Osteopenia: Causes & Reasons

Possible Causes for Osteopenia

Osteopenia -- or seeing it turn into osteoporosis for that matter -- is not inevitable. [webmd.com]

Most fractures in postmenopausal women occur in those with osteopenia, so therapies that are effective in women with osteopenia are needed. [doi.org]

If they're hardy, you may never get osteopenia. If your bones aren't naturally dense, you may get it earlier. [webmd.com]

Gaucher Disease

Generalized rarefaction of bone (osteopenia) was present in 83.8%, and well-defined radiolucent lesions in 40.5%. [ncbi.nlm.nih.gov]

Dual-energy X-ray absorptiometry (DEXA) scanning: evaluation of osteopenia. [patient.info]

Elderly Parkinson disease/dementia Organomegaly Malignancies Hematological abnormalities Bone dysfunction, especially osteopenia Because Gaucher disease is inherited as an [emedicine.medscape.com]

Primary Hyperparathyroidism

[…] and bone demineralization [ edit ] Osteopenia and bone demineralization are present in all forms of hyperparathyroidism ===Subperiosteal. [en.wikibooks.org]

The resultant bone resorption produces cortical thinning (subperiosteal resorption) and osteopenia. [radiopaedia.org]

This leads to porous, brittle bones known as osteopenia and osteoporosis. [healthcentral.com]

Hypogonadotropic Hypogonadism Type 18

Women with hypogonadotropic hypogonadism are at a high risk of dislipidemia, urogenital disorders and osteopenia. [endocrine-abstracts.org]

Related symptoms: Autosomal dominant inheritance Hearing impairment Abnormality of the dentition Osteoporosis Osteopenia SOURCES: OMIM UMLS More info about HYPOGONADOTROPIC [mendelian.co]

[…] range from lack of energy, depressed mood, loss of vitality, muscle atrophy (sarcopenia), muscles aches, low libido, erectile dysfunction, and weight gain...to bone loss (osteopenia [tupincho.net]

Hyperparathyroidism

The resultant bone resorption produces cortical thinning (subperiosteal resorption) and osteopenia. [radiopaedia.org]

Surgery may also help decrease bone loss for patients with osteopenia or osteoporosis. [froedtert.com]

Abstract Neonatal severe hyperparathyroidism (NSHPT) is a rare, life-threatening condition that presents with severe hypercalcemia, hyperparathyroidism, and osteopenia in [ncbi.nlm.nih.gov]

Hyper-IgE Syndrome

Patients have coarse facial features, delayed shedding of baby teeth, osteopenia, and recurrent fractures. [msdmanuals.com]

Significant osteopenia should be screened for and managed under current guidelines for patients without a primary immunodeficiency disorder. [msdmanuals.com]

Hypercalcemia

Williams syndrome Idiopathic Maternal hypoparathyroidism or maternal hypocalcemia may cause secondary fetal hyperparathyroidism, with changes in fetal mineralization (eg, osteopenia [msdmanuals.com]

[…] found during evaluation of patients with symptoms or findings that can be related to hypercalcemia, such as constipation, weakness, fatigue, depression, nephrolithiasis, or osteopenia [accessmedicine.mhmedical.com]

Hypogonadotropic Hypogonadism Type 21

Osteopenia MedGen UID: 148180 • Concept ID: C0747078 • Disease or Syndrome Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis [ncbi.nlm.nih.gov]

[…] and psychological disturbances. [5], [6], [7], [8] In addition to being infertile, women with HH suffer from conditions associated with a low estrogenic milieu, including osteopenia [fertilityscienceresearch.org]

[…] abnormalities (eg, a narrow bitemporal dimension, almond-shaped eyes, a mouth with thin upper lips and down-turned corners), and skeletal abnormalities (eg, scoliosis, kyphosis, osteopenia [merckmanuals.com]

Alpha-Mannosidosis

The skeletal abnormalities that can occur in this disorder include reduced bone density (osteopenia), thickening of the bones at the top of the skull (calvaria), deformations [clinicaltrials.gov]

Meanwhile, skeletal abnormalities characteristic of the disease may include osteopenia, bone thickening calvarial, deformation of the vertebrae, bowlegged or knock knees, [ivami.com]

[…] appearance of an affected individual includes the following: Intellectual disability; distinctive facial features; and skeletal abnormalities such as reduced bone density (osteopenia [ismrd.org]

Pompe Disease

Neurological & hearing impairment Osteoporosis/osteopenia Treatment Enzyme replacement therapy (ERT) Until recently in the UK treatment for Pompe disease was limited to supportive [cuh.nhs.uk]

Osteopenia and osteoporosis Osteopenia and osteoporosis have recently been recognized as complications of Pompe disease. [dx.doi.org]

Other symptoms may include osteopenia, delayed development and growth. [joe.bioscientifica.com]

Congenital Disorder of Glycosylation Type 1A

Osteopenia or osteoporosis was present in all patients of our cohort, sometimes with severe clinical implications. [ojrd.biomedcentral.com]

