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220 Possible Causes for orexins

  • Streptococcal Infection

    Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain.[aasmnet.org]

  • Endocrine Dysfunction

    Messina G, Dalia C, Tafuri D, “Orexin A Controls Glucose Metabolism,” J Diabete Metab 2014; 5(7): 398. doi:10.4172/2155-6156.1000398 64.[sleepdisorders.sleepfoundation.org] Tsuneki H, Tokai E, Nakamura Y, “Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice,” Diabetes[sleepdisorders.sleepfoundation.org] Orexin plays an important role in glucose metabolism (including through its involvement in the production of a circadian glucose rhythm), preventing or promoting insulin resistance[sleepdisorders.sleepfoundation.org]

  • Narcolepsy

    Murine models of narcolepsy-cataplexy, generated by disrupting the prepro-orexin gene ( orexin knockout mice) or inducing postnatal death of orexin-producing neurons ( orexin[doi.org] […] limited presence of orexin (n 10) (Group 2).[ncbi.nlm.nih.gov] KEYWORDS: CD4 T-cell proliferation; HLA-DQB1*06:02.; Narcolepsy type 1; autoimmune disease; orexin/hypocretin[ncbi.nlm.nih.gov]

  • Narcolepsy-Cataplexy Syndrome

    Mercola It’s estimated that up to 200,000 Americans have narcolepsy, a disorder that involves the loss of hypocretin-producing neurons. 1 Hypocretin, also known as orexin,[articles.mercola.com] Orexin A in the CSF of typical NA-CA patients is known to be reduced or undetectable. 5 , 6 A minority of NA w/o CA patients have low concentrations of CSF orexin A levels[nature.com] […] strike after the patient experiences a sleep attack , although there may be episodes where the cataplexic spell strikes first in the symptomatic manifestation. ( Hypocretin-Orexin[bedroom.solutions]

  • Cataplexy

    In both the orexin knockout and the orexin-ataxin-3 mouse models of narcolepsy we have found that cataplexy can be blocked if the surrogate neurons are part of the circuit[ncbi.nlm.nih.gov] Their occurrence in an independent narcolepsy mouse model, the orexin/ataxin 3 transgenic mouse, undergoing loss of orexin neurons, was confirmed.[ncbi.nlm.nih.gov] Orexin, also known as Hypocretin, is a primary chemical important in regulating sleep as well as states of arousal.[en.wikipedia.org]

  • Idiopathic Hypersomnia

    There is no association with any particular HLA marker or with a decrease in the orexin/hypocretin levels.[orpha.net] Orexins activate histaminergic neurons via the orexin 2 receptor. Biochem Biophys Res Commun . 2002. 290:1237-45. [Medline] . [Full Text] .[emedicine.com] Hypocretin/orexin and narcolepsy: new basic and clinical insights. Acta Physiol (Oxf) . 2009 Jun 25. [Medline] . [Full Text] . Nishino S, Kanbayashi T.[emedicine.com]

  • Hypersomnia

    Aquaporin 4 (AQP4), a member of the AQP superfamily, is strongly expressed in the hypothalamus in which orexin (hypocretin)-containing neurons are primarily concentrated.[ncbi.nlm.nih.gov] Orexin A in the CSF was decreased. Hypersomnia and a decrease of the CNS orexin A improved after corticosteroid therapy.[ncbi.nlm.nih.gov] Orexins activate histaminergic neurons via the orexin 2 receptor. Biochem Biophys Res Commun . 2002. 290:1237-45. [Medline] . [Full Text] .[emedicine.com]

  • Narcolepsy 3

    Orexin is also critical in the Second Brain because the nerves in the intestines sense orexin… remember I said earlier that there are orexin receptors in the gut?[madcapnarcolepsy.com] […] to have lower levels of orexin.[geneticdisorders.info] You may be able to boost hypocretin/orexin in your body.[wikihow.com]

  • Autosomal Dominant Cerebellar Ataxia - Deafness - Narcolepsy

    Neuropathological results revealed loss of purkinje cells in the cerebellum and a relative decrease in orexin immunostaining in the hypothalamus, with reactive astrocytes[neurology.org] Mignot, Emmanuel; Kornum, Birgitte R // European Journal of Human Genetics;Nov2015, Vol. 23 Issue 11, p1573 Type 1 narcolepsy, an autoimmune disease affecting hypocretin (orexin[connection.ebscohost.com] Hypocretin, or Orexin, is a chemical that helps a person stay awake and avoid falling asleep.[yourceus.com]

  • Modafinil

    The orexinergic system controls arousal through the histaminergic system, and the modafinil-induced increment of histamine release is abolished in orexin neuron-ablated mice[ncbi.nlm.nih.gov] […] the therapeutic value of modafinil appears to stem from its ability to stimulate a specific circuit within the hypothalamus, which ties together the neuropeptide Y, the orexin[ncbi.nlm.nih.gov] Modafinil is an FDA-approved eugeroic that directly increases cortical catecholamine levels, indirectly upregulates cerebral serotonin, glutamate, orexin, and histamine levels[ncbi.nlm.nih.gov]

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