Osteopenia and Osteoporosis & Sjogren's Syndrome: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Osteopenia and Osteoporosis, Sjogren's Syndrome,

Negated

None

Unsure

None

Possible Causes

Chronic Obstructive Pulmonary Disease

syndrome, bronchiolitis obliterans, lymphangioleiomyomatosis, and eosinophilic granuloma. [merckmanuals.com]

Co‐morbidity such as increased risk of cardiovascular disease ( Sin 2003 ), osteopenia or osteoporosis ( Biskobing 2002 ), metabolic disease ( Marquis 2005 ), cachexia and [doi.org]

[…] disorders that may have a component of airflow limitation may suggest COPD; they include HIV infection, abuse of IV drugs (particularly cocaine and amphetamines), sarcoidosis, Sjögren [merckmanuals.com]

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Rheumatoid Arthritis

syndrome, vasculitis, or amyloidosis, and/or emergence of an "overlap" syndrome or other rheumatic disorder. [ncbi.nlm.nih.gov]

Osteopenia or osteoporosis What tests to perform? [rheumatologyadvisor.com]

Sjogren’s Syndrome. [hopkinsarthritis.org]

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Celiac Disease

Celiac disease and markers of celiac disease latency in patients with primary Sjogren’s syndrome. Am J Gastroenterol. 1990;94:1042–6. Google Scholar 15. [doi.org]

Osteopenia and osteoporosis might cause bone pain for several reasons, including defective calcium transport by the diseased small intestine, vitamin D deficiency, and binding [symptoma.com]

Sjogren's syndrome (a disorder that causes insufficient moisture production by the glands). Autoimmune liver disorders. [my.clevelandclinic.org]

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Primary Biliary Cirrhosis

syndrome and Hashimoto's thyroiditis. [ncbi.nlm.nih.gov]

Osteopenia and osteoporosis. [albi-france.org]

PBC is associated with other autoimmune diseases such as Sjogren's syndrome, scleroderma, Raynaud's phenomenon and CREST syndrome and is regarded as an organ specific autoimmune [ncbi.nlm.nih.gov]

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Renal Tubular Acidosis

Classification criteria for Sjogren's syndrome: A critical review. J Autoimmun 2012;39:9-14. 19. Crooks GW, Zweiman B. An unusual presentation of Sjögren's syndrome. [sjkdt.org]

[…] or osteoporosis. [emedicine.medscape.com]

Prevalence and characterization of renal tubular acidosis in patients with osteopenia and osteoporosis and in non-porotic controls. [ccforum.biomedcentral.com]

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Osteoporosis

syndrome, systemic sclerosis, and healthy patients. [ncbi.nlm.nih.gov]

osteopenia and osteoporosis. [mag365.co.uk]

Osteopenia is the early stage of Osteoporosis. Having osteopenia places a person at risk of developing Osteoporosis. [irishosteoporosis.ie]

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Scurvy

Dry mouth and dry eyes similar to Sjögren syndrome may occur. [web.archive.org]

[…] of hip On physical examination, demonstrates acute hip pain On imaging studies, demonstrates sub-chondoral cortical loss and diffuse osteopenia of the femoral neck On history [wikidoc.org]

Other ocular impairments can be seen which include dry eye similar to the diagnosis of Sjögren syndrome, subconjunctival hemorrhage, and bleeding in the eyelid, retrobulbar [physio-pedia.com]

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Parkinson Disease

’s syndrome, Neurological Sciences, 10.1007/s10072-014-1907-1, 36, 5, (803-804), (2014). [dx.doi.org]

Parkinson's Tied to Higher Risk of Osteoporosis and Osteopenia. Medscape. Apr 3 2014. [Full Text]. Torsney KM, Noyce AJ, Doherty KM, et al. [emedicine.medscape.com]

syndrome administered ineffective immunosuppressant therapies, Medicine, 10.1097/MD.0000000000014984, 98, 14, (e14984), (2019). [oadoi.org]

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Proximal Renal Tubular Acidosis

’s Syndrome (see Sjogren’s Syndrome, [[Sjogrens Syndrome]]) Carbonic Anhydrase-Related Conditions Acetazolamide (Diamox) (see Acetazolamide, [[Acetazolamide]]) Physiology [mdnxs.com]

Inherited fructose intolerance Multiple myeloma Primary hyperparathyroidism Sjogren syndrome Wilson disease Vitamin D deficiency Clinical Features of PRTA Due to acidemia [medvin2u.net]

Inherited fructose intolerance Multiple myeloma Primary hyperparathyroidism Sjogren syndrome Wilson disease Vitamin D deficiency Symptoms Symptoms of distal renal tubular [coordinatedhealth.com]

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Sjögren Syndrome

Sjogren's syndrome. Lancet. 2005 Jul 23-29. 366(9482):321-31. [Medline]. Jonsson R, Haga H-J, Gordon TP. Sjogren's syndrome. [emedicine.com]

Osteopenia is a consequence of RA, decreased physical activity, and treatment with corticosteroids [ 185 – 188 ]. [doi.org]

