Pachyonychia: Causes & Reasons

Possible Causes for Pachyonychia

Pachyonychia congenita in pediatric patients natural history, features, and impact. [scholars.northwestern.edu]

There are two main clinical subtypes of pachyonychia congenita: Pachyonychia congenita-1 and pachyonychia congenita-2. [file.scirp.org]

Proteomic profiling of Pachyonychia congenita plantar callus. [ucdavis.pure.elsevier.com]

Onychomycosis

There was no family history of psoriasis, Darier's disease, pachyonychia congenita, or lichen planus. [jamanetwork.com]

Pachyonychia congenita This is a rare condition but must be excluded in children with thick nails. [tandfonline.com]

Pachyonychia congenita – Marked subungual hyperkeratosis with accumulation of hard keratinous material resulting in uplifting of the nail plate. [visualdx.com]

Ovarian Cyst

Pachyonychia congenita cornered: report on the 11th Annual International Pachyonychia Congenita Consortium Meeting. [ghr.nlm.nih.gov]

Oral lesions accompanying pachyonychia congenital. Oral Surg 1958;11:541-4. [PUBMED] 16. Hannaford RS, Stapleton K. Pachyonychia congenita tarda. [jiaomr.in]

How is pachyonychia congenita diagnosed? Pachyonychia congenita is usually diagnosed by its clinical appearance. [dermnetnz.org]

Psoriasis

Cutis. 2018 Mar;101(3S):10-12. Author information 1 School of Medicine, Stony Brook University, New York, USA. 2 Clinical Laboratory for Epidemiology and Applied Research in Skin, Department of Dermatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. Abstract Psoriasis is a complex chronic[…] [ncbi.nlm.nih.gov]

Upper Urinary Tract Infection

Pachyonychia congenita cornered: report on the 11th Annual International Pachyonychia Congenita Consortium Meeting. [ghr.nlm.nih.gov]

Svenska synonymer Jadassohn-Lewandowskys syndrom Engelska synonymer Pachyonychia Congenita Syndrome — Congenital Pachyonychia — Pachyonychia, Congenital — Pachyonychia Congenita [mesh.kib.ki.se]

How is pachyonychia congenita diagnosed? Pachyonychia congenita is usually diagnosed by its clinical appearance. [dermnetnz.org]

Diffuse Palmoplantar Keratoderma

Pachyonychia congenita is a very close differential diagnosis for this entity. [ncbi.nlm.nih.gov]

Pachyonychia congenita 5. Focal PPK associated w/esophageal carcinoma 32. [slideshare.net]

It is seen commonly in pachyonychia congenita with prominent nail involvement. [ijpd.in]

Pancytopenia

Pachyonychia congenita cornered: report on the 11th Annual International Pachyonychia Congenita Consortium Meeting. [ghr.nlm.nih.gov]

Oral lesions accompanying pachyonychia congenital. Oral Surg 1958;11:541-4. [PUBMED] 16. Hannaford RS, Stapleton K. Pachyonychia congenita tarda. [jiaomr.in]

How is pachyonychia congenita diagnosed? Pachyonychia congenita is usually diagnosed by its clinical appearance. [dermnetnz.org]

Palmoplantar Keratosis

Congenita ◦ KRT17-Related Pachyonychia Congenita ◦ KRT6A-Related Pachyonychia Congenita ◦ KRT6B-Related Pachyonychia Congenita ◦ Keratitis-Ichthyosis-Deafness Syndrome, Autosomal [genetests.org]

Pachyonychia congenita Orphanet Encylopedia., ( online PDF ) accessed 21/12/2008. 5. Thost A. Über erbliche Ichtyosis palmaris et plantaris cornea. Dissertation. [faoj.org]

Costa (10) Arsenhyperkeratosen (4) Dyskeratosis congenita (12) Fokale akrale Hyperkeratose (12) Hyperkeratotisch-rhagadiformes Hand- / Fußekzem (8) Lichen ruber planus (102) Pachyonychia [dermis.net]

Pachyonychia Congenita Type 1

Congenita Jadassohn-Lewandowsky Syndrome PACHYONYCHIA CONGENITA, JADASSOHN-LEWANDOWSKY TYPE Pachyonychia Congenita Type 1 edit English pachyonychia congenita rare group of [wikidata.org]

Follicular keratosis on the fathers knee and pachyonychia. Pachyonychia Congenita 25 section at 10 mo because of cephalopelvic disproportion. [docslide.com.br]

