Pachyonychia: Causes & Reasons

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Possible Causes for Pachyonychia

Pachyonychia Congenita

Pachyonychia Congenita. 1993. [Medline]. Leachman SA, Kaspar RL, Fleckman P, et al. Clinical and pathological features of pachyonychia congenita. [emedicine.com]

Pachyonychia congenita Pachyonychia congenita has an autosomal dominant pattern of inheritance. [en.wikipedia.org]

Pachyonychia congenita. J Am Acad Dermatol. 1988 Oct. 19(4):705-11. [Medline]. Munro CS. Pachyonychia congenita: mutations and clinical presentations. [emedicine.com]

Onychomycosis

There was no family history of psoriasis, Darier's disease, pachyonychia congenita, or lichen planus. [jamanetwork.com]

Pachyonychia congenita This is a rare condition but must be excluded in children with thick nails. [tandfonline.com]

Pachyonychia congenita – Marked subungual hyperkeratosis with accumulation of hard keratinous material resulting in uplifting of the nail plate. [visualdx.com]

Ovarian Cyst

How is pachyonychia congenita diagnosed? Pachyonychia congenita is usually diagnosed by its clinical appearance. [dermnetnz.org]

Pachyonychia Congenita. 1993. [Medline]. Leachman SA, Kaspar RL, Fleckman P, et al. Clinical and pathological features of pachyonychia congenita. [emedicine.medscape.com]

A study in pachyonychia congenita. Clin Exp Dermatol. 2016; 41:26-33. [rarediseases.org]

Psoriasis

Signs and symptoms of psoriasis may include the following: Family history of similar skin condition Pruritus (mostly seen in eruptive, guttate psoriasis) Cutaneous erythematous plaques, pustules or small papules Erythema and scaling Joint pain Pain (mostly seen in erythrodermic psoriasis and in some instances of[…] [symptoma.com]

Upper Urinary Tract Infection

How is pachyonychia congenita diagnosed? Pachyonychia congenita is usually diagnosed by its clinical appearance. [dermnetnz.org]

A study in pachyonychia congenita. Clin Exp Dermatol. 2016; 41:26-33. [rarediseases.org]

Svenska synonymer Jadassohn-Lewandowskys syndrom Engelska synonymer Pachyonychia Congenita Syndrome — Congenital Pachyonychia — Pachyonychia, Congenital — Pachyonychia Congenita [mesh.kib.ki.se]

Palmoplantar Keratosis

Pachyonychia congenita Orphanet Encylopedia., ( online PDF ) accessed 21/12/2008. 5. Thost A. Über erbliche Ichtyosis palmaris et plantaris cornea. Dissertation. [faoj.org]

Congenita ◦ KRT17-Related Pachyonychia Congenita ◦ KRT6A-Related Pachyonychia Congenita ◦ KRT6B-Related Pachyonychia Congenita ◦ Keratitis-Ichthyosis-Deafness Syndrome, Autosomal [genetests.org]

Costa (10) Arsenhyperkeratosen (4) Dyskeratosis congenita (12) Fokale akrale Hyperkeratose (12) Hyperkeratotisch-rhagadiformes Hand- / Fußekzem (8) Lichen ruber planus (102) Pachyonychia [dermis.net]

Diffuse Palmoplantar Keratoderma

Pachyonychia congenita is a very close differential diagnosis for this entity. [ncbi.nlm.nih.gov]

Pachyonychia congenita 5. Focal PPK associated w/esophageal carcinoma 32. [slideshare.net]

It is seen commonly in pachyonychia congenita with prominent nail involvement. [ijpd.in]

Pancytopenia

How is pachyonychia congenita diagnosed? Pachyonychia congenita is usually diagnosed by its clinical appearance. [dermnetnz.org]

Pachyonychia Congenita. 1993. [Medline]. Leachman SA, Kaspar RL, Fleckman P, et al. Clinical and pathological features of pachyonychia congenita. [emedicine.medscape.com]

A study in pachyonychia congenita. Clin Exp Dermatol. 2016; 41:26-33. [rarediseases.org]