The good news is that Sjogren’s syndrome does not have to impede your normal lifestyle. Several remedies are used to treat Sjogren’s syndrome effects. [symptoma.com]

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Vitamin D Deficiency

In fact, low levels of Vitamin D may cause flair ups of symptoms in people with these disorders: Lupus Sjogren's Syndrome Rheumatoid Arthritis Multiple Sclerosis Crohn's Disease [vitamins.lovetoknow.com]

Severe, prolonged vitamin D deficiency causes growth retardation and rickets in children and osteomalacia, osteopenia, and osteoporosis in adults. [bestpractice.bmj.com]

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by progressive lymphocyte infiltration of the exocrine glands. [ncbi.nlm.nih.gov]

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Systemic Lupus Erythematosus

We report the case of a 44-year-old woman admitted with pancytopenia and clinical features of systemic lupus erythematosus, Sjogren's syndrome and antiphospholipid antibodies [ncbi.nlm.nih.gov]

Osteopenia was present in 50.3% of patients and osteoporosis in 17.4%. At least one vertebral fracture was detected in 26.1%. [ncbi.nlm.nih.gov]

The test results showed peripheral cytopenias, hypoproteinemia, renal dysfunction and elevated CA 125, antidouble-stranded DNA antibodies, and anti-Sjogren's syndrome A antigen [ncbi.nlm.nih.gov]

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Cystic Fibrosis

Autoimmune conditions like reactive airways disease, interstitial cystitis, microscopic colitis, and Sjogren’s syndrome often occur in people with CF. [blogs.scientificamerican.com]

INTRODUCTION: In 2015, 11.9% of people with cystic fibrosis (CF) in the United States had osteopenia, 5.1% osteoporosis, and 0.3% experienced a fracture. [ncbi.nlm.nih.gov]

Weakened bones can lead to bone fractures, osteopenia, or osteoporosis. Cystic fibrosis can also cause swollen or painful joints (arthropathy or arthritis ). [northshore.org]

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Biliary Cirrhosis

calpastatin and alpha-fodrin in primary Sjögren's syndrome. [karger.com]

Osteopenia and osteoporosis. [albi-france.org]

Poorly calcified bones (osteopenia) characterize both osteoporosis and osteomalacia. [emedicinehealth.com]

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Cerebral Palsy

Complications of cerebral palsy include spasticity and contractures; feeding difficulties; drooling; communication difficulties; osteopenia; osteoporosis; fractures; pain; [ncbi.nlm.nih.gov]

Prevalence of 12 chronic conditions was evaluated, including existing diagnoses or historical record of osteopenia/osteoporosis, myocardial infarction, stroke, coronary artery [ncbi.nlm.nih.gov]

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Klinefelter Syndrome

Recently, a higher risk for RA, SLE and Sjogren’s syndrome in patients with KS has been clearly demonstrated. [content.sciendo.com]

Presently, it is not known when bone loss in KS begins and what interventions might prevent the progression of osteopenia into osteoporosis. [pediatricnursing.org]

Men who have Klinefelter syndrome also have an increased risk for autoimmune disorders such as lupus, rheumatoid arthritis and Sjogren's syndrome. [genome.gov]

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Adult Fanconi Syndrome

This led to the establishment of the diagnosis of Sjogren's syndrome. [neurologyindia.com]

and osteoporosis) Renal insufficiency References Please rate topic. [medbullets.com]

Skeletal X-Rays rickets, osteopenia, or osteoporosis Fanconi’s syndrome :aquired · An inherited blood disease · bone marrow fails to produce all types of blood cells. · Lack [sinoemedicalassociation.org]

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Myasthenia Gravis

Other less common associated conditions include: red cell aplasia, hypogammaglobulinemia polymyositis systemic lupus erythematosus rheumatoid arthritis Sjogren syndrome thyroiditis [rogelcancercenter.org]

A person with SMM may be prescribed bisphosphonates for symptoms of osteoporosis or osteopenia and/or a new therapy being studied in a clinical trial. [cancer.net]

syndrome. [reumatologiaclinica.org]

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Trisomy 21

We provide data on thyroid disease, cervical spine disease, hearing impairment, overweight-obesity, sleep apnea, congenital heart disease, and osteopenia-osteoporosis. [ncbi.nlm.nih.gov]

The prevalence of osteopenia ranged from 48% to 52%, and that of osteoporosis ranged from 19% to 22% depending on the site of measurement (femoral neck or lumbar spine, respectively [ncbi.nlm.nih.gov]

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Autoimmune Interstitial Lung Disease - Arthritis Syndrome

Interstitial lung disease in primary Sjogren’s syndrome: clinical-pathological evaluation and response to treatment. [kjim.org]

osteoporosis) · Thoracic imaging · Anemia · Dyspnea score · Anxiety & depression Pulmonary rehabilitation (optimal exercise program, patient education) Maintain ideal body-mass [transrespmed.springeropen.com]

