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53 Possible Causes for Orthokeratosis in Epidermis

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  • Tinea Corporis

    Commonly described histologic 'clues' to the diagnosis of dermatophytosis include neutrophils in the stratum corneum and/or epidermis, compact orthokeratosis and identification[ncbi.nlm.nih.gov]

  • Parapsoriasis

    Histologic Features Thin orthokeratosis An epidermis of normal thickness containing atypical lymphoid cells singly and in collections Minimal spongiosis Vacuolar degeneration[dxpath.com]

  • Lipoid Proteinosis

    Histologic Features Compact orthokeratosis Slight papillation of the epidermis Large masses of hyalin-like material running perpendicular to the skin surface in the papillary[dxpath.com]

  • Hyperkeratosis Lenticularis Perstans

    Histologic Features A thick laminated overlying orthokeratosis Depressed, flattened epidermis with hypogranulosis Epidermal hyperplasia at the periphery of the lesion Moderate[dxpath.com] Figure 3 Basket-weave orthokeratosis and an adjacent area showing thicker epidermis with a preserved granular layer.[aocd-grandrounds.org] The adjacent epidermis revealed preservation of granular layer with overlying basket-weave orthokeratosis (Fig 3 and Fig 4).[aocd-grandrounds.org]

  • Elastosis perforans serpiginosa

    The epidermis showed irregular hyperplasia, acanthosis and dyskeratotic cells [Figure 1] b, c]. There was dense lymphoplasmacytic infilterate in upper dermis.[ijpmonline.org] Histopathological evaluations revealed three types of lesions: Histopathological features of two cases showed a shallow cup shaped epidermal invagination filled with compact orthokeratosis[ijpmonline.org]

  • Erythema Elevatum Diutinum

    Histologic Features Compact orthokeratosis of the volar skin with a normal epidermis and a narrow grenz zone A dense, diffuse dermal infiltrate consisting predominantly of[dxpath.com]

  • Epidermodysplasia Verruciformis

    Areas of epidermis showed compact orthokeratosis, coarse hypergranulosis, and keratinocytes with abundant steel-blue-gray cytoplasm, indicative of viral cytopathic changes[ncbi.nlm.nih.gov] Biopsy of a papule from chest showed irregularly acauthotic epidermis with basket weave orthokeratosis overlying papillornatous dermis.[jpma.org.pk] Histopathology revealed vertically oriented anastomosing strands of basaloid epithelium arising from multiple points along the epidermis in a background fibrovascular stroma[ncbi.nlm.nih.gov]

  • Familial Reactive Perforating Collagenosis

    The epidermis showed irregular hyperplasia, acanthosis and dyskeratotic cells [Figure 1] b, c]. There was dense lymphoplasmacytic infilterate in upper dermis.[ijpmonline.org] Orthokeratosis, parakeratosis and abnormal keratinization are seen sometimes.[jfmpc.com] Histopathological evaluations revealed three types of lesions: Histopathological features of two cases showed a shallow cup shaped epidermal invagination filled with compact orthokeratosis[ijpmonline.org]

  • Erythrokeratoderma

    Skin biopsy showed epidermis with mild acanthosis, confluent parakeratosis interposed between orthokeratosis.[ijpd.in] Skin biopsy showed epidermis with acanthosis, papillomatosis, orthokeratosis, and parakeratosis with preserved granular layer.[ijpd.in] (c and d) Ill-defined erythema with scaling along with geographical border present on chest, and gluteal region Click here to view Figure 5: Epidermis showing acanthosis,[ijpd.in]

  • Cutaneous Amyloidosis

    Histopathological features showed orthokeratosis, thinning of epidermis, basal cell vacuolar degeneration and diffuse mild degree of lymphocytic infiltration in the upper[ijpmonline.org]

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