Hidrotic Ectodermal Dysplasia

Clouston syndrome can mimic pachyonychia congenita. J Invest Dermatol. 2003 Nov;121(5):1035-8 Lamartine et al. Mutations in GJB6 cause hidrotic ectodermal dysplasia. [genedx.com]

Congenita 1 Pachyonychia Congenita 2 Palmoplantar Keratoderma and Congenital Alopecia 2 Palmoplantar Keratoderma and Congenital Alopecia, Autosomal Dominant Papillon-Lefevre [nfed.org]

Clouston syndrome can mimic pachyonychia congenita. [ncbi.nlm.nih.gov]

Pachyonychia Congenita Type 1

Congenita Jadassohn-Lewandowsky Syndrome PACHYONYCHIA CONGENITA, JADASSOHN-LEWANDOWSKY TYPE Pachyonychia Congenita Type 1 edit English pachyonychia congenita rare group of [wikidata.org]

Rittié, Pachyonychia congenita cornered: report on the 11th Annual International Pachyonychia Congenita Consortium Meeting, British Journal of Dermatology, 171, 5, (974-977 [doi.org]

1; Pachyonychia Congenita, Jadassohn-Lewandowsky Type; Type 1 Pachyonychia Congenita; Type 2 Pachyonychia Congenita; Congenita, Pachyonychia; Jackson Lawler Type Pachyonychia [curehunter.com]

Pfeiffer-Palm-Teller Syndrome

Pachydermoperiostosis Pachygyria Pachygyria with mental retardation and seizures Pachygyria frontotemporal Pachyonychia congenita Pachyonychia congenita type 1 Pachyonychia [personalizedcause.com]

Congenita 1; PC1 OMIM:167210 Pachyonychia Congenita 2; PC2 OMIM:615726 Pachyonychia Congenita 3; PC3 OMIM:615728 Pachyonychia Congenita 4; PC4 OMIM:260130 Pachyonychia Congenita [informatics.jax.org]

Pachyonychia congenita Jackson Lawler type[?] Pacman syndrome[?] Paes Whelan Modi syndrome[?] Paget disease extramammary[?] Paget disease juvenile type[?] [encyclopedia.kids.net.au]

White Sponge Nevus

Leukoedema may be confused with leukoplakia, Darier's disease, white sponge nevus, pachyonychia congenita, or candidal infection. [ncbi.nlm.nih.gov]

Mutation of a type II keratin gene (K6a) in pachyonychia congenita. Nat Genet 10:363365. [doi.org]

Keratin 16 and keratin 17 mutations cause pachyonychia congenita. Nat Genet 9: 273 - 278. [doi.org]

Sebocystomatosis

Like steatocystoma multiplex, pachyonychia congenita involves the growth of steatocystomas. [ghr.nlm.nih.gov]

In the familial form of steatocystoma multiplex, mutations are localized to the keratin 17 ( K17 ) gene in areas identical to mutations found in patients with pachyonychia [emedicine.medscape.com]

Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2. Br J Dermatol. 1998 Sep;139(3):475-80. [ghr.nlm.nih.gov]

Steatocystoma Multiplex With Natal Teeth

A study in pachyonychia congenita. Clin Exp Dermatol. 2016; 41:26-33. [rarediseases.org]

Keywords: Late onset pachyonychia congenita, pachyonychia congenita, Pachyonychia congenita tarda How to cite this article: Sravanthi A, Srivalli P, Gopal K, Rao T N. [idoj.in]

J Investig Dermatol Symp Proc 2005 A large mutational study in pachyonychia congenita Wilson et al. [pubfacts.com]

Congenital Leukonychia

[…] congenita syndrome Pachyonychia congenita type II of Jackson-Lawler Pachyonychia congenita type III of Schafer-Brunauer Polyonychia Racket nail Ridged nails Splinter hemorrhages [icd9data.com]

[…] disorder 5 nonsyndromic congenital nail disorder 6 nonsyndromic congenital nail disorder 7 nonsyndromic congenital nail disorder 8 Odontomicronychial Dysplasia Onycholysis + pachyonychia [rgd.mcw.edu]

For a discussion of pachyonychia congenita, see Chapter 650. [clinicalgate.com]

