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12 Possible Causes for Osteopenia and Osteoporosis, Proximal Interphalangeal Joint Space Narrowed

  • Hemochromatosis

    Involvement of proximal interphalangeal joints, radiographic joint space narrowing and cartilage destruction is often evident in hemochromatosis.[clinicaladvisor.com] […] and osteoporosis [5] Hair loss Koilonychia (spoon nails) Lab tests The diagnosis of hemochromatosis is based on clinical features of the disease.[emedicine.com] The second and third metacarpophalangeal joints are usually the first to be affected.[clinicaladvisor.com]

  • Rheumatoid Arthritis

    Abbreviations DAS: Disease Activity Score DMARD: disease-modifying antirheumatic drugs JSN: joint space narrowing MRI: magnetic resonance imaging PIP: proximal interphalangeal[doi.org] Complications of therapy may be seen, such as generalized osteoporosis from steroid usage.[emedicine.medscape.com] Large bony erosions and severe osteopenia predispose patients to relatively atraumatic fractures. Long-term steroid use also predisposes patients to avascular necrosis.[emedicine.medscape.com]

  • Primary Hyperparathyroidism

    Review Topic QID: 106788 1 Joint space narrowing at the proximal and distal interphalangeal joints 2 Osteoid matrix accumulation around bony trabeculae 3 Subperiosteal cortical[medbullets.com] This leads to porous, brittle bones known as osteopenia and osteoporosis.[healthcentral.com] Excess parathyroid hormone increases osteoclastic activity and bone turnover which causes osteopenia and osteoporosis.[clinicaladvisor.com]

  • Secondary Hyperparathyroidism

    Review Topic QID: 106788 1 Joint space narrowing at the proximal and distal interphalangeal joints 2 Osteoid matrix accumulation around bony trabeculae 3 Subperiosteal cortical[medbullets.com] Subperiosteal bone resorption of the distal phalanges, femoral and spine osteopenia, and osteoporosis in the radius were found.[ncbi.nlm.nih.gov] Osteopenia or osteoporosis was not present.[edmcasereports.com]

  • Juvenile Psoriatic Arthritis

    Joints mostly involved are distal interphalangeal, proximal interphalangeal, metatarsophalangeal, and metacarpophalangeal joints.[boneandspine.com] Basic radiographic changes in JIA include the following: Soft tissue swelling Osteopenia or osteoporosis Joint-space narrowing Bony erosions Intra-articular bony ankylosis[emedicine.medscape.com] Joint space narrowing is the earliest change visible change. Joint erosions can progress to complete dissolution of the bone. Pencil-in-cup deformity may be seen.[boneandspine.com]

  • Progressive Pseudorheumatoid Dysplasia

    Figure 2 Bony enlargement of metacarpophalangeal andproximal interphalangeal joints Figure 3 X-ray of the hands revealing swelling of themetacarpophalangeal and proximal[docslide.net] The characteristic radiographical features : narrow joint space with wide metaphyses and flat epiphyses, Osteopenia/ osteoporosis enlarged femoral heads with irregular acetabular[slideshare.net] Hands show enlarged epiphyses, widened metaphyses, and loss of or narrow joint spaces in the metacarpophalangeal and interphalangeal joints, particularly in the proximal interphalangeal[ncbi.nlm.nih.gov]

  • Enthesitis-Related Arthritis

    Long-term sequelae of polyarticular disease includes periarticular osteopenia, generalized increase in the size of epiphyses, accelerated bone age, narrowed joint spaces ([emedicine.medscape.com] They reveal findings such as soft tissue swelling, osteopenia, osteoporosis, narrowing of the joint spaces, periostitis, growth abnormalities, intra-articular bony ankylosis[symptoma.com] […] especially at the fourth and fifth proximal interphalangeal joints [PIPs] bilaterally), boutonniere deformities (at left third and fourth interphalangeal joints), and medial[emedicine.medscape.com]

  • X-Linked Spondyloepiphyseal Dysplasia Tarda

    There was minimal joint space narrowing at proximal interphalangeal joints, but there were no bone erosions.[ncbi.nlm.nih.gov] […] renal tubular acidosis Osteopetrosis-hypogammaglobulinemia syndrome Osteoporosis-macrocephaly-blindness-joint hyperlaxity syndrome Osteoporosis-oculocutaneous hypopigmentation[se-atlas.de] The range of motion was limited in the spine and the peripheral joints and she had deformities.[ncbi.nlm.nih.gov]

  • Spondyloepiphyseal Dysplasia - Spondyloepimetaphyseal Dysplasia

    X-ray of the hands showed periarticular osteoporosis, significant narrowing of the joint spaces of proximal interphalengial and distal interphalangeal joints and osseous enlargement[clinmedjournals.org] Because of generalize osteopenia in vertebral radiographs osteoporosis was assessed with dual energy X-ray absorptiometry (DEXA).[clinmedjournals.org] X-ray of the hands showed periarticular osteoporosis, significant narrowing of the joint spaces of PIP and distal interphalangeal (DIP) joints and osseous enlargement of the[clinmedjournals.org]

  • Hereditary Koilonychia

    Involvement of proximal interphalangeal joints, radiographic joint space narrowing and cartilage destruction is often evident in hemochromatosis.[clinicaladvisor.com] […] and osteoporosis: A cross-sectional study. 30226477 Slowly growing nodule in supralabial region. 30226476 Vismodegib treatment in a HIV positive patient on antiretroviral[nlm.life] The second and third metacarpophalangeal joints are usually the first to be affected.[clinicaladvisor.com]

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