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111 Possible Causes for Orthokeratosis

  • Actinic Keratosis

    Histologically, the rosette sign may correspond to changes of orthokeratosis and parakeratosis (flag sign) ( Figure 5 [case shown in Figure 3 ]).[] […] atrophic types are the most common variants. 4 Characteristic histological features of hypertrophic actinic keratosis include hyperkeratotic stratum corneum, pronounced orthokeratosis[] A "flag sign" is often described, referring to alternating areas of orthokeratosis and parakeratosis.[]

  • Pityriasis Rubra Pilaris

    Microscopically follicular plugging, in addition to checkerboard alternating orthokeratosis/parakeratosis, may serve as clues to PRP diagnosis.[] Histologically, PRP is characterized by psoriasiform acanthosis with alternating orthokeratosis and parakeratosis and rarely small acantholytic foci.[] The skin biopsy showed acanthosis, alternating orthokeratosis, parakeratosis, and follicular plugging suggestive of pityriasis rubra pilaris.[]

  • Palmoplantar Keratosis

    Histology of the representative plantar lesion in the child showed orthokeratosis and parakeratosis but absence of cornoid lamellae or elastorrhexis, confirming the diagnosis[] The second biopsy specimen from the thenar region revealed orthokeratosis without significant epidermal changes or altered acrosyringium [Figure 2] b.[] —There is epidermal hyperplasia with hypergranulosis, a thin layer of parakeratosis, and overlying orthokeratosis.[]

  • Pityriasis Circinata

    There is epidermis with orthokeratosis and a suggestion of a slightly diminished granular layer in the epidermis. A PAS stain was negative for fungus.[]

  • Vasculitis

    Orthokeratosis Orthokeratosis is the normal ‘basket weave’ appearance of the stratum corneum seen in normal skin.[] Orthokeratosis ‘Basket weave’ appearance of the stratum corneum, as in normal skin. There are no nuclei within the stratum corneum cells.[] In acral skin (palms or soles), the stratum corneum exhibits thickening and compaction (“compact orthokeratosis ”).[]

  • Familial Angiolipomatosis

    (A) Microscopic examination of haematoxylin and eosin (H&E) stained sections reveals hyper-orthokeratosis, flattening of the epidermis, and extensive sclerosis of reticular[]

  • Verruca Vulgaris

    (Med J Indones 2008; 18: 135-8) Key words: papilloma viruses, hyperkeratosis, orthokeratosis Copyright (c) 2009 Mona S. Haroen, Herliyani M.[] Clinical Hyperkeratotic papules with a rough, irregular surface ranging from 1 mm to 1 cm Histology Digitated epidermal hyperplasia, acanthosis, papillomatosis, compact orthokeratosis[] […] spreads, but it is locally destructive. [9] [10] Histopathology Common Histopathologic features include acanthosis, digitated epidermal hyperplasia, papillomatosis, compact orthokeratosis[]

  • Actinic Lichen Planus

    Histologic examination demonstrated an atrophic epidermis with mild hyperkeratosis and orthokeratosis (Figure 3).[] […] the lower trunk and limbs and snake-like patterns on the scalp and face. 8 In histopathological examinations, linear lichen planus is identical to lichen planus, compact orthokeratosis[] True lichen planus shows no retained nuclei in the outer dead layer of skin (orthokeratosis).[]

  • Syringocystadenoma papilliferum

    Histologic Features Compact orthokeratosis with focal parakeratosis Papillated skin surface A cup-shaped invagination from the epidermal surface by squamous epithelium Papillary[] […] revealed marked verrucous papillomatosis with a crateriform shape ( Fig. 1A ), the differentiation of the epithelium being infundibular with a well-defined granular layer and orthokeratosis[]

  • Acrodermatitis Continua of Hallopeau

    Psoriasiform acanthosis of variable extent; rete ridges of equal lengths Suprapapillary plates thin slightly Wedge-shaped hypergranulosis, especially in infundibula Compact orthokeratosis[]

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