Osmotic Fragility of Red Blood Cells: Causes & Reasons

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Possible Causes for Osmotic Fragility of Red Blood Cells

Congenital Dyserythropoietic Anemia Type 2

A patient with multiorgan involvement of non-iatrogenic hemochromatosis secondary to congenital dyserythropoietic anemia (CDA) type 2 is described. The clinical manifestations of hemochromatosis preceded the diagnosis of CDA. CDA should be included among the hematological disorders associated with iron overload. Iron[…] [ncbi.nlm.nih.gov]

Hereditary Spherocytosis

Testing Location Flow Cytometry Testing Frequency Mondays Alternate Name(s) Erythrocyte Fragility, Osmotic Fragility - Erythrocyte, Red Blood Cell Osmotic Fragility Reference [calgarylabservices.com]

Osmotic fragility test Red blood cells are incubated for 18-24 hours under sterile conditions at 37°C, and osmotic fragility is checked. [medicaljoyworks.com]

The samples were examined by flow-cytometric osmotic fragility test and the percentage of residual red blood cells was used to determine HS. [ncbi.nlm.nih.gov]

Acquired Spherocytosis

One blood test used to diagnose HS is called osmotic fragility. The patient’s red blood cells are placed in different concentrations of salt water (saline) for 24 hours. [ihtc.org]

However, they have a high osmotic fragility—when placed into water, they are more likely to burst than normal red blood cells. [en.wikipedia.org]

Interpret the osmotic fragility test and distinguish between normal and HS red blood cells using this assay. [hematology.org]

Non-Oliguric Renal Failure

III: Mechanisms and complications of hemoglobinuria in patients with thermal burns: Spherocytosis and increased osmotic fragility of red blood cells. [link.springer.com]

Studies on the destruction of red blood cells. [link.springer.com]

Spherocytosis

Spherocytes are spherical red blood cells without an area of central pallor and are usually slightly smaller in size than the average red cell. [msdmanuals.com]

Spherocytes have increased osmotic fragility (because of decreased distensibility associated with reduced surface membrane area) in hypotonic saline, and this test (osmotic [msdmanuals.com]

Erythrocyte Membrane Abnormality

Erythrocyte osmotic fragility [ edit ] Osmotic fragility (OF) refers to the degree or proportion of hemolysis that occurs when a sample of red blood cells are subjected to [en.wikipedia.org]

However, they have a high osmotic fragility–when placed into water, they are more likely to burst than normal red blood cells. [theartofmed.wordpress.com]

blood cells, is shown on the horizontal axis. [oncohemakey.com]

Waters-West Syndrome

These rotund red cells (spherocytes) are osmotically fragile and less flexible than normal red cells and tend to get trapped in narrow blood passages, particularly in the [medicinenet.com]

[…] of the jaundice pigment bilirubin due to the breakup of the red cells) and increased osmotic fragility of the red cells. [medicinenet.com]

Laboratory studies show evidence not only of many spherocytes but also increased numbers of reticulocytes (young red blood cells), hyperbilirubinemia (increased blood levels [medicinenet.com]

Hereditary Elliptocytosis 2

The red blood cells in paroxysmal nocturnal hemoglobinuria (PNH) demonstrate a(n) ___________________ osmotic fragility test. [quizlet.com]

[…] smear Significantly decreased or absent haptoglobin Mildly increased osmotic fragility Increased osmolarity index (Omin=osmolality at which 50% of red blood cells hemolyze [centogene.com]

red cells Differential Must be distinguished from autoimmune hemolysis, which also has spherocytes autoimmune hemolysis is Coombs positive note it is also osmotically fragile [medbullets.com]

Diuretic Therapy

Osmotic fragility of red blood cells may be determined as a screening tool for hypertensive patients who will benefit from diuretic therapy. [ncbi.nlm.nih.gov]

Abstract To determine the effect of diuretic therapy on osmotic fragility of red blood cells of hypertensive patients, 25 hypertensive and 15 normotensive subjects were followed [ncbi.nlm.nih.gov]

The osmotic fragility also became similar in the two groups with control of blood pressure in the hypertensive group. [ncbi.nlm.nih.gov]

Acquired Hemolytic Anemia

Interpret the osmotic fragility test and distinguish between normal and HS red blood cells using this assay. [hematology.org]

In PNH, the red blood cells are missing certain proteins. The test for PNH can detect red blood cells that are missing these proteins. Osmotic fragility test. [theoncologyinstitute.com]

