Osteopenia: Causes & Reasons

Possible Causes for Osteopenia

Osteopenia -- or seeing it turn into osteoporosis for that matter -- is not inevitable. [webmd.com]

Most fractures in postmenopausal women occur in those with osteopenia, so therapies that are effective in women with osteopenia are needed. [doi.org]

If they're hardy, you may never get osteopenia. If your bones aren't naturally dense, you may get it earlier. [webmd.com]

Gaucher Disease

Generalized rarefaction of bone (osteopenia) was present in 83.8%, and well-defined radiolucent lesions in 40.5%. [ncbi.nlm.nih.gov]

Dual-energy X-ray absorptiometry (DEXA) scanning: evaluation of osteopenia. [patient.info]

Elderly Parkinson disease/dementia Organomegaly Malignancies Hematological abnormalities Bone dysfunction, especially osteopenia Because Gaucher disease is inherited as an [emedicine.medscape.com]

Primary Hyperparathyroidism

[…] and bone demineralization [ edit ] Osteopenia and bone demineralization are present in all forms of hyperparathyroidism ===Subperiosteal. [en.wikibooks.org]

The resultant bone resorption produces cortical thinning (subperiosteal resorption) and osteopenia. [radiopaedia.org]

This leads to porous, brittle bones known as osteopenia and osteoporosis. [healthcentral.com]

Hypogonadotropic Hypogonadism Type 18

Women with hypogonadotropic hypogonadism are at a high risk of dislipidemia, urogenital disorders and osteopenia. [endocrine-abstracts.org]

Related symptoms: Autosomal dominant inheritance Hearing impairment Abnormality of the dentition Osteoporosis Osteopenia SOURCES: OMIM UMLS More info about HYPOGONADOTROPIC [mendelian.co]

[…] range from lack of energy, depressed mood, loss of vitality, muscle atrophy (sarcopenia), muscles aches, low libido, erectile dysfunction, and weight gain...to bone loss (osteopenia [tupincho.net]

Hyperparathyroidism

The resultant bone resorption produces cortical thinning (subperiosteal resorption) and osteopenia. [radiopaedia.org]

Abstract Neonatal severe hyperparathyroidism (NSHPT) is a rare, life-threatening condition that presents with severe hypercalcemia, hyperparathyroidism, and osteopenia in [ncbi.nlm.nih.gov]

Surgery may also help decrease bone loss for patients with osteopenia or osteoporosis. [froedtert.com]

Hypercalcemia

Williams syndrome Idiopathic Maternal hypoparathyroidism or maternal hypocalcemia may cause secondary fetal hyperparathyroidism, with changes in fetal mineralization (eg, osteopenia [msdmanuals.com]

[…] found during evaluation of patients with symptoms or findings that can be related to hypercalcemia, such as constipation, weakness, fatigue, depression, nephrolithiasis, or osteopenia [accessmedicine.mhmedical.com]

Hypogonadotropic Hypogonadism Type 21

Osteopenia MedGen UID: 148180 • Concept ID: C0747078 • Disease or Syndrome Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis [ncbi.nlm.nih.gov]

[…] and psychological disturbances. [5], [6], [7], [8] In addition to being infertile, women with HH suffer from conditions associated with a low estrogenic milieu, including osteopenia [fertilityscienceresearch.org]

[…] abnormalities (eg, a narrow bitemporal dimension, almond-shaped eyes, a mouth with thin upper lips and down-turned corners), and skeletal abnormalities (eg, scoliosis, kyphosis, osteopenia [merckmanuals.com]

Alpha-Mannosidosis

The skeletal abnormalities that can occur in this disorder include reduced bone density (osteopenia), thickening of the bones at the top of the skull (calvaria), deformations [clinicaltrials.gov]

Meanwhile, skeletal abnormalities characteristic of the disease may include osteopenia, bone thickening calvarial, deformation of the vertebrae, bowlegged or knock knees, [ivami.com]

[…] appearance of an affected individual includes the following: Intellectual disability; distinctive facial features; and skeletal abnormalities such as reduced bone density (osteopenia [ismrd.org]

Pompe Disease

Neurological & hearing impairment Osteoporosis/osteopenia Treatment Enzyme replacement therapy (ERT) Until recently in the UK treatment for Pompe disease was limited to supportive [cuh.nhs.uk]

Osteopenia and osteoporosis Osteopenia and osteoporosis have recently been recognized as complications of Pompe disease. [dx.doi.org]

Other symptoms may include osteopenia, delayed development and growth. [joe.bioscientifica.com]

Congenital Disorder of Glycosylation Type 1A

Osteopenia or osteoporosis was present in all patients of our cohort, sometimes with severe clinical implications. [ojrd.biomedcentral.com]

Adults with PMM2-CDG may live until their 7th or 8th decades with stable cognitive delay, peripheral neuropathy, and progressive thoracic and spinal kyphoscoliosis with osteopenia [ncbi.nlm.nih.gov]

