleration of wound healing. Eye and pancreas are especially rich in zinc. [healio.com] The patient denied any oral ulcers. [mdedge.com] Idiopathic Neutropenia Eosinophilic ulcer of oral mucosa: A case report. Ann Stomatol (Roma) 2012;3:11-3. 8. Khocht A, Viera-Negron YE, Ameri A, Abdelsayed R. [jisponline.com] Life-threatening infections can follow neutropenic nadir of the cycle, with frequent aphthous gingivitis, periodontitis, oral ulcerations, fever and occasional sepsis. [news-medical.net] The nonspecific oral ulcerations, precocious exfoliation of teeth, advanced periodontal disease associated with otitis media, and anemia as reported in some of the investigations [jisponline.com] Hand-Foot-Mouth Disease It is marked by fever, oral ulcers, and skin manifestations affecting the palms, soles, and buttocks, with symptoms usually lasting less than 1 week. [ncbi.nlm.nih.gov] The diagnosis is usually based on the characteristic clinical aspect: vesicles and papules on the hands and feet and superficial oral ulcers. [ncbi.nlm.nih.gov] The diagnostic hallmarks are oral ulcers and maculo-papular or vesicular rash on the hands and feet. [ncbi.nlm.nih.gov] Stevens-Johnson Syndrome TREATMENT: Oral ulcers had been topically treated with an oral balance gel. [ncbi.nlm.nih.gov] […] dry oral mucous membranes, ulceration of the head of the penis, and a generalized rash that consisted of target lesions with central erosions. [web.archive.org] Oropharyngeal (mouth) lesions may be so intolerable as to prevent eating, and there may be recurring oral ulcers. [healthcentral.com] Squamous Cell Carcinoma of the Head and Neck Noteworthy, the patient presented with multiple oral ulcers[28]. Oral involvement in PR Oral lesions in PR are more common in dark skinned people[29]. [ncbi.nlm.nih.gov] The lesions are difficult to differentiate from aphthous ulcers. Its appearance should coincide with a generalized eruption with the characteristics of PR[4]. [ncbi.nlm.nih.gov] Acute Myeloid Leukemia Induction therapy of acute myeloid leukemia (AML) with standard-dose chemotherapy will result in 52% to 72% of patients achieving a complete remission (CR) on bone marrow morphology. Newer agents that appear to improve the outcome of induction therapy are etoposide, idarubicin, and high-dose cytarabine. New[…] [ncbi.nlm.nih.gov] HIV-2 Infection The presence of cervical ectopia, oral contraceptive use, or pregnancy in women, intact foreskin in men, and genital ulcer disease in either sex increases the risk for HIV [library.med.utah.edu] Congenital AIDS Resistant thrush, oral ulcers and conjunctivitis. Diarrhoea and malabsorption. Failure to thrive and delayed or incomplete recovery from illness. 7. [slideshare.net] ulcerations Absolute neutropenia, relative monocytosis Bone marrow aspirate: normal or decreased cellularity; arrest of myeloid lineage Complement disorders Immunodeficiency [amboss.com] […] without any pus exudate and oral ulcers [Figure 5]. [idoj.in] Tongue Ulcer Epidemiology [ 1, 2 ] Oral ulceration is a common condition. [patient.info] pigmented » Lips, swollen » Oral mucosa, blue pigmentation » Oral mucosa, cysts » Oral mucosa, hyperpigmentation » Oral mucosa, papules and nodules » Oral mucosa, ulceration [medical-photographs.com] Local causes of oral ulceration Mechanical trauma The most common cause of oral mucosal ulceration. It is most often caused by dentures, braces or sharp/broken teeth. [patient.info] Acatalasia The disorder is relatively benign, although it causes an increased incidence of oral ulcers, and can under rare circumstances lead to gangrene. [en.wikipedia.org] The disorder is usually asymptomatic but may be associated with oral ulcerations and gangrene, or diabetes mellitus and atherosclerosis in certain populations. [assignmentpoint.com] […] recurrent infection or ulceration of the gums and related oral structures. [dictionary.university] Recurrent Oral Ulceration Behçet's syndrome (BS), 42 with other ulcerative oral lesions, 35 patients with non-ulcerative oral lesions and in 78 controls. [ncbi.nlm.nih.gov] Types of ulceration covered in this paper include traumatic, infective, aphthous, ulceration related to the oral