In PNH, the red blood cells are missing certain proteins. The test for PNH looks for red blood cells that are missing these proteins. Osmotic fragility test. [daviddarling.info]

Acute Renal Failure with Oliguria

III: Mechanisms and complications of hemoglobinuria in patients with thermal burns: Spherocytosis and increased osmotic fragility of red blood cells. [link.springer.com]

Studies on the destruction of red blood cells. [link.springer.com]

Congenital Hemolytic Anemia

[…] by shortened red blood cell survival, lack of spherocytosis, and normal osmotic fragility associated with erythrocyte membrane defects, multiple intracellular enzyme deficiencies [en.academic.ru]

fragility Direct Antiglobulin (Direct Coombs) Test The direct antiglobulin (direct Coombs) test is used to determine whether red blood cell (RBC)-binding antibody (IgG) or [merckmanuals.com]

Hemolytic Anemia

fragility, a reduced half-life of red blood cells, and increased expression of heme oxygenase 1. [ncbi.nlm.nih.gov]

Interpret the osmotic fragility test and distinguish between normal and HS red blood cells using this assay. [hematology.org]

Acquired Toxic Hemolytic Anemia

In PNH, the red blood cells are missing certain proteins. The test for PNH looks for red blood cells that are missing these proteins. Osmotic fragility test. [daviddarling.info]

fragility Direct Antiglobulin (Direct Coombs) Test The direct antiglobulin (direct Coombs) test is used to determine whether red blood cell (RBC)-binding antibody (IgG) or [msdmanuals.com]

Hereditary Elliptocytosis

The red blood cells in paroxysmal nocturnal hemoglobinuria (PNH) demonstrate a(n) ___________________ osmotic fragility test. [quizlet.com]

fragility test Osmotic fragility is increased because of red cell membrane instability. [17] Autohemolysis test, the hypertonic cryohemolysis test, and the acidified glycerol [explainmedicine.com]

MCHC more than 36% C. increased osmotic fragility D. all of the above D. all of the above spherocytes on the peripheral smear MCHC more than 36% increased osmotic fragility [quizlet.com]

Rh Deficiency Syndrome

[…] in this report with spherocytic haemolytic anaemia, stomatocytosis and increased osmotic fragility of red cells. [jpma.org.pk]

Regulator type Rh-null hemolytic anemia (RHN) [MIM:268150]: Form of chronic hemolytic anemia in which the red blood cells have a stomatocytosis and spherocytosis morphology [genecards.org]

Disease description Form of chronic hemolytic anemia in which the red blood cells have a stomatocytosis and spherocytosis morphology, an increased osmotic fragility, an altered [uniprot.org]

Chronic Meningitis

One blood test used to diagnose HS is called osmotic fragility. The patient’s red blood cells are placed in different concentrations of salt water (saline) for 24 hours. [ihtc.org]

Additionally, the hematologist will examine the red blood cells under a microscope to determine their shape, size, and characteristics. [ihtc.org]

Hypochromic Microcytic Anemia with Iron Overload Type 2

[…] salt solution; spherocytes show ↑ in osmotic fragility compared to normal red blood cells), flow cytometry, or molecular testing finding the underlying mutation. [nextgencombatmedic.com]

Laboratory studies show an increased red cell distribution width (RDW). [basicmedicalkey.com]

Count: Increased Mean Corpuscular Hemoglobin Concentration (MCHC), increased RDW PBS: Spherocytes, Howell-Jolly bodies Labs: Osmotic Fragility Test (incubate in hypotonic [nextgencombatmedic.com]

Hereditary Cryohydrocytosis with Reduced Stomatin

HS and HSt both show osmotically sensitive red cells on an osmotic fragility (OF) test and patients with HSt can have some spherocytes on peripheral blood smears, but HS red [cancertherapyadvisor.com]

Erythrocyte osmotic fragility is either normal or slightly increased. [medtextfree.wordpress.com]

[…] of haemolysis § Rigid and hyperstable red cells – tiger cells (double stoma) § 25% or more ovalocytes § SDS-PAGE detects slower migrating Band 3 Stomatocytosis Overhydrated [ihaematology.com]

Rubeosis Iridis

The patient's infancy was remarkable for transient hemolytic anemia associated with increased osmotic fragility of red blood cells with a negative Coombs' test, suggesting [retinalphysician.com]

Myelophthisis

Investigation in patient with anemia Specific Initial • Inclusion body• CBC, blood smear • Osmotic fragility• Red cell indicies • Saline agglutination • Coombs’ test• Reticulocyte [pt.slideshare.net]