Adults with PMM2-CDG may live until their 7th or 8th decades with stable cognitive delay, peripheral neuropathy, and progressive thoracic and spinal kyphoscoliosis with osteopenia [ncbi.nlm.nih.gov]

As a rule there is osteopenia. A very common feature is cerebellar hypoplasia, which can usually be documented at or shortly after birth. [nature.com]

Kallmann Syndrome Type 2

Osteopenia MedGen UID: 18222 •Concept ID: C0029453 • Disease or Syndrome Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis [ncbi.nlm.nih.gov]

[…] of corpus callosum 0001274 Clinodactyly Permanent curving of the finger 0030084 Ectrodactyly Cleft hand Lobster claw hand [ more ] 0100257 Iris coloboma Cat eye 0000612 Osteopenia [rarediseases.info.nih.gov]

By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5. [ncbi.nlm.nih.gov]

Hypogonadotropic Hypogonadism Type 20

Affiliated tissues include pituitary and olfactory bulb, and related phenotypes are osteopenia and osteoporosis Disease Ontology : 12 A hypogonadotropic hypogonadism that [malacards.org]

By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5. [ncbi.nlm.nih.gov]

Gaucher Disease Type 1

They manifest as deformations, osteopenia that sometimes causes pathological fractures or vertebral compression, bone infarctions or even aseptic osteonecrosis. [orpha.net]

Dual-energy X-ray absorptiometry (DEXA) scanning: evaluation of osteopenia. [patient.info]

[…] evaluation and subsequent monitoring of hepatosplenomegaly, radiography and bone scintigraphy to detect bone lesions and complications, osteodensitometry for the evaluation of osteopenia [orpha.net]

Cadmium Poisoning

[…] normochromic anemia, renal lesions characterized by tubular atrophy and interstitial fibrosis (Cd nephropathy), and bone lesions characterized by an increase of osteoid and osteopenia [ncbi.nlm.nih.gov]

They can't do the surgery to allow him to pitch again until they find the cause of the osteopenia. [house.wikia.com]

A study by Kido et al. (1989) indicates that exposure to cadmium could cause osteopenia, particularly in women. [inchem.org]

Schimmelpenning-Feuerstein-Mims Syndrome

Generalized weakness, osteopenia, and intracranial aneurysms are features in some patients. Bone involvement may be highly asymmetrical. [disorders.eyes.arizona.edu]

[…] defects, irregularities in the bone contour and surface (20), altered size of individual bones, in particular bony enlargement (79), and more generalized findings such as osteopenia [iv.iiarjournals.org]

Fabry Disease

Osteopenia is common in Fabry disease patients. 20 Gastrointestinal symptoms were found to be common patients with Fabry disease, as reported by Hoffmann et al in 2008. [dermaamin.com]

Osteopenia and osteoporosis: previously unrecognized manifestations of Fabry disease. Clin Genet 2005; 68 : 93–95. 81 Schiffmann R, Murray GJ, Treco D, Daniel P, et al. [nature.com]

Progressive infiltration of Gaucher cells in the bone marrow may lead to thinning of the cortex, pathologic fractures, bone pain, bony infarcts, and osteopenia. [emedicine.medscape.com]

Hypogonadotropic Hypogonadism Type 19

Affiliated tissues include pituitary and olfactory bulb, and related phenotypes are osteopenia and hearing impairment Disease Ontology : 12 A hypogonadotropic hypogonadism [malacards.org]

An abdominal CT and DEXA scan revealed undescended testes and osteopenia, respectively. He was diagnosed as IHH. [omicsonline.org]

Congenital Disorder of Glycosylation Type 1B

Other features include pleural effusions, osteopenia, recurrent fractures, kyphosis, dystrophic limbs, weakness, and joint contractures. [accessanesthesiology.mhmedical.com]

[…] is variable initial mortality 20% if survive, psychomotor retardation, hypotnoia, ataxia, polyneuropathy, retinitis pigmentosa, transient stroke-like episodes, seizures osteopenia [emilytam.com]

Osteopenia or osteoporosis was present in all patients of our cohort, sometimes with severe clinical implications. [ojrd.biomedcentral.com]

Wolcott-Rallison Syndrome

In our patient, osteopenia and generalized epiphyseal dysplasia were present. [jcrpe.org]

In our patient, osteopenia and generalized epiphyseal dysplasia were present. Figure 1. [docksci.com]

Conclusion: Major skeletal abnormalities of WRS are osteoporosis/osteopenia, thoracolumbar kyphosis, and bowing of the femur. [abstracts.eurospe.org]

Osteitis Fibrosa Cystica

CT chest demonstrated diffuse osteopenia with brown tumor on the left fourth rib. [shmabstracts.com]

Brown tumors are seen as expansile osteolytic lesions with osteopenia on plain radiographs and as well enhanced masses on CT. [shmabstracts.com]

