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202 Possible Causes for Osteopenia and Osteoporosis, Progressive Polyneuropathy

  • Chronic Alcoholism

    The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show[…][ncbi.nlm.nih.gov]

  • Diabetes Mellitus

    Lipodystrophies are a group of heterogeneous disorders characterized by varying degrees of body fat loss and predisposition to insulin resistance and its metabolic complications. Lipodystrophy associated metabolic abnormalities include insulin resistance, that often lead to diabetes mellitus and its complications,[…][ncbi.nlm.nih.gov]

  • Multiple Myeloma

    […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[radiopaedia.org] Fractures may occur if plasma cell tumors cause loss of bone density ( osteopenia or osteoporosis ) and weaken bones.[merckmanuals.com] Bisphosphonates (alendronate or zoledronic acid) have been shown to improve bone mineral density in MGUS patients with osteopenia/osteoporosis or osteoporotic fractures (grade[doi.org]

  • Waldenstrom Macroglobulinemia

    Neuropathy is typically slowly progressive, distal, symmetrical, and sensorimotor.[emedicine.medscape.com] POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) also may be associated with Waldenström macroglobulinemia.[emedicine.medscape.com]

  • Systemic Amyloidosis

    Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[doi.org] Bisphosphonates (alendronate or zoledronic acid) have been shown to improve bone mineral density in MGUS patients with osteopenia/osteoporosis or osteoporotic fractures (grade[doi.org] Patients usually present with familial amyloid polyneuropathy, with progressive peripheral and autonomic neuropathy; involvement of the heart or kidneys is variable.[doi.org]

  • Klinefelter Syndrome

    Two years before admission, the patient had difficulty in walking with progressive weakness.[ncbi.nlm.nih.gov] The percentage of osteopenia/osteoporosis in subjects with 25-hydroxyvitamin D deficiency was higher with respect to subjects with normal 25-hydroxyvitamin D and was not related[ncbi.nlm.nih.gov] […] and osteoporosis, tumors (breast and germ cells), systemic lupus erythematosus, rheumatoid arthritis, and Sjögren syndrome. [11, 12] This higher risk is comparable to the[emedicine.com]

  • Lethal Ataxia with Deafness and Optic Atrophy

    […] external ophthalmoplegia, sensorimotor polyneuropathy MRI: leukoencephalopathy (but they have no CNS dysfunction) Holocarboxylase Synthase Def AKA early-onset multiple carboxylase[quizlet.com] […] renal tubular acidosis Osteopetrosis-hypogammaglobulinemia syndrome Osteoporosis-macrocephaly-blindness-joint hyperlaxity syndrome Osteoporosis-oculocutaneous hypopigmentation[se-atlas.de] Clinical features in P3 were particularly misleading for an OPA1 related condition, with manifestations of early onset progressive spastic ataxia and sensory motor polyneuropathy[link.springer.com]

  • Fabry Disease

    […] sensomotor polyneuropathy and oesophagitis after 12 months of treatment.[ncbi.nlm.nih.gov] Osteopenia and osteoporosis: previously unrecognized manifestations of Fabry disease. Clin Genet 2005; 68 : 93–95. 81 Schiffmann R, Murray GJ, Treco D, Daniel P, et al.[nature.com] […] or osteoporosis, retarded growth, delayed puberty, priapism, unexplained fever, obstructive airway disease Diagnostic Criteria Fabry disease is diagnosed under the following[medicalhomeportal.org]

  • Endocrine Dysfunction

    [Familial progressive external opthalmoplegia, parkinsonism and polyneuropathy associated with POLG1 mutation] . Rinsho Shinkeigaku 54 , 417–422 (2014) 97. Pierce, S.[nature.com] Gonadal failure, sterility, and growth failure are common, as well as osteopenia and osteoporosis.[thalassemia.com] A small proportion also had osteopenia, osteoporosis, or hypercalciuria.[ncbi.nlm.nih.gov]

  • Paraparesis

    Results of a lumbar puncture were normal, and nerve conduction studies were suggestive of acquired demyelinating polyneuropathy.[cmaj.ca] Complex HSP involves additional neurologic symptoms and signs like ataxia, extra pyramidal signs, polyneuropathy, and cognitive decline.[ojrd.biomedcentral.com] Of the potential causes of primary adrenal insufficiency ( Table 1 ), adrenomyeloneuropathy (AMN) is the only one that is associated with progressive spastic paraparesis.[cmaj.ca]

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