As a rule there is osteopenia. A very common feature is cerebellar hypoplasia, which can usually be documented at or shortly after birth. [nature.com]

Kallmann Syndrome Type 2

Osteopenia MedGen UID: 18222 •Concept ID: C0029453 • Disease or Syndrome Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis [ncbi.nlm.nih.gov]

[…] of corpus callosum 0001274 Clinodactyly Permanent curving of the finger 0030084 Ectrodactyly Cleft hand Lobster claw hand [ more ] 0100257 Iris coloboma Cat eye 0000612 Osteopenia [rarediseases.info.nih.gov]

By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5. [ncbi.nlm.nih.gov]

Hypogonadotropic Hypogonadism Type 20

Affiliated tissues include pituitary and olfactory bulb, and related phenotypes are osteopenia and osteoporosis Disease Ontology : 12 A hypogonadotropic hypogonadism that [malacards.org]

By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5. [ncbi.nlm.nih.gov]

Gaucher Disease Type 1

They manifest as deformations, osteopenia that sometimes causes pathological fractures or vertebral compression, bone infarctions or even aseptic osteonecrosis. [orpha.net]

Dual-energy X-ray absorptiometry (DEXA) scanning: evaluation of osteopenia. [patient.info]

[…] evaluation and subsequent monitoring of hepatosplenomegaly, radiography and bone scintigraphy to detect bone lesions and complications, osteodensitometry for the evaluation of osteopenia [orpha.net]

Cadmium Poisoning

[…] normochromic anemia, renal lesions characterized by tubular atrophy and interstitial fibrosis (Cd nephropathy), and bone lesions characterized by an increase of osteoid and osteopenia [ncbi.nlm.nih.gov]

They can't do the surgery to allow him to pitch again until they find the cause of the osteopenia. [house.wikia.com]

A study by Kido et al. (1989) indicates that exposure to cadmium could cause osteopenia, particularly in women. [inchem.org]

Schimmelpenning-Feuerstein-Mims Syndrome

Generalized weakness, osteopenia, and intracranial aneurysms are features in some patients. Bone involvement may be highly asymmetrical. [disorders.eyes.arizona.edu]

[…] defects, irregularities in the bone contour and surface (20), altered size of individual bones, in particular bony enlargement (79), and more generalized findings such as osteopenia [iv.iiarjournals.org]

Hypogonadotropic Hypogonadism Type 19

Affiliated tissues include pituitary and olfactory bulb, and related phenotypes are osteopenia and hearing impairment Disease Ontology : 12 A hypogonadotropic hypogonadism [malacards.org]

An abdominal CT and DEXA scan revealed undescended testes and osteopenia, respectively. He was diagnosed as IHH. [omicsonline.org]

Congenital Disorder of Glycosylation Type 1B

Other features include pleural effusions, osteopenia, recurrent fractures, kyphosis, dystrophic limbs, weakness, and joint contractures. [accessanesthesiology.mhmedical.com]

[…] is variable initial mortality 20% if survive, psychomotor retardation, hypotnoia, ataxia, polyneuropathy, retinitis pigmentosa, transient stroke-like episodes, seizures osteopenia [emilytam.com]

Osteopenia or osteoporosis was present in all patients of our cohort, sometimes with severe clinical implications. [ojrd.biomedcentral.com]

Winchester Syndrome

[…] content Torg-Winchester syndrome Joe Segen 2016-11-28T07:07:36+00:00 ORTHOPAEDICS An autosomal recessive disorder (OMIM:259600) characterised by generalised osteolysis and osteopenia [newmedicalterms.com]

An autosomal recessive syndrome (OMIM:259600) characterised by generalised osteolysis and osteopenia, coarse face, corneal opacities, patches of thickened, hyperpigmented [medical-dictionary.thefreedictionary.com]

Torg-Winchester syndrome An autosomal recessive syndrome (OMIM:259600) characterised by generalised osteolysis and osteopenia, coarse face, corneal opacities, patches of thickened [medical-dictionary.thefreedictionary.com]

Wolcott-Rallison Syndrome

In our patient, osteopenia and generalized epiphyseal dysplasia were present. [jcrpe.org]

In our patient, osteopenia and generalized epiphyseal dysplasia were present. Figure 1. [docksci.com]

Conclusion: Major skeletal abnormalities of WRS are osteoporosis/osteopenia, thoracolumbar kyphosis, and bowing of the femur. [abstracts.eurospe.org]

Osteitis Fibrosa Cystica

CT chest demonstrated diffuse osteopenia with brown tumor on the left fourth rib. [shmabstracts.com]

Brown tumors are seen as expansile osteolytic lesions with osteopenia on plain radiographs and as well enhanced masses on CT. [shmabstracts.com]

X-ray showed pathologic fracture of the right femoral midshaft, severe osteopenia and multiple lytic intramedullary lesions with endosteal scalloping. [shmabstracts.com]

Senile Osteoporosis

The most common cause by far of osteopenia is osteoporosis. [rad.washington.edu]