Pachyonychia congenita. J Paediatr Child Health 2008;44(6):386. [acta.tums.ac.ir]

White Sponge Nevus

Leukoedema may be confused with leukoplakia, Darier's disease, white sponge nevus, pachyonychia congenita, or candidal infection. [ncbi.nlm.nih.gov]

Mutation of a type II keratin gene (K6a) in pachyonychia congenita. Nat Genet 10:363365. [doi.org]

Keratin 16 and keratin 17 mutations cause pachyonychia congenita. Nat Genet 9: 273 - 278. [doi.org]

Sebocystomatosis

In the Jackson-Lawler form (PC-2), pachyonychia is accompanied by multiple pilosebaceous cysts, natal teeth, and hair abnormalities. [ncbi.nlm.nih.gov]

Department of Medical Genetics Indiana University School of Medicine 1100 West Michigan Street Indianapolis, Indiana 46202 U.S.A Abstract Pachyonychia congenita and steatocystoma [onlinelibrary.wiley.com]

Molloy, Pachyonychia congenita with laryngeal involvement, International Journal of Pediatric Otorhinolaryngology, 1987, 13, 2, 205 CrossRef [onlinelibrary.wiley.com]

Steatocystoma Multiplex With Natal Teeth

“Pachyonychia congenita”. 1996. pp. 246-7. (A clinical guide to identifying, diagnosing, and treating pachyonychia congenita.) Haber, RM. “Drummond D. [dermatologyadvisor.com]

Keywords: Late onset pachyonychia congenita, pachyonychia congenita, Pachyonychia congenita tarda How to cite this article: Sravanthi A, Srivalli P, Gopal K, Rao T N. [idoj.in]

A study in pachyonychia congenita. Clin Exp Dermatol. 2016; 41:26-33. [rarediseases.org]

Hidrotic Ectodermal Dysplasia

Clouston syndrome can mimic pachyonychia congenita. J Invest Dermatol. 2003 Nov;121(5):1035-8 Lamartine et al. Mutations in GJB6 cause hidrotic ectodermal dysplasia. [genedx.com]

Congenita 1 Pachyonychia Congenita 2 Palmoplantar Keratoderma and Congenital Alopecia 2 Palmoplantar Keratoderma and Congenital Alopecia, Autosomal Dominant Papillon-Lefevre [nfed.org]

Clouston syndrome can mimic pachyonychia congenita. [ncbi.nlm.nih.gov]

Congenital Leukonychia

[…] congenita syndrome Pachyonychia congenita type II of Jackson-Lawler Pachyonychia congenita type III of Schafer-Brunauer Polyonychia Racket nail Ridged nails Splinter hemorrhages [icd9data.com]

[…] disorder 5 nonsyndromic congenital nail disorder 6 nonsyndromic congenital nail disorder 7 nonsyndromic congenital nail disorder 8 Odontomicronychial Dysplasia Onycholysis + pachyonychia [rgd.mcw.edu]

For a discussion of pachyonychia congenita, see Chapter 650. [clinicalgate.com]

Chronic Arsenic Poisoning

We report a case of idiopathic portal hypertension which is related to chronic arsenic poisoning. Only 7 cases have been reported previously. The patient presented with bleeding esophageal varices. Splenomegaly and hyperkeratosis of palms and soles were later noted and led to the discovery of chronic arsenic[…] [ncbi.nlm.nih.gov]

Congenital Onychodysplasia

In 1991, Paller et al., have reported a late-onset form, termed 'pachyonychia congenita tarda'. In these cases pachyonychia is apparent during the teenage years. [handresearch.com]

Congenita 1 Pachyonychia Congenita 2 Palmoplantar Keratoderma and Congenital Alopecia 2 Palmoplantar Keratoderma and Congenital Alopecia, Autosomal Dominant Papillon-Lefevre [nfed.org]

Spondyloepimetaphyseal Dysplasia-Hypotrichosis Syndrome

[…] congenita 1 (PC1) [MIM: 167200 ] KRT6B P04259 non-pleiotropic Pachyonychia congenita 2 (PC2) [MIM: 167210 ] KRT74 Q7RTS7 pleiotropic Woolly hair autosomal dominant (ADWH) [sbg.bio.ic.ac.uk]

[…] congenita type 1 KRT16 Pachyonychia congenita type 2 KRT17 Pachyonychia congenita type 3 KRT6A Pachyonychia congenita type 4 KRT6B Paget disease of bone SQSTM1 Paget disease [centogene.com]