dermatoses, drug-induced, ulceration as a manifestation of [ncbi.nlm.nih.gov] BACKGROUND: Some inflammatory factors play an important role in recurrent oral ulceration (ROU). [ncbi.nlm.nih.gov] Gingivostomatitis Materials and Methods: 135 patients infected with HIV developing oral ulcers were included in this study. [jioh.org] On physical exam, infectious mononucleosis is characterized by oral petechiae with occasional gingivostomatitis and ulceration. [ncbi.nlm.nih.gov] […] and peri oral ulceration frequently occur. [nature.com] Hughes-Stovin Syndrome The patient had history of bilateral iliofemoral thrombosis and recurrent oral ulcers. [lungindia.com] He had erythematous macules, follicular papules, oral ulcers and weight loss with positive pathergy. [ard.bmj.com] We present a case of hemoptysis with multiple pulmonary artery aneurysms, femoral vein thrombosis, and oral ulcers with emphasis on its CT features. [lungindia.com] Behçet Disease Whilst the primary aim of many trials for Behç̧et's disease is not necessarily reduction of oral ulceration, reporting of oral ulcers in these studies should be standardised [ncbi.nlm.nih.gov] Types of outcome measures Primary outcomes Pain associated with oral ulcers. Episode duration associated with oral ulcers. Episode frequency associated with oral ulcers. [doi.org] The use of a core outcome set for oral ulcer trials would be beneficial. Read the full abstract... [cochrane.org] Acute Myelomonocytic Leukemia C hemotherapy-induced mucositis and infection, including herpes simplex ulcers and oral candidiasis are commonly observed complications of leukemia in the oral cavity. [cda-adc.ca] The most frequently observed oral findings of leukemia are mucosal bleeding and ulceration, petechiae, and gingival hyperplasia. [ncbi.nlm.nih.gov] […] leukemia is erythematous or cyanotic gingival hyperplasia with or without necrosis, petechiae, ecchymosis, mucosal ulcers and hemorrhage. [2], [3] In 1936, Love reported the [jisponline.com] Lupus Erythematosus ulceration, abdominal pain), cardiac (atherosclerosis, chest pain), pulmonary (serositis, pleurisy), musculoskeletal (arthralgia, myalgia), renal (nephritis, hematuria), [orpha.net] Oral Ulcers OR Nasal Ulcers Oral: palate, buccal, tongue Nasal ulcers In the absence of other causes, such as vasculitis, Behcet’s disease, infection (herpesvirus), inflammatory [rheumtutor.com] Oral ulcers Oral or nasopharyngeal ulceration, usually painless, observed by physician 5. [pedclerk.bsd.uchicago.edu] Radiation Stomatitis oral ulcers that are initially pin-point but fuse to produce irregular painful ulcers. [nature.com] Differential Diagnosis: Oral Local, Denture-Related Lesion Oral Thrush Aphthous Ulcer Oral Mucositis* Because these conditions can coexist in immunocompromised patients, [slideshare.net] Figure 2 Minor aphthous ulcer, labial mucosa Causes of oral ulceration Ulcers and erosions can also be the final common manifestation of a spectrum of conditions. [nature.com] Severe Aplastic Anemia Ann Hematol. 2015 Jul;94(7):1105-10. doi: 10.1007/s00277-015-2348-5. Epub 2015 Mar 19. Zhao X 1, Zhang L, Jing L, Zhou K, Li Y, Peng G, Ye L, Li Y, Li J, Fan H, Song L, Yang W, Zhang F. Author information 1 Department of Anemia Therapeutic Center, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of[…] [ncbi.nlm.nih.gov] Vulvar Ulceration She denied recent sexual intercourse, trauma and oral ulcerations, but referred a history of flu-like symptoms 1 week before. [casereports.bmj.com] Such ulcers can, as in this patient’s case, have a white coagulum initially, and can be large (up to 3 cm) in comparison with oral ulcers. [consultant360.com] A review of systems should include: Systemic symptoms (fever, malaise, headache, GI symptoms, respiratory symptoms, myalgia) Oral ulcers, skin lesions, ocular symptoms. [rch.org.au] Drug-induced Neutropenia Drug induced neutropenia manifesting as oral ulcerations. [jiaomr.in] In most cases, throat and mucous membrane infections develop first, presenting with oral ulcerations and a sore throat, whereas a range of skin lesions (ulcers, abscesses [symptoma.com] Focal symptoms (eg, oral ulcers) may develop but are often subtle. [merckmanuals.com]
