Create issue ticket

220 Possible Causes for orexins

  • Streptococcal Infection

    Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain.[]

  • Endocrine Dysfunction

    Messina G, Dalia C, Tafuri D, “Orexin A Controls Glucose Metabolism,” J Diabete Metab 2014; 5(7): 398. doi:10.4172/2155-6156.1000398 64.[] Tsuneki H, Tokai E, Nakamura Y, “Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice,” Diabetes[] Orexin plays an important role in glucose metabolism (including through its involvement in the production of a circadian glucose rhythm), preventing or promoting insulin resistance[]

  • Narcolepsy

    Murine models of narcolepsy-cataplexy, generated by disrupting the prepro-orexin gene ( orexin knockout mice) or inducing postnatal death of orexin-producing neurons ( orexin[] […] limited presence of orexin (n 10) (Group 2).[] KEYWORDS: CD4 T-cell proliferation; HLA-DQB1*06:02.; Narcolepsy type 1; autoimmune disease; orexin/hypocretin[]

  • Narcolepsy-Cataplexy Syndrome

    Mercola It’s estimated that up to 200,000 Americans have narcolepsy, a disorder that involves the loss of hypocretin-producing neurons. 1 Hypocretin, also known as orexin,[] Orexin A in the CSF of typical NA-CA patients is known to be reduced or undetectable. 5 , 6 A minority of NA w/o CA patients have low concentrations of CSF orexin A levels[] […] strike after the patient experiences a sleep attack , although there may be episodes where the cataplexic spell strikes first in the symptomatic manifestation. ( Hypocretin-Orexin[]

  • Cataplexy

    In both the orexin knockout and the orexin-ataxin-3 mouse models of narcolepsy we have found that cataplexy can be blocked if the surrogate neurons are part of the circuit[] Their occurrence in an independent narcolepsy mouse model, the orexin/ataxin 3 transgenic mouse, undergoing loss of orexin neurons, was confirmed.[] Orexin, also known as Hypocretin, is a primary chemical important in regulating sleep as well as states of arousal.[]

  • Idiopathic Hypersomnia

    There is no association with any particular HLA marker or with a decrease in the orexin/hypocretin levels.[] Orexins activate histaminergic neurons via the orexin 2 receptor. Biochem Biophys Res Commun . 2002. 290:1237-45. [Medline] . [Full Text] .[] Hypocretin/orexin and narcolepsy: new basic and clinical insights. Acta Physiol (Oxf) . 2009 Jun 25. [Medline] . [Full Text] . Nishino S, Kanbayashi T.[]

  • Hypersomnia

    Aquaporin 4 (AQP4), a member of the AQP superfamily, is strongly expressed in the hypothalamus in which orexin (hypocretin)-containing neurons are primarily concentrated.[] Orexin A in the CSF was decreased. Hypersomnia and a decrease of the CNS orexin A improved after corticosteroid therapy.[] Orexins activate histaminergic neurons via the orexin 2 receptor. Biochem Biophys Res Commun . 2002. 290:1237-45. [Medline] . [Full Text] .[]

  • Narcolepsy 3

    Orexin is also critical in the Second Brain because the nerves in the intestines sense orexin… remember I said earlier that there are orexin receptors in the gut?[] […] to have lower levels of orexin.[] You may be able to boost hypocretin/orexin in your body.[]

  • Autosomal Dominant Cerebellar Ataxia - Deafness - Narcolepsy

    Neuropathological results revealed loss of purkinje cells in the cerebellum and a relative decrease in orexin immunostaining in the hypothalamus, with reactive astrocytes[] Mignot, Emmanuel; Kornum, Birgitte R // European Journal of Human Genetics;Nov2015, Vol. 23 Issue 11, p1573 Type 1 narcolepsy, an autoimmune disease affecting hypocretin (orexin[] Hypocretin, or Orexin, is a chemical that helps a person stay awake and avoid falling asleep.[]

  • Modafinil

    The orexinergic system controls arousal through the histaminergic system, and the modafinil-induced increment of histamine release is abolished in orexin neuron-ablated mice[] […] the therapeutic value of modafinil appears to stem from its ability to stimulate a specific circuit within the hypothalamus, which ties together the neuropeptide Y, the orexin[] Modafinil is an FDA-approved eugeroic that directly increases cortical catecholamine levels, indirectly upregulates cerebral serotonin, glutamate, orexin, and histamine levels[]

Further symptoms