[…] congenita type 1 (KRT16) Cost: 30000.00 Test Offer Pachyonychia congenita type 2 (KRT17) Cost: 30000.00 Test Offer Pachyonychia congenita type 3 (KRT6A) Cost: 30000.00 Test [dnalabsindia.com]

Anonychia Congenita Totalis

Home Pachyonychia Congenita Home Pachyonychia Congenita Pachyonychia Congenita, Congenital Pachyonychia, Pachyonychia Congenita Type 1, Jadassohn Lewandowsky Syndrome, Pachyonychia [xpertdox.com]

Genetic diseases such as PACHYONYCHIA CONGENITA can result in malformed nails. [reference.md]

Such cases of pachyonychia congenita should be termed Garrick-Wilson pachyonychia congenita. (Pachyonychia Congenita [J&L].) [sites.google.com]

Oculo-Osteo-Cutaneous Syndrome

Congenita 1 Pachyonychia Congenita 2 Palmoplantar Keratoderma and Congenital Alopecia 2 Palmoplantar Keratoderma and Congenital Alopecia, Autosomal Dominant Papillon-Lefevre [nfed.org]

Tuomaala-Haapanen syndrome 211370 Oculotrichodysplasia 257960 Odontoonychodysplasia Odontotrichomelic syndrome Feire-Maia syndrome 273400 OroFacioDigital (OFD) syndrome 311200 Pachyonychia [keratin.com]

Oculodentodigital Dysplasia Oculotrichodysplasia Odonoonychodermal Dysplasia Ondontomicronychial Dysplasia Onychotrichodysplasia and Neutropenia Orofaciodigital Syndrome I Pachyonychia [nfed.org]

Prata-Libéral-Gonçalves Syndrome

PEPCK deficiency, mitochondrial Pachyonychia congenita Jackson Lawler type Paes Whelan Modi syndrome Paget disease extramammary Paget disease juvenile type Paget's disease [mindmappedia.com]

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Pa-Pd Pachydermoperiostosis Pachygyria Pachyonychia congenita Jackson Lawler type Pacman syndrome Paes Whelan Modi syndrome [bioreference.net]

Pachyonychia congenita Jackson Lawler type[?] Pacman syndrome[?] Paes Whelan Modi syndrome[?] Paget disease extramammary[?] Paget disease juvenile type[?] [encyclopedia.kids.net.au]

Hereditary Koilonychia

Such cases of pachyonychia congenita should be termed Garrick-Wilson pachyonychia congenita. (Pachyonychia Congenita [J&L].) [sites.google.com]

[Figure 9]. [1], [3], [7] Differential diagnoses included various hereditary PPKs with digital constriction like Olmsted's syndrome, striate PPK, Mal de Meleda syndrome, pachyonychia [jdrntruhs.org]

Garrick-Wilson Pachyonychia Congenita In my personal practice I have never seen a moderate to full-blown pachyonychia congenita. [sites.google.com]

Laryngeal Obstruction

A 2-year-old girl presented with typical clinical features of pachyonychia congenita shortly after birth. [ncbi.nlm.nih.gov]

Pachyonychia congenita is a genetic syndrome of epithelial dysplasia. [ncbi.nlm.nih.gov]

Pachyonychia congenita is a rare genodermatosis that can affect the larynx. Laryngeal obstruction is very unusual with only a few cases reported. [ncbi.nlm.nih.gov]

Pseudotyphus of California

Pachyonychia congenita PC What do we feel? It's a rare disease which normally occurs at any age, Its prevalence is unknown. Transmission: Autosomal dominant ... [aidweb.org]

■Pachyonychia congenita, Jackson-Lawler type ■Pachyonychia congenita, Jadassohn-Lewandowsky type ■Pacman dysplasia ■PACNS ■PAD ■PAF ■Pagetoid amyotrophic lateral sclerosis [wikicure.fandom.com]

[…] overgrowth, overgrowth-craniosynostosis-arthrogryposis, overhydrated, overlapping, overload, overriding, oxidase, oxycephaly, oxydase, oxydoreductase, P p2y12, pachygyria, pachyonychia [rapsodyonline.eurordis.org]

Congenital Ankyloblepharon

“Pachyonychia congenita”. 1996. pp. 246-7. (A clinical guide to identifying, diagnosing, and treating pachyonychia congenita.) Haber, RM. “Drummond D. [dermatologyadvisor.com]