Anemia

[…] disease An osmotic fragility test to see if your red blood cells are more fragile than usual Your doctor may use more tests to search for the cause of your anemia. [radiologyinfo.org]

[…] smear to see if your red blood cells are an abnormal shape Hemoglobin electrophoresis to evaluate for abnormal hemoglobin, which is present in thalassemia and sickle cell [radiologyinfo.org]

[…] red blood cells at an accelerated rate (this is a sign of prior blood loss) Serum iron and ferritin tests to check the amount of iron in your blood and body A peripheral blood [radiologyinfo.org]

Hereditary Xerocytosis

Dehydrated hereditary stomatocytosis, also known as "hereditary xerocytosis," is caused by a red blood cell-membrane defect characterized by stomatocytic morphology, increased [ncbi.nlm.nih.gov]

Erythrocyte osmotic fragility is either normal or slightly increased. [medtextfree.wordpress.com]

Acute Hemolytic Anemia

Interpret the osmotic fragility test and distinguish between normal and HS red blood cells using this assay. [hematology.org]

fragility Direct Antiglobulin (Direct Coombs) Test The direct antiglobulin (direct Coombs) test is used to determine whether red blood cell (RBC)-binding antibody (IgG) or [msdmanuals.com]

[…] syndrome with suicidal red blood cell death. [omicsonline.org]

Overhydrated Hereditary Stomatocytosis

Regulator type Rh-null hemolytic anemia (RHN) [MIM:268150]: Form of chronic hemolytic anemia in which the red blood cells have a stomatocytosis and spherocytosis morphology [genecards.org]

Ektacytometry testing for HS is characterized by decreased deformability index (DI), increased in osmotic fragility (increased Omin; osmolality at which 50% of red blood cells [oatext.com]

Congenital Heinz Body Hemolytic Anemia

fragility Direct Antiglobulin (Direct Coombs) Test The direct antiglobulin (direct Coombs) test is used to determine whether red blood cell (RBC)-binding antibody (IgG) or [merckmanuals.com]

However, they have a high osmotic fragility–when placed into water, they are more likely to burst than normal red blood cells. [theartofmed.wordpress.com]

[…] laboratory tests that can help discern the causes of hemolysis include the following: Quantitative hemoglobin electrophoresis RBC enzyme assays Flow cytometry Cold agglutinins Osmotic [merckmanuals.com]

Varicose Veins

These cells were more sensitive to hemolysis than red blood cells from the peripheral blood vein. [ncbi.nlm.nih.gov]

Changes in the plasma membrane of the erythrocytes from varicose vein were also confirmed by measuring osmotic fragility. [ncbi.nlm.nih.gov]

Febrile Transfusion Reaction

Red cell osmotic fragility was decreased. The cytofluorimetric analysis of red cells labelled with eosin 5 maleimide gave normal results. [bloodjournal.org]

The patient's blood group assessed by molecular biology testing was: genotype O1A2, phenotype A2; ccDee; K-k+; Jk(a+b-); Fy(a-b+); M+N+S+s-. [ashpublications.org]

The patient's blood group assessed by molecular biology testing was: genotype O 1 A 2, phenotype A 2 ; ccDee; K-k+; Jk(a+b-); Fy(a-b+); M+N+S+s-. [bloodjournal.org]

Capillary Fragility

[…] of red blood cells under conditions of increased stress. capillary fragility a condition in which weakened capillaries rupture easily when stressed, observed as bleeding [medical-dictionary.thefreedictionary.com]

A test of osmotic fragility is used in diagnosis of some types of hemolytic anemia. cap·il·lar·y fra·gil·i·ty the susceptibility of capillaries to breakage and extravasation [medical-dictionary.thefreedictionary.com]

Posthemorrhagic Anaemia of the Newborn

asymptomatic carrier state to severe hemolysis Elliptocytes 25 percent or more of red blood cells elliptocytic on peripheral blood smear G6PD deficiency Transient hemolysis [aafp.org]

target cells Hemoglobin electrophoresis Hereditary spherocytosis Childhood anemia, splenomegaly, jaundice Spherocytes Osmotic fragility test Hereditary elliptocytosis Variable [aafp.org]

Generally similar to homozygous sickle cell disease, except associated with fewer infections, less hemolysis and fewer crises, but more retinopathy and aseptic necrosis Sickle cells [aafp.org]