Congenital Onychodysplasia

In 1991, Paller et al., have reported a late-onset form, termed 'pachyonychia congenita tarda'. In these cases pachyonychia is apparent during the teenage years. [handresearch.com]

Congenita 1 Pachyonychia Congenita 2 Palmoplantar Keratoderma and Congenital Alopecia 2 Palmoplantar Keratoderma and Congenital Alopecia, Autosomal Dominant Papillon-Lefevre [nfed.org]

Chronic Arsenic Poisoning

Abstract Symptomatic arsenic poisoning is not often seen in occupational exposure settings. Attempted homicide and deliberate long-term poisoning have resulted in chronic toxicity. Skin pigmentation changes, palmar and plantar hyperkeratoses, gastrointestinal symptoms, anemia, and liver disease are common.[…] [ncbi.nlm.nih.gov]

Spondyloepimetaphyseal Dysplasia-Hypotrichosis Syndrome

[…] congenita 1 (PC1) [MIM: 167200 ] KRT6B P04259 non-pleiotropic Pachyonychia congenita 2 (PC2) [MIM: 167210 ] KRT74 Q7RTS7 pleiotropic Woolly hair autosomal dominant (ADWH) [sbg.bio.ic.ac.uk]

[…] congenita type 1 KRT16 Pachyonychia congenita type 2 KRT17 Pachyonychia congenita type 3 KRT6A Pachyonychia congenita type 4 KRT6B Paget disease of bone SQSTM1 Paget disease [centogene.com]

[…] congenita type 1 (KRT16) Cost: 30000.00 Test Offer Pachyonychia congenita type 2 (KRT17) Cost: 30000.00 Test Offer Pachyonychia congenita type 3 (KRT6A) Cost: 30000.00 Test [dnalabsindia.com]

Prata-Libéral-Gonçalves Syndrome

PEPCK deficiency, mitochondrial Pachyonychia congenita Jackson Lawler type Paes Whelan Modi syndrome Paget disease extramammary Paget disease juvenile type Paget's disease [mindmappedia.com]

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Pa-Pd Pachydermoperiostosis Pachygyria Pachyonychia congenita Jackson Lawler type Pacman syndrome Paes Whelan Modi syndrome [bioreference.net]

Pachyonychia congenita Jackson Lawler type[?] Pacman syndrome[?] Paes Whelan Modi syndrome[?] Paget disease extramammary[?] Paget disease juvenile type[?] [encyclopedia.kids.net.au]

Oculo-Osteo-Cutaneous Syndrome

Congenita 1 Pachyonychia Congenita 2 Palmoplantar Keratoderma and Congenital Alopecia 2 Palmoplantar Keratoderma and Congenital Alopecia, Autosomal Dominant Papillon-Lefevre [nfed.org]

Tuomaala-Haapanen syndrome 211370 Oculotrichodysplasia 257960 Odontoonychodysplasia Odontotrichomelic syndrome Feire-Maia syndrome 273400 OroFacioDigital (OFD) syndrome 311200 Pachyonychia [keratin.com]

Oculodentodigital Dysplasia Oculotrichodysplasia Odonoonychodermal Dysplasia Ondontomicronychial Dysplasia Onychotrichodysplasia and Neutropenia Orofaciodigital Syndrome I Pachyonychia [nfed.org]

Patterson Pseudoleprechaunism Syndrome

OMIM:600356 Pachydermodactyly, Familial OMIM:610279 Pachygyria, Frontotemporal OMIM:600176 Pachygyria with Mental Retardation, Seizures, and Arachnoid Cysts OMIM:167200 Pachyonychia [informatics.jax.org]

Anonychia Congenita Totalis

Home Pachyonychia Congenita Home Pachyonychia Congenita Pachyonychia Congenita, Congenital Pachyonychia, Pachyonychia Congenita Type 1, Jadassohn Lewandowsky Syndrome, Pachyonychia [xpertdox.com]

Genetic diseases such as PACHYONYCHIA CONGENITA can result in malformed nails. [reference.md]

Such cases of pachyonychia congenita should be termed Garrick-Wilson pachyonychia congenita. (Pachyonychia Congenita [J&L].) [sites.google.com]

Hereditary Koilonychia

Such cases of pachyonychia congenita should be termed Garrick-Wilson pachyonychia congenita. (Pachyonychia Congenita [J&L].) [sites.google.com]