Congenita 1 Pachyonychia Congenita 2 Palmoplantar Keratoderma and Congenital Alopecia 2 Palmoplantar Keratoderma and Congenital Alopecia, Autosomal Dominant Papillon-Lefevre [nfed.org]

Enrollment in the International Pachyonychia Congenita Research Registry and involvement with the Pachyonychia Congenita Project should be offered for social support and patient [dermatologyadvisor.com]

Autosomal Recessive Nail Dysplasia

O'Toole EA, Kaspar RL, Sprecher E, et al. (2014) Pachyonychia congenita cornered: report on the 11th Annual International Pachyonychia Congenita Consortium Meeting. [els.net]

6 Neuropathy, Hereditary Sensory, Type ID Oculotrichodysplasia Odontoonychodermal Dysplasia Odontotrichoungual-Digital-Palmar Syndrome Otopalatodigital Syndrome, Type I Pachyonychia [familydiagnosis.com]

Pfeiffer-Palm-Teller Syndrome

Pachydermoperiostosis Pachygyria Pachygyria with mental retardation and seizures Pachygyria frontotemporal Pachyonychia congenita Pachyonychia congenita type 1 Pachyonychia [personalizedcause.com]

Congenita 1; PC1 OMIM:167210 Pachyonychia Congenita 2; PC2 OMIM:615726 Pachyonychia Congenita 3; PC3 OMIM:615728 Pachyonychia Congenita 4; PC4 OMIM:260130 Pachyonychia Congenita [informatics.jax.org]

Pachyonychia congenita Jackson Lawler type[?] Pacman syndrome[?] Paes Whelan Modi syndrome[?] Paget disease extramammary[?] Paget disease juvenile type[?] [encyclopedia.kids.net.au]

Ectodermal Dysplasia

[…] differential considerations include: alopecia areata aplasia cutis congenita focal dermal hypoplasia syndrome incontinentia pigmenti Naegeli-Franceschetti-Jadassohn syndrome pachyonychia [radiopaedia.org]

The phenotypic and molecular genetic features of pachyonychia congenita. J Invest Dermatol. 2011 May. 131 (5):1015-7. [Medline]. [emedicine.medscape.com]

Pachyonychia congenita in pediatric patients: natural history, features, and impact. JAMA Dermatol. 2014 Feb. 150 (2):146-53. [Medline]. [emedicine.medscape.com]

Spondyloepiphyseal Dysplasia Type Cantú

[…] glomerulopathy Mandibuloacral dysplasia with type A lipodystrophy Neuralgic amyotrophy Osteogenesis imperfecta type 2 Osteogenesis imperfecta type 3 Osteogenesis imperfecta type 4 Pachyonychia [csbg.cnb.csic.es]

Ectodermal Dysplasias Hypohidrotic Ectodermal Dysplasia Rapp-Hodgkin Ectodermal Dysplasia Tricho-Dento-Osseous Syndrome Clouston Syndrome Cranioectodermal Dysplasia GAPO Syndrome Pachyonychia [amazon.co.jp]

Transcarbamylase Deficiency Orthostatic tremors Osteogenesis Imperfecta Osteoperosis Osteopetrosis Oxalosis & Hyperoxaluria Oxalosis & Hyperoxaluria P P450 Enzyme (HLADQ8) Pachygyria Pachyonychia [geneticalliance.org.au]

Exfoliative Ichthyosis

Preview Abstract A family with affected members, previously reported to carry an R94H mutation of keratin K17, and characterized by a variable and oligosymptomatic form of pachyonychia [karger.com]

[…] congenita KRT6B Pachyonychia congenita KRT6C Palmoplantar keratoderma, nonepidermolytic, focal or diffuse KRT16 Pachyonychia congenita, Palmoplantar keratoderma, nonepidermolytic [genda.com.ar]

[…] heels Corn and callus Juvenile plantar dermatosis Exfoliative keratolysis Pompholyx Palmoplantar psoriasis Keratoderma Acquired keratoderma Diffuse hereditary keratoderma Pachyonychia [dermnetnz.org]

Ainhum

Hereditary causes include pachyonychia congenita, Mal de Meleda, mutilating keratoderma, 6 lamellar ichthyosis, 7 and psoriasis. 8 – 10 Nonhereditary diseases include vascular [mhmedical.com]

Pseudo-ainhum may also occur in association with certain hereditary diseases such as Vohwinkel′s palmoplantar keratoderma, pachyonychia congenita, erythropoietic protoporphyria [ijdvl.com]