In summary, calcium-placebo and calcium-25-OHD treatment were both associated with stable appendicular bone mineral content in women with senile osteopenia. [ncbi.nlm.nih.gov]

[…] patient-specific score determined from certain anatomic areas T score BMD relative to normal young matched controls (30-year-old women) Z score BMD relative to similar aged patients Osteopenia [orthobullets.com]

X-Linked Osteoporosis with Fractures

The most common cause by far of osteopenia is osteoporosis. [rad.washington.edu]

A T-score of minus 2.5 SD or less defines osteoporosis, while a score between minus 1 and minus 2.5 SD is considered osteopenia. [consumerreports.org]

Neonatal Severe Hyperparathyroidism

[…] in some infants and that appropriate medical management can preclude the need for surgical intervention in selected cases. hyperparathyroidism hypercalcemia hypocalciuria osteopenia [pediatrics.aappublications.org]

[…] patients with clinical histories of nephrolithiasis, nephrocalcinosis, osseous pain, subperiosteal resorption, and pathologic fractures, as well as in those with osteoporosis–osteopenia [reumatologiaclinica.org]

Chest radiograph revealed bell-shaped thoracic cage, multiple rib fractures and generalized osteopenia. [abstracts.eurospe.org]

Coats Plus Syndrome

Other features of Coats plus syndrome include low bone density (osteopenia), which causes bones to be fragile and break easily, and a shortage of red blood cells (anemia), [rarediseases.oscar.ncsu.edu]

We now provide an update on this family documenting the occurrence of skeletal defects comprising abnormal bone marrow, osteopenia, and sclerosis with a tendency to fractures [research.manchester.ac.uk]

[…] probable case of CRMCC with pre- and postnatal growth restriction, bilateral exudative retinopathy, a pathognomonic pattern of intracranial calcification, white matter disease, osteopenia [ncbi.nlm.nih.gov]

Infantile-Onset Pompe Disease

2019 Aug 1;117(4):271-278. doi: 10.5546/aap.2019.eng.271. [Article in English, Spanish] Affiliations PMID: 31339275 DOI: 10.5546/aap.2019.eng.271 Free article Infantile-onset Pompe disease: Diagnosis and management [Article in English, Spanish] Luisa B Bay et al. Arch Argent Pediatr. 2019. Free article Abstract in English,[…] [pubmed.ncbi.nlm.nih.gov]

Idiopathic Hypercalciuria

Recently, osteopenia has been found in a high percentage of IH children even at the time of diagnosis. [eurekaselect.com]

Morbidity associated with idiopathic hypercalciuria is chiefly related to kidney stone disease and bone demineralisation leading to osteopenia and osteoporosis. [cochrane.org]

When you finish that section, return to the menu page and click on "osteopenia". Be sure to try all the nephron segments to see the movies! [courses.washington.edu]

Rothmund-Thomson Syndrome

[…] sparse hair, eyelashes, and/or eyebrows small stature skeletal anomalies skeletal dysplasias 4 absent or malformed bones: radial ray anomalies (absent radii, absent thumb) osteopenia [radiopaedia.org]

These findings include atrophic skin and pigment changes, alopecia, osteopenia, cataracts, and an increased incidence of cancer for patients carrying RECQL4 germline mutations [ncbi.nlm.nih.gov]

[…] the subjects had at least one significant skeletal abnormality, the more common being abnormal metaphyseal trabeculation, brachymesophalangy, thumb aplasia or hypoplasia, osteopenia [ncbi.nlm.nih.gov]

Hypogonadotropic Hypogonadism Type 8

Osteopenia was equally severe in men with immature and mature bone ages, suggesting that abnormal bone development plays an important role in the osteopenia of men with idiopathic [annals.org]

Decreased testicular size ; Delayed skeletal maturation ; Gonadotropin deficiency ; Gynecomastia ; Hypogonadotrophic hypogonadism ; Hypoplasia of the uterus ; Micropenis ; Osteopenia [mousephenotype.org]

Affiliated tissues include pituitary, olfactory bulb and uterus, and related phenotypes are osteopenia and delayed skeletal maturation Disease Ontology : 12 A hypogonadotropic [malacards.org]

Bruck Syndrome

Our patient, S.K., is a 12-year-old male who presented with a diagnosis of osteogenesis imperfecta (OI) based on radiographic findings of generalized osteopenia, incomplete [jim.bmj.com]

We report on a boy who had congenital contractures with pterygia at birth and severe OI-like osteopenia and multiple fractures. [ncbi.nlm.nih.gov]

There are 21 reported cases of Bruck syndrome (BS), a rare autosomal recessive condition characterized by congenital contractures affecting the large joints, generalized osteopenia [jim.bmj.com]

Cerebrotendinous Xanthomatosis

Continuing Education Activity Cerebrotendinous xanthomatosis is a rare autosomal recessive lipid storage disease associated with abnormally high cholestanol levels in the blood, accumulating in the nervous system and other organ systems. The cholestanol accumulates most notably in the brain, tendons, eyes, arteries[…] [ncbi.nlm.nih.gov]