[Figure 9]. [1], [3], [7] Differential diagnoses included various hereditary PPKs with digital constriction like Olmsted's syndrome, striate PPK, Mal de Meleda syndrome, pachyonychia [jdrntruhs.org]

Garrick-Wilson Pachyonychia Congenita In my personal practice I have never seen a moderate to full-blown pachyonychia congenita. [sites.google.com]

Ectodermal Dysplasia

[…] differential considerations include: alopecia areata aplasia cutis congenita focal dermal hypoplasia syndrome incontinentia pigmenti Naegeli-Franceschetti-Jadassohn syndrome pachyonychia [radiopaedia.org]

The phenotypic and molecular genetic features of pachyonychia congenita. J Invest Dermatol. 2011 May. 131 (5):1015-7. [Medline]. [emedicine.com]

Pachyonychia congenita in pediatric patients: natural history, features, and impact. JAMA Dermatol. 2014 Feb. 150 (2):146-53. [Medline]. [emedicine.com]

Congenital Ankyloblepharon

“Pachyonychia congenita”. 1996. pp. 246-7. (A clinical guide to identifying, diagnosing, and treating pachyonychia congenita.) Haber, RM. “Drummond D. [dermatologyadvisor.com]

Congenita 1 Pachyonychia Congenita 2 Palmoplantar Keratoderma and Congenital Alopecia 2 Palmoplantar Keratoderma and Congenital Alopecia, Autosomal Dominant Papillon-Lefevre [nfed.org]

Enrollment in the International Pachyonychia Congenita Research Registry and involvement with the Pachyonychia Congenita Project should be offered for social support and patient [dermatologyadvisor.com]

Autosomal Recessive Nail Dysplasia

O'Toole EA, Kaspar RL, Sprecher E, et al. (2014) Pachyonychia congenita cornered: report on the 11th Annual International Pachyonychia Congenita Consortium Meeting. [els.net]

6 Neuropathy, Hereditary Sensory, Type ID Oculotrichodysplasia Odontoonychodermal Dysplasia Odontotrichoungual-Digital-Palmar Syndrome Otopalatodigital Syndrome, Type I Pachyonychia [familydiagnosis.com]

Pseudotyphus of California

Pachyonychia congenita PC What do we feel? It's a rare disease which normally occurs at any age, Its prevalence is unknown. Transmission: Autosomal dominant ... [aidweb.org]

■Pachyonychia congenita, Jackson-Lawler type ■Pachyonychia congenita, Jadassohn-Lewandowsky type ■Pacman dysplasia ■PACNS ■PAD ■PAF ■Pagetoid amyotrophic lateral sclerosis [wikicure.fandom.com]

[…] overgrowth, overgrowth-craniosynostosis-arthrogryposis, overhydrated, overlapping, overload, overriding, oxidase, oxycephaly, oxydase, oxydoreductase, P p2y12, pachygyria, pachyonychia [rapsodyonline.eurordis.org]

Ainhum

Hereditary causes include pachyonychia congenita, Mal de Meleda, mutilating keratoderma, 6 lamellar ichthyosis, 7 and psoriasis. 8 – 10 Nonhereditary diseases include vascular [mhmedical.com]

Rapp-Hodgkin Syndrome

[…] ectodermal dysplasia syndrome, is related to split-hand/foot malformation 1 and ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3, and has symptoms including pachyonychia [malacards.org]

Congenita 1 Pachyonychia Congenita 2 Palmoplantar Keratoderma and Congenital Alopecia 2 Palmoplantar Keratoderma and Congenital Alopecia, Autosomal Dominant Papillon-Lefevre [nfed.org]

Milium

[…] shall be stated: Congenital milia may indicate more severe pathologies, e.g., Bazex-Dupré-Christol syndrome, Brooke–Spiegler syndrome, oral-facial-digital syndrome type I, pachyonychia [symptoma.com]

Juvenile milia Associated with Rombo syndrome, basal cell naevus syndrome, Bazex-Dupre-Christol syndrome, pachyonychia congenita, Gardner syndrome and other genetic disorders [dermnetnz.org]