’s syndrome Systemic lupus erythematosus Polymyositis Dermatomyositis Mixed connective tissue disease Undifferentiated connective tissue disease CTD-ILD causes inflammation [uclahealth.org]

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Non-Hodgkin Lymphoma

People with certain types of inflammatory autoimmune diseases, including rheumatoid arthritis, lupus, Sjogren's syndrome and celiac disease, are at greater risk of non-Hodgkin [health.ny.gov]

[…] or osteoporosis at the start of therapy; bone density may worsen after therapy for lymphoma.[ 18 ] References Mudie NY, Swerdlow AJ, Higgins CD, et al.: Risk of second malignancy [web.archive.org]

1 infection, Acquired hypogammaglobulinemia Autoimmune disease: Sjogren’s syndrome, Celiac sprue, Rheumatoid arthritis, Systemic lupus erythematosus Chemical or drug exposures [symptoma.com]

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Osteomalacia

Sjogren's syndrome (SS) is a connective tissue disorder commonly involving exocrine glands; however kidney involvement is also encountered, leading to abnormal phosphorus [ncbi.nlm.nih.gov]

Its causes are the same as those for Osteopenia (milder form of bone loss that usually precedes Osteoporosis.) [osteopenia3.com]

Investigations concluded to the diagnosis of primary Sjogren's syndrome. [ncbi.nlm.nih.gov]

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Fluoride Poisoning

Osteopenia thus resulted from osteonecrosis and osteoporosis. Subperiosteal exostoses were not observed in long bones. [ncbi.nlm.nih.gov]

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Hypergonadotropic Hypogonadism-Cataract Syndrome

Kuwait Farah et al. (1997) found two brothers affected with Marinesco-Sjogren syndrome (MSS) in a consanguineous Bedouin family. [cags.org.ae]

Osteopenia and osteoporosis are both characterized by a reduced bone mass and increased susceptibility to bone fracture. [bloodjournal.org]

In another series of 87 patients with hereditary hemochromatosis, osteoporosis was detected in 25% and osteopenia in 41%. [ojrd.biomedcentral.com]

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Diabetes Mellitus

syndrome patients is linked to proinflammatory cytokine exposure, Arthritis & Rheumatism, 62, 5, (1280-1289), (2010). [doi.org]

Isabel Castro, María‐José Barrera, Rafael Romo, Marcela Hermoso, Cecilia Leyton and María‐Julieta González, Disruption of tight junction structure in salivary glands from Sjögren's [doi.org]

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Aromatase Deficiency

Personal or family history of autoimmune disease, such as Addison’s, thyroid, DM I, SLE, rheumatoid arthritis, vitiligo, Crohn’s disease, and Sjogren’s syndrome, may suggest [clinicaladvisor.com]

At presentation, all men with aromatase deficiency have tall stature, delayed bone maturation, osteopenia or osteoporosis and eunuchoid skeletal proportions. [ncbi.nlm.nih.gov]

Estrogen deficiency can induce delayed epiphyseal closure, eunuchoid body habitus, osteopenia, and osteoporosis in both genders. [ncbi.nlm.nih.gov]

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Calcium Deficiency

It has also been reported in rheumatoid arthritis, scleroderma, and Sjogren syndrome. Rarely it is seen in porphyria cutanea tarda. [ncbi.nlm.nih.gov]

It saddens me to see older women diagnosed with “osteopenia” or “osteoporosis” listening to their doctors and taking supplemental calcium and even problematic drugs called [greenmedinfo.com]

Chronic untreated calcium deficiency can cause many severe consequences, including rickets, osteopenia, and osteoporosis. [naturalhealthadvisory.com]

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Iatrogenic Cushing's Disease

syndrome Skeletal muscle relaxants Skin and skin appendage Skin and soft tissue infections Skull Skull base syndromes Sleep and sleep disorders Slipped capital femoral epiphysis [amboss.com]

Bone mineral density measurement will determine the level of osteopenia or osteoporosis. [symptoma.com]

[…] and osteoporosis, depression and other psychological symptoms, hypertension, and menstrual disturbances ( oligomenorrhea and amenorrhea ) in women. [britannica.com]

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Polymyositis

There is also debate on whether or not to consider annular polycyclic subacute cutaneous lupus erythematosus (SCLE) and annular erythema associated with Sjögren's syndrome [ncbi.nlm.nih.gov]

Steroids can lead to an increased risk of thin bones (osteopenia or osteoporosis). [musculardystrophyuk.org]

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Primrose Syndrome

Sjogren's syndrome is also associated with rheumatic disorders. Sjogren's syndrome affects 1-4 million people in the United States. [massagetherapylaketahoe.com]

It is also used for rheumatoid arthritis, a type of arthritis that affects people with psoriasis, weak bones (osteoporosis), bone loss (osteopenia), Raynaud's syndrome, multiple [rxlist.com]

Dry eyes and mouth, called Sicca Syndrome, is common not only in Sjogren's but also in fibromyalgia and in common life. [tasteforlife.com]

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