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36 Possible Causes for Overproduction of Uric Acid and Purines

  • Hyperuricemia

    The typical cases with the type of uric acid overproduction are hypoxanthine guanine phosphoribosyl transferase deficiency due to HPRT gene abnormality, excessive consumption[ncbi.nlm.nih.gov] Abstract Xanthine oxidoreductase plays an important role in formation of uric acid and its regulation during purine catabolism.[ncbi.nlm.nih.gov] In humans, uric acid is the end product of purine metabolism, and hyperuricemia might be caused by an overproduction of or by disturbances in the elimination of uric acid.[doi.org]

  • Gouty Arthritis

    […] error of purine metabolism leads to the overproduction of retention of uric acid accounts for 90% of cases occures in middle aged men may be related to another acquired disorder[quizlet.com] Normal production of uric acid is considered to be 600 mg per day in men with normal renal function on a purine-free diet. 4 Overproduction of uric acid may occur because[aafp.org] Most of the remaining patients either overconsume purines or produce excessive amounts of uric acid endogenously (overproduction).[emedicine.com]

  • Gout

    Overproduction of uric acid Uric acid is the end product of purine metabolism.[symptoma.com] Humans do not express the enzyme uricase which degrades uric acid; an end product of purine nucleotide catabolism.[rheumatologyadvisor.com] Most of the remaining patients either overconsume purines or produce excessive amounts of uric acid endogenously (overproduction).[emedicine.com]

  • Pseudogout

    acid by the kidney, and not a problem with overproduction of uric acid (which is the result of overproduction of purine) Many patients have a uric acid level high enough[almostadoctor.co.uk] Most of the remaining patients either overconsume purines or produce excessive amounts of uric acid endogenously (overproduction).[emedicine.medscape.com] HGPRT – hypoxanthine guanine phosphoribosyl, OR, an overproduction of PRPP – 5-phosphoribosyl-1-pyrophosphate. in 75% of cases, the problem is a problem with excretion of uric[almostadoctor.co.uk]

  • Lesch Nyhan Syndrome

    It is a rare anomaly consisting of deficiency in the production of hypoxanthine phosphoribosyltransferase that leads to the overproduction of purine and accumulation of uric[ncbi.nlm.nih.gov] A complete deficiency of HPRT leads to severe purine overproduction and to uric acid renal lithiasis as a consequence.[ncbi.nlm.nih.gov] […] the accumulation of uric acid.[ncbi.nlm.nih.gov]

  • Urolithiasis

    Uric Acid Stones • Main determinants of uric acid stone formation – Urinary pH 5.5,  urine volume Hyperuricosuria • Genetic overproduction • Myeloproliferative disorders[de.slideshare.net] Uric Acid Stones 89.[de.slideshare.net] • High purine diet • Drugs 90.[de.slideshare.net]

  • Calcium-containing Renal Stone

    Uric Acid Stones Uric acid (UA) is an end product of purine metabolism that the body excretes in urine.[aacc.org] Both purine overproduction and excess purine ingestion favor formation of UA stones.[aacc.org]

  • Urate Kidney Stone

    Overproduction Overproduction of uric acid increases the likelihood of precipitation and therefore kidney stone formation.[healthhype.com] Uric Acid Stones Uric acid (UA) is an end product of purine metabolism that the body excretes in urine.[aacc.org] Further investigation is needed to determine the cause of the overproduction or decreased elimination of uric acid.[labtestsonline.org]

  • Crystal Arthropathy

    Synovial fluid analysis (look for crystals under polarized light) What percentage of patients with hyperuricemia and gout have abnormal OVERPRODUCTION of uric acid?[cram.com] Most of the remaining patients either overconsume purines or produce excessive amounts of uric acid endogenously (overproduction).[emedicine.medscape.com] 10% Primary- genetic defects, HGPRT deficiency (inhibits the purine salvage pathway so more urate is produced).[cram.com]

  • Acute Polyarticular Gouty Arthritis

    Humans do not express the enzyme uricase which degrades uric acid; an end product of purine nucleotide catabolism.[rheumatologyadvisor.com] : decreased renal clearance of urate Primary idiopathic uric and underexcretion Secondary uric acid underexcretion Chronic renal failure Hypertension Dehydration Obesity Hyperparathyroidism[rheumaknowledgy.com] In the majority, hyperuricemia is due to impaired renal uric acid excretion, rather than urate overproduction – which can largely occur in the setting of genetic or enzymatic[rheumatologyadvisor.com]

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