X-ray showed pathologic fracture of the right femoral midshaft, severe osteopenia and multiple lytic intramedullary lesions with endosteal scalloping. [shmabstracts.com]

Winchester Syndrome

[…] content Torg-Winchester syndrome Joe Segen 2016-11-28T07:07:36+00:00 ORTHOPAEDICS An autosomal recessive disorder (OMIM:259600) characterised by generalised osteolysis and osteopenia [newmedicalterms.com]

An autosomal recessive syndrome (OMIM:259600) characterised by generalised osteolysis and osteopenia, coarse face, corneal opacities, patches of thickened, hyperpigmented [medical-dictionary.thefreedictionary.com]

Torg-Winchester syndrome An autosomal recessive syndrome (OMIM:259600) characterised by generalised osteolysis and osteopenia, coarse face, corneal opacities, patches of thickened [medical-dictionary.thefreedictionary.com]

Senile Osteoporosis

The most common cause by far of osteopenia is osteoporosis. [rad.washington.edu]

In summary, calcium-placebo and calcium-25-OHD treatment were both associated with stable appendicular bone mineral content in women with senile osteopenia. [ncbi.nlm.nih.gov]

[…] patient-specific score determined from certain anatomic areas T score BMD relative to normal young matched controls (30-year-old women) Z score BMD relative to similar aged patients Osteopenia [orthobullets.com]

X-Linked Osteoporosis with Fractures

The most common cause by far of osteopenia is osteoporosis. [rad.washington.edu]

A T-score of minus 2.5 SD or less defines osteoporosis, while a score between minus 1 and minus 2.5 SD is considered osteopenia. [consumerreports.org]

Coats Plus Syndrome

[…] characteristic features are: retinal telangiectasia and exudates (Coats disease); distinctive pattern of intracranial calcification with an associated leukodystrophy and brain cysts; osteopenia [anuariohde.com]

We now provide an update on this family documenting the occurrence of skeletal defects comprising abnormal bone marrow, osteopenia, and sclerosis with a tendency to fractures [research.manchester.ac.uk]

[…] probable case of CRMCC with pre- and postnatal growth restriction, bilateral exudative retinopathy, a pathognomonic pattern of intracranial calcification, white matter disease, osteopenia [ncbi.nlm.nih.gov]

Neonatal Severe Hyperparathyroidism

[…] in some infants and that appropriate medical management can preclude the need for surgical intervention in selected cases. hyperparathyroidism hypercalcemia hypocalciuria osteopenia [pediatrics.aappublications.org]

[…] patients with clinical histories of nephrolithiasis, nephrocalcinosis, osseous pain, subperiosteal resorption, and pathologic fractures, as well as in those with osteoporosis–osteopenia [reumatologiaclinica.org]

Chest radiograph revealed bell-shaped thoracic cage, multiple rib fractures and generalized osteopenia. [abstracts.eurospe.org]

Infantile-Onset Pompe Disease

2019 Aug 1;117(4):271-278. doi: 10.5546/aap.2019.eng.271. [Article in English, Spanish] Affiliations PMID: 31339275 DOI: 10.5546/aap.2019.eng.271 Free article Infantile-onset Pompe disease: Diagnosis and management [Article in English, Spanish] Luisa B Bay et al. Arch Argent Pediatr. 2019. Free article Abstract in English,[…] [pubmed.ncbi.nlm.nih.gov]

Idiopathic Hypercalciuria

Recently, osteopenia has been found in a high percentage of IH children even at the time of diagnosis. [eurekaselect.com]

Morbidity associated with idiopathic hypercalciuria is chiefly related to kidney stone disease and bone demineralisation leading to osteopenia and osteoporosis. [cochrane.org]

When you finish that section, return to the menu page and click on "osteopenia". Be sure to try all the nephron segments to see the movies! [courses.washington.edu]

Rothmund-Thomson Syndrome

[…] stenosis) and hypogonadism.1-3 Skeletal pathologies are present in up to two-thirds of the patients and include congenital long bone defects, absent or malformed bones, osteopenia [geneskin.org]

[…] sparse hair, eyelashes, and/or eyebrows small stature skeletal anomalies skeletal dysplasias 4 absent or malformed bones: radial ray anomalies (absent radii, absent thumb) osteopenia [radiopaedia.org]

These findings include atrophic skin and pigment changes, alopecia, osteopenia, cataracts, and an increased incidence of cancer for patients carrying RECQL4 germline mutations [ncbi.nlm.nih.gov]

Bruck Syndrome

Our patient, S.K., is a 12-year-old male who presented with a diagnosis of osteogenesis imperfecta (OI) based on radiographic findings of generalized osteopenia, incomplete [jim.bmj.com]

We report on a boy who had congenital contractures with pterygia at birth and severe OI-like osteopenia and multiple fractures. [ncbi.nlm.nih.gov]

There are 21 reported cases of Bruck syndrome (BS), a rare autosomal recessive condition characterized by congenital contractures affecting the large joints, generalized osteopenia [jim.bmj.com]